150 results about "ChloraPrep" patented technology

PCT No. PCT / US96 / 20932 Sec. 371 Date Jun. 30, 1998 Sec. 102(e) Date Jun. 30, 1998 PCT Filed Dec. 23, 1996 PCT Pub. No. WO97 / 25085 PCT Pub. Date Jul. 17, 1997The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.

The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.

Improved film-forming skin protectant compositions are provided which are capable of forming a long-lasting elastic barrier film when applied to skin; the compositions have particular utility as barrier teat dips, for protecting cows against mastitis, especially during their susceptible non-lactating periods. The compositions include a film-forming component (preferably a mixture of polyether polyurethane and nitrocellulose) dispersed in a compatible carrier and further having a quantity of a tackifier resin incorporated therein in order to increase the time of adherence of the composition to skin, as compared with an otherwise identical composition without a tackifier resin. The compositions may also include a germicide (e.g., chlorhexidine diacetate), and a coloring dye.

The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight / weight ratio of between about 1:1 to about 1:5, preferably about 1:1.

The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.

Therapeutic, flexible, tough, rawhide pet chews impregnated with an emulsion and / or surfactant containing antimicrobially active chlorhexidine suitable for releasing said antimicrobially active chlorhexidine over the chew-life of the chew to: help control, disrupt and remove biofilms, treat fetid breath and treat gum disease in pets.

Belonging to the technical field of disinfection, the invention discloses a skin disinfection gel to solve the disadvantages of existing disinfection technologies, especially preoperative disinfection technologies. The skin disinfection gel is composed of the following active components by mass: 1.5%-6% of chitosan, 1.5-10% of chitosan oligosaccharide, 2%-8% of baicalin, 0.5%-2% of chlorhexidine, 0.5%-1.5% of sodium alginate, 2%-5% of agarose, and 1.5%-5% of a mint extract. And the disinfection effect is good. The disinfection gel disclosed in the invention can be used for hand disinfection or skin disinfection in sanitary disinfection or preoperative disinfection, and with excellent disinfection effects and lasting function, it has very good application prospects and economic benefits.

The oral formulations of the present invention comprise: (a) chlorhexidine or a salt thereof; (b) a zinc salt; (c) masking and / or flavouring agents, including: (i) a sweetening agent having an immediate but transient effect and (ii) a sweetening agent having a delayed but prolonged effect; and (d) other conventional components of oral formulations. The formulations are, for example, toothpastes, dentifrices, mouthwashes, chewing gum or lozenges.

The invention relates to a disinfectant, in particular to the rapid skin disinfectant and a preparation method thereof. The alcohol-containing chlorhexidine iodine disinfectant comprises components with the following percentages by weight: 0.1 to 4 percent of chlorhexidine; 0.1 to 5 percent of iodine; 30 to 80 percent of alcohol; 0.1 to 2 percent of stabilizer; 0.1 to 1 percent of penetrating agent; 0.1 to 2 percent of skin car agent; 0.1 to 0.8 percent of phosphoric acid solution with the concentration of 10 percent and the rest of water. The preparation method of any disinfectant is that: the chlorhexidine, the iodine and the alcohol are heated and mixed for 1 to 3 hours at the temperature of 40 to 60 DEG C according to the components and the contents, the stabilizer, the penetrating agent, the skin protective agent and the phosphoric acid of 10 percent are then respectively added, the water is added to 100 percent to be evenly mixed, and the disinfectant is obtained. The disinfectant of the invention can not only have high-efficient broad-spectrum and rapid special effects of sterilization, but can also have good safety and simple and rapid usage.

An antiseptic solution including, a cationic antiseptic agent, a film forming polymer, an anionic tinting agent, and a solvent, wherein the cationic antiseptic agent, the film forming polymer and the anionic tinting agent each remain solubilized within the solution for greater than about 1 hour at 25° C. and 60% relative humidity. The antiseptic agent is preferably octenidine dihydrochloride or chlorhexadine gluconate. The film forming polymer is preferably an acrylate polymer. The solvent is preferably ethanol, isopropanol, and n-propanol. When a drape is adhered to a dried surgical film via the antiseptic solution, the force required to peel the drape from the surgical film is at least about 105 g / 25 mm.

The invention relates to sterile cleansing solution for women. The cleansing solution is composed of chitosan with a specific molecular weight and deacetylation degree, chlorhexidine, glycerol, acidifier and purified water. The cleansing solution is applied in the environment with hundred-thousand-level cleanliness, the chitosan and the purified water are mixed to form suspension liquid, acidifier is added in the suspension liquid to adjust the pH value to be within the range from 3.8 to 5.8, and chitosan gel is obtained. The chlorhexidine is additionally taken and is dissolved in the glycerol and is added in the chitosan gel, the chitosan gel is evenly stirred, degasification is conducted, filling sealing is conducted and sterilization is conducted, wherein the acidifier is lactic acid or acetic acid or the mixture of hydrochloric acid and acetic acid, and Co-60 irradiation processing or high-temperature damp and hot sterilization is conducted during the sterilization process. The invention further relates to the manufacturing method of the cleansing solution for curing the gynecological disease and the application of the cleansing solution in preparation of medicines for curing women monilial vaginitis, bacterial vaginitis, trichomonas vaginitis or cervicitis, and the sterile cleansing solution for women can be used for daily hygiene care of the vagina of a woman.

The invention provides a foam disinfectant for medical use. The foam disinfectant consists of chlorhexidine acetate, glycerol, alcohol, grape seed essential oil, an emulsifier op, betaine cocoate, tocopherol, lavender essential oil and de-ionized water. The invention also provides a preparation method of the disinfectant. The foam disinfectant prepared by the invention is rich in foam amount, and the volume content of foam is 40-46%; when the foam disinfectant is heat-stored at 52-56 DEG C, only 0.5-1.0% of foam is reduced after 14d; the foam disinfectant is good in disinfecting effect, and when the foam disinfectant is used for disinfecting skin of hands of a human body, a killing rate on escherichia coli, staphylococcus aureus and pseudomonas aeruginosa within 30s is 99.999-100%, and a killing rate on candida albicans reaches 99.99-100%; the foam disinfectant is long in antibacterial duration, and compared with disinfection with simple using of alcohol, the effective antibacterial duration of the foam disinfectant is increased by 2.5-3 times; and the disinfection is high in volatilizing speed, and the disinfection, after being smeared to the hands, volatilizes within 5-7s without residue on the hands.

The embodiment of the invention discloses an antibacterial preparation and a preparation method thereof. The antibacterial preparation adopts compatibility of chlorhexidine acetate, borneol, menthol and glycerol, can effectively kill pathogenic bacteria and has good killing effect on pathogenic bacteria resulting in gynecological inflammation, namely pathogens such as staphylococcus aureus, candida albicans and escherichia coli, antibacterial rate is more than or equal to 90%, and the lowest content of heavy metals is less than 1ppm. The antibacterial preparation disclosed by the embodiment of the invention also has good biocompatibility, low cytotoxicity and no delayed type hypersensitivity; and each index meets relevant national standards or regulations. Meanwhile, the antibacterial preparation has good anti-inflammation, sterilization and itching relieving effects, is wide in application range and can also be applied to antibacteria and anti-inflammation of human skin and mucosae.

The invention relates to the technical field of bacteria resisting gels, and particularly relates to a bacteria resistance and inhibiting private care gel for resisting gynecological diseases. The gelcomprises, by weight, 86.0-90.0% of water, 0.3-0.5% of carbomer-940, 3.0-5.0% of glycerol, 3.0-5.0% of butanediol, 0.1-0.2% of allantoin, 0.1-0.2% of methyl hydroxybenzoate, 0.5-1.5% of colloidal silver, 0.05-0.15% of chlorhexidine gluconate, 0.05-0.15% of chlorhexidine acetate, 0.02-0.15% of borneol, 0.2-3% of radix sophorae flavescentis extracts, 0.2-3% of fructus cnidii extracts, 0.05-3.0% ofchitosan, 0.3-0.5% of triethanolamine, 0.02-0.2% of fullerene, 1.5-2.5% of polyquaternium, 0.1-0.2% of 1,2-hexanediol, 0.09-0.2% of phenoxetol, 0.03-0.1% of ethylhexyl glycerin, 0.1-0.3% of PEG-40 hydrogenated castor oil and 0.01-0.05% of mentholum. According to the gel, by adding various kinds of effective ingredients of the radix sophorae flavescentis extracts, the fructus cnidii extracts, the colloidal silver, the chlorhexidine gluconate, the chlorhexidine acetate, the fullerene and the like,the care gel has strong bacteria resistance on staphylococcus aureus, bacillus coli and candida albicans, there exists no irritation on vaginal mucosa, and there exists no irritation reaction on skin.

The invention provides a cream composition which comprises bacteriostatic agents, glycerin and deionized water. The mass ratio of the bacteriostatic agents to the glycerin to the deionized water is 0.1-22:10-97:3-9. The bacteriostatic agents are at least one type of polyhexamethylene guanidine hydrochloride, polyhexamethylene biguanidine hydrochloride, iodopropynyl butylcarbamate, 2-methyl-4-amino-6-methoxy s-triazine, benzalkonium bromide, chloretone, sulfoacid pyrimidine sodium, diclofenac sodium, chlorhexidine and myristylpicolinum bromide. The invention further provides paper comprising the cream composition. The cream composition is formed on the outer surface of the paper, so that the paper realizes moisture retention, sterilization and bacteriostasis effects when used for wiping the skin of a user, and feels comfortable and soft.

The invention discloses a disinfection sterilization medical ultrasonic coupling medium with the bactericidal function and used in the ultrasonic detection and treatment of skin and cavitary mucosa and a preparation method of the coupling medium, wherein, the ultrasonic coupling medium comprises propylene glycol, de-ionized water and one viscosity modifier of the hydroxy ethyl cellulose, carbomerand hydroxy propyl cellulose. The coupling medium further comprises a fungicide of 0.05 to 0.15 percent and the constituents of the fungicide are any one of polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, trichlorobenzene phenoxy diphenyl ether and nanometer silver or any combination of the olyhexamethylene biguanide, the benzalkonium chloride, thebenzalkonium bromide, the chlorhexidine acetate, the trichlorobenzene phenoxy diphenyl etherand, and the nanometer silver; the preparation method used for preparing the ultrasonic coupling medium is as follows: dispersing the hydroxy ethyl cellulose in the propylene glycol, stirring and dispersing the hydroxy ethyl cellulose by adding enough water, heating to 75 to 80 DEG C, preserving the heat for 30 minutes to cool the hydroxy ethyl cellulose and the propylene glycol to 45 DEG C, adding the fungicide to stir and cool the fungicide, the hydroxy ethyl cellulose and the propylene glycol to obtain the filled coupling medium. Tests show that the products of the coupling medium have fast and long sterilization effect and meet the requirements of various related standards.

The invention relates to a disinfectant, and aims to provide a compound chlorhexidine acetate microemulsion disinfectant having the advantages of good water solubility, strong disinfection effect, long disinfection effect maintenance time and good stability, and its preparation method. The compound chlorhexidine acetate microemulsion disinfectant is prepared through using the following raw materials, by weight, 0.02-11.0 parts of chlorhexidine acetate, 0-11.0 parts of benzalkonium bromide, 18.5-30.2 parts of a surfactant, 0-18.6 parts of a cosurfactant, 2.7-5.0 parts of oil and 36.6-67.2 parts of distilled water. The compound chlorhexidine acetate microemulsion disinfectant has the advantages of high chlorhexidine acetate content, use convenience, simple production technology, low production cost, and convenience for the scale production.

The invention relates to a chlorhexidine and oligochitosan-containing pharmaceutical composition, wherein the mass proportion of the chlorhexidine to oligochitosan is (0.1-1):1, the chlorhexidine comprises chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride or chlorhexidine citrate, and the molecular weight of the oligochitosan is less than 5,000. The invention further relates to an application of the pharmaceutical composition in preparing a skin or object surface sanitizer, an application of the pharmaceutical composition in preparing an air-atomizing sanitizer, an application of the pharmaceutical composition in preparing an oral cavity sanitizer, an application of the pharmaceutical composition in preparing a vaginal irrigation solution, or an application of the pharmaceutical composition in preparing vaginal gels. According to the chlorhexidine and oligochitosan-containing pharmaceutical composition, the oligochitosan plays a role in obviously improving the antibacterial action of the chlorhexidine.

The invention discloses a Metronidazole, Clotrimazole and Chlorhexidine Acetate Effervescent Tablet and the preparation method. Each tablet has the following proportion of contents: metronidazole 0.2 gram, clotrimazole 0.16 gram, acetic acid chlorhexidine acetate 0.008 gram, fumaric acid 0.108 to 0.162 gram, tartaric acid 0.012 to 0.018 gram, solium bicarbonate 0.12 to 0.18 gram, starch 0.02 to 0.04 gram, dextrin 0.003 to 0.007 gram, hydroxypropyl cellulose 0.007 to 0.013 gram, talc 0.01 to 0.017 gram, sodium dodecyl sulfate 0.01to 0.02 gram, and proper proportion of povidone K30 water solution. According to the preparation method, the components are mixed to produce granule (1) and granule (2); the talc, sodium dodecyl sulfate and the granule (1) and granule (2) are mixed uniformly; granule content is tested and according to the granule content, the tablet weight is identified for tabletting. The invention overcomes the shortages with prior art, enables the acetic acid chlorhexidine acetate to perform functions normally, performs synergistic effects of the three drugs, and greatly enhances the cure rate. Besides, the frothing volume is high, and within storage period, the quality is stable and the drug effects are not affected.

The invention relates to a cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals. The purpose of the invention is to provide a cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals with the characteristics of simple preparation, good stability, ease use and good use effect. The technical solution provided by the invention is as follows: the cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals is characterized in that the combination type preparation comprises a weakly alkaline cleaner and a skin antibacterial spray; the raw materials of the weakly alkaline cleaner include benzalkonium chloride or benzalkonium bromide, 30% dodecyl dimethyl amine oxide solution and polysorbate 20; the raw materials of the skin antibacterial spray include benzalkonium bromide, or benzalkonium chloride, or chlorhexidine, or chlorhexidine acetate, or chlorhexidine hydrochloride, or chlorhexidine citrate, or 20% chlorhexidine gluconate solution and polysorbate 20. The preparation provided by the invention is applied to the treatments of cleaning and sterilizing the skin wounds after being bitten or scratched by dogs, cats and other animals.

The invention discloses a nano iodine-chitosan cervical disease treating membrane agent and a preparation method of the membrane. The treating membrane is prepared by adding plasticizer and adsorbent to chitosan, povidone iodine, dialkyl quaternary ammonium salt and chlorhexidine acetate used as main effective ingredients. The treating membrane disclosed by the invention has killing activity to multiple pathogenic microorganisms, has no irrigation to mucosa, can relieve itching, arrest bleeding and promote the growth of epidermic tissues, can be used for treating colpitis, trichomonas vaginalis, cervicitis, cervical erosion and other gynecological diseases, has better repair action on vaginal and cervical injury, and can effectively prevent the propagation of venereal diseases such as gonorrhoea, syphilis, AIDS (acquired immunodeficiency syndrome) and the like.

The invention relates to the technical field related to elimination of thalli, and particularly provides a preparation for strongly eliminating vibrios and a preparing method of the preparation. On one hand, provided is the preparation for strongly removing vibrios, wherein the preparation comprises the components in percentage by weight: 65-85% of a first guanidine derivative, 2-12% of a second guanidine derivative and the balance being ethanol, wherein the first guanidine derivative is polyhexamethylene guanidine salt and / or polyhexamethylene biguanide salt; and the relative molecular weightof the second guanidine derivative is 500-1500. The vibrios can be effectively removed by utilizing polyhexamethylene guanidine hydrochloride and chlorhexidine hydrochloride under the specific content. The preparation provided by the invention has a strong removal effect on pathogenic vibrios, such as vibrio parahaemolyticus, vibrio anguillarum, vibrio alginolyticus, vibrio cholerae, vibrio fluorescens and the like, has a good cracking effect on aeromonas hydrophila, aeromonas punctata, escherichia coli, salmonella and other gram-negative bacteria, and has a quite high removal rate after being used for 48 hours.

The invention discloses fresh fruit mint mouthwash, and belongs to the technical field of personal care products. The fresh fruit mint mouthwash comprises the following components in parts by weight: 95 to 98 parts of water, 1 to 2.5 parts of glycerin, 0.5 to 1.2 parts of PEG-40 hydrogenated castor oil, 3 to 5 parts of essence, 0.01 to 0.05 part of saccharin sodium, 0.01 to 0.02 part of menthol, 0.01 to 0.3 part of chlorhexidine digluconate, 0.1 to 0.3 part of cetyl pyridinium chloride, 0.05 to 0.3 part of methyl benzoate, 0.05 to 0.3 part of ethyl hydroxybenzoate, 0.05 to 0.3 part of nipasol, 0.01 to 0.3 part of butoben, 0 to 0.005 part of eugenol and 0 to 0.005 part of limonene. According to the mouthwash, bad breath can be effectively removed, fresh breath can be kept persistent, and antibacterial effects and anti-caries effects can be achieved.

The invention relates to an antibacterial transparent dressing, a preparing method of the antibacterial transparent dressing and application of the antibacterial transparent dressing. The antibacterial transparent dressing comprises a polymer gel lining pad and a transparent protective film, wherein the polymer gel lining pad has moisture absorption performance and long-acting bacteriostasis performance; antibacterial drug is contained in the polymer gel lining pad; the polymer gel lining pad is prepared from materials of the following polymer monomers including hydroxyethyl methylacrylate, methyl methacrylate, cinnamic acid, alpha-cyanoacrylate, alpha-carboxymethyl crylic acid, methyl alpha-chloroacrylate and crylic acid-2-hydroxyl ethyl ester; the antibacterial drug is selected from chlorhexidine gluconate, chlorhexidine acetate, polyhexamethylene guanide salts and triclosan; the transparent protective film is a polyurethane thin film.

The invention discloses a sprayable metronidazole gel composition. The composition comprises metronidazole, water, a water-miscible solvent, carboxymethylcellulose, gamma-type carrageen glycan and 2000-20000 parts of PEG1 (polyethylene glycol 1). The gel composition is high in physical stability, high in salt-resistant capacity and convenient to use.

Methods for reduction of aggregate levels in antibody and other protein preparations comprising the steps of treatment with an organic multivalent cation (e.g., ethacridine, chlorhexidine, or polyethylenimine) and treatment with a composition having a combination of surfaces bearing electronegative chemical moieties and surfaces bearing electropositive chemical moieties.

The invention discloses an efficacy type sterilization and disinfection liquid containing a natural citral-bletilla striata polysaccharide polymer and a preparation method thereof; the efficacy type sterilization and disinfection liquid containing the natural citral-bletilla striata polysaccharide polymer comprises the following components by the weight percentage: 45%-75% of ethanol, 0.5%-2.0% of chlorhexidine gluconate, 0.5%-2.0% of the natural citral-bletilla striata polysaccharide polymer, 0.3%-1.5% of trehalose, and the balance deionized water. The preparation process comprises the following steps: (1) adding the natural citral-bletilla striata polysaccharide polymer to water, stirring and dissolving; (2) then adding trehalose and chlorhexidine gluconate, stirring and dissolving; and after the system is cooled, adding ethanol, stirring and dissolving; and (3) cooling, to obtain the efficacy type sterilization and disinfection liquid. The efficacy type sterilization and disinfection liquid has thorough sterilization and disinfection effects, and has the function of moistening skin.

The invention relates to a gel preparation for treating gynecological diseases. The gel preparation consists of chitosan with specific molecular weight and degree of deacetylation, chlorhexidine, glycerin, an acidifying agent and purified water. The preparation method comprises the following steps of: mixing the chitosan with the purified water to form suspension liquid in an environment with cleanliness at one-hundred-thousand level; adding the acidifying agent to regulate pH to 3.8-5.8 to obtain chitosan gel; dissolving chlorhexidine in the glycerin, adding into the chitosan gel, uniformly stirring, degassing, filling, sealing, and sterilizing to obtain the gel preparation, wherein the acidifying agent is lactic acid, acetic acid or a hydrochloric acid-acetic acid mixture; and the sterilizing mode is cobalt-60 irradiation treatment or high-temperature damp-hot sterilization. The gel has good adhesion force, uniform color and good stability, is used for treating women monilial vaginitis, bacterial vaginitis, mixed vaginitis, cervicitis, cervical erosion and the like, and has the advantages of being good in curative effect, safe, natural, good in biocompatibility and the like. The invention further relates to a preparation method and medical application of the gel preparation.