The invention relates to empladstrum of Shexiang Zhuifeng acesodyne plaster and a preparation method of the empladstrum. The empladstrum is prepared from plaster and an independently-packaged wettingagent, wherein the plaster comprises a viscous backing layer, an agentia layer adhered to the viscous backing layer and a covering layer covering the backing layer and the agentia layer. Agentia in the agentia layer is powdery ointment of the Shexiang Zhuifeng acesodyne plaster. The powdery ointment is mainly prepared from the following raw materials: radix aconiti agrestis, raw common monkshood mother root, frankincense, myrrh, raw semen strychni, flos caryophylli, cortex cinnamomi, herba schizonepeta, radix saposhnikoviae, geranium wilfordii, cortex periplocae, herba centellae, rhizoma drynariae, radix angelicae dahuricae, rhizoma kaempferiae, rhizoma zingiberis, moschus, folium rutae graveolens extract powder, belladonna liquid extract, camphor, borneolum syntheticum, menthol, methyl salicylate, rosin and zinc oxide. The plaster disclosed by the invention has the advantages of good curative effects, high air permeability, no allergic irritation and easiness in evulsion; the method has the advantages of simple technology, low energy consumption, no environmental pollution and suitability for large-scale production.