58 results about "Antimicrobial effect" patented technology

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

Disclosed in the present invention are a long-acting antimicrobial and antiviral building coating and a preparation method therefor. The building coating is formed by mixing an inorganic antimicrobial material, a cationic resin emulsion, a pigment, an inorganic filler, deionized water, a dispersing agent, a defoaming agent, a thickening agent, and a film-forming auxiliary. The present invention exhibits a safe, efficient and broad-spectrum antimicrobial and antiviral effect by means of a synergistic effect of various components using the inorganic antimicrobial material as a functional filler, and shows long-acting and fast antimicrobial and antiviral characteristics using the cationic resin emulsion as a film-forming material. The obtained antimicrobial and antiviral building coating requires a small addition amount of an antimicrobial agent, can maintain the antimicrobial effect for a long time, satisfies the need for safe, environmentally friendly, and long-acting effects, and is suitable for building exterior walls and indoor coating applications.

This invention relates to the field of food preservation technology and discloses a liquid preservative for preserving fresh walnut kernels. The preservative comprises a natural preservative, a solubilizing and stabilizing agent, and a solvent. This liquid preservative uses natural phloretin as the preservative component, combined with Tween 80 as a solubilizing and stabilizing agent and ethanol as a solvent. This effectively solves the problems of poor water and oil solubility and inadequate stability of phloretin, allowing it to be stably dispersed in the preservative system and fully exert its antioxidant and antimicrobial effects. Furthermore, the preparation method is simple and easy to implement, and the production process is safe and controllable. It is convenient to use; the preservation of fresh walnut kernels can be achieved through dilution and soaking. The diluted solution can be reused, reducing usage costs. Simultaneously, it can inhibit bacterial growth during the storage of fresh walnut kernels, delay oxidative deterioration, maintain their good appearance and quality, extend shelf life, and meet the market demand for high-quality fresh walnut kernels.

The present invention relates to an antimicrobial composition characterized in that it comprises rosemary essential oil, cultured dextrose, and pH-regulating vinegars, wherein the rosemary essential oil is present at a concentration of 1% or less, the cultured dextrose is present at a concentration of 1% or less, and the pH-regulating vinegar is present at a concentration of 0.1% or less, and wherein the composition exhibits synergistic antimicrobial activity.

The invention relates to the technical field of biological materials, and discloses a low-hemolytic broad-spectrum antibacterial combined peptide and application thereof. The amino acid sequence of the amino acid sequence is one of the following sequences: Meta211: X2IRRLWRX3X2RLIR, Meta201: IWRX3X1RX3LRLX1RR, Meta185: X2LRRX1LTRLIRX2I, MetaLRRX1LTRLIRX2I, MetaLRRX1LTRLIRX2I, MetaLRRX1LTRLRX2I, MetaLRRX1LTRLRX2I Wherein X1, X2 and X3 are random sites, X1 is L or I, X2 is V or L, and X3 is I or V; the Meta211, the Meta201 and the Meta185 are mixtures selected from all the random sites respectively. The antibacterial combined peptide can have a powerful antibacterial effect on various bacteria, particularly has a remarkable antibacterial effect on bacillus subtilis, shows excellent low hemolysis, provides a sustainable, economical and efficient solution for upgrading of antibacterial drugs, and has important social significance.

The invention discloses an antimicrobial composition and application thereof. The antimicrobial composition comprises: (a) isohexylene glycol; and (b) a second antimicrobial preparation, wherein the second antimicrobial preparation is selected from at least one of capryloyl hydroxamic acid and p-hydroxyacetophenone; the isohexylene glycol disclosed by the invention has good solubility on the capryloyl hydroximic acid or the p-hydroxyacetophenone, so that the capryloyl hydroximic acid and / or the p-hydroxyacetophenone still have good stability under a low-temperature condition; according to the present invention, the synergistic interaction between the isohexylene glycol and the capryloyl hydroximic acid and / or p-hydroxyacetophenone is completely performed, such that the antimicrobial effect is significantly improved, and the antimicrobial composition can be used in daily chemical products, cosmetics, personal care compositions or cleaning compositions, and has advantages of low use amount, safety, effectiveness, nature, low irritation and the like.

An antimicrobial agent with synergistic antimicrobial effects, comprising iodide ions encapsulated within silver cages, as well as its preparation method and application, relates to the technical field of antimicrobial materials. The antimicrobial agent utilizes a 16-core silver cage as its basic structural unit, encapsulating iodide ions within the cages and assembling them into a one-dimensional chain structure using thiols as connectors. This antimicrobial agent, by encapsulating iodide ions within the silver cages, achieves diversified antimicrobial material performance and structure through the synergistic action of multiple antimicrobial mechanisms.

The invention discloses an antibacterial peptide with multiple phytopathogen antibacterial activity, a biological antibacterial agent and application of the antibacterial peptide and the biological antibacterial agent, and the amino acid sequence of the antibacterial peptide is FKLIRNLIILRQAWKLIKRRR and is marked as RR-21. Experiments show that the antibacterial peptide disclosed by the invention has a similar alpha-helical structure with a known antibacterial peptide LL-37, and has antibacterial activity on plant pathogenic bacteria represented by pseudomonas syringae and plant pathogenic fungi represented by fusarium pseudograminearum and fusarium oxysporum; compared with the LL-37 polypeptide, the MIC of the RR-21 is 4-8 [mu] g / mL, and the RR-21 has a more significant bacteriostatic effect; meanwhile, under the conventional bacteriostatic concentration (less than or equal to 16 mu g / mL), the RR-21 shows no hemolytic activity; the above fully proves that the antibacterial peptide has high biological safety to eukaryotic cells while exerting multiple antibacterial effects, and can be used as an active component of a biological antibacterial agent, and the biological antibacterial agent has the potential of being developed into an efficient and safe plant disease resistant drug or a plant green pesticide.

The invention discloses an efficient antibacterial long glass fiber reinforced polypropylene composite material for packaging and a preparation method thereof. The composite material is prepared from the following raw materials in parts by weight: 50 to 80 parts of polypropylene resin, 20 to 30 parts of continuous glass fiber, 1 to 2 parts of nano-silver antibacterial additive, 1 to 2 parts of titanium dioxide master batch, 1 to 3 parts of compatilizer and 0.1 to 1 part of antioxidant. The high-efficiency antibacterial long glass fiber reinforced polypropylene composite material for packaging is a material which can be subjected to direct injection molding to enable parts to have an excellent long-acting antibacterial effect. Through a mode of coating the surface of continuous glass fiber with a silver ion antibacterial agent nano coating and adding titanium dioxide of a polypropylene matrix, the prepared glass fiber reinforced polypropylene material has the characteristics of high mechanical property and uniform surface antibacterial effect distribution, and can achieve long-acting bacteriostatic and antibacterial effects when being used as an outer package.

The invention belongs to the technical field of biology, and particularly relates to an antibacterial polypeptide LAB-129 and application thereof. Based on the Shanxi mature vinegar-derived antibacterial peptide LAB-4 with antibacterial activity excavated in the early stage, a complete sequence is split into a plurality of short peptide fragments with 5-50 amino acid residues by adopting a random fragmentation strategy, and a novel antibacterial peptide LAB-129 with higher antibacterial activity is screened out. Compared with LAB-4, LAB-129 has higher antibacterial activity, lower MIC (minimal inhibitory concentration) and higher membrane destruction capability and cell destruction effect, shows better overall antibacterial effect, and lays a good foundation for developing a novel microbial proliferation inhibitor for replacing traditional antibiotics.

System, devices, and methods for providing treatment to tissue are disclosed herein. In some embodiments, a device is provided that includes a delivery catheter having an elongated shaft and an inner lumen therethrough, the delivery catheter being configured to pass through tissue such that a distal end of the delivery catheter is positioned at a target tissue, a support in the form of an inner slidable tube that is configured to be positioned inside the inner lumen of the delivery catheter, the support being configured to provide rigid or semi-rigid support for the delivery catheter during insertion of the delivery catheter through tissue, and one or more optical fibers configured to pass through the inner slidable tube and being configured to deliver light energy to provide an antimicrobial effect to the target tissue.

A process, and the resultant product, for effectively binding plant-based antimicrobials to various fabrics which process provides for long term antimicrobial effect of the fabric.

System, devices, and methods for providing treatment to tissue are disclosed herein. In some embodiments, a device is provided that includes a delivery catheter having an elongated shaft and an inner lumen therethrough, the delivery catheter being configured to pass through tissue such that a distal end of the delivery catheter is positioned at a target tissue, a support in the form of an inner slidable tube that is configured to be positioned inside the inner lumen of the delivery catheter, the support being configured to provide rigid or semi-rigid support for the delivery catheter during insertion of the delivery catheter through tissue, and one or more optical fibers configured to pass through the inner slidable tube and being configured to deliver light energy to provide an antimicrobial effect to the target tissue.

This invention discloses an antimicrobial peptide RY-10 and its application in the preparation of antimicrobial drugs, belonging to the field of biomedical technology. The amino acid sequence of the antimicrobial peptide RY-10 is shown in SEQ ID NO.2. The antimicrobial peptide RY-10 provided by this invention has a highly efficient killing ability against a variety of Gram-negative / positive bacteria, effectively retaining antimicrobial activity while significantly reducing cytotoxicity. Simultaneously, this antimicrobial peptide RY-10 can also produce synergistic antimicrobial effects with various antibiotics, showing significant application value in improving efficacy, overcoming antibiotic resistance, reducing drug dosage, delaying the development of drug resistance, and addressing complex infections. This invention provides a highly promising candidate material resource for the development of highly effective and low-toxicity antimicrobial drugs, and also provides an efficient, safe, and sustainable solution for developing novel combination therapies and addressing the global drug resistance crisis, possessing significant clinical application value and industrialization potential.

Disclosed are thermoplastic polymer materials, and polymer products (e.g., medical devices) made therefrom, that incorporate metal nanoparticles. The metal nanoparticles impart antimicrobial activity to the thermoplastic polymer materials. The thermoplastic polymer materials can be manufactured or processes in a manner that causes metal nanoparticles within the interior of the thermoplastic polymer to beneficially migrate to the surface portion of the thermoplastic polymer (i.e., an outer 100 nm of the thermoplastic polymer), where contact with microbes is more likely to occur. Resulting polymer products, such as medical devices, include a higher concentration of metal nanoparticles at the surface portion, where antimicrobial effects are most useful, as compared to the interior bulk portion of the thermoplastic polymer. The surface portion can include up to 10 times the concentration of metal nanoparticles than the interior bulk portion. The concentration of metal nanoparticles in at least the surface portion can be 2-2000 ppm, 10-1400 ppm, 20-1000, 30-500 ppm, 50-250 ppm, or 70-150 ppm.

Compositions comprising 2-hydroxycarboxylic acid for dysregulating the metabolism of planktonic bacteria and their use. This disclosure provides compositions for dysregulating the metabolism of planktonic bacteria, the compositions comprising preferred enantiomers of 2-hydroxycarboxylic acid. This disclosure further provides compositions for dysregulating the metabolism of planktonic bacteria, the compositions comprising preferred enantiomers of 2-hydroxycarboxylic acid and antimicrobial compounds. Dysregulation of the metabolism of planktonic bacteria can be measured, among other examples, by a decrease in the MIC of concomitant antimicrobial agents, an enhancement of in vivo antimicrobial effects, or aerobic respiration of metabolically active cells (reduction of non-fluorescent resazurin to highly fluorescent resorphine), which can lead to sensitization of planktonic bacteria to antimicrobial compounds and / or disruption of resistance of planktonic bacteria to antimicrobial compounds.

Provided is a use of a combined composition in preparing a drug for resisting fungal and bacterial infections. Active components of the combined composition are an antibiotic and an antibiotic adjuvant, wherein the antibiotic adjuvant is celastrol or a pharmaceutical salt thereof. The present application creatively discovers that celastrol or the pharmaceutical salt thereof can be combined with the antibiotic and the combination has a very excellent effect in resisting the fungal and bacterial infections, especially in resisting the fungal infections. Celastrol or the pharmaceutical salt thereof can enhance an antimicrobial effect of the antibiotic, especially an antifungal effect of the antibiotic, significantly increasing an antimicrobial sensitivity of the antibiotic and inhibiting the occurrence of fungal or bacterial drug-resistance. As an antibiotic adjuvant-antibiotic drug platform, the combined composition provides a new strategy for achieving an efficient antimicrobial effect, and the application dosage forms and the application scenarios are very diverse.

The invention provides a rare earth composite fiber with long-acting antibacterial performance and a preparation method thereof, the rare earth composite fiber is prepared by adding a specific rare earth complex into a spinning raw material, and performing mixing, melt spinning, stretching and other steps to obtain the fiber with excellent antibacterial performance. The fiber not only has a good antibacterial effect, but also keeps good mechanical properties of the fiber, and is suitable for manufacturing medical textiles, hygienic products, daily textiles and the like.

Disclosed are thermoplastic polymer materials, and polymer products (e.g., medical devices) made therefrom, that incorporate metal nanoparticles. The metal nanoparticles impart antimicrobial activity to the thermoplastic polymer materials. The thermoplastic polymer materials can be manufactured or processes in a manner that causes metal nanoparticles within the interior of the thermoplastic polymer to beneficially migrate to the surface portion of the thermoplastic polymer (i.e., an outer 100 nm of the thermoplastic polymer), where contact with microbes is more likely to occur. Resulting polymer products, such as medical devices, include a higher concentration of metal nanoparticles at the surface portion, where antimicrobial effects are most useful, as compared to the interior bulk portion of the thermoplastic polymer. The surface portion can include up to 10 times the concentration of metal nanoparticles than the interior bulk portion.

The invention discloses an antimicrobial composition and application thereof. The antimicrobial composition comprises (a) capryloyl hydroxamic acid; and (b) a second antimicrobial preparation, wherein the second antimicrobial preparation is selected from at least one of p-hydroxyacetophenone, glycerol caprylate and ethylhexylglycerin; according to the antimicrobial composition, the synergistic interaction between the capryloyl hydroxamic acid and the second antimicrobial preparation is fully exerted, the antimicrobial effect is remarkably improved, and the antimicrobial composition can be used in daily chemical products, cosmetics, personal care compositions or cleaning compositions and has the advantages of being low in dosage, safe, effective, natural, low in irritation and the like.

A long-lasting hydrogel for use against drug-resistant bacteria, and a preparation method and use thereof are provided. In the present disclosure, polyvinyl alcohol (PVA) is mainly adopted as a matrix, and phytic acid and honey including glucose and fructose are added to modify the PVA to obtain the hydrogel. During preparation of the antimicrobial hydrogel, no toxic chemical crosslinking agent or initiator is added, and the antimicrobial hydrogel is mainly obtained by crosslinking PVA, phytic acid, and monosaccharides through ester bonds, hydrogen bonds, and electrostatic adsorption. In addition, the hydrogel obtained by adding phytic acid and honey to the PVA matrix exhibits a significant long-lasting antimicrobial effect for Staphylococcus aureus (S. aureus), drug-resistant S. aureus, and Pseudomonas aeruginosa (P. aeruginosa), and the antimicrobial effect can last for about 3 months.

The present invention relates to cosmetic compositions comprising a combination of lacto-N-tetraose (LNT) or lacto-N-neotetraose (LNnT) with an aliphatic diol or an aliphatic triol or an ether or an ester thereof. These cosmetic compositions or the respective combinations show a significant antimicrobial effect on microorganisms.

The invention discloses an antibacterial peptide fragment intercepted from a mined fly IDGF4 protein and application of the antibacterial peptide fragment in preparation of antibacterial drugs. According to the invention, oligopeptide fragments at different parts in the collected fly IDGF4 protein are screened, three candidate peptides are obtained through chemical synthesis, the antibacterial performance of the candidate peptides is systematically evaluated, antibacterial experiment results show that the oligopeptide with the amino acid sequence shown as SEQ ID No.2 can effectively inhibit the growth of salmonella and staphylococcus aureus under the concentration of 1mg / mL, and the oligopeptide with the amino acid sequence shown as SEQ ID No.2 can effectively inhibit the growth of salmonella and staphylococcus aureus under the concentration of 1mg / mL. The antibacterial effect of the peptide is confirmed in inhibition zone experiments, enzyme-labeled turbidimetry and growth curve monitoring, and the peptide shows stable and remarkable antibacterial activity, which indicates that the peptide can be used as a novel antibacterial molecule. The invention provides a new candidate sequence for developing the antibacterial peptide with high efficiency and low drug resistance risk, and has application potential in the aspect of preparing clinical antibacterial drugs.

The present disclosure relates to the field of antimicrobial compositions. More particularly, it concerns the use of a composition as an antimicrobial agent, the composition comprising ingredients selected from the group consisting of: (i) nona-2,6-dien-1-ol in combination with at least one ingredient selected from the group consisting of 3-neopentylpyridine, 2-methylhexan-3-one oxime, terpineol and 2-isopropyl-5-methylphenol; (ii) gamma-dodecalactone in combination with at least one ingredient selected from the group consisting of 1-Methyl-4-(1-methylethenyl)-cyclohexene, 4-Methoxybenzaldehyde, and 1,3-Benzodioxole-5-carbaldehyde; (iii) (Z)-3,7-Dimethyl-2,6-octadien-1-ol and gamma-dodecalactone; (iv) cis-4(Isopropyl)cyclohexanemethanol and 4-Methoxybenzaldehyde; and (v) 1,3-Benzodioxole-5-carbaldehyde and 4-Methoxybenzaldehyde, wherein the ingredients are present in an amount sufficient to provide an antimicrobial effect. The composition and its use for the preparation of antimicrobially active perfuming compositions and consumer products are also objects of the disclosure.

Disclosed herein are lipid nanoparticles that demonstrate effective antimicrobial effects. An example lipid nanoparticle includes an unsaturated monoglyceride, a saturated monoglyceride, and a glycerol behenate. Also disclosed herein are microfluidic methods of making the lipid nanoparticles, pharmaceutical compositions that include the lipid nanoparticles, methods of modulating a microorganism's activity, and methods of promoting beneficial health effects in an animal.

This invention discloses a silver-carbon quantum dot composite nanomaterial loaded with an antimicrobial peptide, comprising silver-carbon quantum dots (AgCQDs) and an antimicrobial peptide CKKII14. The antimicrobial peptide CKKII14 is loaded onto the silver-carbon quantum dots (AgCQDs) via Ag-S bonds, and its serial number is CIKKIIKKIIKKII-NH2. This silver-carbon quantum dot composite nanomaterial loaded with the antimicrobial peptide enhances the antimicrobial properties of the peptide, exhibiting significant antimicrobial effects against *Escherichia coli* and *Staphylococcus aureus*. The optimal inhibitory concentration (MIC) against *Escherichia coli* reaches 3 µg / mL, and against *Staphylococcus aureus* reaches 5 µg / mL.

The invention discloses an antibacterial peptide GV-16 and application of the antibacterial peptide GV-16 in preparation of antibacterial drugs, and belongs to the technical field of biological medicines. The amino acid sequence of the antibacterial peptide GV-16 is as shown in SEQ ID NO. 2. The antibacterial peptide GV-16 provided by the invention has an efficient killing capability on various gram negative / positive bacteria, and the cytotoxicity is greatly reduced while the antibacterial activity is effectively retained. Meanwhile, the antibacterial peptide GV-16 can also generate a synergistic antibacterial effect with various antibiotics, and has remarkable application values in the aspects of improving the curative effect, overcoming the drug resistance of the antibiotics, reducing the dosage, delaying the generation of the drug resistance, dealing with complex infection and the like. The invention provides a promising candidate material resource for developing high-efficiency and low-toxicity antibacterial drugs, also provides a high-efficiency, safe and sustainable solution for developing a novel combination therapy and coping with global drug resistance crisis, and has important clinical application value and industrialization potential.