53 results about "ChloraPrep" patented technology

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.

The application belongs to the technical field of detection, and particularly relates to a method for determining the content of chlorhexidine acetate in a disinfectant. The method for determining the content of chlorhexidine acetate in the disinfectant comprises the following steps: (1) dispersing the sample with glacial acetic acid, releasing chlorhexidine acetate combined with sample matrix components, and extracting with a methanol aqueous solution; and (2) taking a tetrabutylammonium bromide-acetic acid-acetonitrile solution as a mobile phase, and detecting with a high-performance liquid chromatograph. The method for detecting chlorhexidine acetate is simple in operation, good in reproducibility, complete in separation from impurities, high in accuracy, and has a good application prospect.

The invention belongs to the technical field of detection, and particularly relates to a method for determining the content of chlorhexidine acetate in a disinfectant. The method for determining the content of chlorhexidine acetate in the disinfectant comprises the following steps: (1) dispersing a sample by using glacial acetic acid, releasing chlorhexidine acetate combined with matrix components of the sample, and extracting by using a methanol aqueous solution; and (2) detecting by using a high performance liquid chromatograph by taking a tetrabutylammonium bromide-acetic acid-acetonitrile solution as a mobile phase. The method for detecting chlorhexidine acetate is simple and convenient to operate, good in reproducibility, complete in impurity separation and high in accuracy, and has a good application prospect.

The present disclosure is directed to a device for delivering an antimicrobial composition into a medical device. Some embodiments disclosed herein provide a method for preventing infection and microbial ingress in medical device connections. The device includes a male connector with a distal tip and a recess at the distal tip. The surface of the recess includes an antimicrobial composition. In certain implementations a male luer comprises a tapered sealing member further comprising a recess containing chlorhexidine acetate.

The invention discloses zero-additive total-effect mouthwash and a preparation method thereof, and belongs to the technical field of oral care. The mouthwash comprises a natural substrate, a bacteriostatic and deodorant component, an anti-dental calculus, whitening and repairing component, a gingival maintenance component, a natural fragrance retention system and a natural solubilizer, purified water is added to 100%, and the pH value is adjusted to 5.5-6.5. All the components are from pure plants or natural minerals, do not contain alcohol, chemical preservatives, artificial pigments, artificial essence, SLS and chlorhexidine, and can be swallowed. The green tea extract, the pomegranate peel extract and the pogostemon cablin alcohol are compounded to realize synergistic bacteriostasis, and the nano zinc-loaded hydroxyapatite is combined to resist dental calculus and the papain is used for mildly whitening, so that multiple oral care effects are realized. The preparation method is simple in process and suitable for industrial production.

The invention relates to the technical field of biological medicine, and particularly discloses application of Xinjiang pomegranate rind ellagic acid in caries prevention, in-vivo and in-vitro experiments prove that the ellagic acid can effectively inhibit floating growth and biofilm formation of streptococcus mutans, streptococcus sobrinus and streptococcus sanguis, MICs of the ellagic acid are 4 mmol / L, 2 mmol / L and 1 mmol / L respectively, and MBICs of the ellagic acid are 8 mmol / L, 4 mmol / L and 1 mmol / L respectively; meanwhile, the ellagic acid can obviously inhibit the acid production capacity of the cariogenic bacteria, the generation of water-insoluble exopolysaccharides and the adhesion to hydroxyapatite; in a rat caries model, by locally applying 1-8 mmol / L ellagic acid, the number of streptococcus in the oral cavity can be reduced in a dose-dependent manner, the caries damage degree of smooth surfaces of molar teeth and fossa and fissure can be relieved, the effect of the ellagic acid is equivalent to that of positive control drugs chlorhexidine and sodium fluoride under the high dose (8 mmol / L), and the ellagic acid shows good biological safety. Therefore, ellagic acid can be used for preparing safe and effective anti-caries drugs or oral care products.

The invention relates to the field of medicine, in particular to a sterilization composition and application thereof.The sterilization composition comprises water, chlorhexidine acetate and saussurea involucrata extract, and the mass ratio of chlorhexidine acetate to saussurea involucrata extract is 1: (10-40). The bactericidal composition has the following effects: (1) inhibiting the growth and reproduction of vaginal pathogenic bacteria; (2) relieving and anti-inflammatory effects are achieved; (3) a synergistic effect is achieved, the cost is low, and the bacteriostatic effect is good.

This utility model discloses a metering and spraying device for chlorhexidine acetate solution. The metering spraying mechanism includes a cavity located on one side of the inner wall of the housing. A first connecting rod is rotatably connected to one side of the cavity. Both ends of the outer wall of the first connecting rod are fixedly connected to rings. Two fixed seats are fixedly connected to the top of each ring. A first connecting rod is rotatably connected to one side of each of the two fixed seats. A second connecting rod is rotatably connected to the other side of the cavity. A cam is fixedly connected to the middle of the outer wall of the second connecting rod. In this utility model, when spraying chlorhexidine acetate solution, the metering cavity is first filled with chlorhexidine acetate solution. When the pressing rod is pressed, the pressure generated by the push plate will squeeze out the chlorhexidine acetate solution inside. Then, it will be re-fed through the feeding mechanism, so that the same amount of chlorhexidine acetate solution will be sprayed out each time, thereby achieving the purpose of metering and spraying, thus improving the efficiency of using chlorhexidine acetate solution.

The invention belongs to the technical field of medical supplies, and particularly relates to an implant restoration screw channel sealing material and a preparation method thereof.The preparation method comprises the following steps that S1, a polytetrafluoroethylene belt is prepared, and an expanded polytetrafluoroethylene film is obtained; s2, sodium-naphthalene complex surface modification: soaking the expanded polytetrafluoroethylene film in a sodium-naphthalene complex treatment solution to defluorinate the surface and form a carbonized layer, and then cleaning with ethanol and deionized water; s3, chitosan-chlorhexidine acetate modification: spraying a chitosan / chlorhexidine acetate stable solution on the surface of the expanded polytetrafluoroethylene film treated in S2 to form a chitosan-chlorhexidine acetate modified coating; and S4, preparing the expanded polytetrafluoroethylene film treated in S3 into a columnar solid, and performing high-temperature steam sterilization to obtain the implant restoration screw channel sealing material.

Compositions and methods for the treatment of inflammatory skin diseases. The compositions include a pharmaceutically effective amount of polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), and / or chlorhexidine (CHG) in a petrolatum carrier.

The invention discloses liquid foundation suitable for sensitive skin and a preparation method, and belongs to the technical field of cosmetics. The invention relates to a liquid foundation suitable for sensitive skin. The liquid foundation comprises an active core component: 3-8% of an aloe barbadensis leaf extract; the base component comprises 45%-60% of A-phase raw materials, 25%-35% of B-phase raw materials and 8%-15% of C-phase raw materials; synergistic soothing and repairing components: 0.5%-1.2% of a purslane extract, 0.3%-0.8% of a crocus sativus flower extract and 0.2%-0.6% of a cardiospermum halicacabum flower and leaf extract; a low-irritation antibacterial auxiliary component: 0.01% to 0.05% of chlorhexidine digluconate; by adopting a synergistic antibacterial system of the aloe barbadensis leaf extract and the low-concentration chlorhexidine digluconate, while the dosage of a synthetic antibacterial agent is reduced, broad-spectrum efficient antibacterial is realized, and the sensitization rate of a human patch test is less than or equal to 0.1%; on the other hand, the plant-derived emulsifier is used for replacing part of the synthetic thickening agent and matched with the relieving and repairing effects of the peptide compound component, so that the overall irritation of the formula is further reduced, and the composition is further suitable for sensitive skin and barrier damaged skin to be used for a long time.

The invention provides an antibacterial dressing composition and a medical gynecological protection pad, and belongs to the technical field of medical dressings. The composition is prepared from 70 to 90 parts of water, 8 to 10 parts of polyethylene glycol, 4 to 6 parts of glycerol, 0.3 to 0.7 part of carbomer, 0.06 to 0.15 part of L-cysteine, 4 to 8 parts of chitosan quaternary ammonium salt, 0.3 to 0.8 part of panthenol, 0.4 to 0.7 part of tocopheryl acetate, 0.2 to 0.4 part of sodium hyaluronate, 0.1 to 0.3 part of chlorhexidine digluconate, 3 to 4 parts of polyvinylpyrrolidone, 1 to 5 parts of sodium alginate, 0.1 to 0.3 part of polysorbate, 0.6 to 0.9 part of luteoloside, 0.1 to 0.2 part of quercetin and 0.05 to 0.2 part of sophocarpidine. Chitosan quaternary ammonium salt and chlorhexidine digluconate are used as bactericidal components, quercetin and sophocarpidine are added to serve as bacteriostatic agents, and the bactericidal components, active components such as panthenol, tocopheryl acetate and galuteolin and a film-forming agent form a dispersion system. The antibacterial facial mask has remarkable antibacterial property, and has the effects of resisting inflammation, preserving moisture, promoting tissue repair and the like. The gynecological protection pad acts on the surface of vulva inflammation, and the exact treatment effect can be achieved.

The invention discloses a preparation method of a gold (I) coordination compound and an application in antibiosis, a series of gold (I) coordination compounds have obvious inhibition effects on common oral germs such as staphylococcus aureus (S.a), porphyromonas gingivalis (P.g) and fusobacterium nucleatum (F.n), and the action effects of the gold (I) coordination compounds are better than those of common oral antibacterial drug chlorhexidine; the invention discloses improved preparation and purification methods of the gold (I) complexes, and the gold (I) complexes have good bacteriostatic activity on common oral germs.

The present application relates to the technical field of gynecological bacteriostatic gel, and particularly relates to a ulipristal bacteriostatic gel and a preparation method thereof; the ulipristal bacteriostatic gel comprises the following components in parts by weight: chlorhexidine acetate 1-3 parts, meihua grass extract 4-8 parts, carbomer 0.8-1.2 parts, triethanolamine 0.4-0.6 parts, penetration enhancer 0.5-1.5 parts, modified nano-silver 0.04-0.07 parts, glycerol 5-8 parts, hydrogenated polyisobutylene 0.03-0.07 parts, disodium edetate 0.1-0.3 parts and purified water in a remainder amount; the chlorhexidine acetate and the meihua grass ethanol extract are compounded at a ratio of 1:(2.5-4), the flavones and polyphenols in the meihua grass can destroy the cell membrane permeability of microorganisms, promote the chlorhexidine acetate to enter the inside of the microorganism, and significantly reduce the minimum bacteriostatic concentration.

An improved aqueous teat dip comprising iodine and chlorhexidine in an aqueous solution.

The present invention relates to compositions for administration to the oral cavity, suitable for prophylaxis or treatment of diseases of the teeth and / or gums and / or the oral cavity, which comprises chlorhexidine and one or more peroxides that are decomposed into active oxygen, preferably hydrogen peroxide and / or carbamide peroxide and / or calcium peroxide.

The invention discloses a hydrocortisone compound ointment preparation for treating haemorrhoids, and belongs to the technical field of medicines. The technical problem to be solved is to provide a hydrocortisone compound ointment preparation which has a good hemorrhoid treatment effect and is stable. The hydrocortisone compound ointment preparation comprises the following components in percentage by weight: 0.15%-1% of corticoid, 0.025%-0.1% of a vasoconstrictor, 2%-4% of a local anesthetic, 0.1%-1.5% of L-menthol, 0.02%-0.5% of chlorhexidine acetate and 0.05%-1% of allantoin. The hydrocortisone compound ointment preparation disclosed by the invention has the medicinal effects of relieving pain and discomfort of patients suffering from haemorrhoids, promoting healing and repairing of haemorrhoids tissues, preventing infection and relieving inflammatory response, and has obvious effects of stopping bleeding and relieving swelling and pain in haemorrhoids treatment.

The present invention provides a new use of a class of compounds in the inhibition of alpha-1,6-fucosyltransferase. Specifically, the present invention provides the use of an active ingredient comprising one or more compounds containing the structure of - (M) n or not containing the structure of - (M) n such as NH125, chlorhexidine, sulfo-N-succinimidyl oleate, etc., or a pharmaceutically acceptable salt, isomer or mixture of isomers, solvate or crystal form thereof, as an alpha-1,6-fucosyltransferase targeted inhibitor in the treatment or prevention of related diseases.

This invention discloses a long-acting antipruritic and antibacterial topical skin preparation, comprising N-ethyl-γ-L-glutamine, 1-1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphate-N-(L-γ-glutamyl-N-ethyl)-ethanolamine (POPE-N-Et-Gln-α), chlorhexidine acetate, and saffron extract as active ingredients, formulated into a hydrogel or cream with a pharmaceutically acceptable matrix. POPE-N-Et-Gln-α provides rapid transdermal action, while N-ethyl-γ-L-glutamine offers sustained-release and long-lasting effects; saffron extract provides anti-inflammatory and antioxidant effects, and chlorhexidine acetate provides antibacterial and antifungal effects. This invention is hormone-free and non-addictive, achieving both rapid and long-lasting antipruritic effects, and is suitable for eczema, urticaria, dry skin, neurodermatitis, psoriasis, microbial infections, and skin itching caused by insect bites.

A composition, in particular for the prophylaxis and / or treatment of caries, gingivitis, halitosis and / or arteriosclerosis, comprises N-cetylpyridinium chloride, at least one flavonoid, at least one polymer, in particular a homopolymer comprising at least one monomer having a polar functional group, in particular polylysine, and optionally chlorhexidine, wherein the weight ratio of chlorhexidine to N-cetylpyridinium chloride is between 0 and 7, in particular between 0.01 and 6, especially between 0.1 and 5, more especially between 0.2 and 4, for example between 0.4 and 3.2.

Compositions and methods for the treatment of inflammatory skin diseases. The compositions include a pharmaceutically effective amount of polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), and / or chlorhexidine (CHG) in a petrolatum carrier.

The invention discloses a chlorhexidine gluconate solution and a preparation method thereof. The method comprises the following steps: dispersing chlorhexidine free alkali in purified water, introducing carbon dioxide, pressurizing and carbonizing, and constructing a homogeneous or quasi-homogeneous reaction system; adding gluconic acid-delta-lactone under the condition that the system pressure is not lower than 0.30 MPa, maintaining the pressure, carrying out constant-pressure stirring reaction, and inhibiting carbonic acid decomposition by utilizing back pressure so as to match lactone hydrolysis kinetics; and after the reaction is finished, carrying out gradient pressure relief, vacuum degassing and filtering. According to the present invention, the gas-liquid-solid three-phase coupling and the variable pressure-pressure maintaining delayed release process are adopted, such that the low-temperature total synthesis of chlorhexidine is achieved, the generation of parachloroaniline impurities and the discoloration of the product caused by the high temperature are effectively avoided, and the technical problems of incomplete reaction and easy muddy reaction at the low temperature are solved. The process has the advantages of no residue, high product purity and good safety.

The invention discloses an aloe barbadensis leaf water composition for removing acnes and application thereof, and the composition is prepared from the following components in percentage by mass: 91 to 97 percent of aloe barbadensis leaf water, 1 to 4 percent of nicotinamide, 1 to 4 percent of arbutin, 0.1 to 0.4 percent of benzalkonium bromide and 0.1 to 0.6 percent of chlorhexidine acetate. The invention also provides a preparation method and application of the composition. The method comprises the following steps: weighing the raw materials in proportion, then mixing the aloe barbadensis leaf water, nicotinamide, arbutin, benzalkonium bromide and chlorhexidine acetate in a container, stirring and dissolving uniformly, sampling and detecting to be qualified, disinfecting and sterilizing, and finally, sealing, packaging and storing the aloe barbadensis leaf water, the nicotinamide, the arbutin, the benzalkonium bromide and the chlorhexidine acetate. The composition is used for preparing skin care products for removing acnes. The aloe barbadensis leaf water composition for removing acnes, prepared by the preparation method disclosed by the invention, adopts acnes-removing components derived from the nature, is safe in acnes removal without hurting the skin, restores the skin to a healthy state while repairing the damaged skin, and inhibits the re-breeding of acnes and bacteria.

The invention relates to the technical field of oral medical materials, and discloses an antibacterial composite resin-based filling material for root canal filling in the dental pulp department. The material is prepared from ethyl dicarbamate dimethacrylate, a diluting monomer, 10-methacryloyloxydecyl dihydrogen phosphate, chlorhexidine, an amino modified fumed silica carrier, an inorganic filler and an initiator. In the preparation process, chlorhexidine alkali and an acidic functional monomer are subjected to in-situ reaction to generate a hydrophobic compound, and interface chemical anchoring is formed on the surface of the amino carrier through static heat curing. By constructing a'carrier-antibacterial agent-resin 'ternary assembly structure, the problems that a hydrophilic antibacterial agent is poor in dispersion and easy to dissolve out are solved, and meanwhile, a dynamic ionic bond network is utilized to dissipate polymerization shrinkage stress, so that the edge sealing property and long-acting antibacterial ability of the material are remarkably improved.

This invention discloses the application of L-tryptophan in the preparation of anti-caries oral care products, belonging to the field of biomedical technology. Addressing the safety issues, oral microecological disruption, and susceptibility to drug resistance associated with existing anti-caries agents (such as fluoride and chlorhexidine), this invention proposes using L-tryptophan as the effective active ingredient in anti-caries agents. Utilizing the specific effects of L-tryptophan on *Streptococcus mutans*, it achieves the effects of inhibiting tooth decay, maintaining oral microecological balance, and reducing the risk of bacterial drug resistance. This specific effect, without affecting the survival of *Streptococcus mutans*, simultaneously inhibits the synthesis of water-insoluble extracellular polysaccharides, inhibits acid production and acid tolerance, and inhibits oxygen tolerance and interspecies competition. It is characterized by its clear efficacy and high safety.

This invention provides a leather antibacterial soaking agent, its preparation method, and its application, as well as a leather soaking method, belonging to the technical field of leather soaking agents. This invention utilizes two anionic surfactants, sodium diisooctyl sulfosuccinate and sodium dodecylbenzenesulfonate, in a composite, and adds chlorhexidine, citric acid, and ethylenediaminetetraacetic acid as composite antibacterial materials. Applied to the leather soaking process, it not only effectively loosens the fibers of the raw hide and provides excellent stretching for the leather, but also penetrates deep into the leather without damaging its surface material and structure, achieving a deep sterilization effect. This saves on subsequent sterilization processes, thereby improving production efficiency and reducing costs.

A method of using a pharmaceutical composition comprising metronidazole, clotrimazole and chlorhexidine for treating patients suffering from hemorrhoids, is disclosed. The mixture of metronidazole, clotrimazole and chlorhexidine can be applied to contact the hemorrhoids to relieve and / or reduce the symptoms caused by the hemorrhoids. Various application forms including solid forms and solution forms of the mixture of compounds can be used to treat the hemorrhoids.

This application relates to a novel chlorhexidine lauryl sulfate salt, which provides enhanced chlorhexidine stability and enhanced anti-bacterial activity, and to formulations and methods utilizing the novel salt.

This application provides, in particular, novel aqueous oral care compositions that can be used to combine and deliver poorly compatible ingredients, especially chlorhexidine and polyphosphates, by formulating the compositions with surfactants.

The invention discloses stable and low-irritation benzalkonium chloride contraceptive gel and a preparation method, and belongs to the technical field of biological medicine manufacturing, and the method comprises the following steps: dissolving hydroxypropyl methylcellulose in purified water, and then adding benzalkonium chloride and chlorhexidine gluconate to obtain an antibacterial matrix phase; in addition, beta-sitosterol and hydroxypropyl-beta-cyclodextrin are premixed, aloe gel freeze-dried powder, glycerin, an adjusting auxiliary material, undecylenic acid glyceride and Ectoin are added, and the mixture is homogenized to obtain an active enhanced phase; adding the activity enhancing phase into the antibacterial matrix phase, uniformly mixing, and sterilizing by ozone. Compared with the prior art, the bactericidal effect is remarkably enhanced while the dosage of the bactericide is reduced, and mucous membrane irritation is reduced; the stability of the product is effectively improved, a suitable subacid environment is created, and the unification of sterilization, protection and stability is realized.