A Chinese herbal medicine extract preparation for the treatment of Alzheimer's disease - Naofukang

Abstract

The invention discloses a drug combination for treating Alzheimer's disease and a preparation method thereof. The raw materials are as follows by weight: 10 parts of ginseng, 20 parts of Acanthopanax senticosus, 15 parts of processed Strychnos nux vomica, 27 parts of Placenta, 12 parts of Sanguisorba officinalis, 12 parts of Gastrodia elata, 23 parts of Earthworm, 6 parts of Polygala tenuifolia, 6 parts of Semen Gepu, and 3 parts of Licorice. Compared with conventional quality drugs for treating Alzheimer's disease, the drug combination has the effects of anti-aging and enhancing memory, can effectively treat Alzheimer's disease, sequelae of brain trauma, cranial nerve diseases, etc., with precise efficacy, low side effects, and broad medical application prospects.

Description

Technical Field This invention belongs to the field of traditional Chinese medicine compositions, and more specifically, relates to a drug composition for treating Alzheimer's disease. Furthermore, this invention also relates to a method for preparing a drug composition for treating Alzheimer's disease. This invention relates to a method for preparing a traditional Chinese medicine composition for treating Alzheimer's disease. Background Technology Alzheimer's disease, also known as multi-infarct dementia, is clinically characterized primarily by varying degrees of intellectual impairment. It is accompanied by personality disorders, emotional disturbances, memory impairment, behavioral disturbances, and irritable neurological symptoms and signs. Clinically, it has two main characteristics:

[0003] 1. Changes in personality: The patient becomes subjective, willful, selfish, narrow-minded, dislikes socializing, lacks affection and moral sense towards family members, and is suspicious. In severe cases, the patient may be unable to take care of themselves, appear naked in public, or even commit illegal acts.

[0004] 2. Memory impairment, with memory decline being particularly significant. Things that have just been done will be forgotten, the way home cannot be remembered when going out, and people seen a few days ago cannot be recognized. In traditional Chinese medicine, this disease falls under the categories of "forgetfulness" and "depression". As people age, their qi and blood are deficient, nutrition is imbalanced, the functions of the five internal organs are disordered, clear yang fails to rise, and external evils invade, which can trigger this disease.

[0005] Currently, there are many Western medicines for treating Alzheimer's disease. These drugs can only temporarily alleviate the decline in patients' cognitive function, but cannot slow down the progression of the disease. Moreover, Western medicines have serious adverse reactions such as liver and kidney toxicity, and are expensive. Summary of the Invention

[0006] The purpose of this invention is to provide a drug combination for treating Alzheimer's disease and its preparation method, so as to solve the problems mentioned in the background art.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A drug combination for treating Alzheimer's disease, the raw materials of which are as follows by weight: Compared with the prior art, the beneficial effects of the present invention are: Compared with conventional Alzheimer's drugs, the present invention has anti-aging and memory-enhancing effects, can effectively treat Alzheimer's disease, has a definite curative effect, low side effects, and has broad medical application prospects; Ginseng, greatly replenishes qi and blood; Polygala tenuifolia: calms the mind and nourishes intelligence, relieves forgetfulness and palpitations, insomnia and dreaminess; Gynostemma pentaphyllum: opens the orifices and clears phlegm, relieves forgetfulness and deafness, and improves appetite; Licorice: tonifies the spleen and replenishes qi, harmonizes the effects of other drugs. It also has the following effects: disperses nodules and reduces swelling, unblocks the meridians and relieves pain, removes blood stasis; invigorates blood, relieves pain, removes blood stasis and stops bleeding, promotes tissue regeneration and heals sores; Acanthopanax senticosus; for spleen and lung qi deficiency, physical weakness and fatigue, loss of appetite; Placenta hominis; warms the kidneys and replenishes essence, invigorates qi and nourishes blood; Eupolyphaga sinensis; breaks up blood stasis and eliminates symptoms, removes blood stasis; Strychnos nux-vomica, carefully processed.

[0011] A method for preparing a drug combination for treating Alzheimer's disease includes the following steps:

[0012] S1. Ginseng 10 parts, Acanthopanax senticosus 20 parts, Polygala tenuifolia 6 parts, Poria cocos 9 parts, Glycyrrhiza uralensis 3 parts. Dragon's blood 12 parts, Strychnos nux-vomica 15 parts, Gastrodia elata 12 parts, Eupolyphaga sinensis 23 parts. Grind into small pieces and pass through a 50-mesh sieve. The material that passes through the sieve is further crushed and sieved repeatedly to ensure the particle size of the raw materials.

[0013] S2. Add water and decoct 3-5 times. Add eight times the amount of water for the first time, and gradually reduce the amount of water for the remaining times. After each decoction, pass the liquid through a 150-mesh sieve to remove the dregs and obtain the filtrate.

[0014] S3. Mix the filtrates obtained after each decoction together, simmer over low heat for 15-30 minutes, and then concentrate the mixed filtrate to remove water under low pressure using a Chinese medicine concentration device.

[0015] S4. Use a drug drying device to dry the concentrate in S3 to obtain a clear extract or extract. Crush the clear extract or extract and filter it using a 200-mesh sieve. Drugs with qualified particle size are vacuum-packed.

[0016] Preferably, in S3, simmering over low heat is used, with each simmering time being 1-2 hours, and the first simmering time being the longest.

[0017] Preferably, the low-pressure conditions for concentration in S3 are 0.05-0.08 MPa, and all equipment used for concentration is disinfected and sterilized.

[0018] Preferably, the vacuum packaging bag in S4 is sterilized by high-pressure steam and then dried in a sterile room to prevent the vacuum packaging bag from being contaminated and affecting the quality of the drug.

[0019] Compared with existing technologies, the beneficial effects of this invention are: Compared with conventional drugs for Alzheimer's disease, this invention has anti-aging and memory-enhancing effects, can effectively treat Alzheimer's disease, has a definite curative effect, low side effects, and has broad medical application prospects; Ginseng, greatly replenishes qi and blood; Polygala tenuifolia: calms the mind and nourishes intelligence, relieves forgetfulness, palpitations, insomnia, and excessive dreaming; Gynostemma pentaphyllum: opens the orifices and resolves phlegm, relieves forgetfulness and deafness, and improves appetite; Licorice: tonifies the spleen and replenishes qi, harmonizes various drugs. It disperses nodules and reduces swelling, unblocks meridians and relieves pain, and treats blood stasis; it invigorates blood, relieves pain, resolves blood stasis and stops bleeding, promotes tissue regeneration and heals sores; Acanthopanax senticosus: for spleen and lung qi deficiency, physical weakness and fatigue, and loss of appetite; Placenta hominis: for warming the kidneys and replenishing essence, replenishing qi and nourishing blood; Eupolyphaga sinensis: for breaking up blood stasis and resolving masses. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0021] Ginseng 10 parts, Acanthopanax senticosus 20 parts, Polygala tenuifolia 6 parts, Poria cocos 9 parts, Pueraria lobata 3 parts, Glycyrrhiza uralensis 3 parts. Dragon's blood 12 parts, Strychnos nux-vomica 15 parts, Gastrodia elata 12 parts, Eupolyphaga sinensis 23 parts.

[0022] Specifically, the ginseng produced from Changbai Mountain forest ginseng

[0023] Specifically, the Gastrodia elata variety mentioned is Changbai Mountain Gastrodia elata. Strychnine seeds are carefully prepared

[0024] This invention also provides a method for preparing a drug combination for treating Alzheimer's disease, comprising the following steps:

[0025] S1. Grind 10 parts ginseng, 20 parts Acanthopanax senticosus, 6 parts Polygala tenuifolia, 9 parts Poria cocos, 3 parts Glycyrrhiza uralensis, 12 parts Dragon's Blood, 15 parts Strychnos nux-vomica, 12 parts Gastrodia elata, and 23 parts Eupolyphaga sinensis into small pieces and pass them through a 50-mesh sieve. Continue to crush the material that is not sieved through a 50-mesh sieve and repeat the sieving process to ensure the particle size of the raw materials.

[0026] S2. Add water and decoct 3-5 times. Add eight times the amount of water for the first time, and gradually reduce the amount of water for the remaining times. After each decoction, pass the liquid through a 150-mesh sieve to remove the dregs and obtain the filtrate.

[0027] S3. Mix the filtrates obtained after each decoction together, simmer over low heat for 15-30 minutes, and then concentrate the mixed filtrate to remove water under low pressure using a Chinese medicine concentration device.

[0028] S4. Use a drug drying device to dry the concentrate in S3 to obtain a clear extract or extract. Crush the clear extract or extract and filter it using a 200-mesh sieve. Drugs with qualified particle size are vacuum-packed.

[0029] Specifically, S3 uses a low heat for simmering, with each simmering time being 1-2 hours, and the first simmering time being the longest.

[0030] Specifically, the low-pressure conditions for concentration in S3 are 0.05-0.08 MPa, and all equipment used for concentration is disinfected and sterilized.

[0031] Specifically, the vacuum packaging bags in S4 are sterilized by high-pressure steam and then dried in a sterile room to prevent contamination of the vacuum packaging bags and thus avoid affecting the quality of the medicine.

[0032] Case: Mr. Wang, 73 years old, was in a daze all day, talking to himself, doubting his family, forgetful, unable to recognize relatives, and constipated. After taking the medicine according to Example 1 for 30 days, his daze and talking to himself improved significantly, and his constipation also improved. After taking the medicine for 4 months, he was cured.

[0033] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A drug combination for treating Alzheimer's disease, characterized in that, The raw materials are as follows by weight: 10 parts ginseng, 20 parts Acanthopanax senticosus, 6 parts Polygala tenuifolia, 9 parts Poria cocos, 9 parts Acorus gramineus, 3 parts Glycyrrhiza uralensis, 12 parts Dragon's Blood, 15 parts Strychnos nux-vomica, 12 parts Gastrodia elata, and 23 parts Eupolyphaga sinensis. The ingredients are crushed and passed through a 50-mesh sieve.

2. The drug combination for treating Alzheimer's disease according to claim 1, characterized in that... The ingredients are as follows by weight: 10 parts ginseng, 20 parts Acanthopanax senticosus, 6 parts Polygala tenuifolia, 9 parts Poria cocos, 9 parts Acorus tatarinowii, 3 parts Glycyrrhiza uralensis, 12 parts Dragon's Blood, 10 parts Strychnos nux-vomica, 12 parts Gastrodia elata, and 23 parts Eupolyphaga sinensis.

3. A method for preparing the drug combination for treating Alzheimer's disease according to claim 1, characterized in that, Includes the following steps: S1. Grind 10 parts of ginseng, 20 parts of Acanthopanax senticosus, 6 parts of Polygala tenuifolia, 9 parts of Poria cocos, 9 parts of Acorus tatarinowii, 6 parts of Citrus reticulata peel, 3 parts of Glycyrrhiza uralensis, 12 parts of Draconis draco, 10 parts of Strychnos nux-vomica, 12 parts of Gastrodia elata, and 23 parts of Eupolyphaga sinensis into small pieces and pass them through a 50-mesh sieve. Continue to crush the material that passes through the sieve and repeat the sieving process to ensure the particle size of the raw materials. S2. Add water and decoct 3-5 times. Add eight times the amount of water for the first time, and gradually reduce the amount of water for the remaining times. After each decoction, pass the liquid through a 150-mesh sieve to remove the dregs and obtain the filtrate. S3. Mix the filtrates obtained after each decoction together, simmer over low heat for 15-30 minutes, and then concentrate the mixed filtrate to remove water under low pressure using a traditional Chinese medicine concentration device.

4. Use a drug drying device to dry the concentrate in S3 to obtain a clear extract or an extract. Crush the clear extract or extract and filter it through a 200-mesh sieve. Drugs with qualified particle size are vacuum-packed.

5. The method for preparing a drug combination for treating Alzheimer's disease according to claim 4, characterized in that: S3 uses a low heat for simmering, with each simmering time being 1-2 hours, and the first simmering time being the longest.

6. The method for preparing a drug combination for treating Alzheimer's disease according to claim 4, characterized in that: The low-pressure conditions for concentration in S3 are 0.05-0.08 MPa, and all equipment used for concentration is disinfected and sterilized.