81 results about "Antimicrobial effect" patented technology

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

The invention discloses a baicalin and boric acid antibacterial peptide assembly and a preparation method and application thereof, belongs to the technical field of biological medicine, and provides a baicalin and boric acid antibacterial peptide assembly which comprises baicalin and boric acid antibacterial peptide. The amino acid sequence of the boric acid antibacterial peptide is one of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5 or SEQ ID NO. 6. According to the baicalin and boric acid antibacterial peptide assembly, phenylboronic acid molecules introduced to the C end of boric acid antibacterial peptide polypeptide can form boric acid ester bonds with the baicalin, the water solubility and membrane permeability of the baicalin can be improved, the baicalin can enter bacterial cells more easily to play a role, and the baicalin and the boric acid antibacterial peptide can form a multi-target synergistic antibacterial effect; therefore, the antibacterial effect is obviously improved.

Novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation are described herein. Methods and devices disclosed herein utilize a synergistic combination of two or more antiseptic agents to reduce contact time, enhance antimicrobial effects, and reduce the likelihood of allergy and other side effects from the antiseptic agents in subjects. In one embodiment, devices include a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

Disclosed in the present invention are a long-acting antimicrobial and antiviral building coating and a preparation method therefor. The building coating is formed by mixing an inorganic antimicrobial material, a cationic resin emulsion, a pigment, an inorganic filler, deionized water, a dispersing agent, a defoaming agent, a thickening agent, and a film-forming auxiliary. The present invention exhibits a safe, efficient and broad-spectrum antimicrobial and antiviral effect by means of a synergistic effect of various components using the inorganic antimicrobial material as a functional filler, and shows long-acting and fast antimicrobial and antiviral characteristics using the cationic resin emulsion as a film-forming material. The obtained antimicrobial and antiviral building coating requires a small addition amount of an antimicrobial agent, can maintain the antimicrobial effect for a long time, satisfies the need for safe, environmentally friendly, and long-acting effects, and is suitable for building exterior walls and indoor coating applications.

The present disclosure describes cleaning and treating formulations including components that interact together to form stable combinations of hydrogen peroxide and a probiotic bacterial solution to provide an immediate oxidative cleaning or treatment effect and a residual antimicrobial effect when applied to a substrate. Cleaning and treating formulations of the present disclosure may include about 0.05% to about 7.00% of hydrogen peroxide, about 5.0×104 to about 5.5×108 cfu / ml of bacterial spores, about 0.20% to about 6.00% of a surfactant; and about 78.00% to about 84.00% of an aqueous carrier. The formulation may also include about 0.01% to about 0.05% of a stabilizer, such as an acid-based stabilizer, and about 0.05% to about 2.00% of a buffer system to control pH fluctuation over the shelf life of the product. Furthermore, formulations may include a fragrance, odor neutralizer, and / or malodor counteractant; and optional ingredients which do not adversely affect the composition.

The invention relates to the technical field of touch screen antibacterial detection, and discloses an antifouling and antibacterial effect detection device for a touch screen, which comprises a base assembly, a wear simulation assembly and a moving assembly, the wear simulation assembly comprises a finger simulation structure and a sebum secretion mechanism, the finger simulation structure communicates with the sebum secretion mechanism, and the sebum secretion mechanism can provide sebum-like secretion liquid for the finger simulation structure; the moving assembly can move back and forth along the base assembly, the abrasion simulation assembly is installed on the moving assembly, and friction simulation is conducted when the abrasion simulation assembly makes contact with the touch screen. The sebum secretion mechanism is used for releasing sebum-like secretions, damage generated by a biofilm on the touch screen and mechanical friction in actual use is simulated, the scene that multiple persons use the touch screen for a long time in public places can be effectively simulated, the accuracy of touch screen antibacterial performance detection is greatly improved, and the detection cost is reduced. And a high-simulation test platform is provided for product quality control.

This invention relates to the field of food preservation technology and discloses a liquid preservative for preserving fresh walnut kernels. The preservative comprises a natural preservative, a solubilizing and stabilizing agent, and a solvent. This liquid preservative uses natural phloretin as the preservative component, combined with Tween 80 as a solubilizing and stabilizing agent and ethanol as a solvent. This effectively solves the problems of poor water and oil solubility and inadequate stability of phloretin, allowing it to be stably dispersed in the preservative system and fully exert its antioxidant and antimicrobial effects. Furthermore, the preparation method is simple and easy to implement, and the production process is safe and controllable. It is convenient to use; the preservation of fresh walnut kernels can be achieved through dilution and soaking. The diluted solution can be reused, reducing usage costs. Simultaneously, it can inhibit bacterial growth during the storage of fresh walnut kernels, delay oxidative deterioration, maintain their good appearance and quality, extend shelf life, and meet the market demand for high-quality fresh walnut kernels.

Novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation are described herein. Methods and devices disclosed herein utilize a synergistic combination of two or more antiseptic agents to reduce contact time, enhance antimicrobial effects, and reduce the likelihood of allergy and other side effects from the antiseptic agents in subjects. In one embodiment, devices include a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

The present invention relates to an antimicrobial composition characterized in that it comprises rosemary essential oil, cultured dextrose, and pH-regulating vinegars, wherein the rosemary essential oil is present at a concentration of 1% or less, the cultured dextrose is present at a concentration of 1% or less, and the pH-regulating vinegar is present at a concentration of 0.1% or less, and wherein the composition exhibits synergistic antimicrobial activity.

Inexpensive and highly effective methods and devices for convenient and effective wound irrigation are described herein. The synergistic combination of two or more antiseptic agents reduces contact time, enhances antimicrobial effects, and reduces the likelihood of allergy and other side effects from the antiseptic agents in subjects. In one embodiment, devices include a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

The invention relates to a cover (0) suitable for accommodating a medical accessory (1), such as eye protection (1.1) or thyroid protection (1.2). The accessory (1) is preferably formed flat from a foam and has a continuous material layer of a radiation protection material. Due to the use of the foam, the accessory cannot be disinfected and / or sterilized and is sold as a disposable article. The cover (0) according to the invention is formed from a silicone material and can preferably consist of a silicone material approved for medical technology, which in one embodiment has an antimicrobial finish and / or has an antimicrobial effect via its surface properties. Furthermore, the invention relates to a kit comprising this cover and at least one medical accessory, in particular at least one eye protection and / or thyroid protection.

The invention relates to the technical field of biological materials, and discloses a low-hemolytic broad-spectrum antibacterial combined peptide and application thereof. The amino acid sequence of the amino acid sequence is one of the following sequences: Meta211: X2IRRLWRX3X2RLIR, Meta201: IWRX3X1RX3LRLX1RR, Meta185: X2LRRX1LTRLIRX2I, MetaLRRX1LTRLIRX2I, MetaLRRX1LTRLIRX2I, MetaLRRX1LTRLRX2I, MetaLRRX1LTRLRX2I Wherein X1, X2 and X3 are random sites, X1 is L or I, X2 is V or L, and X3 is I or V; the Meta211, the Meta201 and the Meta185 are mixtures selected from all the random sites respectively. The antibacterial combined peptide can have a powerful antibacterial effect on various bacteria, particularly has a remarkable antibacterial effect on bacillus subtilis, shows excellent low hemolysis, provides a sustainable, economical and efficient solution for upgrading of antibacterial drugs, and has important social significance.

The invention discloses an antimicrobial composition and application thereof. The antimicrobial composition comprises: (a) isohexylene glycol; and (b) a second antimicrobial preparation, wherein the second antimicrobial preparation is selected from at least one of capryloyl hydroxamic acid and p-hydroxyacetophenone; the isohexylene glycol disclosed by the invention has good solubility on the capryloyl hydroximic acid or the p-hydroxyacetophenone, so that the capryloyl hydroximic acid and / or the p-hydroxyacetophenone still have good stability under a low-temperature condition; according to the present invention, the synergistic interaction between the isohexylene glycol and the capryloyl hydroximic acid and / or p-hydroxyacetophenone is completely performed, such that the antimicrobial effect is significantly improved, and the antimicrobial composition can be used in daily chemical products, cosmetics, personal care compositions or cleaning compositions, and has advantages of low use amount, safety, effectiveness, nature, low irritation and the like.

An antimicrobial agent with synergistic antimicrobial effects, comprising iodide ions encapsulated within silver cages, as well as its preparation method and application, relates to the technical field of antimicrobial materials. The antimicrobial agent utilizes a 16-core silver cage as its basic structural unit, encapsulating iodide ions within the cages and assembling them into a one-dimensional chain structure using thiols as connectors. This antimicrobial agent, by encapsulating iodide ions within the silver cages, achieves diversified antimicrobial material performance and structure through the synergistic action of multiple antimicrobial mechanisms.

The invention discloses an antibacterial peptide with multiple phytopathogen antibacterial activity, a biological antibacterial agent and application of the antibacterial peptide and the biological antibacterial agent, and the amino acid sequence of the antibacterial peptide is FKLIRNLIILRQAWKLIKRRR and is marked as RR-21. Experiments show that the antibacterial peptide disclosed by the invention has a similar alpha-helical structure with a known antibacterial peptide LL-37, and has antibacterial activity on plant pathogenic bacteria represented by pseudomonas syringae and plant pathogenic fungi represented by fusarium pseudograminearum and fusarium oxysporum; compared with the LL-37 polypeptide, the MIC of the RR-21 is 4-8 [mu] g / mL, and the RR-21 has a more significant bacteriostatic effect; meanwhile, under the conventional bacteriostatic concentration (less than or equal to 16 mu g / mL), the RR-21 shows no hemolytic activity; the above fully proves that the antibacterial peptide has high biological safety to eukaryotic cells while exerting multiple antibacterial effects, and can be used as an active component of a biological antibacterial agent, and the biological antibacterial agent has the potential of being developed into an efficient and safe plant disease resistant drug or a plant green pesticide.

The invention discloses an efficient antibacterial long glass fiber reinforced polypropylene composite material for packaging and a preparation method thereof. The composite material is prepared from the following raw materials in parts by weight: 50 to 80 parts of polypropylene resin, 20 to 30 parts of continuous glass fiber, 1 to 2 parts of nano-silver antibacterial additive, 1 to 2 parts of titanium dioxide master batch, 1 to 3 parts of compatilizer and 0.1 to 1 part of antioxidant. The high-efficiency antibacterial long glass fiber reinforced polypropylene composite material for packaging is a material which can be subjected to direct injection molding to enable parts to have an excellent long-acting antibacterial effect. Through a mode of coating the surface of continuous glass fiber with a silver ion antibacterial agent nano coating and adding titanium dioxide of a polypropylene matrix, the prepared glass fiber reinforced polypropylene material has the characteristics of high mechanical property and uniform surface antibacterial effect distribution, and can achieve long-acting bacteriostatic and antibacterial effects when being used as an outer package.

The invention belongs to the technical field of biology, and particularly relates to an antibacterial polypeptide LAB-129 and application thereof. Based on the Shanxi mature vinegar-derived antibacterial peptide LAB-4 with antibacterial activity excavated in the early stage, a complete sequence is split into a plurality of short peptide fragments with 5-50 amino acid residues by adopting a random fragmentation strategy, and a novel antibacterial peptide LAB-129 with higher antibacterial activity is screened out. Compared with LAB-4, LAB-129 has higher antibacterial activity, lower MIC (minimal inhibitory concentration) and higher membrane destruction capability and cell destruction effect, shows better overall antibacterial effect, and lays a good foundation for developing a novel microbial proliferation inhibitor for replacing traditional antibiotics.

System, devices, and methods for providing treatment to tissue are disclosed herein. In some embodiments, a device is provided that includes a delivery catheter having an elongated shaft and an inner lumen therethrough, the delivery catheter being configured to pass through tissue such that a distal end of the delivery catheter is positioned at a target tissue, a support in the form of an inner slidable tube that is configured to be positioned inside the inner lumen of the delivery catheter, the support being configured to provide rigid or semi-rigid support for the delivery catheter during insertion of the delivery catheter through tissue, and one or more optical fibers configured to pass through the inner slidable tube and being configured to deliver light energy to provide an antimicrobial effect to the target tissue.

A process, and the resultant product, for effectively binding plant-based antimicrobials to various fabrics which process provides for long term antimicrobial effect of the fabric.

System, devices, and methods for providing treatment to tissue are disclosed herein. In some embodiments, a device is provided that includes a delivery catheter having an elongated shaft and an inner lumen therethrough, the delivery catheter being configured to pass through tissue such that a distal end of the delivery catheter is positioned at a target tissue, a support in the form of an inner slidable tube that is configured to be positioned inside the inner lumen of the delivery catheter, the support being configured to provide rigid or semi-rigid support for the delivery catheter during insertion of the delivery catheter through tissue, and one or more optical fibers configured to pass through the inner slidable tube and being configured to deliver light energy to provide an antimicrobial effect to the target tissue.

This invention discloses an antimicrobial peptide RY-10 and its application in the preparation of antimicrobial drugs, belonging to the field of biomedical technology. The amino acid sequence of the antimicrobial peptide RY-10 is shown in SEQ ID NO.2. The antimicrobial peptide RY-10 provided by this invention has a highly efficient killing ability against a variety of Gram-negative / positive bacteria, effectively retaining antimicrobial activity while significantly reducing cytotoxicity. Simultaneously, this antimicrobial peptide RY-10 can also produce synergistic antimicrobial effects with various antibiotics, showing significant application value in improving efficacy, overcoming antibiotic resistance, reducing drug dosage, delaying the development of drug resistance, and addressing complex infections. This invention provides a highly promising candidate material resource for the development of highly effective and low-toxicity antimicrobial drugs, and also provides an efficient, safe, and sustainable solution for developing novel combination therapies and addressing the global drug resistance crisis, possessing significant clinical application value and industrialization potential.

Disclosed are thermoplastic polymer materials, and polymer products (e.g., medical devices) made therefrom, that incorporate metal nanoparticles. The metal nanoparticles impart antimicrobial activity to the thermoplastic polymer materials. The thermoplastic polymer materials can be manufactured or processes in a manner that causes metal nanoparticles within the interior of the thermoplastic polymer to beneficially migrate to the surface portion of the thermoplastic polymer (i.e., an outer 100 nm of the thermoplastic polymer), where contact with microbes is more likely to occur. Resulting polymer products, such as medical devices, include a higher concentration of metal nanoparticles at the surface portion, where antimicrobial effects are most useful, as compared to the interior bulk portion of the thermoplastic polymer. The surface portion can include up to 10 times the concentration of metal nanoparticles than the interior bulk portion. The concentration of metal nanoparticles in at least the surface portion can be 2-2000 ppm, 10-1400 ppm, 20-1000, 30-500 ppm, 50-250 ppm, or 70-150 ppm.

Compositions comprising 2-hydroxycarboxylic acid for dysregulating the metabolism of planktonic bacteria and their use. This disclosure provides compositions for dysregulating the metabolism of planktonic bacteria, the compositions comprising preferred enantiomers of 2-hydroxycarboxylic acid. This disclosure further provides compositions for dysregulating the metabolism of planktonic bacteria, the compositions comprising preferred enantiomers of 2-hydroxycarboxylic acid and antimicrobial compounds. Dysregulation of the metabolism of planktonic bacteria can be measured, among other examples, by a decrease in the MIC of concomitant antimicrobial agents, an enhancement of in vivo antimicrobial effects, or aerobic respiration of metabolically active cells (reduction of non-fluorescent resazurin to highly fluorescent resorphine), which can lead to sensitization of planktonic bacteria to antimicrobial compounds and / or disruption of resistance of planktonic bacteria to antimicrobial compounds.

Provided is a use of a combined composition in preparing a drug for resisting fungal and bacterial infections. Active components of the combined composition are an antibiotic and an antibiotic adjuvant, wherein the antibiotic adjuvant is celastrol or a pharmaceutical salt thereof. The present application creatively discovers that celastrol or the pharmaceutical salt thereof can be combined with the antibiotic and the combination has a very excellent effect in resisting the fungal and bacterial infections, especially in resisting the fungal infections. Celastrol or the pharmaceutical salt thereof can enhance an antimicrobial effect of the antibiotic, especially an antifungal effect of the antibiotic, significantly increasing an antimicrobial sensitivity of the antibiotic and inhibiting the occurrence of fungal or bacterial drug-resistance. As an antibiotic adjuvant-antibiotic drug platform, the combined composition provides a new strategy for achieving an efficient antimicrobial effect, and the application dosage forms and the application scenarios are very diverse.

This application relates to a nanomolecular complex comprising: a zeolite imidazolate framework (ZIF-8); and pyrithione (PT); wherein the pyrithione (PT) is supported on the ZIF-8 framework. The nanoantimicrobial agent of this application uses nanomaterials as carriers and incorporates a dual antimicrobial mechanism to target bacterial infections and other sites. While exhibiting highly effective antimicrobial effects, it does not induce bacterial resistance and can significantly reduce or even eliminate the development of superbugs.

The invention provides a rare earth composite fiber with long-acting antibacterial performance and a preparation method thereof, the rare earth composite fiber is prepared by adding a specific rare earth complex into a spinning raw material, and performing mixing, melt spinning, stretching and other steps to obtain the fiber with excellent antibacterial performance. The fiber not only has a good antibacterial effect, but also keeps good mechanical properties of the fiber, and is suitable for manufacturing medical textiles, hygienic products, daily textiles and the like.

The present invention provides a silage additive, functional silage, and a preparation method and application, which belong to the technical field of animal husbandry feed. The present invention provides a silage additive, comprising: Morinda officinalis, Achyranthes bidentata, Callicarpa nudiflora and Blumea balsamifera. The Chinese herbal medicines of Morinda officinalis, Achyranthes bidentata, Callicarpa nudiflora and Blumea balsamifera described in the present invention are rich in bioactive ingredients, have antibacterial and antimicrobial effects, antioxidant effects, etc., and as silage additives, can significantly improve the quality of silage fermentation, increase the lactic acid content of silage, reduce the content of acetic acid, propionic acid and butyric acid in silage, reduce the pH value, and improve the microbial community structure of silage. In addition, the Morinda officinalis described in the present invention has the effects of promoting kidney yang and treating infertility, and Achyranthes bidentata has the effects of promoting blood circulation, unblocking menstruation, and nourishing the liver and kidneys. The silage prepared by fermenting silage raw materials using the silage additive containing Morinda officinalis and Achyranthes bidentata provided by the present invention can significantly improve the production performance and reproductive performance of animals, thereby improving the efficiency of the breeding industry.

A method of preparing antimicrobial 3D-printed material with antimicrobial agents integrated with the 3D-printed material. The 3D-printed material fabricated with the method of the present disclosure includes antimicrobial agent (s) fully integrated throughout the product and display antimicrobial effect throughout the product, which is resistant to daily wear and tear.