Application of a Compound Chinese Medicine in Prevention and Treatment of Osteoporosis
A technology of osteoporosis and compound traditional Chinese medicine, which is applied in the field of medicine, can solve the problems of no osteoporosis, uncertain long-term curative effect, and many side effects, so as to increase the number of osteoblasts per unit, enhance the developmental function of sexual organs, The effect of improving bone structure
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Embodiment 1
[0025] Example 1 Experimental Study of VAOF in the Prevention and Treatment of Osteoporosis in Ovariectomized Rats
[0026] Decreased androgen is one of the important causes of osteoporosis in elderly men. In this study, the model of kidney deficiency and porosis reproduced by detestation of 8-month-old male rats was used to prevent and treat with different doses of VAOF, and to conduct a comparative study with the positive drug Tridin. The curative effect mechanism of porosis provides a scientific basis for the further development and research of VAOF.
[0027] 1. Materials
[0028] (1) Drugs: VAOF, provided by the Institute of Traditional Chinese Medicine of Guangdong College of Pharmacy (Ligustrum lucidum 15, Daji 10, Atractylodes macrocephala 10, Salvia miltiorrhiza 10, Coptis 5, Sanqi 5, Eucommia 10 and Bergamot 10), batch number: 100502, The positive drug, Tridin, was provided by Italian Rotta Pharmaceuticals, batch number: 2010024. This drug is used for the treat...
example 2
[0050] Example 2 Prevention and treatment effect of VAOF on ovariectomized osteoporosis in rats
[0051] 1. Materials
[0052] (1) Drugs: VAOF, provided by the Institute of Traditional Chinese Medicine of Guangdong College of Pharmacy (Ligustrum lucidum 15, Daji 10, Atractylodes macrocephala 10, Salvia miltiorrhiza 10, Coptis 5, Sanqi 5, Eucommia 10 and Bergamot 10), batch number: 100502, Positive drug oyster calcium carbonate tablets, Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd., batch number: T90016; E 2 The detection kit was provided by Beijing Kemei Dongya Biotechnology Co., Ltd., batch number: 110325.
[0053] (2) Animals: 72 32-week-old, clean-grade, SD female rats with a body weight of (390±20g) were selected and fed with common feeds formulated by the Guangdong Provincial Experimental Branch Center, referring to AIN-93M rodents For animal feed formulations, replace ingredients derived from soybeans in the feed with appropriate substances to avoid interfer...
Embodiment 4
[0137] Example 4 : Effect of VAOF on hydrocortisone-induced osteoporosis in rats
[0138] Excessive use of cortisol drugs is one of the important causes of drug-induced osteoporosis. In this study, adult male rats were subcutaneously injected with hydrocortisone (36mg / kg) to reproduce the drug-induced osteoporosis model induced by excessive cortisol drugs, and different doses of VAOF were used for prevention and treatment. (Tridin) conducted a comparative study, aiming to explore the efficacy of Zhenzhu Tiaozhi Decoction in treating osteoporosis induced by excessive use of corticosteroids, and to provide a scientific basis for the further development and research of Zhenzhu Tiaozhi Decoction.
[0139] 1. Materials and methods
[0140] (1) Drugs: VAOF, provided by the Institute of Traditional Chinese Medicine of Guangdong College of Pharmacy (Ligustrum lucidum 15, Daji 10, Atractylodes macrocephala 10, Salvia miltiorrhiza 10, Coptis 6, Sanqi 6, Eucommia 10 and Bergamot 10)...
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