24 results about "Methyl hydroxybenzoate" patented technology

The present application relates to toothpaste technical field, specifically, it relates to the bacteriostatic oral care toothpaste based on active ingredient of mountain ardisia. It includes sorbitol, hydrated silicon stone, deionized water, polyethylene glycol-8, sodium lauryl sulfate, essence, polyquaternium-22, cellulose glue, sodium saccharin, hydroxypropyl guar gum, sodium methyl hydroxybenzoate and mountain ardisia extract;The bacteriostatic oral care toothpaste based on active ingredient of mountain ardisia, by introducing the mountain ardisia extract with specific chemical composition into the formula system, effectively solve the problem that the existing oral care product is not strong in specificity to periodontal pathogenic bacteria, and the bacteriostatic spectrum is relatively single;The mutual synergistic effect relationship exists between the extract, not only broaden the inhibition spectrum of periodontal pathogenic microorganism, also can reduce the oxidative stress and inflammatory response of gingival tissue, thereby maintaining oral cleaning, improve the comprehensive performance of oral care product and the mildness of use.

The present invention belongs to the field of drug therapy, and specifically relates to the use of methyl parahydroxybenzoate and its sodium salt in the preparation of drugs for treating viral infectious diseases. The present invention discloses the use of methyl parahydroxybenzoate, its sodium salt and its inhalation preparation in the treatment of coronavirus infectious diseases. By verifying the new use of methyl parahydroxybenzoate and its sodium salt inhalation solution in a mouse test infected with human coronavirus HCoV-229E, the technical solution has novelty, and an efficacy test of meta-cresol inhalation solution in treating pneumonia caused by HCoV-229E virus infection was conducted. The results showed that methyl parahydroxybenzoate and its sodium salt inhalation solution showed good efficacy in the lung index and inhibition rate of pneumonia mice infected with HCoV-229E virus, and could significantly reduce the mouse lung index.

This invention discloses a biocatalytic method for the synthesis of resorcinol-based O-glycosides, belonging to the field of bioengineering technology. This invention uses CaGT83 as a biocatalyst, and 3,5-dihydroxypropylbenzene, 3,5-dihydroxytoluene, resorcinol, 3,5-dihydroxybenzonitrile, methyl 3,5-dihydroxybenzoate, and 6-hydroxyindole as acceptor substrates, with endogenously generated UDP-glucose from *E. coli* as the donor substrate, catalyzing the synthesis of various O-glycosides. The whole-cell catalyst of this invention exhibits over 95% activity and specific selectivity for all six tested substrates at a substrate concentration of 3 mM, demonstrating application value in the synthesis of resorcinol-based O-glycosides.

The invention relates to a novel total synthesis method of a natural product Atriicepheol A and an analogue thereof, and belongs to the technical field of organic chemistry. Economical and easily available 2, 4-dihydroxy methyl benzoate is used as a raw material, a compound 1 is synthesized through a functional group protection strategy, and the compound 1 is subjected to methylation and hydrolysis reaction to obtain a compound 3; introducing an aldehyde group into sesamol to obtain a compound 4; the compound 3 and the compound 4 are subjected to a condensation reaction to obtain a compound 5, and the compound 5 is subjected to MOM group removal under the acidic condition to obtain the natural product Atriicepheol A (6). And then the compound 6 is respectively subjected to methylation and acetylation to synthesize analogues 7 and 8 of the compound Atriicepheol A. The synthesis method has the advantages of economical and easily available raw materials, simple operation and high yield, is suitable for large-scale production, and can provide a large amount of raw materials for biological activity research.

The invention relates to the technical field of polycarboxylic acid dispersing agents, and discloses a preparation method and application of a polycarboxylic acid dispersing agent, hydroxyl in 3, 5-dihydroxy methyl benzoate and epoxypropane are subjected to ring opening polymerization under the catalysis of boron trifluoride diethyl ether to obtain a polyether intermediate 1, the polyether intermediate 1 is placed in a sodium hydroxide solution for a reaction, and the polycarboxylic acid dispersing agent is obtained. The allyl carboxyl polyether is obtained. Allyl carboxyl polyether, sodium 4-vinyl benzene sulfonate and hydroxyethyl acrylate are subjected to initiation copolymerization under the action of ammonium persulfate to obtain the polycarboxylic acid dispersing agent. Finally, adding talcum powder, a polycarboxylic acid dispersing agent, a defoaming agent, a flatting agent and a coalescing agent into the styrene-acrylic solution, and uniformly stirring to obtain the styrene-acrylic coating. The polycarboxylic acid dispersing agent prepared by the preparation method disclosed by the invention is applied to a coating, and can play a better dispersing role on the coating and enhance the stability of the coating.

This invention discloses a gel formulation containing human platelet-derived growth factor (PDGF). The components and dosages are as follows: PDGF 50,000-300,000 IU / mL, sodium carboxymethyl cellulose 3.0-4.5%, polyvinyl alcohol 0.5-3%, disodium hydrogen phosphate dodecahydrate 0.258-0.774%, sodium dihydrogen phosphate monohydrate 0.039-0.116%, sodium chloride 0.6-0.95%, methylparaben 0.15-0.18%, propylparaben 0.015-0.020%, and protein protectant 0.4-0.6%. This invention, through optimization of the gel matrix combination and ratio, enables the gel to possess excellent stability and skin adhesion, improves the biological activity of the formulation, and promotes cell proliferation and wound repair at the wound site. It also offers advantages such as a pleasant user experience and simple processing.

The invention relates to a poly (aromatic ester-ether)-based biodegradable material polyester and a preparation method thereof. The method comprises the following steps: firstly, taking 3-allyl-4-hydroxybenzoate and cyclohexyl-1, 4-dimethyl alcohol monovinyl ether as monomers, and synthesizing poly (aromatic ester-ether) dihydric alcohol through emulsion polymerization; and carrying out esterification and polycondensation on the polyester, organic dibasic acid, 2, 4-methyl dihydroxybenzoate, a polyfunctional cross-linking agent and a stabilizer under the action of a catalyst to prepare the novel poly (aromatic ester-ether)-based biodegradable material polyester. According to the method, traditional 1, 4-butanediol is replaced with methyl 2, 4-dihydroxybenzoate, so that cyclization side reaction is effectively inhibited, tetrahydrofuran is prevented from being generated, and consistency and stability of product quality are guaranteed. The obtained polyester material has excellent biodegradability and mechanical tensile property, and is suitable for plastic products such as mulching films, packaging bags and the like which need to be completely degraded and have enough mechanical strength requirements.

The application discloses a kind of 4-methyl 4-hydroxybenzoate organic single crystals and preparation method and application thereof, and relates to the technical field of organic crystal.The method comprises uniformly dispersing 4-methyl 4-hydroxybenzoate polycrystal material in acetone, then removing impurities and insoluble substances by filtration to obtain a filtered solution;the filtered solution is placed at 0-5℃ for 12-48 hours to obtain 4-methyl 4-hydroxybenzoate organic single crystals.The application effectively overcomes the problems of poor crystalline quality, small crystal size, complex process and high equipment requirement in the growth of existing 4MHB crystals by combining low-temperature solvent evaporation method with low-temperature seed crystal method, thereby realizing the growth of large-size and high-quality 4MHB single crystals.

The invention provides a broad-spectrum feed for artificial feeding of subfamily shin longhorn beetles, which comprises the following components in percentage by weight: 20% of cellulose, 10% of wheat germ powder, 6% of yeast powder, 5% of casein powder, 2.5% of agar powder, 0.8% of cane sugar, 0.8% of glucose, 0.8% of Webster salt, 0.6% of sorbic acid, 0.6% of methyl parahydroxybenzoate, 0.4% of vitamin C, 0.1% of cholesterol, 0.1% of choline chloride, 0.05% of inositol, 0.0025% of riboflavin, 0.0015% of folic acid and the balance of water. And the balance of deionized water. The broad-spectrum feed provided by the invention is convenient to prepare, perfect in preservative system and long in service life, and the labor amount caused by frequent feed replacement in the larva breeding process is obviously reduced.

The present invention provides a stable aqueous hydroxycarbamide solution comprising: hydroxycarbamide; a pH adjuster being sodium hydroxide, potassium hydroxide, sodium bicarbonate, and sodium carbonate, or a mixture of one or more of these substances; and optionally a preservative being a base of methyl hydroxybenzoate and / or ethyl hydroxybenzoate; wherein: the solution is controlled to have a pH of between 6.1 and 7.1. The solution of the present invention is beneficial as compared to solutions according to the prior art in that it can be safely stored at ambient temperatures for prolonged periods of time without significant degradation.

The utility model discloses a sodium methyl p-hydroxybenzoate drying machine which comprises a machine body, and a power assembly is arranged on one side of the machine body. A filter plate is arranged in the screening box, and the filter plate is inclined; the hole area on the filter plate can be adjusted; the side face, close to the lower end of the filter plate, of the screening box is provided with a discharging channel. The upper end of the crushing box is communicated with the discharging channel; the inner space of the crushing box is cylindrical, a blanking port communicated with the machine body is formed in the lower end of the crushing box, and a filter plate II is arranged in the blanking port; and a crushing structure is arranged in the crushing box. Before entering the drying machine, the raw materials are firstly screened, so that the raw materials entering the machine body are all crushed without caking, and the drying effect is improved.

The invention discloses a synthetic method of raceme dihydromyricetin, which comprises the following steps: by taking 3, 4, 5-methyl trihydroxybenzoate and 2, 4, 6-trihydroxyacetophenone as raw materials, carrying out phenolic hydroxyl group protection, ester reduction oxidation, Aldol condensation, epoxidation, ring opening and phenolic hydroxyl group etherification under acidic conditions, and carrying out separation, purification and crystallization after the reaction is finished to obtain the high-purity dihydromyricetin. The method has the characteristics of high efficiency, high yield, simple equipment and green and environment-friendly production procedures, and has relatively high economic benefits and social benefits.

A mouthwash composition consisting of: 1-2% w / w Triphala powder; 0-0.02 wt% of a leaf extract of Satpudina (Mentha spp.); 8-9% by weight of an invert sugar syrup; 85-90 wt.% of warm, purified water; 0.5-1 wt% sodium benzoate; 0.05-0.1 wt% of methyl paraben sodium; 0.02-0.05 wt% of propyl paraben sodium; 0.05-0.1 wt% citric acid as acidifying agent; 0-0.02 wt% of an apple-green color; and 0.10-0.15% by weight peppermint flavoring.

The application discloses a kind of bacteriostatic polypeptide and its preparation pet shower gel application, belong to bacteriostatic polypeptide technical field.The bacteriostatic polypeptide includes the following weight parts of raw materials: glycerol 2-5 parts, plant polypeptide 3-5 parts, sorbitol 20-40 parts, carboxymethyl cellulose 1-2 parts, xanthan gum 0.5-1 part, sodium methyl hydroxybenzoate 2-5 parts, surfactant 0.5-1 part, chlorhexidine 0.5-1 part, triclosan 0.05-0.3 part, deionized water 100 parts;The bacteriostatic polypeptide prepared in the application can be applied in the preparation process of pet shower gel, and has good bacteriostatic performance.

The invention relates to a cryopreservation protective solution suitable for vaginal flora of a human body, which mainly comprises the following components in percentage by weight: 10% of glycerol, 5% of D-trehalose, 0.2% of lactose, 1% of sodium lactate, 1% of hyaluronic acid, 1% of L-tartaric acid, 0.3% of sodium methyl p-hydroxybenzoate, and the balance of NaCl (sodium chloride), 10% of glycerol, 5% of D-trehalose, 0.2% of lactose, 1% of sodium lactate, 1% of hyaluronic acid, 1% of L-tartaric acid, 0.3% of sodium methyl p-hydroxybenzoate and the balance of water. The balance is NaCl with the concentration of 0.9%. The bacteria-preserving liquid is prepared according to the proportion and is uniformly mixed. The bacteria-preserving liquid can improve the preservation activity of vaginal probiotics.

The invention belongs to the technical field of insect feeding, and particularly relates to semi-artificial feed and an artificial feeding method for multihole transverse gallosoma elegans. The semi-artificial feed for the rhynchophorus multifortunei, provided by the invention, is prepared from fraxinus chinensis phloem powder, fraxinus chinensis xylem sapwood powder, soybean meal, cane sugar, agar, cholesterol, Webster salt, potassium sorbate, methyl p-hydroxybenzoate, compound vitamin B and distilled water according to a specific weight part ratio. The artificial feeding method comprises the whole processes of adult collection, egg laying induction, egg incubation, single larva feeding, pupa management and adult polyculture. The feed disclosed by the invention is comprehensive and balanced in nutrition, can fully meet the requirement of the whole life history of the multihole transverse gallosopterus, remarkably improves the survival rate of larvae and the eclosion rate of adults, realizes large-scale standardized feeding, and provides a stable insect source for research on pest control.

The present invention discloses ginseng extract, a preparation method and its application in whitening, rejuvenating and wrinkle-removing products. The whitening skin care product used is mainly diglucosyl gallic acid containing ginseng powder. First, a cyclic γ-polyglutamic acid resin is synthesized. The resin has a good pore structure. Then, the synthesized cyclic γ-polyglutamic acid resin is added to the diglucosyl gallic acid to modify it. The resin has good biocompatibility and can increase the hydrophilicity and stability of the protein. At the same time, based on the unique properties of American ginseng, it is ground and added to the diglucosyl gallic acid after modification; acetylation reaction is used to synthesize diglucosyl gallic acid, that is, methyl gallate and α-pentaacetyl glucose are mixed in xylene, using boron trifluoride ether complex as a catalyst, pentaacetyl glucose is added and introduced into the phenolic hydroxyl group of methyl trihydroxybenzoate, and then salified, acidified and separated to obtain diglucosyl gallic acid.

The invention discloses a method for determining a preservative in a children oral liquid preparation, and belongs to the technical field of detection. Comprising the following steps: preparing a mixed reference substance standard stock solution; preparing a series of standard solutions; the method comprises the following steps: precisely measuring a to-be-measured sample, putting the to-be-measured sample into a measuring flask, diluting the to-be-measured sample to a scale by using an acetonitrile-water solution with a volume ratio of 1: 1, uniformly shaking, and passing through a 0.22 mu m filter membrane to obtain a sample solution for later use; and precisely sucking the series of standard solutions and the sample solution, injecting into a gas chromatograph, and determining. According to the method, whether various preservative components such as p-benzyl alcohol, sorbic acid, benzoic acid, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate and butyl p-hydroxybenzoate exist in the oral liquid preparation for children or not can be determined at the same time through the gas chromatography, and the recovery rate and precision are high. When an acetonitrile aqueous solution with the volume fraction of 50% is selected as an extraction solvent, a sample to be detected can be quickly and uniformly dispersed and dissolved.

The present invention provides a stable aqueous hydroxycarbamide solution comprising: hydroxycarbamide; a pH adjuster being sodium hydroxide, potassium hydroxide, sodium bicarbonate, and sodium carbonate, or a mixture of one or more of these substances; and optionally a preservative being a base of methyl hydroxybenzoate and / or ethyl hydroxybenzoate; wherein: the solution is controlled to have a pH of between 6.1 and 7.1. The solution of the present invention is beneficial as compared to solutions according to the prior art in that it can be safely stored at ambient temperatures for prolonged periods of time without significant degradation.

This invention relates to a desonide lotion and its preparation method. The desonide lotion comprises desonide, an oil phase component, a humectant, a surfactant, 1,3-butanediol, propylene glycol alginate, a preservative, and water. Specifically, the desonide lotion is composed of desonide, liquid paraffin, dimethyl silicone oil, glycerin, Span 80, sodium dodecyl sulfate, 1,3-butanediol, propylene glycol alginate, methylparaben, propylparaben, and water. This invention, by combining 1,3-butanediol and propylene glycol alginate as a stabilizing matrix and functional additive, has successfully developed a desonide lotion with excellent physicochemical stability, good spreading and wetting properties, high transdermal absorption rate, and a simple preparation process, possessing extremely high clinical value and promising industrial application prospects.

The application discloses a lining concrete for large-section tunnels and a preparation method thereof, and belongs to the technical field of building materials. The lining concrete comprises the following components in parts by weight: cement 300-400 parts, fly ash 40-50 parts, mineral powder 40-70 parts, fine aggregate 600-650 parts, coarse aggregate 1050-1150 parts, water 150-200 parts, water reducing agent 7-11 parts, and air entraining agent 5-10 parts. The water reducing agent comprises the following raw materials in parts by weight: polyether macromonomer 100 parts, unsaturated carboxylic acid monomer 5-7 parts, 3,4-dihydroxybenzoic acid methyl ester 4-6 parts, unsaturated amide 2-4 parts, oxidizing agent 1.0-2.0 parts, reducing agent 0.5-1.0 parts, chain transfer agent 0.5-1.5 parts, and deionized water 300-350 parts. The lining concrete has low bleeding rate, good fluidity, and 1h lossless slump, is beneficial to the discharge of air bubbles, and can solve the problems of bleeding, honeycomb pitted surface, air holes and water bubbles of the tunnel lining concrete in the prior art.

A topical antimicrobial gel composition consisting of an ethanolic extract of Anacyclus pyrethrum roots dispersed in a Carbopol 940 hydrogel, propylene glycol, glycerin, methylparaben, triethanolamine and distilled water, wherein the composition is adjusted to a skin-compatible pH and configured to provide spreadable, homogeneous gel properties.

To provide a grape sap which can stably be formulated in cosmetics and quasi-drugs by a prescription for suppressing the amount of a preservative to the minimum unlike a combination of an organic solvent such as 1, 3-butylene glycol, methyl p-hydroxybenzoate (methylparaben), ethyl p-hydroxybenzoate (ethylparaben) or phenoxyethanol with a preservative, and to provide cosmetics and quasi-drugs formulated with the grape sap.SOLUTION: Without using an organic solvent such as 1, 3-butylene glycol, methyl p-hydroxybenzoate (methylparaben), ethyl p-hydroxybenzoate (ethylparaben) or phenoxyethanol, the preservability of the grape sap can be enhanced by the baked powder of the scallop and the plant extract having the antiseptic auxiliary action, and the grape sap can further stably be formulated with cosmetics and quasi-drugs.SELECTED DRAWING: None

This invention discloses a preparation process for the ROCK2 immunomodulator and its key intermediate. The invention uses methyl 3-hydroxybenzoate as a raw material to prepare the key intermediate compound E, and then further prepares besudinil and its salt through a substitution reaction of compound E with 5-aminoindazole. The preparation process of this invention avoids the use of chlorination reagents, expensive reagents, and heavy metal catalysts, reducing costs and process safety risks while ensuring yield, thus providing a more suitable route for the industrial production of the drug besudinil.