23 results about "Triclosan" patented technology

This invention relates to biomarkers and their applications for predicting the risk of prostate cancer induced by triclosan, belonging to the fields of environmental health and tumor biology. This invention systematically identifies oncogenes CHRM5, PLK1, ALB, and TOP2A associated with triclosan exposure and constructs a predictive model for the risk of prostate cancer induced by triclosan using machine learning methods. Therefore, this invention provides novel biomarkers and potential therapeutic targets for predicting the risk of prostate cancer induced by triclosan.

The invention relates to the technical field of food fresh-keeping bags, and discloses a high-temperature-resistant functional food fresh-keeping bag and a manufacturing method thereof.The food fresh-keeping bag is obtained by taking polyethylene as a base material and taking a high-temperature-resistant modifier, hydroxyapatite antibacterial filler and the like as auxiliary materials through mixing, extrusion, film blowing and bag manufacturing, the high-temperature-resistant modifier contains hydroxyl and a hindered phenol antioxidant structure, and acts with the compatilizer through melt blending, so that the high-temperature-resistant performance of polyethylene is improved, polypropylene is endowed with oxidation resistance, and the problem of oxygen aging is avoided; the hydroxyapatite antibacterial filler is prepared by grafting the triclosan on the hydroxyapatite, the dispersity of the hydroxyapatite is improved through grafting, the strength and toughness of the polyethylene can be effectively improved through uniform dispersion, and the triclosan has broad-spectrum antibacterial property and endows the polyethylene with antibacterial property.

The present application relates to the technical field of antibacterial coating, in particular to a processing method of triclosan antibacterial coating for suture, and the specific steps are as follows: S1, preparation of moxa tablet-triclosan antibacterial solution; S2, preparation of moxa tablet-triclosan spraying solution; S3, suture pretreatment; S4, suture spraying.The present application has the following beneficial effects: 1. Good versatility: the suture with moxa tablet-triclosan antibacterial coating prepared by the present application is sprayed by ultrasonic spraying machine, and the same production process is used for different suture materials and single or multi-strand sutures, so that the production cost is greatly reduced, and the development of enterprises is facilitated; 2. Broad-spectrum bacteriostasis: the suture has good bacteriostatic rate for staphylococcus aureus, escherichia coli and stenotrophomonas maltophilia; 3. Low allergenicity.

The application provides a functional fiber membrane for bacterial visual monitoring and response antibacterial and a preparation method and application thereof, and belongs to the field of biological medical materials. The functional fiber membrane is a fiber membrane with a double-layer structure. A lower membrane of the fiber membrane is prepared from TCS@ZIF-8 nanoparticles and poly-epsilon-caprolactone as raw materials. An upper membrane of the fiber membrane is prepared from poly-epsilon-caprolactone, polyethylene glycol and bromo-musk toluene phenol blue as raw materials. The TCS@ZIF-8 nanoparticles are prepared from the following raw materials in a weight ratio: zinc nitrate hexahydrate 1-5 parts, triclosan 1-5 parts and 2-methyl imidazole 1-5 parts. The functional fiber membrane can realize naked-eye monitoring of various bacteria in a short time, has high monitoring sensitivity and can meet the clinical diagnosis requirements. Meanwhile, the membrane has excellent antibacterial performance and can synergistically antibacterial with photocatalysis. The functional fiber membrane has a simple preparation process, is convenient to operate and is convenient to carry, provides a feasible scheme for bacterial monitoring and has application prospects.

Described herein are polymerizable compositions useful as surgical adhesives, where the compositions include at least one antimicrobial agent dissolved in a cyanoacrylate monomer, where the at least one antimicrobial agent includes a cinnamon derivative comprising at least one of cinnamaldehyde, a cinnamic ester, a cinnamon essential oil, and where the at least one antimicrobial agent optionally further includes triclosan or a derivative thereof and / or povidone iodine. The antimicrobial agent is soluble in and compatible with the cyanoacrylate monomer.

This invention discloses a compound traditional Chinese medicine detoxifying ointment and its preparation method. The compound traditional Chinese medicine detoxifying ointment comprises a traditional Chinese medicine extract, triclosan, a gel matrix, a cooling and antipruritic agent, a moisturizer, a surfactant, a pH adjuster, and purified water. The traditional Chinese medicine extract is prepared by a group extraction process using five medicinal slices—honeysuckle, scutellaria, coptis, rhubarb, and corydalis—in a specific ratio: honeysuckle, scutellaria, and corydalis form the first group, while coptis and rhubarb form the second group. These are extracted separately by ethanol reflux extraction and microfiltration purification, then a colloidal dispersion system is formed using a pH segmented control method, followed by concentrating the extracts. This invention, through the synergistic combination of the traditional Chinese medicine extract, low-concentration triclosan, and the cooling and antipruritic agent, enables the product to possess multiple effects, including highly effective broad-spectrum antibacterial properties, cooling and antipruritic effects, and blood-activating and analgesic effects. Furthermore, it is non-irritating to the skin, exhibits good stability, and is suitable for industrial production.

The invention discloses a self-adaptive phase-change microstructure antibacterial antifouling coating as well as a preparation method and application thereof. The method comprises the following steps: (1) synthesizing a bacteriostatic active silane functional element; (2) synthesizing a phase change type active silane functional element; (3) synthesizing antibacterial organic silicon resin with a phase change function; and (4) preparing the composite array microstructure antibacterial antifouling coating. The preparation method comprises the following steps: firstly constructing a triclosan and / or coumarin-based synergistic antibacterial element, then preparing a long-chain alkyl phase-change functional element, then preparing organic silicon resin through polycondensation, and finally compounding the organic silicon resin with a nano filler, and molding to obtain the array microstructure coating. Under high temperature or strong light, the modulus of the microstructure coating is reduced, large-amplitude swing is generated, and contamination attachment is inhibited; in a low-temperature or dark environment, the modulus is increased, the microstructure is stable, and the durability is improved. A phase change driven modulus regulation and control mechanism is coupled with antibacterial elements, microstructures and low surface energy characteristics of organic silicon, so that self-adaptive antifouling in a complex environment is realized.

The invention relates to the technical field of industrial wastewater, in particular to a method for producing an amino water reducing agent by using triclosan etherification wastewater extract, which comprises the following steps: (1) taking collected triclosan etherification wastewater, adjusting the pH value to be acidic, layering, and collecting upper-layer extract and lower-layer wastewater; (2) taking lower-layer wastewater, adding an extracting agent, stirring, and concentrating and crystallizing the collected lower-layer potassium chloride solution to obtain a potassium chloride product; an upper-layer extract and condensate water are reserved for use; and (3) taking condensate water, adding phenol, sodium sulfanilate, the upper-layer extract and the upper-layer extract, stirring, adjusting the pH value to be alkaline, heating, dropwise adding formaldehyde, continuously heating for reaction, cooling, adjusting the pH value, and adding water to adjust the solid content, thereby obtaining the amino water reducer. According to the method, zero discharge of the triclosan etherification waste liquid is realized, the current pollution situation of the phenol-containing waste water is effectively improved, the environment is protected, the triclosan etherification waste water is comprehensively utilized, and the method has good economic benefits and environmental protection benefits.

The utility model discloses a triclosan preparation device relates to triclosan production technical field, including first reactor, the inlet of first reactor is respectively through pipeline intercommunication with 2,4 - dichlorophenol jar, sodium hydroxide solution jar, xylene jar I and tetrabutyl ammonium bromide jar, the outlet of first reactor is through pipeline intercommunication with second reactor, the inlet of second reactor is respectively through pipeline intercommunication with 2 - chloro - 5 - nitrobenzene methyl ether jar, dilute hydrochloric acid solution jar, ZnCl2 - Al2O3 solid acid jar, nano TiO2 jar and xylene jar II, the outlet of second reactor is through pipeline intercommunication with third reactor, the inlet of third reactor is through pipeline intercommunication with acetic acid jar, the top gas phase export of third reactor is through pipeline intercommunication with first condenser, and the outlet of first condenser is through pipeline intercommunication with crude product jar, improves the yield of product.

A composition, for example an oil-in-water emulsion, comprising an amphoteric surfactant, alkoxylated cetyl alcohol, a polar dmg and a preservative, wherein the total amount of preservative present in the composition is about 0.2% w / w or less and is not benzyl alcohol and / or triclosan. The drug may be sodium cromoglicate and / or nedocromil sodium. The formulation may be useful in the treatment of skin diseases such as atopic dermatitis.

The invention relates to the technical field of dental implants, in particular to a dental implant, a surface treatment method of the dental implant and a composite material for the dental implant. The surface treatment method of the dental implant comprises the following steps: uniformly mixing zirconium oxide, tricalcium phosphate, monocalcium phosphate, tricalcium silicate, calcium hydroxide, triclosan and polyethylene glycol according to a preset proportion to obtain an initial mixture; grinding the initial mixed material to obtain a composite material; carrying out sand blasting-acid etching treatment on the cleaned and pretreated dental implant, and cleaning and drying; and coating the surface of the cleaned and dried dental implant with the composite material to finish surface treatment. According to the treatment method, the antibacterial property and hydrophilicity of the dental implant can be improved.

The degerming and acarus killing laundry detergent based on lysozyme and BZK is prepared from the following raw materials in percentage by mass: 0.01 to 0.5 percent of lysozyme, 0.01 to 1.0 percent of BZK benzalkonium chloride, 0.02 to 1.5 percent of triclosan, 0.01 to 1.5 percent of chelating agent, 12 to 35 percent of composite surfactant, 0.01 to 0.5 percent of protease, 0.01 to 0.5 percent of lipase, 0.05 to 2.0 percent of modified cellulose derivative, 0.01 to 1.5 percent of pH regulator and the balance of deionized water. According to the invention, the lysozyme can synergistically remove bacteria and mites, the effect is remarkable, after the lysozyme destroys bacterial cell walls, the BZK and the triclosan can quickly kill residual microorganisms, the 20-min bacteriostasis rate on escherichia coli, staphylococcus aureus and candida albicans is greater than or equal to 99.9% aiming at mite body surface penetration, the mite removal rate is greater than or equal to 99.9%, and the problem that the effect of a single component is limited is solved.

The present invention relates to a composition for the treatment of fungal infections of C. albicans and C. non-albicans, such as C. auris, C. glabrata, C. tropicalis, C. krusei and Trichophyton spp., in particular Trichophyton mentagrophytes complex, Tricophyton rubrum.

The invention discloses a disinfectant containing plant extracts and a preparation method of the disinfectant. The core of the disinfectant is that a honeysuckle extract, a scutellaria baicalensis extract, a coptis chinensis extract, a rheum officinale extract and triclosan are compounded through a nano-loading technology and placed in a gel matrix to form a slow-release system. The preparation method comprises the following steps: performing HPLC quantitative monitoring on the plant active ingredients; the triclosan and the nano-carrier are processed into a nano-carrier with the average particle size smaller than or equal to 100 nm through technologies such as high-pressure homogenization; and mixing the components with the gel base material, and stabilizing the pH value of the system at 5.5-6.5 by using a pH regulator. The disinfectant disclosed by the invention realizes rapid and broad-spectrum killing of gram-positive bacteria, gram-negative bacteria and fungi by virtue of a synergistic effect of multiple components, and has lasting antibacterial ability by virtue of a nano slow-release effect. The pH value of the product is close to the skin, and the product is detected to be in a non-irritating level and has the advantages of good stability, high safety and suitability for mothers and infants.

The application relates to the technical field of external drug preparations, and discloses a skin bacteriostatic gel and a preparation method thereof, and aims to solve the technical problems that in the prior art, Mongolian medicine multi-polar active ingredient extraction is insufficient, and when natural extract and chemical bacteriostatic agents are compounded, uneven dispersion, strong irritability and poor stability are prone to occur. The skin bacteriostatic gel is composed of Mongolian medicine extract, polyvinyl alcohol, xanthan gum, triclosan, glycerol, nicotinamide and other auxiliary materials; and the key of the preparation method is that: the Mongolian medicine is extracted by adopting a gradient process combining ultrasonic water extraction and microwave alcohol extraction, so that different polar active ingredients are fully reserved; triclosan is subjected to compound micro-capsulation treatment by being compounded with trehalose and sodium hyaluronate wall materials; an interpenetrating network matrix is constructed by using polyvinyl alcohol and xanthan gum, and laurocapram is introduced to optimize the transdermal performance, so that the extraction efficiency of the Mongolian medicine components is improved; the obtained gel has reliable bacteriostatic effect, stable long-term storage performance and low skin irritability, and can meet the skin bacteriostatic care demand.

The utility model relates to the technical field of triclosan production, in particular to a production system for a triclosan diazonium reaction process, which comprises an amino sulfate reaction kettle, a discharge port of the amino sulfate reaction kettle is communicated with a heat exchanger, and a discharge port of the heat exchanger is communicated with a first feed port of a tubular static mixer. The nitrosyl sulfuric acid conveying pipeline is communicated with a second feed port of the tubular static mixer, a discharge port of the tubular static mixer is communicated with a feed pipe of the tubular reactor, the feed pipe is provided with an external circulation inlet, and a discharge pipe of the tubular reactor is respectively communicated with the external circulation inlet and the dilution kettle. According to the production system, amino sulfate is prepared in advance through the amino sulfate reaction kettle, part of reaction heat is diluted in one step, the risk of concentrated release of the reaction heat is reduced, and the production safety is improved. The tubular reactor is adopted, so that the reaction time is shortened, side reactions are reduced, the reaction controllability and the reaction yield are improved, and the subsequent post-treatment difficulty and the production cost are reduced.

The invention relates to the technical field of analysis and detection, in particular to a method for detecting drugs and personal care products in soil. According to the extraction, separation and enrichment steps of the traditional Chinese medicines and the personal care products, accelerated solvent extraction and solid-phase extraction are combined, so that the extraction rate of the various medicines and the personal care products in the soil can be remarkably increased, the sample loss rate is reduced, and the extraction time is shortened. According to the method, accelerated solvent extraction and solid-phase extraction are combined with a high-performance liquid chromatography coupling technique, isocratic elution is performed for 15-20 minutes, so that various trace drugs and personal care products with different structures and different polarities, such as ibuprofen, carbamazepine, bisphenol A and triclosan, which are remained in soil can be simply, quickly, accurately and universally detected, and the sensitivity is high. Moreover, the detection method provided by the invention is high in accuracy and good in reproducibility, and a rapid, accurate, visual, qualitative and quantitative determination method for the soil traditional Chinese medicines and the personal care products is provided for environmental detection departments, governments and enterprises.

The application provides an antibacterial coating, comprising a modified polylactic acid antibacterial coating; the modified polylactic acid antibacterial coating comprises modified polylactic acid and a phenolic antibacterial agent; the modified polylactic acid is prepared by the following method: S1) hydrophobic modification of lignin to obtain a macromolecular initiator; and S2) ring-opening reaction of lactide and the macromolecular initiator to obtain modified polylactic acid. Compared with the prior art, the modified polylactic acid in the antibacterial coating provided by the application not only can increase the loading amount of the phenolic antibacterial agent triclosan, slow down the release rate of the antibacterial agent, thereby providing reliable antibacterial performance, but also can improve the mechanical properties of polylactic acid, so as to ensure stable coating performance, and is particularly suitable for surface antibacterial modification of long-term implantable medical devices, complex structure implantable devices and the like.

The invention discloses a pharmaceutical composition for treating bacterial infection, and belongs to the technical field of medical preparations. The invention aims to solve the technical problem of how to effectively treat diseases caused by bacterial infection, especially diseases caused by antibiotic-resistant bacterial infection. In order to solve the technical problem, the invention provides the pharmaceutical composition for resisting bacterial infection, bacteria contain MexL protein, active ingredients of the pharmaceutical composition can comprise a component A and a component B, the component A can be a bacteriostatic agent taking the MexL protein as a target spot, and the component B can be a broad-spectrum bacteriostatic agent. The inventor of the application finds two antibiotics, namely tetracycline and triclosan, which interact with MexL through crystal structure analysis of MexL, and the generation of PYO and the toxicity of pseudomonas aeruginosa can be reduced. In-vivo studies show that the MexL targeted drug can be combined with clinical antibiotics to be used as an effective method for resisting pseudomonas aeruginosa infection.

The invention belongs to the field of biological medicine, and provides a selective bacteriostatic agent for resisting vaginal infection and application thereof. The selective bacteriostatic agent comprises at least one of triclosan (12.5 to 300 [mu] g / mL), parachlorometaxylenol (100 to 200 [mu] g / mL), chlorhexidine acetate (25 [mu] g / mL) and chlorhexidine gluconate (50 [mu] g / mL); the inhibiting effect of the selective bacteriostatic agent on harmful bacteria in the vagina is obviously higher than that of the selective bacteriostatic agent on probiotics. The invention also discloses an application of the selective bacteriostatic agent in preparing a medicine for treating vaginitis, and a preparation for resisting vaginal infection, which comprises the selective bacteriostatic agent. The four bacteriostatic agents disclosed by the invention can effectively inhibit the growth of harmful bacteria in the vagina in respective concentration and pH ranges, have weak inhibitory effect on probiotics in the vagina, have remarkable selective bacteriostatic activity, and can be effectively used for vagina cleaning and disinfection and prevention and treatment of infection.

The invention provides a method for detecting the influence of microplastics and triclosan on the structure and function of a sediment microbial community. The method comprises the following specific steps: firstly, collecting a sediment sample in a specified sampling area; then adding the micro-plastic particles and a triclosan solution into the sediment sample, and incubating; dNA of the microorganisms is extracted, and 16S rRNA sequencing is carried out; and finally, analyzing the diversity of the microbial community and evaluating the structure and function of the microbial community according to the sequencing data. The comprehensive influence of micro-plastic and triclosan combined pollution on the structure and function of the sediment microbial community is systematically analyzed for the first time, the efficiency and accuracy of sediment microbial community detection are effectively improved by adopting a 16S rRNA detection technology, and a reliable basis is provided for formulating an environment protection strategy, optimizing pollution control and promoting ecological restoration engineering.

Described herein are polymerizable compositions useful as surgical adhesives, where the compositions include at least one antimicrobial agent dissolved in a cyanoacrylate monomer, where the at least one antimicrobial agent includes povidone iodine and optionally further includes triclosan or a derivative thereof and / or a cinnamon derivative comprising at least one of cinnamaldehyde, a cinnamic ester, or a cinnamon essential oil. The antimicrobial agent is soluble in and compatible with the cyanoacrylate monomer.

The present invention provides a wafer cleaning solution and a method for producing the same. [Solution] The wafer cleaning solution comprises a nonionic surfactant, an anionic surfactant, an antibacterial agent, a pH adjuster, and water. The number-average molecular weight of the nonionic surfactant is 3,000 to 6,000. The anionic surfactant is selected from at least one of the group consisting of sodium lauryl sulfate and polyethylene glycol tridecyl ether phosphate. The acid dissociation constant (pKa) of the pH adjuster is 1.38 to 4.76. The antibacterial agent is selected from at least one of the group consisting of kathon, methylisothiazolinone, triclosan, chloroxyllenol, methacrylate oxide decylpyridinium bromide salt, and quaternary ammonium salt compounds.