147 results about "Antimicrobial substance" patented technology

The invention discloses antibacterial easy-to-clean ceramic and a preparation method thereof.The antibacterial easy-to-clean ceramic comprises glaze and a blank, the glaze comprises 30-60 parts of potassium feldspar, 30-60 parts of albite, 44-60 parts of phosphate, 20-28 parts of a first antibacterial agent and the like; the first antibacterial agent comprises an active component and a carrier, and the active component comprises zirconium oxide nano powder and zinc oxide nano powder; the blank comprises 45-75 parts of rutile titanium dioxide, 50-60 parts of sodium alginate, 50-70 parts of composite fibers, 20-36 parts of a surfactant, 40-50 parts of a second antibacterial agent and the like; the second antibacterial agent comprises cuprous oxide; the composite fiber comprises a first fiber body and a second fiber body, and the first fiber body comprises TiB fiber. Zirconium oxide and zinc oxide nano powder with efficient antibacterial ability is added into the glaze, and phosphate is combined to consolidate the glaze, so that antibacterial substances are prevented from flowing out; cuprous oxide is used as a second antibacterial active component in the blank and is combined with the TiB non-continuous reinforced fibers to obtain excellent antibacterial performance and mechanical strength.

The invention relates to the field of microorganisms, and discloses a complex microbial inoculant for preventing and treating clubroot of rape. Comprising the following raw materials in parts by weight: 10 to 12 parts of acid-resistant bacillus, 12 to 15 parts of pseudomonas fluorescens PF-5, 8 to 10 parts of bacillus mucilaginosus, 5 to 7 parts of halophilic bacillus, 8 to 10 parts of bacillus amyloliquefaciens, 12 to 15 parts of trichoderma atroviride ReTv2, 6 to 8 parts of azotobacter chroococcum, 10 to 12 parts of chitosan-gamma-polyglutamic acid microspheres, 12 to 15 parts of diatomite and 8 to 12 parts of humic acid. And 2-4 parts of algal polysaccharides. The living space of plasmodiophora brassicae is preempted by the acid-resistant bacillus; the pseudomonas fluorescens PF-5 directly strikes pathogenic bacteria and stimulates the defense system of the oilseed rape; the bacillus amyloliquefaciens releases a plurality of antibacterial substances; the trichoderma atroviride ReTv2 rapidly destroys the structure of the plasmodiophora brassicae in a manner of hyperparasitism and exoenzyme secretion.

The invention discloses an application of an antibacterial peptide and an application of the antibacterial peptide in preparation of antibacterial drugs for treating carbapenem-resistant pseudomonas aeruginosa, klebsiella pneumoniae (ATCC700603), escherichia coli (ATCC25922), staphylococcus aureus and methicillin-resistant staphylococcus aureus, the antibacterial peptide is characterized in that the sequence is w-r-r-w-k-r-w-w-r-r, and the sequence is shown in the description. All amino acids are D-type amino acids; the antibacterial peptide can be used as an antibacterial substance in wash supplies, food preservative additives, medical consumable antibacterial agents and cosmetics, can be synthesized through an Fmoc solid-phase chemical method, and is low in synthesis difficulty and good in in-vivo antibacterial activity. Particularly, the antibacterial peptide has broad-spectrum killing activity against carbapenem pseudomonas aeruginosa, klebsiella pneumoniae (ATCC700603), escherichia coli (ATCC25922), staphylococcus aureus and methicillin-resistant staphylococcus aureus, the cell survival rate of the antibacterial peptide within the range of medium and low concentration (2 mu g / mL-32 mu g / mL) reaches half or more, the toxicity is small, the toxicity is almost avoided, the operability is high, and the antibacterial peptide can be widely applied to the field of medical application. The cost is low.

The invention discloses bacillus tequilensis P61 and application thereof in prevention and treatment of kiwi fruit soft rot, and belongs to the field of biological prevention and treatment. The bacillus tequilensis P61 provided by the invention is preserved in the China Center for Type Culture Collection on September 5, 2024, and the preservation number of the bacillus tequilensis P61 is CCTCC (China Center for Type Culture Collection) NO: M 20241916. According to the invention, the lipopeptide antibacterial substance is prepared according to the bacillus tequilensis P61. Experimental results show that the bacillus tequilensis P61 and lipopeptide antibacterial substances have an outstanding prevention and treatment effect on the soft rot of the kiwi fruits, have a remarkable bacteriostasis effect on pathogenic bacteria of the soft rot of the kiwi fruits such as botryosphaeria dothidea, alternaria alternata and phomopsis, remarkably reduce the damage rate of the kiwi fruits, are green and safe, are harmless to people and livestock, and are worthy of popularization and application. No pollution is caused to the environment. The invention provides a new biocontrol strain for biological prevention and control of kiwi fruit diseases, and has a wide application prospect.

The invention provides bacillus velezensis H5 capable of producing broad-spectrum antibacterial substances and application of the bacillus velezensis H5. The preservation number of the bacillus velezensis H5 in the China General Microbiological Culture Collection Center is CGMCC No.32671. The bacillus velezensis H5 is separated from sea mud in a specific sea area, can generate antibacterial substances with broad-spectrum antibacterial activity, and mainly comprises bacitracin, surfactin and mycostatin. The antibacterial substance of the bacillus velezensis H5 is applied to preservation of perishable fruits such as grapes and the like and mildew prevention of cereals such as corn and the like, and can effectively inhibit spoilage of the perishable fruits and synthesis of mycotoxins such as aflatoxin and the like, and the action effect of the antibacterial substance is obviously superior to that of a food preservative natamycin. The invention provides a novel, green, safe and broad-spectrum antibacterial substance for preservation and fresh-keeping of fruits and mildew prevention of grains, and has important application value.

The invention discloses a bacteriophage lyase and application thereof, and particularly relates to a bacteriophage lyase with an amino acid sequence as shown in SEQ INNO.2. The bacteriophage lyase can inhibit the growth of escherichia coli, staphylococcus and salmonella, can be used as an antibacterial substance in splitting gram-negative bacteria and can be used for preparing drugs for resisting gram-negative bacteria. The lyase can be used independently or compounded with other substances, the use concentration of antibiotics can be reduced by combining the lyase with the antibiotics, toxic and side effects (such as renal toxicity of polymyxin) of drugs are reduced, and meanwhile, generation of bacterial drug resistance is delayed. After the lyase and the chitosan are combined for use, remarkable antibacterial activity is generated, the antibacterial effect can be achieved without pre-treatment on bacteria, and the practicability is improved.

The invention relates to the technical field of biomedical materials, and discloses a degradable non-woven fabric and a preparation process thereof, the non-woven fabric is prepared from polylactic acid, polycaprolactone, periodate, a copolyester oligomer containing a cis-1, 2-cyclohexanediol structural unit, and a solid biocompatible weakly alkaline salt; the preparation process comprises the following steps: mixing the components, and performing melt blending and melt-blowing spinning to prepare the non-woven fabric. The periodate and the copolyester oligomer are used as latent reaction precursors, the alkalescent salt is used as a pH regulating agent, when the non-woven fabric is in contact with an aqueous environment, the alkalescent salt is dissolved out to establish an alkalescent microenvironment, the periodate is promoted to carry out oxidative cracking on the copolyester oligomer, and thus the aldehyde compound with antibacterial activity is generated in situ. According to the invention, the on-demand generation of antibacterial substances is realized, so that the non-woven fabric has high antibacterial rate and low cytotoxicity, and the technical problem that the activity and safety of a traditional antibacterial material are difficult to balance is solved.

The invention provides a dual-response antibacterial nanofiber membrane and a preparation method thereof, an antibacterial aminated gelatin nano inclusion compound is loaded into a polyvinyl alcohol-chitosan matrix through an electrostatic spinning technology to prepare a nanofiber membrane, citral is further loaded in a closed adsorption mode, and the dual-response antibacterial nanofiber membrane is prepared. The antibacterial nanofiber membrane with the humidity and gelatinase dual responsiveness is obtained. The antibacterial nanofiber membrane disclosed by the invention can directly wrap the periphery of a meat product, and citral is adaptively released by increasing the environmental humidity so as to inhibit the proliferation of microorganisms; besides, when endogenous or exogenous microorganisms infect the surfaces of the meat products, gelatinase secreted by the microorganisms is used as a sensor to further release antibacterial substances, the antibacterial substances can be released according to actual fresh-keeping requirements in the storage, transportation and circulation process of the meat products, the problems that antibacterial components are released too early and the timeliness is short are solved, the storage time of the meat products can be remarkably prolonged, and the safety of the meat products is improved. And the spoilage is delayed.

The invention provides a composite sustained-release material as well as a preparation method and application thereof. The composite slow-release material comprises a porous metal framework and an organic phase, and pores of the porous metal framework are filled with the organic phase; the porous metal framework comprises self-degradable metal and sterilization elements; the organic phase comprises a water-soluble polymer and an organic functional substance. The composite slow-release material provided by the invention can realize differential synchronous release of inorganic sterilization elements and organic functional substances, and can be used in the washing device, so that the compounding of sterilization and other functions is realized, or the synergistic cooperation of various antibacterial substances is realized to improve the antibacterial effect.

The application discloses a plant lactobacillus and application thereof in improving stretchability of acid coagulated cheese. Lactiplantibacillus plantarum The plant lactobacillus is named as plant lactobacillus (Lactobacillus plantarum) B11, is preserved in China Center for Type Culture Collection, has a preservation number of CCTCC NO: M 2025778 and a preservation address of Wuhan University, No. 299, Bayi Road, Wuchang District, Wuhan City, Hubei Province. The strain provided by the application can be directionally fermented to produce viscous exocellular polysaccharide and antibacterial substances. The acid whey fermented by the strain is combined with phosphate and sodium caseinate quality improver, so that the stretchability of the acid coagulated cheese is improved, the product is inhibited from being mildewed in the airing and storage processes, and meanwhile, the product quality safety can be ensured. The problems of stretching difficulty, low product yield and easy mildewing in the airing and storage processes in the prior art are solved.

The invention provides a bactericidal anticorrosive composite coating and a preparation method thereof. The composite coating is obtained by reacting and curing raw materials including epoxy resin, an antibacterial substance based on a Schiff base structure and a curing agent, the antibacterial substance based on the Schiff base structure is characterized in that the antibacterial substance based on the Schiff base structure is obtained by carrying out a Schiff base reaction on components including polyethyleneimine and an aldehyde antibacterial agent. In some embodiments, the feedstock further includes a functional polymer PBFGn; the functional polymer PBFGn is obtained by carrying out free radical copolymerization reaction on components including butyl acrylate, hexafluorobutyl methacrylate and glycidyl methacrylate. According to the preparation method of the composite coating, efficient antibacterial components are stably integrated into a tough polymer network through a chemical method and automatically migrate to the surface, and long-acting and stable anti-corrosion and antibacterial effects and improved mechanical properties can be achieved.

This application discloses an antibacterial and easy-to-clean ceramic and its preparation method. The antibacterial and easy-to-clean ceramic includes a glaze and a blank. The glaze includes 30-60 parts of potassium feldspar, 30-60 parts of sodium feldspar, 44-60 parts of phosphate, and 20-28 parts of a first antibacterial agent. The first antibacterial agent includes an active ingredient and a carrier, and the active ingredient includes zirconium oxide nanopowder and zinc oxide nanopowder. The blank includes 45-75 parts of rutile titanium dioxide, 50-60 parts of sodium alginate, 50-70 parts of composite fiber, 20-36 parts of surfactant, and 40-50 parts of a second antibacterial agent. The second antibacterial agent includes cuprous oxide. The composite fiber includes a first fiber body and a second fiber body, and the first fiber body includes TiB fiber. This application achieves excellent antibacterial properties and mechanical strength by adding zirconium oxide and zinc oxide nanoparticles with high antibacterial capabilities to the glaze and consolidating them with phosphates. Cuprous oxide is used as a second antibacterial active ingredient in the blank and combined with discontinuous TiB reinforcing fibers.

The application provides a food preservation method using plant exosome loaded with natural antibacterial substances, relates to the field of food preservation and biological materials, and comprises the following steps: loading natural antibacterial substances and the plant exosome under preset loading conditions to obtain a plant exosome loaded with natural antibacterial substances; and applying the plant exosome loaded with natural antibacterial substances to the food preservation method, wherein the natural antibacterial substances are loaded into the plant exosome, the obtained composite is dispersed in a dispersion medium for food surface treatment to obtain a preservation preparation, and the preservation preparation is applied to the surface of food to be preserved to form a preservation layer, so that the natural antibacterial substances are stably loaded, uniformly distributed and continuously delivered on the surface of the food, the problems of volatilization, inactivation and short action time of the natural antibacterial substances during use are reduced, the food preservation effect is more stable, and the shelf life is prolonged.

One embodiment of the present specification provides a method for preparing a low-crystallinity calcium phosphate-based antibacterial bone graft material, comprising the steps of: (a) adding a calcium precursor and a phosphate precursor at one time to synthesize calcium phosphate; (b) putting the calcium phosphate into an antibacterial substance precursor solution to react; (c) a step of freeze-drying the product of step (b); (d) a step of mixing the product of step (c) with a shape control agent and performing press molding to prepare a molded body; and (e) a step in which the shape control agent of the molded body is removed in a solvent having a temperature equal to or higher than the boiling point and then dried.

The invention belongs to the technical field of biological medicines, and particularly relates to a dual-targeting broad-spectrum chimeric bacteriophage antibacterial pharmaceutical preparation as well as a preparation method and application thereof. The antibacterial drug preparation comprises a bioactive substance and a liposome for coating the bioactive substance, the bioactive substance is a targeting chimeric M13 bacteriophage coupled with an antibacterial substance, and the surface of the liposome is coupled with a targeting antibody. According to the invention, the liposome and bacteriophage dual-targeting design is adopted, specific targeting to bacterial focuses can be realized, and the antibacterial substance is loaded on the mild M13 bacteriophage, so that the dosage of the antibacterial substance is reduced, and meanwhile, uncontrollable release of endotoxin is avoided; and finally, the intracellular and extracellular bacteria at the in-vivo focus are thoroughly killed under the cooperation of the liposome with the targeting capability and the customizable chimeric bacteriophage.

This disclosure relates to antimicrobial compositions comprising at least one cationic antimicrobial substance and at least one acidic glycolipid, as well as the use of such compositions in product formulations, particularly anionic formulations such as personal care, home care, and other product formulations.

The present invention relates to an antibacterial cosmetic puff, which is treated with an antibacterial substance comprising one or more substances selected from the group consisting of hydroxyacetophenone (Hydroxyacetophenone) and cetylpyridinium chloride (cetylpyridinium chloride), and to a method for preparing the antibacterial cosmetic puff, said antibacterial cosmetic puff being characterized in that the antibacterial cosmetic puff has been treated with an antibacterial substance comprising one or more substances selected from the group consisting of hydroxyacetophenone (Hydroxyacetophenone) and cetylpyridinium chloride (cetylpyridinium chloride). Furthermore, the present disclosure relates to a method for manufacturing a cosmetic antibacterial puff, the method comprising a step of treating the puff with a composition comprising an antibacterial substance, the antibacterial substance comprising one or more substances selected from the group consisting of hydroxyacetophenone and cetylpyridinium chloride. The antibacterial powder puff for cosmetic use has antibacterial power against bacteria and fungi and has durability and foaming physical properties.

The invention discloses a method for efficiently preparing a nylon 6 micro-nano fiber antibacterial air filtering membrane material, which comprises the following steps: etching porous ceramic microspheres, mixing with a non-polar material solution, coating, drying, and injecting charges to obtain electret microspheres; mixing an antibacterial substance solution with the electret microspheres in the step S1, and drying to obtain antibacterial-electret microspheres; meanwhile, spinning a bottom layer of the filtering membrane by using a crude fiber spinning solution and a fine fiber spinning solution through blowing spinning; adding a crude fiber spinning solution and antibacterial-electret microspheres into a cross-linking agent for mixing and spraying to form a middle layer with the surface of the bottom layer; repeating bottom layer operation and spraying again to form a top layer with the middle layer to obtain the filtering membrane with a multi-layer structure; carrying out hot press molding on the filtering membrane with the multi-layer structure; the dynamic interaction between a flow field and particles is enhanced, so that fine particles are more easily adsorbed or intercepted by the fiber surface, and efficient filtration is realized.

The invention discloses an implant with a honeycomb-shaped micro-nano topological structure on the surface and a preparation method and application thereof, and the implant with the honeycomb-shaped micro-nano topological structure on the surface is a honeycomb-shaped micro-nano topological structure layer prepared on the surface of a titanium substrate through a template method. According to the invention, a unique hydrogenated titanium dioxide honeycomb-shaped surface micro-nano topological structure is designed on the surface of the titanium-based implant through a template method and plasma hydrotreating on the basis of not introducing an antibacterial substance coating and complex chemical components; the special surface treatment not only has excellent 800-815nm near-infrared light response photocatalytic performance and can generate a large number of reactive oxygen species to quickly eliminate bacterial infection, but also can regulate polarization of macrophages due to the unique surface morphology, effectively inhibit inflammatory response and regulate and control bone immune microenvironment to promote osteogenesis, and has a good application prospect. And therefore, more than two invasive operations are not required to be carried out on the patient, and the postoperative healing effect is better.

The invention relates to a fungicide composition for preventing and treating peanut root rot as well as preparation and application of the fungicide composition. The invention aims to solve the technical problems of unstable field control effect, high chemical pesticide residue and high drug resistance risk of biological control in peanut root rot control. Bacillus velezensis YJ02 with good biocompatibility is compounded with azoxystrobin (a biological fungicide generates antibacterial substances and induces plant defensive enzymes, and a chemical fungicide is combined to rapidly inhibit respiration of pathogenic bacteria) to prevent and treat peanut root rot; the technical effects that the efficient synergistic control effect (for example, the control effect reaches up to 86.79%) is achieved, the application amount of chemical pesticides is reduced (for example, the dosage of azoxystrobin is only 9.82% of the conventional dosage), the drug resistance risk of pathogenic bacteria is effectively reduced, the morbidity and disease index are reduced, and environment friendliness is achieved are achieved, and high economic benefits and social benefits are achieved.

The invention relates to the technical field of electrical equipment, and discloses a water pump base and electrical equipment. The water pump base comprises a base body provided with an installation space of a water pump; the antibacterial box is mounted on the seat body, and the antibacterial box is provided with an accommodating chamber for antibacterial substances; and the accommodating chamber is communicated with the mounting space. The antibacterial box is arranged on the base body, the base body can be directly taken out of the water tank when the antibacterial box needs to be disassembled and assembled, operation is convenient, and the convenience of replacing antibacterial substances by a user is improved.

The invention relates to a strain of biocontrol and growth-promoting brevibacillus brevis LJQJ21 and an application of the strain of biocontrol and growth-promoting brevibacillus brevis LJQJ21 in prevention and treatment of plant oomycetes diseases, and belongs to the field of research and development of microbial pesticides. The Brevibacillus formis LJQJ21 has the capabilities of promoting growth and preventing diseases, has a relatively strong inhibition effect on mycelial growth of various pathogenic oomycetes (phytophthora capsici, phytophthora infestans, peronophythora litchii and pythium aphanidermatum) causing crop diseases, and can secrete pentapeptide antibacterial substances Edeine A and B, and the Edeine can remarkably inhibit germination of zoospores of the phytophthora capsici. In addition, the microbial agent taking the LJQJ21 spore fermentation bacterial liquid as a main active component has a relatively good prevention and treatment effect on fruit rot caused by phytophthora capsici. The Brevibacillus forts LJQJ21 has obvious growth promoting and disease preventing effects, is safe to human and livestock and environment-friendly, and has potential field application value and development prospect.

The application provides a composite absorbent core suitable for diapers, the composite absorbent core is composed of a sequentially stacked infiltration layer, a polymer layer 1, a guide layer, a polymer layer 2 and a diffusion layer; the polymer layer 1 and / or the polymer layer 2 is made of a sodium acrylate composite water-absorbing material added with antibacterial substances. The composite absorbent core of the application has the characteristics of strong water and urine absorption capacity and fast speed.

A method of producing a filament is disclosed. The method includes extruding a material for a filament core and a material for a filament sheath using an extruder, using a core portion and a sheath portion of a die in order to direct the material extruded from the extruder, and forming a filament by cooling during or after using the die. A method and apparatus for post-processing a 3D printed product using at least one of laser radiation or plasma processing is disclosed. In addition, a core / sheath structure composed of the forming material or a formed product produced from the forming material is disclosed. The core / sheath structure comprises a core and a sheath, the core and sheath comprising: one or both of fibers or particles; and at least one of: a soluble substance; an antimicrobial substance; an ultraviolet protection substance; an odor management substance; or a moisture management substance.

The invention discloses an antibacterial substance management information system based on artificial intelligence, and relates to the field of medical information, a plurality of historical antibacterial grade sequences sorted according to time are acquired from historical antibacterial treatment data, and a gradient sequence based on adjacent time step difference values is generated; the system calculates the continuous gradient length based on the sliding window, wherein the continuous gradient length reflects the continuous upgrading or degrading trend of the antibacterial grade; in a self-attention layer of the Transform network, a time step with a larger continuous gradient length is endowed with a higher attention weight, so that a key change fragment in the antibacterial grade sequence is highlighted, and the Transform network is trained based on a historical antibacterial grade sequence to obtain an antibacterial grade prediction model. According to the invention, intelligent prediction and management optimization of the antibacterial drug grade in the future can be realized by using the antibacterial grade change characteristics.

The invention discloses a preparation method of an enhanced warp-knitted lace fabric, and aims to solve the problems that fibers such as cotton fibers with relatively high water absorption capacity do not have a quick-drying characteristic, have poor antibacterial performance after long-term retention of water, still go mouldy and stink, and are low in skin-friendly property. According to the technical scheme, the method is characterized by comprising the following steps that S1, spandex filaments are stretched to a certain drafting length, then nylon filaments are evenly wound on the outer surfaces of the stretched spandex filaments according to a certain twist degree, and the nylon elastic covering yarn is obtained. The antibacterial acarus killing layer is made of cotton fibers with high water absorption, and treatment is conducted through composite alkali liquor, alkali liquor, a mercaptoacetic acid solution and a silver nitrate solution in sequence in the preparation process, so that antibacterial substances can be stably embedded into the fibers instead of being only attached to the surface layers of the fibers, and the antibacterial acarus killing effect is achieved. Furthermore, good antibacterial performance can be kept in the states of multiple times of water washing and long-term soaking.

The invention provides bacillus subtilis, a microbial agent of the bacillus subtilis and application of the bacillus subtilis to prevention and treatment of cucumber bacterial angular leaf spot. The bacillus subtilis is a bacillus subtilis strain A45, and the preservation number is CGMCC No.33289. The invention further provides a preparation method of the bacillus subtilis. The microbial agent of the bacterial strain can be used for efficiently inhibiting the growth of the Pseudomonas amygdali pv.lachrymans (Pseudomonas amygdali pv.lachrymans) of the cucumber bacterial angular leaf spot pathogen, and can be used for efficiently inhibiting the growth of the Pseudomonas amygdali pv.lachrymans. The strain code not only can be used for synthesizing known gene clusters of antibacterial substances such as abeleventin, bacitene, tripeptide tripeptide, catechol siderophore, pexamic acid, subtilosin A, lysobacin and the like, but also can be used for synthesizing a new gene cluster of surfactin, 1-carbapaen-2-em-3-carboxylic acid and tylosin A as well as a gene cluster synthesized by two brand-new terpenoids. The microbial agent disclosed by the invention not only can prevent cucumber angular leaf spot, but also has a remarkable promoting effect on cucumber growth.

The present application belongs to the technical field of surgical implant medical devices for foot and ankle, and discloses a preset angle ankle arthrodesis device with functions of promoting bone integration and resisting bacteria, which has a preset angle suitable for tibiodal joint, ranging from 3° to 7°. The device further comprises a three-dimensional porous bone implant body, a surface of the three-dimensional porous bone implant body in contact with host bone tissue is a porous titanium alloy, a plurality of convex anti-rotation ridges are arranged on the upper and lower end faces of the three-dimensional porous bone implant body, the three-dimensional porous bone implant body is fixed by occlusion with the host bone through the anti-rotation ridges, an in-situ growth film layer is grown on the surface of the three-dimensional porous bone implant body, and the in-situ growth film layer comprises functional substances and antibacterial substances. The present application effectively solves the technical problems of slow bone integration, high risk of infection, rotation instability and insufficient mechanical support in ankle arthrodesis, significantly improves the success rate of fusion and reduces postoperative complications.

The invention relates to the technical field of poultry breeding, and discloses application of brevibacillus laterosporus in Qingyuan partridge chicken breeding, the application is achieved by feeding a feed containing brevibacillus laterosporus BL01 powder and bacillus subtilis coagulin protein, and the feed comprises the following components in parts by mass: 2-4 parts of brevibacillus laterosporus BL01 powder; 0.5 to 1 part of bacillus subtilis coagulin protein; 60 to 70 parts of corn; 20 to 25 parts of soybean meal; 2-4 parts of fish meal; 3-5 parts of vegetable oil; 1.5 to 2.5 parts of calcium hydrogen phosphate; 1-2 parts of stone powder; and 0.1 to 0.2 part of DL-methionine. The brevibacillus laterosporus and the bacillus subtilis coagulin protein are added into the feed, and the brevibacillus laterosporus and the bacillus subtilis coagulin protein can promote the proliferation speed, the metabolic activity and the secretion of antibacterial substances of the brevibacillus laterosporus and the bacillus subtilis coagulin protein, so that the aims of regulating the intestinal flora structure, reducing the oxidative stress and improving the health condition of poultry are fulfilled.

The invention discloses a gelled cell as well as a preparation method and application thereof. Relates to the field of synthetic biology and biomedicine. The gelated cell is a cell structure without cell viability, and comprises: a carrier cell framework comprising a cell membrane which retains the membrane protein content, the type and the lipid order of an original carrier cell; the intracellular hydrogel is formed in situ in the carrier cell framework through supramolecular host-guest interaction or cross-linking reaction, and is fused with the inner surface of a cell membrane; the antibacterial substance is loaded in the intracellular hydrogel; wherein pores are distributed on the cell membrane, the intracellular hydrogel is communicated with the external environment through the pores, and the loaded antibacterial substances are exposed. The gelated cell provided by the invention can simultaneously realize targeted delivery, contact sterilization and endotoxin adsorption, and avoids the problem of secondary inflammation caused by release of endotoxin in traditional antibiotic therapy and the problem of membrane protein loss or disordered arrangement in a cell membrane coating technology.