Cold-dampness-dispelling quick-acting sterilizing and deodorizing spray and preparation method thereof

Abstract

The invention provides a cold-dampness-dispelling quick-acting sterilization and deodorization spray and a preparation method thereof. The cold-dampness-dispelling quick-acting sterilization and deodorization spray integrates quick-acting sterilization, cold-dampness-dispelling and long-acting deodorization. The spray comprises a component A and a component B which are stored separately, the component A contains acidic substances, fatty acid, chlorhexidine acetate, boric acid, menthol and chitosan, and the pH value of the component A is 4.0 + / -0.05; the component B contains sodium chlorite, plant essential oil, ethanol and polyvinylpyrrolidone, and the pH value of the component B is 9.0 + / -0.05. During use, the components are mixed according to a ratio of 1: 1 to trigger a chemical reaction to generate chlorine dioxide, so that rapid broad-spectrum sterilization is realized. The product is subpackaged by a double-cavity spray bottle, so that the active ingredients are prevented from reacting in advance, and the storage stability is ensured. The preparation method comprises the following steps: respectively preparing the component A and the component B, sub-packaging in a double-cavity bottle, and mixing and atomizing during use. The invention has fast-acting property, durability and safety, realizes the integration of sterilization, repair and deodorization through acid-base split charging design and instant reaction mechanism, and is suitable for application in multiple scenes of skin, clothes and environment.

Description

Technical Field

[0001] The present invention relates to the technical field of antibacterial preparations, and in particular to a spray for dispelling cold and dampness, quickly killing bacteria and deodorizing, and a preparation method thereof. Background Art

[0002] Existing technologies are unable to simultaneously achieve deep sterilization, eliminate dampness and coldness, and achieve long-lasting deodorization. Common solutions to the bacterial growth, dysbiosis, and associated odor problems caused by damp environments or constitutions are often inadequate. For example, aromatherapy or perfume can only temporarily mask odors but fail to fundamentally address the problem. Most deodorizing sprays on the market only target superficial bacteria and fungi on the skin, but struggle to completely eliminate harmful bacteria deeper inside and on clothing and the environment, easily leading to recurring infections and treating only the symptoms rather than the root cause.

[0003] In the field of antibacterial therapy, while existing technologies can control the symptoms of bacterial and fungal infections to a certain extent, they have obvious limitations. Chlorine dioxide, as a highly effective fungicide, is easily volatile and ineffective, making it difficult to maintain a lasting effect; and it is difficult to balance skin irritation with user comfort. Topical antifungal ointments are highly targeted, but are not effective for severe or deep fungal infections, require long-term use, and have poor patient compliance. Topical antifungal sprays are convenient to use, but some sprays have a pungent odor and a short duration of effect. Although oral antifungal drugs can kill fungi from within the body, there is a risk of side effects such as liver and kidney damage. Traditional Chinese medicine lotions are relatively mild, but slow to take effect and inconvenient to use. Keratolytics can be used as auxiliary treatments, but they are highly irritating and have limited use. Summary of the Invention

[0004] The purpose of the present invention is to provide a spray for dispelling cold and dampness, killing bacteria and deodorizing quickly, and a preparation method thereof, which can not only quickly kill harmful bacteria, but also relieve the discomfort caused by infection. The spray is suitable for preventing and treating fungal and bacterial infections on human skin, clothing and the environment, and solves the problems in the prior art of being difficult to effectively dispel cold and dampness, thoroughly sterilize, and treating the symptoms but not the root cause.

[0005] By storing components A and B separately, this invention prevents premature reaction between the acidic substance and sodium chlorite to form chlorine dioxide during storage, thus ensuring the stability of the active ingredient. When mixed during use, a chemical reaction is immediately triggered, rapidly releasing high-concentration chlorine dioxide for rapid sterilization. Meanwhile, auxiliary ingredients extend the duration of action and reduce irritation, achieving immediate, long-lasting protection.

[0006] The present invention provides a spray for removing cold and dampness, quickly killing bacteria and deodorizing, comprising components A and B stored separately: Component A: contains acidic substances, fatty acids, chlorhexidine acetate, boric acid, menthol, and chitosan, with a pH of 4.0±0.05; Component B: contains sodium chlorite, plant essential oil, ethanol, polyvinylpyrrolidone, pH 9.0±0.05.

[0007] The acidic substance in component A provides an acidic environment (pH 4.0 ± 0.05), reacting with the sodium chlorite in component B to produce chlorine dioxide, a core bactericidal reactant that also regulates pH. Fatty acids form a moisturizing film, preventing dryness and cracking on the skin and repairing damaged skin barriers. Chlorhexidine acetate is a broad-spectrum antimicrobial agent, enhancing its effectiveness against Gram-positive and Gram-negative bacteria and compensating for the limited effectiveness of chlorine dioxide against some drug-resistant bacteria. Boric acid, a weakly acidic antibacterial agent, inhibits bacterial metabolic enzyme activity, reduces exudate, and helps alleviate inflammation. Menthol activates skin cold receptors, producing a cooling sensation and alleviating symptoms such as itching and burning. Chitosan, a natural cationic polysaccharide, synergizes with PVP to form a film, extending the residence time of chlorine dioxide on the skin and surfaces, achieving sustained-release bactericidal action. Sodium chlorite in component B reacts with acetic acid under alkaline conditions (pH 9.0 ± 0.05) to produce chlorine dioxide, providing a highly effective bactericidal active ingredient. Essential oils can reduce inflammation, promote wound healing, and mask odors produced by bacterial metabolism (such as hydrogen sulfide and ammonia). Ethanol acts as a solvent and volatilizer, accelerating spray drying and reducing dampness. It also synergistically disrupts bacterial cell membranes, enhancing the bactericidal effect. Polyvinylpyrrolidone (PVP), a high-molecular-weight polymer, forms a breathable protective film with chitosan, immobilizing chlorine dioxide and slowing its volatilization, thereby increasing the longevity of the effect.

[0008] The packaging design and ingredient compatibility of the spray formula A and B components of the present invention solve the problems of poor fast-acting, high irritation and single function of traditional fungicides through chemical reaction triggering, complementary functional ingredients and physical barrier construction, and achieve the integrated effect of "removing cold and dampness - sterilization - repair - deodorization", which has significant clinical and practical value. Among them, chlorine dioxide instantly kills surface and deep-layer bacterial flora, and the chitosan-PVP membrane continuously releases active ingredients to inhibit secondary infection, achieving a combination of fast-acting and long-lasting effects. Chlorine dioxide and chlorhexidine acetate sterilize, unsaturated fatty acids and plant essential oils play a repairing role, the cooling feeling of menthol enhances comfort, and chlorine dioxide oxidizes odor molecules for deodorization, realizing the integration of multiple functions. pH is graded and controlled, wherein A is acidic and B is alkaline, reducing the irritation of a single strong acid / strong base to the skin and improving safety. When used on the human body, it can be applied to athlete's foot, axillary odor, private parts care, etc., quickly killing bacteria while repairing the skin barrier; when used for environmental disinfection, it can penetrate deep into the fibers to kill mold and neutralize moldy odors in humid environments such as shoe cabinets and bathrooms; when used for clothing processing, it can be sprayed on shoes, socks, and underwear to avoid cross infection without any residual stains or corrosion.

[0009] In the present invention, component A is scientifically proportioned and synergistically effective, with acetic acid reacting with sodium chlorite in component B to generate chlorine dioxide as the core, thereby achieving rapid and broad-spectrum sterilization. Ingredients such as coconut oil and chitosan are used to repair the skin barrier and prevent dryness and cracking. Menthol relieves itching and discomfort, while boric acid astringes inflammation, enhancing the user experience. Precise pH control (4.0±0.05) ensures reaction efficiency while avoiding irritation. By selecting saturated or unsaturated fatty acids, it can flexibly adapt to different needs (such as antioxidant properties and skin feel), and antioxidants can compensate for the oxidation risk of unsaturated fatty acids.

[0010] The spray of the present invention comprises component A in the formula, in parts by weight, 1-5 parts of an acidic substance, 0.7-1.3 parts of a fatty acid, 0.05-0.1 parts of chlorhexidine acetate, 1-3 parts of boric acid, 0.5-1 parts of menthol, and 0.1-1 parts of chitosan; the acidic substance comprises acetic acid, and the fatty acid is selected from at least one of the following: a) Saturated fatty acids, including coconut oil and palm kernel oil; b) Unsaturated fatty acids, including olive oil, jojoba oil, and sunflower oil; When unsaturated fatty acids are used, an additional 0.1-0.5% antioxidant is added to maintain stability.

[0011] Acidic substance (acetic acid) reacts with sodium chlorite in component B to generate chlorine dioxide. Chemical reaction: 4H + +5ClO2 - →4ClO2↑+Cl -+2H2O; the acidic environment inhibits bacterial metabolism, disrupts microbial cell membranes, and interferes with enzyme activity. Fatty acids provide moisturizing and barrier repair, stabilizing the formula. Saturated fatty acids (such as coconut oil) form a dense protective film, locking in moisture and preventing dryness and cracking. Unsaturated fatty acids (such as olive oil) enhance skin moisturizing properties and provide antioxidant protection. They also regulate emulsion structure and enhance ingredient compatibility. Fatty acids (such as coconut oil) prevent dryness and cracking. Coconut oil, with its high proportion of lauric acid (C12), offers strong permeability and repairs the stratum corneum. Its hydrophobicity reduces water loss and maintains the skin's barrier function. It also regulates the water-oil balance, enhances emulsion stability, and stabilizes the formula. Unsaturated fatty acids (such as oleic acid) contain double bonds and easily penetrate the skin, but require antioxidant protection. Antioxidants are only added when replacing unsaturated fatty acids to inhibit oil rancidity and extend shelf life. Antioxidants such as vitamin E stabilize unsaturated fatty acids by providing hydrogen atoms to block free radical chain reactions. Chlorhexidine acetate protects against both Gram-positive and Gram-negative bacteria, adsorbing to the skin surface and inhibiting bacterial reproduction. Cationic surfactants disrupt bacterial cell membranes, leading to leakage of intracellular substances. This dual bactericidal mechanism, combined with chlorine dioxide, reduces the risk of drug resistance. Boric acid, a pH buffer, maintains an acidic environment to optimize reaction efficiency, reduces exudate, and inhibits bacterial growth. Boric acid's weak acidity modulates the skin's microenvironment and inhibits fungal enzyme activity. Its astringent properties alleviate inflammation. Menthol provides a cooling and antipruritic effect, alleviating itching and burning sensations. It also mildly numbs nerve endings, reducing pain. It activates transient receptor potential (TRPM8) on the skin, producing a cooling sensation. It also inhibits pain signal transmission and improves comfort. Chitosan and PVP synergistically form a breathable membrane, prolonging the action of chlorine dioxide and accelerating skin repair. Chitosan's positive charge binds to the negative charge of microorganisms, disrupting their structure. Its biocompatibility promotes collagen synthesis and accelerates wound healing.

[0012] The formulation of Component A in this invention, through optimized chemical reactions and functionally complementary components, not only addresses the contradictions faced by traditional fungicides in terms of rapid effectiveness, durability, and comfort, but also achieves integrated bactericidal, repairing, and protective properties. Traditional fungicides (such as ointments) require long-term use and are prone to recurrence. This invention leverages the strong oxidizing properties of chlorine dioxide to achieve rapid bactericidal action, while incorporating protective film technology to prevent secondary infection. Natural ingredients (fatty acids and chitosan) reduce irritation, while synthetic components (chlorine dioxide and chlorhexidine acetate) ensure high efficacy, meeting modern consumer needs. The raw materials are readily available, and the repackaging design extends shelf life, making it suitable for large-scale production. Component A of this invention, with chlorine dioxide as its core and combined with a repackaging design, overcomes the limitations of traditional fungicides, achieving both high bactericidal efficacy and skin protection, making it suitable for a variety of applications, including home and medical settings. It also reduces reliance on antibiotics and promotes the development of green antimicrobial products.

[0013] The core function of component B in the present invention is to generate chlorine dioxide through a chemical reaction of sodium chlorite, combined with the synergistic antibacterial effects of plant essential oils, the rapid volatilization and film formation of ethanol, and the stabilizing protective effects of PVP. Sodium chlorite reacts with the acetic acid in component A to generate chlorine dioxide, which rapidly kills bacteria, fungi, and viruses. The plant essential oils enhance the antibacterial spectrum, repair wounds, or mask odors, while ethanol promotes drying and PVP prolongs the duration of action. The alkaline environment (pH 9.0±0.05) ensures the storage stability of sodium chlorite and prevents premature release of chlorine dioxide.

[0014] The spray of the present invention comprises, in a formula, component B comprising, by weight, 0.5-0.8 parts of sodium chlorite, 0.02-0.2 parts of plant essential oil, 50-75 parts of ethanol, and 1-2 parts of polyvinyl pyrrolidone; the plant essential oil comprises myrrh essential oil, soapberry essential oil, tea tree essential oil, or rose essential oil.

[0015] Sodium chlorite reacts with the acetic acid in component A to release chlorine dioxide. Chlorine dioxide destroys microbial structures through oxidation, penetrates cell membranes, and oxidizes intracellular enzymes and genetic material, achieving rapid sterilization. Plant essential oils target specific bacterial species (such as fungi and Gram-positive bacteria); they promote wound healing or mask odors. Myrrh essential oil is anti-inflammatory and promotes healing; tea tree essential oil is a potent antifungal (such as Candida albicans); soapberry essential oil is a natural surfactant that cleans and sterilizes; and rose essential oil soothes the skin and neutralizes odors. Ethanol acts as a solvent and volatile agent, dissolving water-insoluble components and promoting rapid drying. It also aids sterilization by destroying microbial cell membranes. Ethanol evaporates, creating a dry environment that inhibits bacterial growth. Its lipid solubility disrupts microbial cell membrane integrity and enhances chlorine dioxide permeability. Polyvinylpyrrolidone and chitosan synergistically form a breathable protective film, extending the residence time of chlorine dioxide on the surface. The linear polymer structure of PVP forms a network membrane after ethanol evaporates, immobilizing chlorine dioxide and essential oil components, achieving sustained-release sterilization.

[0016] The formulation of component B in this invention leverages the efficient reaction of sodium chlorite and the functional expansion of plant essential oils, combined with the physical synergy of ethanol and PVP. This not only addresses the contradictions between rapid-action, long-lasting effects, and safety of traditional fungicides, but also addresses the synergistic effects of chlorine dioxide and essential oils, protecting against multiple pathogens. The type of essential oil can be adjusted to suit skin, clothing, and the environment. The formulation dries quickly and leaves no residual odor, balancing functionality and comfort. This invention's split packaging design (separated A / B components) addresses the issue of chlorine dioxide's fragility while retaining its high bactericidal properties. Plant essential oils compensate for the functional limitations of synthetic ingredients, achieving integrated bactericidal, remedial, and deodorizing properties. Ethanol, a low-cost solvent, and PVP, a commonly used excipient, facilitate large-scale production. Chlorine dioxide kills bacteria and viruses, while plant essential oils (such as tea tree oil) specifically inhibit fungi, creating a multi-faceted antibacterial mechanism. The combination of physical oxidation (chlorine dioxide) and natural antimicrobial agents (essential oils) reduces the risk of drug-resistant bacteria. Ethanol evaporates, allowing the spray to quickly form a film, preventing moisture from reaching skin or clothing. The PVP film slows the evaporation of chlorine dioxide, maintaining an effective sterilization concentration for 6-8 hours. Essential oil multifunctional design: Choose the type of essential oil you need; the aroma of the essential oil masks the pungent odor of chlorine dioxide, enhancing user comfort and optimizing the experience.

[0017] This invention utilizes a split-pack dual-chamber design, with separate storage for components A and B. This addresses the issue of chlorine dioxide's easy decomposition, ensuring the stability of the active ingredients before use and avoiding the risk of ineffectiveness associated with traditional premixed formulas. Component A (acidic) and component B (sodium chlorite) are mixed in a 1:1 ratio to rapidly generate high-concentration chlorine dioxide, achieving rapid, broad-spectrum sterilization. This multifunctional, integrated sterilization, deodorization, and repair function address skin, clothing, and the environment, transcending the single-use limitations of traditional products. Chlorine dioxide's strong oxidizing properties kill bacteria, fungi, viruses, and spores, making it suitable for deep sterilization in humid environments (such as shoe cabinets and bathrooms). Menthol relieves itching, coconut oil moisturizes, and chitosan repairs, reducing irritation and enhancing the user experience. The split-pack design extends shelf life and reduces waste; natural ingredients (such as chitosan and plant essential oils) are biodegradable, reducing environmental impact. Physical oxidation sterilization replaces some antibiotics, inhibiting the development of drug-resistant bacteria. It addresses odor and infection issues caused by cold and damp environments, improving sanitation in homes and public spaces.

[0018] The spray of the present invention comprises components A and B which are separately packaged in a double-chamber spray bottle and are mixed in the air at a ratio of 1:1 to generate chlorine dioxide when in use, which acts on the target surface after atomization. The spray is used for sterilization, deodorization and repair of skin, clothing and the environment.

[0019] The dual-chamber spray bottle design isolates components A and B, preventing premature chlorine dioxide generation and decomposition. Components A (pH 4.0) and B (pH 9.0) are packaged separately to prevent premature reaction between the acidic environment and sodium chlorite. The dual-channel nozzle ensures a 1:1 mixing ratio, resulting in fine atomized droplets (0.3mm diameter) that are fully exposed to air, accelerating chlorine dioxide generation. A single press completes mixing and spraying, requiring no additional operation, making it suitable for use in homes and public spaces. Atomization enhances the penetration and reach of chlorine dioxide, increasing the surface area of ​​the atomized droplets, allowing chlorine dioxide to be rapidly released and diffused into skin folds, clothing fibers, and even the surrounding environment. Chlorine dioxide penetrates microbial cell membranes, oxidizing enzymes and genetic material, and killing deep-seated bacteria (such as tinea pedis fungus and clothing mildew). Chlorine dioxide reacts with odorous molecules (such as hydrogen sulfide and ammonia) to produce odorless products, eliminating odors at the source. Skin application directly acts on the infected area, rapidly relieving symptoms and preventing recurrence. Chlorine dioxide kills pathogens (such as Candida albicans and Staphylococcus aureus), while menthol relieves itching. Chitosan forms a film to isolate pathogens, while coconut oil moisturizes and prevents cracking, accelerating wound healing. Spraying on the feet and underarms prolongs the duration of the protective film and inhibits bacterial regeneration. For clothing sterilization, it penetrates fibers to kill residual fungi (such as athlete's foot fungus), preventing secondary contamination of shoes, socks, and underwear. For environmental disinfection, spraying in damp areas such as bathrooms and basements inhibits mold growth and eliminates musty odors. Chlorine dioxide decomposes to produce harmless chlorides with no toxic residue, making it suitable for infant clothing and sensitive environments. The synergistic formula of components A and B combines natural and synthetic ingredients, balancing efficacy and safety. The dual bactericidal mechanism of chlorine dioxide and chlorhexidine acetate protects against drug-resistant bacteria, reducing the risk of recurrence. Ethanol accelerates drying, while PVP forms a film that prolongs the duration of chlorine dioxide's action. The essential oils used in this invention, tea tree oil, enhance antifungal properties, rose oil neutralizes odor, and myrrh oil promotes repair.

[0020] The dual-chamber spray of the present invention achieves a balance between rapid effect, durability and safety through a sub-packaging design and instant reaction to generate chlorine dioxide. With the sub-packaging type chlorine dioxide generation as the core, it breaks through the limitations of traditional fungicides; it integrates sterilization, repair and deodorization, and is suitable for multiple scenarios such as skin, clothing and environment.

[0021] After preparation, the spray of the present invention is stored in a double-chamber spray bottle. The interior of the bottle is divided into two independent chambers by a physical partition, which respectively store components A and B to prevent mixing and chemical reactions or deterioration. When the nozzle is pressed, the liquids in the two chambers are sprayed out simultaneously through their respective pipes, atomized and mixed in the air outside the nozzle to form a uniform spray.

[0022] The spray of the present invention, the double-chamber spray bottle includes a double-tube parallel type, an inner-outer nested type, and a pressure-driven type.

[0023] The present invention stores components A and B separately in a double-chamber spray bottle, which completely solves the problem of premature reaction, failure or deterioration of active ingredients in traditional sprays. Only when in use, by pressing the nozzle, components A and B are sprayed out from their respective chambers, atomized and fully mixed in the air, triggering a chemical reaction to generate chlorine dioxide, which plays a key role. This instant reaction mechanism ensures the stability of the active ingredients during storage, while achieving immediate effect, which is essentially different from the form of traditional sprays. The spray of the present invention not only achieves fast-acting sterilization, but also has the functions of removing cold and dampness, long-lasting deodorization and repair. The fatty acids, chitosan and other ingredients in component A, and the plant essential oils in component B, while sterilizing, work together on the skin, clothing and the environment to achieve multiple effects such as repairing the barrier, relieving discomfort, and covering up odors. Most traditional sprays can only achieve a single sterilization or deodorization function, and cannot integrate multiple functions into one.

[0024] The double-tube parallel double-chamber spray bottle has two independent chambers arranged in parallel, and the A and B components are sprayed out synchronously through a common nozzle or a dual-channel nozzle. A mixing chamber is designed inside the nozzle to ensure that the two liquids are fully mixed before atomization. When the nozzle is pressed, components A and B enter the mixing chamber through their respective conduits, and are atomized and mixed under the action of high-speed airflow to generate chlorine dioxide. Its advantages are that the dual-channel design can ensure a 1:1 ratio of mixing and high reaction efficiency; the manufacturing cost is low and it is suitable for large-scale production; the nozzle can be disassembled and cleaned to avoid clogging. The spray of the present invention is suitable for this type of spray bottle, and can make full use of its low cost and easy production characteristics to achieve an efficient and stable sterilization effect.

[0025] The inner and outer nested dual-chamber spray bottle is designed with an inner and outer cavity nested, and packaging is achieved through a coaxial conduit or a layered structure. The nozzle has a built-in dual flow channel to ensure that the two liquids are independently transported to the mixing point. When the nozzle is pressed, the inner and outer cavity liquids are transported through the inner and outer flow channels respectively, mixed and atomized at the nozzle, and chlorine dioxide is instantly generated. The spray of the present invention can be used therein, and its volume saving advantage can be achieved to achieve a portable design to meet the user's need to carry it with them; at the same time, the cross-sectional area of ​​the inner and outer flow channels is fixed, which can ensure a stable mixing ratio and ensure the accurate performance of the drug effect.

[0026] The pressure-driven double-chamber spray bottle has a chamber with compressed gas or an elastic bag built in, which drives the synchronous release of components A and B through the air pressure difference. The mixing chamber can be designed as a built-in reaction chamber or an external atomizer. When the valve is pressed, the compressed gas pushes components A and B into the mixing chamber to react and generate chlorine dioxide, which is then sprayed through the atomizing nozzle. The spray of the present invention is combined with it, and its pressure drive can be used to ensure rapid mixing of liquids and reduce reaction delays. It is especially suitable for scenarios that require rapid response, such as large-scale environmental disinfection; some designs support automatic spraying, which further expands the application scenarios.

[0027] The spray of the present invention utilizes a two-component packaging and an immediate reaction mechanism, addressing the issue of premature reaction and ineffectiveness of the active ingredients in conventional sprays while also achieving multifunctional integration. It is suitable for various spray bottle formats, including dual-tube parallel, nested, and pressure-driven, leveraging the advantages of different spray bottle types. Through structural innovation and functional adaptation, it enables efficient application of chlorine dioxide spray in a variety of scenarios, including household, medical, and industrial settings. The spray of the present invention is applicable to a variety of dual-chamber spray bottles, breaking through the limitations of traditional formulations.

[0028] This invention, through a two-component, packaged spray and precise parameter control, provides a spray with rapid-acting sterilization, dampness-removing, deodorizing, and repairing functions. It utilizes an acidic substance (such as acetic acid) to react with sodium chlorite to instantly generate chlorine dioxide, achieving a sterilization rate exceeding 99.9% within 30 minutes, targeting bacteria, fungi, and viruses. Ingredients such as chitosan and coconut oil repair the skin barrier, while menthol alleviates discomfort and essential oils mask odor, achieving an integrated sterilization, repair, and deodorization solution. The dual-chamber packaging prevents premature decomposition of chlorine dioxide, and precise pH control ensures storage stability. The post-mixing pH range of 6.0-7.0 is optimized for both human and environmental needs. The atomization design enhances permeability, making it suitable for deep disinfection of skin (for athlete's foot and underarm odor), clothing (for shoe and sock sterilization), and the environment (for mold in the bathroom).

[0029] The present invention provides a method for preparing a spray for dispelling cold and dampness, quickly killing bacteria and deodorizing, comprising the following steps: Step 1. Prepare Component A: Dissolve the acidic substance, chlorhexidine acetate, boric acid, menthol, and chitosan in water. Add fatty acid and mix thoroughly. Adjust the pH to 4.0 ± 0.05. Add water to 100% volume. The acidic substance (such as acetic acid) provides H⁺, which reacts with the sodium chlorite in Component B to produce chlorine dioxide. Use 1-5 parts to ensure a complete reaction and avoid irritation caused by excessive amounts. Chlorhexidine acetate, a cationic surfactant, destroys bacterial cell membranes and synergizes with chlorine dioxide to kill resistant bacteria. 0.05-0.1 parts balances bactericidal efficacy and safety. Boric acid, a weak acid buffer, maintains the pH of Component A at 4.0 ± 0.05, optimizes the efficiency of chlorine dioxide production, and provides astringency to the skin, reducing inflammatory exudate. 1-3 parts ensures pH stability and protects against skin damage. Menthol activates the skin's cold receptor (TRPM8), relieving itching and burning sensations. 0.5-1 parts provides a cooling sensation without excessive irritation. Chitosan and PVP synergistically form a film, extending the duration of chlorine dioxide action and promoting wound healing. A 0.1-1 phr formulation ensures film formation without affecting spray flow. Fatty acids (such as coconut oil) moisturize, prevent cracking, and repair the skin barrier. A 0.7-1.3 phr formulation balances moisturizing and formula stability. Antioxidants (0.1-0.5%), added only when replacing unsaturated fatty acids, inhibit oil rancidity and extend shelf life. They provide hydrogen atoms to block free radical chain reactions and maintain the stability of unsaturated fatty acids. The pH is adjusted to 4.0 ± 0.05 to optimize the reaction efficiency between acetic acid and sodium chlorite and prevent premature chlorine dioxide formation.

[0030] Step 2. Prepare Component B: Dissolve sodium chlorite, plant essential oils, and polyvinylpyrrolidone in water. Add anhydrous ethanol to a final concentration of 50-75%, stir to mix, adjust the pH to 9.0 ± 0.05, and add water to 100%. Sodium chlorite reacts with the H⁺ in component A to produce chlorine dioxide, which provides broad-spectrum bactericidal activity. A 0.5-0.8 part chlorine dioxide concentration ensures sufficient chlorine dioxide production while minimizing residual toxicity. Essential oils (such as myrrh and tea tree oils) include tea tree oil for antifungal properties, myrrh oil for anti-inflammatory and healing properties, and rose oil for deodorization. A 0.02-0.2 part chlorine dioxide concentration enhances efficacy while minimizing overpowering odor. Polyvinylpyrrolidone and chitosan form a breathable protective film, securing the chlorine dioxide and essential oils and prolonging their duration of action. A 1-2 part chlorine dioxide concentration balances film strength and spray atomization. Anhydrous ethanol (final concentration 50-75%) acts as a solvent to promote dissolution of ingredients, accelerate volatilization and drying, and aid in sterilization. A high concentration (>75%) can dry out the skin, while a low concentration (<50%) can slow volatilization. The pH is adjusted to 9.0 ± 0.05 to maintain the chemical stability of the sodium chlorite and prevent spontaneous decomposition during storage.

[0031] Step 3. Repackaging and Use: Dispense components A and B into a dual-chamber spray bottle. Dispense simultaneously, mixing in a 1:1 ratio to maintain a pH between 6.0 and 7.0. Apply atomized solution to the target surface. The dual-chamber spray bottle isolates components A and B to prevent premature chlorine dioxide formation. The dual-channel nozzle ensures a 1:1 mixing ratio. The pH after mixing is approximately neutral at 6.0-7.0, minimizing irritation to the skin and the environment. Atomization, with droplet size ≤50μm, maximizes contact area, enhancing chlorine dioxide penetration and bactericidal efficiency.

[0032] The preparation method of the present invention solves the stability problem of chlorine dioxide through double-chamber packaging, and the atomization design improves bactericidal penetration; it quickly relieves itching, provides long-lasting protection, is non-irritating, and is adaptable to the needs of multiple scenarios; the raw materials are easily obtained, the process parameters are clear, and it is suitable for large-scale production.

[0033] Step 1 of the present invention is the core process for preparing component A. By precisely controlling the dissolution conditions (temperature, stirring speed, and time), functional ingredients such as acetic acid and chlorhexidine acetate are fully dissolved to form a homogeneous solution. The emulsification effect of coconut oil is used to balance the water and oil phases, enhance the stability of the formula, and prevent stratification or precipitation. The pH is adjusted to 4.0±0.05 to provide optimal acidic conditions for the subsequent reaction with sodium chlorite in component B to generate chlorine dioxide. By constant volume and filtration, impurities are removed and the component concentrations are controlled to ensure the standardization of each batch of products.

[0034] In the method for preparing the spray of the present invention, step 1 comprises: Step 1.1: Dissolve the water-soluble components: Measure deionized water and add acetic acid, chlorhexidine acetate, boric acid, menthol, and chitosan. Stir at 300-500 rpm at 25±2°C for 20-30 minutes until completely dissolved. The initial volume of deionized water should account for 55-65% of the total mass of component A. This initial volume (55-65%) should reserve room for subsequent rehydration to prevent the solution from being too dilute or too thick during the initial dissolution, which could affect dissolution efficiency. Operate at room temperature to prevent volatilization or decomposition of temperature-sensitive components (such as menthol). A moderate rotation speed ensures complete dissolution while avoiding bubble formation. A timer is set to ensure adequate hydration of macromolecules such as chitosan. Add the components sequentially, dissolving the water-soluble components (acetic acid, boric acid, etc.) first and then the oil phase (coconut oil), adhering to the principle of "like dissolves like." Complete dissolution provides a homogenous foundation for subsequent emulsification and prevents undissolved particles from affecting spray atomization.

[0035] Step 1.2: Add coconut oil and emulsify: Slowly add coconut oil dropwise to the solution and continue stirring for 10-15 minutes to form a uniform emulsion. Control the addition rate to prevent localized aggregation of the oil phase caused by rapid addition, ensuring the gradual formation of stable droplets. Stir for 10-15 minutes to fully shear the oil droplets to a particle size of ≤5μm, forming a uniform emulsion. Coconut oil serves as the oil phase, dispersing it in the aqueous phase. Chitosan (a natural emulsifier) ​​helps stabilize the emulsion and prevent separation during storage. Coconut oil provides moisturizing properties, working together with chitosan to repair the skin barrier, and acts as a carrier to evenly distribute fat-soluble ingredients (such as menthol). When using unsaturated fatty acids, add 0.1-0.5% antioxidant to maintain stability.

[0036] Step 1.3 pH Adjustment and Volume Fixation: Adjust the pH of the solution to 4.0 ± 0.05 using 0.1M NaOH or dilute hydrochloric acid. Add deionized water to 100% of the total weight of Component A. Filter to remove impurities to obtain Component A. The pH range (4.0 ± 0.05) provides the optimal H⁺ concentration for subsequent mixing with Component B (pH 9.0) to generate chlorine dioxide, ensuring reaction rate and completeness. Chlorhexidine acetate is more active in a weakly acidic environment, and chitosan has optimal solubility at pH 4.0. Add water to 100% to precisely control the concentration of Component A to minimize batch-to-batch variability. Fine-tune with 0.1M NaOH or dilute hydrochloric acid to avoid introducing impurities with excess reagents. Filter to remove undissolved particles or microorganisms to ensure the sterility and clarity of the spray.

[0037] This step, through scientific parameter control and meticulous operation, ensures uniform distribution of the active ingredients, providing the material foundation for rapid sterilization. The acidic pH sets the stage for efficient chlorine dioxide production. The emulsion system and filtration process extend shelf life and enhance user experience. This step is key to achieving the functionality of Component A and directly impacts the spray's sterilization efficiency, safety, and applicability.

[0038] The preparation process in step 2 of the present invention ensures stable storage of the sodium chlorite in component B and efficient generation of chlorine dioxide after mixing with component A through precise control of reaction conditions and scientific ratios. The alkaline environment (pH 9.0±0.05) inhibits the decomposition of sodium chlorite and prevents premature generation of chlorine dioxide. Ethanol promotes dissolution and volatilization, PVP forms a protective film, and plant essential oils (such as myrrh essential oil) enhance antibacterial and repair properties. Parameter control (pH, concentration, and water volume) ensures batch consistency in industrial production.

[0039] In the method for preparing the spray of the present invention, step 2 comprises: Step 2.1: Measure deionized water, add sodium chlorite and myrrh essential oil, and stir until dissolved. The initial volume of deionized water should account for 25-35% of the total mass of Component B. The initial volume of deionized water should be 25-35% to provide an appropriate amount of water to dissolve the sodium chlorite and essential oil, avoiding excessive dilution that could lead to insufficient ethanol concentration. The solubility of sodium chlorite increases with increasing water temperature, but excess water will dilute the ethanol concentration, affecting subsequent film formation and volatilization efficiency. As a chlorine dioxide precursor, sodium chlorite reacts with the acetic acid in Component A to produce chlorine dioxide, achieving rapid bactericidal action. Under acidic conditions, sodium chlorite is converted to chlorine dioxide. The addition of myrrh essential oil enhances antibacterial and repair properties, promoting wound healing and masking the pungent odor of chlorine dioxide. Myrrh essential oil contains terpenoids (such as bisabolol), which have anti-inflammatory and antioxidant properties, forming a dual antibacterial mechanism with chlorine dioxide.

[0040] Step 2.2: Slowly add anhydrous ethanol to a final concentration of 50-75%, then add polyvinylpyrrolidone and stir for 10-20 minutes until completely dissolved. Ethanol acts as a solvent and volatile agent, dissolving PVP and essential oils, promoting rapid drying after spraying and preventing moisture on skin or clothing. Ethanol evaporates, removing moisture and accelerating film formation. Its lipid solubility disrupts microbial cell membranes and enhances the permeability of chlorine dioxide. The addition of polyvinylpyrrolidone synergistically forms a breathable protective film with chitosan, extending the duration of chlorine dioxide's action and improving the formulation's adhesion. After ethanol evaporates, the PVP polymer chains form a network structure, securing the chlorine dioxide and essential oil components, achieving sustained-release sterilization.

[0041] Step 2.3: After adjusting the solution pH to 9.0 ± 0.05 with 0.1 M NaOH, add deionized water to 100% of the total mass of Component B and filter to obtain Component B. Adjusting the pH to 9.0 ± 0.05 creates an alkaline environment that inhibits the decomposition of sodium chlorite, preventing premature formation of chlorine dioxide during storage. Sodium chlorite is chemically stable at a pH greater than 8.5, significantly reducing its decomposition rate. The solution is then diluted to 100% and filtered to ensure the final concentration of Component B meets the design requirements, remove undissolved impurities, and prevent nozzle clogging. Filter (0.22 μm microporous membrane) to remove particulate matter and ensure uniform atomization. The solution is then diluted to ensure the precise reaction ratio when mixing Components A and B in a 1:1 ratio.

[0042] Step 2 of the present invention ensures stable storage of sodium chlorite and rapid generation of chlorine dioxide upon use. Ethanol promotes drying, PVP forms a film, and essential oils repair the solution, forming a closed "sterilization-protection-repair" loop. Parameter design balances laboratory and industrial requirements, ensuring product consistency and safety. An ethanol concentration of 50-75% balances solubility and volatility, enabling dissolution of PVP and essential oils while preventing excessive concentrations from drying out the skin. Precise control of the initial water volume of 25-35% ensures sufficient sodium chlorite dissolution while leaving room for subsequent water replenishment, preventing the formulation from being too dilute or too thick. A stepwise dissolution process, dissolving the sodium chlorite and essential oils first before adding ethanol and PVP, prevents ethanol from prematurely affecting the solubility of sodium chlorite. Dual pH control includes maintaining component B at a pH of 9.0 to maintain sodium chlorite stability and maintaining a pH of 6.0-7.0 after mixing, providing optimal reaction conditions. pH gradient control ensures alkaline storage of component B and a neutral reaction after mixing, balancing stability and efficiency.

[0043] In step 3 of the present invention, components A and B are prevented from premature contact reaction through packaging isolation, precise mixing, and pH control, thereby preventing the decomposition and ineffectiveness of chlorine dioxide during storage. A 1:1 ratio of mixing is achieved through a dual-channel nozzle to ensure the generation rate and concentration of chlorine dioxide. After mixing, the pH value is 6.0-7.0, which is close to neutral, thereby avoiding irritation to the skin or the environment and optimizing the sterilization reaction conditions.

[0044] In the spray preparation method of the present invention, step 3 comprises: Step 3.1: Filling and Isolation: The double-chambered bottle is disinfected with 75% ethanol and dried. Component A is injected into the left chamber of the bottle, occupying 50% of the volume, and component B is injected into the right chamber, occupying 50% of the volume, to ensure complete isolation of the two chambers. The 75% ethanol disinfection ensures sterility, killing potential microorganisms within the bottle and preventing contamination. It effectively inactivates bacteria and fungi, and leaves no residue after evaporation, meeting pharmaceutical-grade production standards. The 50% volume ratio of components A and B ensures a 1:1 mixing ratio during use, ensuring a complete reaction. A deviation from the volume ratio can result in insufficient or excessive chlorine dioxide production, compromising sterilization efficacy and safety. The two chambers are completely isolated to prevent premature contact between component A (acidic) and component B (alkaline), thereby preventing the formation and decomposition of chlorine dioxide during storage. Sodium chlorite is stable in an alkaline environment (pH 9.0) but triggers a reaction in an acidic environment (pH 4.0). This packaging and isolation is the core of the technology.

[0045] Step 3.2: Assemble the spray head: Assemble a dual-channel spray pump head with a nozzle orifice of 0.2-0.5mm. Ensure that components A and B are sprayed and atomized simultaneously in a 1:1 ratio when pressed. The dual-channel spray pump head synchronizes atomization, ensuring that components A and B are sprayed simultaneously, allowing the droplets to fully mix and react to form chlorine dioxide. The dual-channel design prevents unilateral blockage or uneven flow rates, ensuring uniform mixing. The nozzle orifice diameter of 0.2-0.5mm optimizes atomization. Fine droplets (particle size ≤50μm) increase the reaction surface area, accelerating chlorine dioxide generation and diffusion. Smaller droplets increase the gas-liquid contact area, resulting in faster reaction rates and greater penetration (e.g., penetrating into clothing fibers or skin folds).

[0046] Step 3.3 pH control: pH verification: The pH range of component A is 3.95-4.05, and the pH range of component B is 8.95-9.05. After mixing A and B in a ratio of 1:1, the pH value is controlled at 6.0-7.0. The pH of component A is 3.95-4.05. The acidic environment ensures the reaction efficiency of acetic acid and sodium chlorite to generate high concentration of chlorine dioxide. When the pH is less than 4, sodium chlorite (ClO2 - ) and H + The reaction rate of generating chlorine dioxide is the highest. The pH of component B is 8.95-9.05. The alkaline environment inhibits the decomposition of sodium chlorite and prolongs the shelf life. Sodium chlorite is chemically stable when the pH is greater than 8, which prevents spontaneous decomposition into ClO2 or ClO3 during storage. - The pH after mixing is 6.0-7.0. A neutral pH reduces corrosiveness to skin or clothing while maintaining the activity of chlorine dioxide. Chlorine dioxide is more stable at a pH of 6-7 and is close to the pH of human skin (5.5-6.5), preventing irritation or damage.

[0047] Step 3 of the present invention solves the problems of easy decomposition of chlorine dioxide, uneven proportions of traditional fungicides, and strong irritation through strict packaging and isolation, precise atomization control, and pH management, thereby achieving "instant effect" of the fungicide; ensuring the rapid generation and long-lasting effect of chlorine dioxide; achieving a neutral pH that is compatible with the human body and the environment, and is non-irritating and non-corrosive; and supporting large-scale production and quality control through standardized operating procedures and parameter control.

[0048] The present invention provides a spray for dispelling cold and dampness, killing bacteria and deodorizing quickly, and a preparation method thereof. The spray can not only quickly kill harmful bacteria, but also relieve the discomfort caused by infection. At the same time, it is safe and non-irritating to the skin and the environment, and solves the problems in the prior art of being difficult to effectively dispel cold and dampness, thoroughly sterilize, and only treating the symptoms but not the root cause.

[0049] In summary, the present invention has the following beneficial effects: 1. The present invention instantly generates high-concentration chlorine dioxide through the acid-base reaction between component A (containing an acidic substance such as acetic acid) and component B (containing sodium chlorite). Its strong oxidizing properties can penetrate microbial cell membranes, destroying enzyme activity and genetic material, and has a highly effective killing effect on bacteria, fungi, viruses, and spores. Compared with traditional ointments that require several weeks of treatment, the present invention can achieve immediate effect by spraying, effectively shortening the treatment cycle, and is particularly advantageous for targeting drug-resistant strains. 2. The chitosan and polyvinylpyrrolidone (PVP) in the spray formulation of this invention form a breathable protective film after ethanol evaporates, which delays the volatilization of chlorine dioxide and fixes the active ingredients, prolonging the effective duration of the bactericidal effect. This film has both breathability and adhesion to prevent secondary infection, making it particularly suitable for conditions prone to recurrence, such as tinea pedis and axillary odor. It overcomes the limitations of traditional sprays that only act on the surface and have a short-lived effect. 3. This invention solves multiple problems caused by cold and damp environments with one dose. Skin application can relieve itching and repair the skin barrier; clothing disinfection can prevent fungal residues; environmental spraying can inhibit mold growth and neutralize odors. To address odor problems caused by cold and damp environments or physical conditions, chlorine dioxide oxidizes odor molecules such as hydrogen sulfide and ammonia to produce odorless products, eliminating odors at the source. At the same time, menthol activates the skin's cold receptors, producing a cooling sensation, alleviating uncomfortable symptoms such as itching and burning caused by cold and dampness, achieving simultaneous deodorization and physical improvement. Plant essential oils promote wound healing and reduce scar formation. Precise pH control (pH 6.0-7.0 after mixing) and the addition of natural ingredients (coconut oil and chitosan) effectively reduce irritation. The product achieves an integrated sterilization, repair, and soothing function, balancing efficacy and user comfort. 4. The fatty acids (such as coconut oil) in this invention repair the skin barrier and prevent dryness and cracking; boric acid regulates the skin microenvironment and inhibits fungal enzyme activity; plant essential oils (such as tea tree oil and rose oil) have antibacterial, soothing and aromatic functions; the natural ingredients in the formula, such as chitosan and plant essential oils, are biodegradable. After decomposition, the product produces harmless chlorides without heavy metal or toxic residues. The sub-packaging design reduces packaging waste, making it green and environmentally friendly and in line with the trend of sustainable development. 5. The spray of the present invention has a separate packaging and isolation design for components A and B. The double-chamber spray bottle (double-tube parallel, nested inside and outside, pressure-driven) achieves physical isolation between components A and B, preventing premature decomposition and ineffectiveness of chlorine dioxide and extending the shelf life. When used, mix them in a 1:1 ratio to ensure sufficient reaction and convenient operation. It is suitable for multiple applications in home, medical and industrial scenarios. DETAILED DESCRIPTION

[0050] This specific embodiment is merely an explanation of the present invention and is not intended to limit the present invention. After reading this specification, those skilled in the art may make non-creative modifications to this embodiment as needed. However, as long as such modifications are within the scope of the claims of the present invention, they are protected by patent law.

[0051] Preparation method of agent A and agent B in the embodiment: Preparation of component A: Dissolve the acidic substance (such as acetic acid), chlorhexidine acetate, boric acid, menthol, and chitosan in an appropriate amount of water, then add fatty acid and stir evenly. Adjust the pH of the solution to 4.0±0.05 using a pH meter, and add water to 100% of the A system. When unsaturated fatty acids are used, add 0.1-0.5% antioxidant to maintain stability. Component B: Dissolve sodium chlorite and plant essential oil in appropriate amount of water, and add anhydrous ethanol to a final concentration of 50-75%. Stir evenly, adjust the pH of the solution to 9.0±0.05 using a pH meter, and add water to 100% of the A system. In the comparative example, only acetic acid was replaced with salicylic acid, and the other ingredients remained unchanged to prepare a spray. The mass percentages of the components are shown in Table 1: Table 1 Summary of the mass percentages of the components in the sprays of the embodiments and comparative examples

[0052] 1. Determination of chlorine dioxide content Components A and B in Examples 1-5 and Comparative Examples 1-3 were mixed in a ratio of 1:1, and the chlorine dioxide content was measured using the five-component iodine method at 0 min, 5 min, 10 min, 20 min, and 30 min, respectively. The test results are shown in Table 2: Table 2 Summary of chlorine dioxide content in each group of sprays (unit: ppm)

[0053] Analysis of the results: Table 2 shows that Examples 1-5 produce chlorine dioxide at a significantly faster rate than Comparative Examples 1-3 and have a higher concentration within 30 minutes. The chlorine dioxide content of the Example group was significantly higher than that of the Comparative Example group within 5 minutes after mixing. The chlorine dioxide content of the Example group reached 50-78ppm within 5 minutes, while the Comparative Example group only had 21-28ppm. The chlorine dioxide content of the Example group reached 185-203ppm at 30 minutes, while the Comparative Example group only had 98-107ppm. This shows that acetic acid, as an acidic substance in the Example group, can more effectively trigger the reaction of sodium chlorite and generate a higher concentration of chlorine dioxide. In addition, the buffering effect of boric acid in the Example group maintains an acidic environment and promotes the continued reaction, while the acidity of salicylic acid in the Comparative Example is weaker, resulting in a lower chlorine dioxide generation rate and total amount. The chlorine dioxide content measurement results in Table 2 show that the Example group, due to the use of acetic acid and optimized ratio, is significantly superior to the Comparative Example in chlorine dioxide generation efficiency and total amount, ensuring rapid and efficient sterilization ability.

[0054] 2. Antibacterial detection Antibacterial tests were conducted according to the "Hygiene Requirements for Disposable Sanitary Products" (GB15979-2024, Appendix E) E5 standard. Components A and B from Examples 1-5 and Comparative Examples 1-3 were mixed at a 1:1 ratio at room temperature. The mixture was then treated with Escherichia coli, Staphylococcus aureus, and Candida albicans for 1, 2, and 3 minutes, respectively. The test results are shown in Table 3. Table 3 Summary of the antibacterial results of each group of sprays on Escherichia coli, Staphylococcus aureus and Candida albicans (unit: %)

[0055] Analysis of results: Table 3 shows that the antibacterial rates of the embodiment group against the three test bacteria are all greater than 99.9%, while the antibacterial rates of comparative examples 1 and 2 are less than 50%, and the antibacterial rate of comparative example 3 is greater than 50% but less than 90%. This shows that the formula of the embodiment group can kill bacteria and fungi quickly and efficiently, while the comparative example has insufficient chlorine dioxide production due to the low reactivity of salicylic acid, and the bactericidal effect is significantly reduced. In addition, the synergistic effect of the plant essential oils in the embodiment enhances the bactericidal spectrum, while the single or missing type of essential oil in the comparative example further weakens the bactericidal effect. The antibacterial experimental results in Table 3 further verify the superiority of the formula of the embodiment group. The bactericidal effect of the comparative example is greatly reduced due to insufficient chlorine dioxide production and formula defects.

[0056] 3. Skin irritation test Test basis and conditions: "Procedures and Methods for Toxicological Evaluation of Safety of Disinfectants" (GB / T3896-2020). Components A and B in Examples 1-5 and Comparative Examples 1-3 were mixed in a 1:1 ratio and tested on the original samples at an ambient temperature of 21°C-24°C and a relative humidity of 49%-52%.

[0057] Test method: 9 female New Zealand rabbits, weighing 2.0kg-2.8kg, were randomly divided into short-term test group 1, long-term test group 2 and control group, with 3 rabbits in each group. 24 hours before the test, the hair on both sides of the New Zealand rabbits' spine was removed with a depilatory agent without damaging the skin. The exposed skin was disinfected with 75% alcohol before medication. The hair removal range was approximately 3cm×3cm (or 2.5×2.5cm) on the left and right sides, and the test product was administered transdermally to the left back of each experimental rabbit. A layer of cellophane (or patch, non-allergic and non-irritating), two layers of gauze and non-irritating adhesive tape were used to fix the skin. Each drug contact with the skin lasted for 4 hours, and then the wrapping and drug were removed, and the administration site was cleaned with warm water. The administration was repeated 14 times. The experimental results are shown in Table 4: Table 4 Summary of skin irritation results of each group of sprays

[0058] Results Analysis: Table 4 shows that the sprays in Examples 1-5 were non-irritating to the skin and mucous membranes. This is primarily attributed to the pH gradient design of the formulations: Component A has a pH of 4.0±0.05, Component B has a pH of 9.0±0.05, and the combined pH is 6.0-7.0, close to the physiological pH of human skin (5.5-6.5), reducing skin irritation. Furthermore, natural ingredients such as fatty acids (coconut oil) and chitosan form a breathable protective film on the skin surface, prolonging the action of the antibacterial ingredients while preventing damage to the stratum corneum caused by traditional strong acid and alkaline formulations. The skin irritation test results in Table 4 demonstrate that the formulation design of the Examples effectively reduces skin irritation and enhances comfort and safety.

[0059] The present invention overcomes the technical bottlenecks of traditional fungicides in terms of rapid effectiveness, durability, safety and applicability in multiple scenarios through the coordinated design of a split-package two-component and a multifunctional formula. It combines the advantages of high-efficiency disinfection, comfortable repair, green environmental protection and industrialization, and provides new solutions for the fields of personal care, household hygiene and public disinfection.

Claims

1. A spray for removing cold and dampness, quickly killing bacteria and deodorizing, characterized in that: Includes components A and B stored separately: Component A: contains acidic substances, fatty acids, chlorhexidine acetate, boric acid, menthol, and chitosan, with a pH of 4.0±0.05; Component B: contains sodium chlorite, plant essential oil, ethanol, polyvinylpyrrolidone, pH 9.0±0.

05.

2. The spray according to claim 1, characterized in that Component A in the formula comprises, by weight, 1-5 parts of an acidic substance, 0.7-1.3 parts of a fatty acid, 0.05-0.1 parts of chlorhexidine acetate, 1-3 parts of boric acid, 0.5-1 parts of menthol, and 0.1-1 parts of chitosan; the acidic substance comprises acetic acid, and the fatty acid is selected from at least one of the following: a) Saturated fatty acids, including coconut oil and palm kernel oil; b) Unsaturated fatty acids, including olive oil, jojoba oil, and sunflower oil; When unsaturated fatty acids are used, an additional 0.1-0.5% antioxidant is added to maintain stability.

3. The spray according to claim 1, characterized in that The component B in the formula comprises, by weight, 0.5-0.8 parts of sodium chlorite, 0.02-0.2 parts of plant essential oil, 50-75 parts of ethanol, and 1-2 parts of polyvinyl pyrrolidone; the plant essential oil comprises myrrh essential oil, soapberry essential oil, tea tree essential oil, or rose essential oil.

4. The spray according to claim 1, characterized in that The A and B components are separately packed in a double-chamber spray bottle and mixed in the air in a ratio of 1:1 to generate chlorine dioxide, which is atomized and acts on the target surface; It is used for sterilization, deodorization and repair of skin, clothing and environment.

5. The spray according to claim 4, characterized in that The double-chamber spray bottle includes a double-tube parallel type, an inner-outer nested type, and a pressure-driven type.

6. A method for preparing a spray for removing cold and dampness, quickly killing bacteria and deodorizing, characterized in that: The following steps are involved: Step 1. Preparation of Component A: Dissolve the acidic substance, chlorhexidine acetate, boric acid, menthol, and chitosan in water, add fatty acid and mix well, adjust the pH to 4.0 ± 0.05, and add water to 100%; Step 2. Preparation of Component B: Dissolve sodium chlorite, plant essential oil, and polyvinylpyrrolidone in water, add anhydrous ethanol to a final concentration of 50-75%, stir to mix, adjust the pH to 9.0 ± 0.05, and add water to 100%; Step 3. Packaging and use: Pack components A and B separately in a double-chamber spray bottle and spray them simultaneously when using. After mixing in a ratio of 1:1, control the pH value at 6.0-7.0 and apply it to the target surface after atomization.

7. The method for preparing the spray according to claim 6, wherein: Step 1 includes: Step 1.1: Measure deionized water, add acetic acid, chlorhexidine acetate, boric acid, menthol, and chitosan; stir at 300-500 rpm at 25±2°C for 20-30 minutes until completely dissolved; the initial volume of the deionized water should be 55-65% of the total mass of component A; Step 1.2: Slowly add the fatty acid dropwise to the solution and continue stirring for 10-15 minutes to form a uniform emulsion. When using unsaturated fatty acids, add an additional 0.1-0.5% antioxidant to maintain stability. Step 1.3: Use 0.1 M NaOH or dilute hydrochloric acid to adjust the pH of the solution to 4.0 ± 0.05, add deionized water to 100% of the total mass of component A, filter to remove impurities, and obtain component A.

8. The method for preparing the spray according to claim 6, wherein: Step 2 includes: Step 2.1: Measure deionized water, add sodium chlorite and myrrh essential oil, and stir until dissolved; the initial volume of the deionized water accounts for 25-35% of the total mass of component B; Step 2.2: Slowly add anhydrous ethanol to a final concentration of 50-75%, then add polyvinylpyrrolidone and stir for 10-20 minutes until completely dissolved; Step 2.3: After adjusting the pH of the solution to 9.0 ± 0.05 with 0.1 M NaOH, add deionized water to 100% of the total mass of component B, and filter to obtain component B.

9. The method for preparing the spray according to claim 6, wherein: Step 3 includes: Step 3.1: Disinfect the double-chamber bottle with 75% ethanol and dry it. Inject component A into the left chamber of the bottle, accounting for 50% of the volume; inject component B into the right chamber, accounting for 50% of the volume, to ensure that the two chambers are completely isolated. Step 3.2: Assemble a dual-channel spray pump head with a nozzle diameter of 0.2-0.5mm. Ensure that when pressing, components A and B are sprayed and atomized simultaneously in a 1:1 ratio; Step 3.3: pH verification: The pH range of component A is 3.95-4.05, and the pH range of component B is 8.95-9.

05. After mixing A and B in a ratio of 1:1, the pH value is controlled at 6.0-7.0.

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