105 results about "Antimicrobial substance" patented technology

The invention discloses an application of an antibacterial peptide and an application of the antibacterial peptide in preparation of antibacterial drugs for treating carbapenem-resistant pseudomonas aeruginosa, klebsiella pneumoniae (ATCC700603), escherichia coli (ATCC25922), staphylococcus aureus and methicillin-resistant staphylococcus aureus, the antibacterial peptide is characterized in that the sequence is w-r-r-w-k-r-w-w-r-r, and the sequence is shown in the description. All amino acids are D-type amino acids; the antibacterial peptide can be used as an antibacterial substance in wash supplies, food preservative additives, medical consumable antibacterial agents and cosmetics, can be synthesized through an Fmoc solid-phase chemical method, and is low in synthesis difficulty and good in in-vivo antibacterial activity. Particularly, the antibacterial peptide has broad-spectrum killing activity against carbapenem pseudomonas aeruginosa, klebsiella pneumoniae (ATCC700603), escherichia coli (ATCC25922), staphylococcus aureus and methicillin-resistant staphylococcus aureus, the cell survival rate of the antibacterial peptide within the range of medium and low concentration (2 mu g / mL-32 mu g / mL) reaches half or more, the toxicity is small, the toxicity is almost avoided, the operability is high, and the antibacterial peptide can be widely applied to the field of medical application. The cost is low.

The invention discloses a bacteriophage lyase and application thereof, and particularly relates to a bacteriophage lyase with an amino acid sequence as shown in SEQ INNO.2. The bacteriophage lyase can inhibit the growth of escherichia coli, staphylococcus and salmonella, can be used as an antibacterial substance in splitting gram-negative bacteria and can be used for preparing drugs for resisting gram-negative bacteria. The lyase can be used independently or compounded with other substances, the use concentration of antibiotics can be reduced by combining the lyase with the antibiotics, toxic and side effects (such as renal toxicity of polymyxin) of drugs are reduced, and meanwhile, generation of bacterial drug resistance is delayed. After the lyase and the chitosan are combined for use, remarkable antibacterial activity is generated, the antibacterial effect can be achieved without pre-treatment on bacteria, and the practicability is improved.

The invention relates to the technical field of biomedical materials, and discloses a degradable non-woven fabric and a preparation process thereof, the non-woven fabric is prepared from polylactic acid, polycaprolactone, periodate, a copolyester oligomer containing a cis-1, 2-cyclohexanediol structural unit, and a solid biocompatible weakly alkaline salt; the preparation process comprises the following steps: mixing the components, and performing melt blending and melt-blowing spinning to prepare the non-woven fabric. The periodate and the copolyester oligomer are used as latent reaction precursors, the alkalescent salt is used as a pH regulating agent, when the non-woven fabric is in contact with an aqueous environment, the alkalescent salt is dissolved out to establish an alkalescent microenvironment, the periodate is promoted to carry out oxidative cracking on the copolyester oligomer, and thus the aldehyde compound with antibacterial activity is generated in situ. According to the invention, the on-demand generation of antibacterial substances is realized, so that the non-woven fabric has high antibacterial rate and low cytotoxicity, and the technical problem that the activity and safety of a traditional antibacterial material are difficult to balance is solved.

The application discloses a plant lactobacillus and application thereof in improving stretchability of acid coagulated cheese. Lactiplantibacillus plantarum The plant lactobacillus is named as plant lactobacillus (Lactobacillus plantarum) B11, is preserved in China Center for Type Culture Collection, has a preservation number of CCTCC NO: M 2025778 and a preservation address of Wuhan University, No. 299, Bayi Road, Wuchang District, Wuhan City, Hubei Province. The strain provided by the application can be directionally fermented to produce viscous exocellular polysaccharide and antibacterial substances. The acid whey fermented by the strain is combined with phosphate and sodium caseinate quality improver, so that the stretchability of the acid coagulated cheese is improved, the product is inhibited from being mildewed in the airing and storage processes, and meanwhile, the product quality safety can be ensured. The problems of stretching difficulty, low product yield and easy mildewing in the airing and storage processes in the prior art are solved.

The invention provides a bactericidal anticorrosive composite coating and a preparation method thereof. The composite coating is obtained by reacting and curing raw materials including epoxy resin, an antibacterial substance based on a Schiff base structure and a curing agent, the antibacterial substance based on the Schiff base structure is characterized in that the antibacterial substance based on the Schiff base structure is obtained by carrying out a Schiff base reaction on components including polyethyleneimine and an aldehyde antibacterial agent. In some embodiments, the feedstock further includes a functional polymer PBFGn; the functional polymer PBFGn is obtained by carrying out free radical copolymerization reaction on components including butyl acrylate, hexafluorobutyl methacrylate and glycidyl methacrylate. According to the preparation method of the composite coating, efficient antibacterial components are stably integrated into a tough polymer network through a chemical method and automatically migrate to the surface, and long-acting and stable anti-corrosion and antibacterial effects and improved mechanical properties can be achieved.

This application discloses an antibacterial and easy-to-clean ceramic and its preparation method. The antibacterial and easy-to-clean ceramic includes a glaze and a blank. The glaze includes 30-60 parts of potassium feldspar, 30-60 parts of sodium feldspar, 44-60 parts of phosphate, and 20-28 parts of a first antibacterial agent. The first antibacterial agent includes an active ingredient and a carrier, and the active ingredient includes zirconium oxide nanopowder and zinc oxide nanopowder. The blank includes 45-75 parts of rutile titanium dioxide, 50-60 parts of sodium alginate, 50-70 parts of composite fiber, 20-36 parts of surfactant, and 40-50 parts of a second antibacterial agent. The second antibacterial agent includes cuprous oxide. The composite fiber includes a first fiber body and a second fiber body, and the first fiber body includes TiB fiber. This application achieves excellent antibacterial properties and mechanical strength by adding zirconium oxide and zinc oxide nanoparticles with high antibacterial capabilities to the glaze and consolidating them with phosphates. Cuprous oxide is used as a second antibacterial active ingredient in the blank and combined with discontinuous TiB reinforcing fibers.

The application provides a food preservation method using plant exosome loaded with natural antibacterial substances, relates to the field of food preservation and biological materials, and comprises the following steps: loading natural antibacterial substances and the plant exosome under preset loading conditions to obtain a plant exosome loaded with natural antibacterial substances; and applying the plant exosome loaded with natural antibacterial substances to the food preservation method, wherein the natural antibacterial substances are loaded into the plant exosome, the obtained composite is dispersed in a dispersion medium for food surface treatment to obtain a preservation preparation, and the preservation preparation is applied to the surface of food to be preserved to form a preservation layer, so that the natural antibacterial substances are stably loaded, uniformly distributed and continuously delivered on the surface of the food, the problems of volatilization, inactivation and short action time of the natural antibacterial substances during use are reduced, the food preservation effect is more stable, and the shelf life is prolonged.

One embodiment of the present specification provides a method for preparing a low-crystallinity calcium phosphate-based antibacterial bone graft material, comprising the steps of: (a) adding a calcium precursor and a phosphate precursor at one time to synthesize calcium phosphate; (b) putting the calcium phosphate into an antibacterial substance precursor solution to react; (c) a step of freeze-drying the product of step (b); (d) a step of mixing the product of step (c) with a shape control agent and performing press molding to prepare a molded body; and (e) a step in which the shape control agent of the molded body is removed in a solvent having a temperature equal to or higher than the boiling point and then dried.

The invention belongs to the technical field of biological medicines, and particularly relates to a dual-targeting broad-spectrum chimeric bacteriophage antibacterial pharmaceutical preparation as well as a preparation method and application thereof. The antibacterial drug preparation comprises a bioactive substance and a liposome for coating the bioactive substance, the bioactive substance is a targeting chimeric M13 bacteriophage coupled with an antibacterial substance, and the surface of the liposome is coupled with a targeting antibody. According to the invention, the liposome and bacteriophage dual-targeting design is adopted, specific targeting to bacterial focuses can be realized, and the antibacterial substance is loaded on the mild M13 bacteriophage, so that the dosage of the antibacterial substance is reduced, and meanwhile, uncontrollable release of endotoxin is avoided; and finally, the intracellular and extracellular bacteria at the in-vivo focus are thoroughly killed under the cooperation of the liposome with the targeting capability and the customizable chimeric bacteriophage.

This disclosure relates to antimicrobial compositions comprising at least one cationic antimicrobial substance and at least one acidic glycolipid, as well as the use of such compositions in product formulations, particularly anionic formulations such as personal care, home care, and other product formulations.

The invention discloses a method for efficiently preparing a nylon 6 micro-nano fiber antibacterial air filtering membrane material, which comprises the following steps: etching porous ceramic microspheres, mixing with a non-polar material solution, coating, drying, and injecting charges to obtain electret microspheres; mixing an antibacterial substance solution with the electret microspheres in the step S1, and drying to obtain antibacterial-electret microspheres; meanwhile, spinning a bottom layer of the filtering membrane by using a crude fiber spinning solution and a fine fiber spinning solution through blowing spinning; adding a crude fiber spinning solution and antibacterial-electret microspheres into a cross-linking agent for mixing and spraying to form a middle layer with the surface of the bottom layer; repeating bottom layer operation and spraying again to form a top layer with the middle layer to obtain the filtering membrane with a multi-layer structure; carrying out hot press molding on the filtering membrane with the multi-layer structure; the dynamic interaction between a flow field and particles is enhanced, so that fine particles are more easily adsorbed or intercepted by the fiber surface, and efficient filtration is realized.

The invention discloses an implant with a honeycomb-shaped micro-nano topological structure on the surface and a preparation method and application thereof, and the implant with the honeycomb-shaped micro-nano topological structure on the surface is a honeycomb-shaped micro-nano topological structure layer prepared on the surface of a titanium substrate through a template method. According to the invention, a unique hydrogenated titanium dioxide honeycomb-shaped surface micro-nano topological structure is designed on the surface of the titanium-based implant through a template method and plasma hydrotreating on the basis of not introducing an antibacterial substance coating and complex chemical components; the special surface treatment not only has excellent 800-815nm near-infrared light response photocatalytic performance and can generate a large number of reactive oxygen species to quickly eliminate bacterial infection, but also can regulate polarization of macrophages due to the unique surface morphology, effectively inhibit inflammatory response and regulate and control bone immune microenvironment to promote osteogenesis, and has a good application prospect. And therefore, more than two invasive operations are not required to be carried out on the patient, and the postoperative healing effect is better.

The invention relates to a fungicide composition for preventing and treating peanut root rot as well as preparation and application of the fungicide composition. The invention aims to solve the technical problems of unstable field control effect, high chemical pesticide residue and high drug resistance risk of biological control in peanut root rot control. Bacillus velezensis YJ02 with good biocompatibility is compounded with azoxystrobin (a biological fungicide generates antibacterial substances and induces plant defensive enzymes, and a chemical fungicide is combined to rapidly inhibit respiration of pathogenic bacteria) to prevent and treat peanut root rot; the technical effects that the efficient synergistic control effect (for example, the control effect reaches up to 86.79%) is achieved, the application amount of chemical pesticides is reduced (for example, the dosage of azoxystrobin is only 9.82% of the conventional dosage), the drug resistance risk of pathogenic bacteria is effectively reduced, the morbidity and disease index are reduced, and environment friendliness is achieved are achieved, and high economic benefits and social benefits are achieved.

A method of producing a filament is disclosed. The method includes extruding a material for a filament core and a material for a filament sheath using an extruder, using a core portion and a sheath portion of a die in order to direct the material extruded from the extruder, and forming a filament by cooling during or after using the die. A method and apparatus for post-processing a 3D printed product using at least one of laser radiation or plasma processing is disclosed. In addition, a core / sheath structure composed of the forming material or a formed product produced from the forming material is disclosed. The core / sheath structure comprises a core and a sheath, the core and sheath comprising: one or both of fibers or particles; and at least one of: a soluble substance; an antimicrobial substance; an ultraviolet protection substance; an odor management substance; or a moisture management substance.

The invention discloses an antibacterial substance management information system based on artificial intelligence, and relates to the field of medical information, a plurality of historical antibacterial grade sequences sorted according to time are acquired from historical antibacterial treatment data, and a gradient sequence based on adjacent time step difference values is generated; the system calculates the continuous gradient length based on the sliding window, wherein the continuous gradient length reflects the continuous upgrading or degrading trend of the antibacterial grade; in a self-attention layer of the Transform network, a time step with a larger continuous gradient length is endowed with a higher attention weight, so that a key change fragment in the antibacterial grade sequence is highlighted, and the Transform network is trained based on a historical antibacterial grade sequence to obtain an antibacterial grade prediction model. According to the invention, intelligent prediction and management optimization of the antibacterial drug grade in the future can be realized by using the antibacterial grade change characteristics.

The invention discloses a preparation method of an enhanced warp-knitted lace fabric, and aims to solve the problems that fibers such as cotton fibers with relatively high water absorption capacity do not have a quick-drying characteristic, have poor antibacterial performance after long-term retention of water, still go mouldy and stink, and are low in skin-friendly property. According to the technical scheme, the method is characterized by comprising the following steps that S1, spandex filaments are stretched to a certain drafting length, then nylon filaments are evenly wound on the outer surfaces of the stretched spandex filaments according to a certain twist degree, and the nylon elastic covering yarn is obtained. The antibacterial acarus killing layer is made of cotton fibers with high water absorption, and treatment is conducted through composite alkali liquor, alkali liquor, a mercaptoacetic acid solution and a silver nitrate solution in sequence in the preparation process, so that antibacterial substances can be stably embedded into the fibers instead of being only attached to the surface layers of the fibers, and the antibacterial acarus killing effect is achieved. Furthermore, good antibacterial performance can be kept in the states of multiple times of water washing and long-term soaking.

The present application belongs to the technical field of surgical implant medical devices for foot and ankle, and discloses a preset angle ankle arthrodesis device with functions of promoting bone integration and resisting bacteria, which has a preset angle suitable for tibiodal joint, ranging from 3° to 7°. The device further comprises a three-dimensional porous bone implant body, a surface of the three-dimensional porous bone implant body in contact with host bone tissue is a porous titanium alloy, a plurality of convex anti-rotation ridges are arranged on the upper and lower end faces of the three-dimensional porous bone implant body, the three-dimensional porous bone implant body is fixed by occlusion with the host bone through the anti-rotation ridges, an in-situ growth film layer is grown on the surface of the three-dimensional porous bone implant body, and the in-situ growth film layer comprises functional substances and antibacterial substances. The present application effectively solves the technical problems of slow bone integration, high risk of infection, rotation instability and insufficient mechanical support in ankle arthrodesis, significantly improves the success rate of fusion and reduces postoperative complications.

The invention discloses a gelled cell as well as a preparation method and application thereof. Relates to the field of synthetic biology and biomedicine. The gelated cell is a cell structure without cell viability, and comprises: a carrier cell framework comprising a cell membrane which retains the membrane protein content, the type and the lipid order of an original carrier cell; the intracellular hydrogel is formed in situ in the carrier cell framework through supramolecular host-guest interaction or cross-linking reaction, and is fused with the inner surface of a cell membrane; the antibacterial substance is loaded in the intracellular hydrogel; wherein pores are distributed on the cell membrane, the intracellular hydrogel is communicated with the external environment through the pores, and the loaded antibacterial substances are exposed. The gelated cell provided by the invention can simultaneously realize targeted delivery, contact sterilization and endotoxin adsorption, and avoids the problem of secondary inflammation caused by release of endotoxin in traditional antibiotic therapy and the problem of membrane protein loss or disordered arrangement in a cell membrane coating technology.

The invention relates to the technical field of bamboo product processing, in particular to a production process of a container based on strip-shaped bamboo splits. In the raw materials of the container, the first bamboo layer, the second bamboo layer, the third bamboo layer and the fourth bamboo layer are all formed by connecting common bamboo splits in series through lines, the bamboo container can be manufactured through multiple specific bonding procedures, the bamboo container has the advantage of being simple and efficient in process, the cross bonding structure of the first bamboo layer and the second bamboo layer can greatly enhance the mechanical strength of the bottom plate, and the service life of the bottom plate is prolonged. By arranging the supporting blocks, on one hand, the bottom plate can be lifted, ventilation of the bottom of a bearing object is facilitated, the bearing object can be used for loading fruits and vegetables, antibacterial substances naturally contained in bamboo wood can be utilized, and the storage period of the fruits and the vegetables is prolonged; the side plate structure can adapt to different shapes of the container by utilizing the curling property of the bamboo layer; certain air permeability is provided, and storage of fruits and vegetables is facilitated.

The application discloses a broad-spectrum bacteriostatic Clostridium subsp. and a preparation method and application thereof, and belongs to the technical field of microorganisms. The strain is named as DMS028, is preserved in the China General Microbiological Culture Collection Center, and has a preservation number of CGMCC No. 38049. The strain has broad-spectrum bacteriostatic activity, can simultaneously inhibit gram-negative bacteria Aeromonas hydrophila in aquaculture, gram-positive bacteria Clostridium perfringens in livestock and poultry breeding, and plant diseases such as Exserohilum longipes and Fusarium oxysporum, and overcomes the defects of narrow bacteriostatic spectrum of existing microbial preparations. The preparation method adopts two-stage temperature anaerobic culture, and adds lysine methyl ester, leucine ethyl ester, palmitoyl glycine and lauroyl arginine ethyl ester as an antibacterial substance synergist and a stabilizer, and has the advantages of simple process, convenient operation, no need of complex equipment, easy scale production, efficient high-activity bacterial body and antibacterial product.

The invention relates to an implant for medical care of humans and / or animals. In order to provide an implant which dissolves in the body during and / or after the healing process and at the same time counteracts possible inflammation after an operation, the implant comprises or consists of: a) a bioresorbable implant main body; b) a bioresorbable fastening body which is connected to the implant main body and by means of which the implant main body can be secured within a human or animal body; c) optionally an antibacterial substance. The invention further relates to a bioresorbable composite material for such an implant and to a method for treating a patient or providing prophylaxis for a patient with such an implant.

The invention provides a visual biological scaffold capable of discharging percolate in a self-pumping manner and a preparation method of the visual biological scaffold. The visual biological scaffold comprises the following components in parts by weight: 5-20 parts of a hydrophobic high polymer material, 80-95 parts of a volatile solvent, 5-10 parts of a hydrophobic component, 3-15 parts of a hydrophilic high polymer material and 0.1-15 parts of an antibacterial agent. A hydrophilic and hydrophobic material is co-spun through electrostatic spinning, the material is endowed with certain hydrophilicity, the attachment and proliferation rate of cells can be increased, wound healing is promoted, a 3D network microchannel is formed, and the channel has a self-pumping drainage effect and can be used as a miniature infusion pump; the antibacterial substance is carried through electrostatic spinning, the antibacterial substance is physically wrapped in the fiber or dispersed in a fiber matrix or adsorbed on the surface of the fiber, and the antibacterial substance has a slow release effect, so that efficient and continuous sterilization is achieved, and wound infection is prevented; the device has the characteristic of visualization, and the wound healing degree can be observed; the electrostatic spinning in-situ forming technology is adopted, and the biological scaffold deposited on the wound has adhesiveness and does not need to be fixed additionally.

The application discloses a plasma modified polyurethane medical dressing and a preparation method and application thereof, and relates to the technical field of medical dressings. The polyurethane sponge is cleaned and dried, and then is treated by using a plasma technology in an oxygen atmosphere to obtain treated polyurethane sponge; then, recombinant collagen with a HIS tag is prepared into a recombinant collagen solution; then, metal ions with antibacterial effects are added into the solution; the treated polyurethane sponge in step S1 is contacted with the recombinant collagen solution; finally, the modified polyurethane medical dressing is immersed into a high-molecular solution with a low isoelectric point and a negative charge under a neutral condition, and the medical dressing is obtained after drying and washing after immersion. The preparation method avoids the use of chemical cross-linking agents, ingeniously uses the tag of the recombinant collagen, simplifies an antibacterial substance loading process, and enables the antibacterial agent not to be excessive, so that the antibacterial agent can be used for a long time at a wound and can be safely applied to the fields of negative pressure drainage and wound care.

The present invention discloses a microbial agent for preventing diseases and promoting growth, as well as a preparation method and application thereof, and belongs to the field of microbial technology. The microbial agent of the present invention includes Bacillus argyi, Pseudomonas guguanyi, and Actinomycetes aurantii. Bacillus argyi, Pseudomonas guguanyi, and Actinomycetes aurantii are screened to form functional microorganisms. After the three bacterial liquids are mixed in equal proportions, a variety of antibacterial substances are produced, which synergistically inhibit the growth of pathogens and have good antagonistic effects on soybean root rot, soybean anthracnose, and soybean gray spot. The microbial agent of the present invention can promote soybean growth and increase soybean yield, while reducing the probability of soybean root rot, soybean anthracnose, and soybean gray spot, solving the problems of low soybean yield and high incidence of diseases in some soybeans, and the ingredients are safe and environmentally friendly, non-toxic to soybeans, and have a positive effect on reducing environmental pollution and pesticide residues.

The invention relates to water-resistant and oil-resistant paper pulp molded tableware based on bagasse paper pulp and lotus stem residues and a preparation method of the water-resistant and oil-resistant paper pulp molded tableware. Research finds that bagasse and lotus stem residues are used as raw materials to be compounded for use, an oil-proofing agent and a waterproof agent are added, lotus stem residue powder with high cellulose content is used as a raw material to achieve a synergistic effect with bagasse, the filling property and formability of the slurry are enhanced, and meanwhile, the lotus stem residue powder has high porosity, so that the filling property and formability of the slurry are improved. The antibacterial agent is beneficial to adsorption of a water-proofing agent and an oil-proofing agent, is beneficial to improvement of the barrier property of the molded tableware, and contains polyphenol antibacterial substances, so that the safety of the molded tableware is improved.

The invention relates to the technical field of natural fiber composite materials, and discloses an apocynum venetum fiber and goose down mixture antibacterial and warming dual-function system which is prepared by the following steps: mixing goose down with apocynum venetum fibers; under the action of selective hydrolase (such as cellulase), the apocynum venetum fiber releases endogenous polyphenol in situ; afterwards, oxidoreductase (such as laccase) is added into the same system to catalyze the polyphenol to react with the keratin of the goose down, so that stable covalent bond grafting is formed. Through integrated mild enzymatic reaction, the natural antibacterial substance is fixed on the goose down in the form of covalent bonds, and the technical problem that the traditional after-finishing function is not washable is solved. The obtained composite material has excellent and lasting antibacterial performance, meanwhile, the original high warmth retention property and filling power of goose down are completely kept, and the improved wet-state anti-caking capacity is additionally obtained.

The invention discloses a tissue culture and rapid propagation method for stephania erecta, and belongs to the technical field of plant tissue culture. The method comprises the following steps: selecting a healthy stephania erecta stock plant, carrying out root irrigation treatment by using an aqueous solution containing antibacterial substances, and shearing a tender rattan section on the stock plant as an explant; after the explants are disinfected, the explants are inoculated to an induction culture medium I, dark culture is conducted for 7 days firstly, then the explants are transferred to an induction culture medium II to be subjected to light culture, and bud germination is promoted; cutting off the germinated tender shoots, inoculating the tender shoots into a proliferation culture medium, and carrying out proliferation culture to obtain blocky cluster buds; dividing the blocky cluster buds into single buds, transferring the single buds into a rooting and seedling strengthening culture medium, and performing rooting culture to obtain tissue culture seedlings; and hardening and transplanting the tissue culture seedlings with good rooting. Through control and optimization of various steps and multiple parameters in the tissue culture process, successful construction of the tissue culture and rapid propagation system of stephania erecta with zero pollution rate, zero browning rate, high proliferation rate, high rooting rate and high survival rate is realized.

This invention relates to the field of biomedical materials technology, and discloses a biodegradable nonwoven fabric and its preparation process. The nonwoven fabric is made of components including polylactic acid, polycaprolactone, periodate, a copolyester oligomer containing cis-1,2-cyclohexanediol structural units, and a solid biocompatible weakly basic salt. The preparation process includes mixing the components and then melt-blending and melt-blowing to prepare the nonwoven fabric. In this invention, periodate and the copolyester oligomer serve as latent reaction precursors, and the weakly basic salt acts as a pH regulator. When the nonwoven fabric comes into contact with an aqueous environment, the weakly basic salt dissolves, establishing a weakly basic microenvironment that promotes the oxidative cleavage of the copolyester oligomer by periodate, thereby generating aldehyde compounds with antibacterial activity in situ. This invention achieves on-demand generation of antibacterial substances, enabling the nonwoven fabric to possess both high antibacterial rates and low cytotoxicity, solving the technical problem of balancing activity and safety in traditional antibacterial materials.

To obtain an antimicrobial fiber product having a substance having antimicrobial activity on the surface and to provide a method for producing the fiber product.SOLUTION: According to one embodiment of the present invention, there is provided an antimicrobial fiber product comprising a fiber containing a thermoplastic resin at least on the surface thereof, and particles carried on the surface side of the fiber and containing a nitride. Further, there is provided a method for producing an antimicrobial fiber product, which comprises a step of preparing a fiber containing a thermoplastic resin at least on the surface thereof and particles containing a nitride, and a step of bringing the particles in a heated state into contact with the fiber to support the particles on the surface of the fiber, thereby obtaining the antimicrobial fiber product.SELECTED DRAWING: Figure 1

The invention discloses a plasma modified polyurethane medical dressing and a preparation method and application thereof.The preparation method comprises the steps that polyurethane sponge is cleaned and then dried, then the polyurethane sponge is treated in the oxygen atmosphere through the plasma technology, the treated polyurethane sponge is obtained, recombinant collagen with an HIS tag is prepared into a recombinant collagen solution, and the plasma modified polyurethane medical dressing is obtained. The preparation method comprises the following steps: preparing a polyurethane sponge solution, adding metal ions with an antibacterial effect into the solution, contacting the polyurethane sponge treated in the step S1 with a recombinant collagen solution, finally immersing the modified polyurethane medical dressing into a polymer solution which is low in isoelectric point and has negative charges under a neutral condition, and drying and washing to obtain the medical dressing after the infiltration is completed. According to the preparation method, the use of a chemical cross-linking agent is avoided, meanwhile, the tag of the recombinant collagen is ingeniously utilized, the antibacterial substance loading process is simplified, and the antibacterial agent is not excessive, can be used at a wound for a long time, and can be safely applied to the fields of negative pressure drainage, wound surface nursing and the like.