Application of linarin in preparation of medicine for preventing or treating renal fibrosis

Abstract

The invention provides application of linarin in preparation of a medicine for preventing or treating renal fibrosis, and belongs to the technical field of medical application. Researches find that the linarin can down-regulate the expression levels of YAP, CTGF and inflammatory factors IL-6, IL-1beta and TNF-alpha, and on the basis, the linarin or the pharmaceutically acceptable salt, ester or solvate thereof can be used for preparing the medicine for preventing and treating renal fibrosis caused by unilateral ureter obstruction or fibroblast hyperplasia. According to the present invention, the pharmaceutical composition can effectively inhibit the one-side ureter obstruction, can reverse the kidney injury caused by the one-side ureter obstruction, can improve the renal dysfunction caused by the one-side ureter obstruction, can provide the new drug selection for the application scenario requiring the down-regulation of the expression levels of YAP, CTGF and the like, and can provide the important guiding significance for the prevention and treatment of the renal fibrosis and the kidney injury, the renal dysfunction and other diseases caused by the renal fibrosis. And the linarin has no obvious toxic or side effect, is definite in curative effect, safe and controllable, and has a relatively high practical application value.