Oil adjuvant of inactivated vaccine

An inactivated vaccine and oil adjuvant technology, which is applied to medical preparations containing active ingredients, antibody medical ingredients, refining to remove heteroatoms, etc., can solve the problem of poor performance stability of white oil injections, unstable vaccine performance, and fragile Dairy product performance and other issues, to achieve the effect of reducing vaccine cost, small resistance, and single component
CN101474403AActive Publication Date: 2009-07-08兆丰华生物科技(南京)有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
兆丰华生物科技(南京)有限公司
Publication Date
2009-07-08

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Abstract

The invention relates to an oil adjuvant of inactivated vaccine. The oil adjuvant consists of white oil for injection and mannitol olein which are mixed in volume proportion of 90:10 to 100:8. The oil adjuvant of the inactivated vaccine has the advantages that: 1) the oil adjuvant of the inactivated vaccine is convenient for use, the process for manufacturing the inactivated vaccine is simplified, the inactivated vaccine is manufactured by one step in stead of three steps at present, and the cost of the vaccine is reduced; 2) the oil adjuvant of the inactivated vaccine is almost nontoxic, the content of aromatic hydrocarbon of the white oil used in the invention is low and is less than 50ppm, after the vaccine is injected into an animal body, the vaccine causes very small erythema and does not influence the quality and the appearance of meat; and 3) the oil adjuvant of the inactivated vaccine has low viscosity coefficient, has low resistance for pushing a pin when being used for animal epidemic prevention injection and is convenient for injecting.
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Description

technical field

[0001] The invention relates to intermediate preparations for animal inactivated vaccines, in particular to oil adjuvants for inactivated vaccines. Background technique

[0002] At present, the production process of inactivated vaccines generally requires three steps: the first step is to mix the white oil for injection and the oil-soluble emulsifier evenly, the second step is to mix the antigen solution and the water-soluble emulsifier evenly, and the third step is to mix the above two steps evenly The solutions are put together for emulsification to prepare a uniform and stable water-in-oil inactivated vaccine. The method is complicated in process, long in process, high in energy consumption and low in production efficiency. The main reason is that oil-soluble emulsifiers are insoluble in water, and water-soluble emulsifiers are insoluble in oil, so the emulsification process must be completed in three steps. Both oil-soluble and water-soluble emulsifiers...

Claims

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