28 results about "Antimicrobial effect" patented technology

This invention relates to the field of food preservation technology and discloses a liquid preservative for preserving fresh walnut kernels. The preservative comprises a natural preservative, a solubilizing and stabilizing agent, and a solvent. This liquid preservative uses natural phloretin as the preservative component, combined with Tween 80 as a solubilizing and stabilizing agent and ethanol as a solvent. This effectively solves the problems of poor water and oil solubility and inadequate stability of phloretin, allowing it to be stably dispersed in the preservative system and fully exert its antioxidant and antimicrobial effects. Furthermore, the preparation method is simple and easy to implement, and the production process is safe and controllable. It is convenient to use; the preservation of fresh walnut kernels can be achieved through dilution and soaking. The diluted solution can be reused, reducing usage costs. Simultaneously, it can inhibit bacterial growth during the storage of fresh walnut kernels, delay oxidative deterioration, maintain their good appearance and quality, extend shelf life, and meet the market demand for high-quality fresh walnut kernels.

The invention discloses an antibacterial peptide with multiple phytopathogen antibacterial activity, a biological antibacterial agent and application of the antibacterial peptide and the biological antibacterial agent, and the amino acid sequence of the antibacterial peptide is FKLIRNLIILRQAWKLIKRRR and is marked as RR-21. Experiments show that the antibacterial peptide disclosed by the invention has a similar alpha-helical structure with a known antibacterial peptide LL-37, and has antibacterial activity on plant pathogenic bacteria represented by pseudomonas syringae and plant pathogenic fungi represented by fusarium pseudograminearum and fusarium oxysporum; compared with the LL-37 polypeptide, the MIC of the RR-21 is 4-8 [mu] g / mL, and the RR-21 has a more significant bacteriostatic effect; meanwhile, under the conventional bacteriostatic concentration (less than or equal to 16 mu g / mL), the RR-21 shows no hemolytic activity; the above fully proves that the antibacterial peptide has high biological safety to eukaryotic cells while exerting multiple antibacterial effects, and can be used as an active component of a biological antibacterial agent, and the biological antibacterial agent has the potential of being developed into an efficient and safe plant disease resistant drug or a plant green pesticide.

This invention discloses an antimicrobial peptide RY-10 and its application in the preparation of antimicrobial drugs, belonging to the field of biomedical technology. The amino acid sequence of the antimicrobial peptide RY-10 is shown in SEQ ID NO.2. The antimicrobial peptide RY-10 provided by this invention has a highly efficient killing ability against a variety of Gram-negative / positive bacteria, effectively retaining antimicrobial activity while significantly reducing cytotoxicity. Simultaneously, this antimicrobial peptide RY-10 can also produce synergistic antimicrobial effects with various antibiotics, showing significant application value in improving efficacy, overcoming antibiotic resistance, reducing drug dosage, delaying the development of drug resistance, and addressing complex infections. This invention provides a highly promising candidate material resource for the development of highly effective and low-toxicity antimicrobial drugs, and also provides an efficient, safe, and sustainable solution for developing novel combination therapies and addressing the global drug resistance crisis, possessing significant clinical application value and industrialization potential.

Compositions comprising 2-hydroxycarboxylic acid for dysregulating the metabolism of planktonic bacteria and their use. This disclosure provides compositions for dysregulating the metabolism of planktonic bacteria, the compositions comprising preferred enantiomers of 2-hydroxycarboxylic acid. This disclosure further provides compositions for dysregulating the metabolism of planktonic bacteria, the compositions comprising preferred enantiomers of 2-hydroxycarboxylic acid and antimicrobial compounds. Dysregulation of the metabolism of planktonic bacteria can be measured, among other examples, by a decrease in the MIC of concomitant antimicrobial agents, an enhancement of in vivo antimicrobial effects, or aerobic respiration of metabolically active cells (reduction of non-fluorescent resazurin to highly fluorescent resorphine), which can lead to sensitization of planktonic bacteria to antimicrobial compounds and / or disruption of resistance of planktonic bacteria to antimicrobial compounds.

Provided is a use of a combined composition in preparing a drug for resisting fungal and bacterial infections. Active components of the combined composition are an antibiotic and an antibiotic adjuvant, wherein the antibiotic adjuvant is celastrol or a pharmaceutical salt thereof. The present application creatively discovers that celastrol or the pharmaceutical salt thereof can be combined with the antibiotic and the combination has a very excellent effect in resisting the fungal and bacterial infections, especially in resisting the fungal infections. Celastrol or the pharmaceutical salt thereof can enhance an antimicrobial effect of the antibiotic, especially an antifungal effect of the antibiotic, significantly increasing an antimicrobial sensitivity of the antibiotic and inhibiting the occurrence of fungal or bacterial drug-resistance. As an antibiotic adjuvant-antibiotic drug platform, the combined composition provides a new strategy for achieving an efficient antimicrobial effect, and the application dosage forms and the application scenarios are very diverse.

A long-lasting hydrogel for use against drug-resistant bacteria, and a preparation method and use thereof are provided. In the present disclosure, polyvinyl alcohol (PVA) is mainly adopted as a matrix, and phytic acid and honey including glucose and fructose are added to modify the PVA to obtain the hydrogel. During preparation of the antimicrobial hydrogel, no toxic chemical crosslinking agent or initiator is added, and the antimicrobial hydrogel is mainly obtained by crosslinking PVA, phytic acid, and monosaccharides through ester bonds, hydrogen bonds, and electrostatic adsorption. In addition, the hydrogel obtained by adding phytic acid and honey to the PVA matrix exhibits a significant long-lasting antimicrobial effect for Staphylococcus aureus (S. aureus), drug-resistant S. aureus, and Pseudomonas aeruginosa (P. aeruginosa), and the antimicrobial effect can last for about 3 months.

The present invention relates to cosmetic compositions comprising a combination of lacto-N-tetraose (LNT) or lacto-N-neotetraose (LNnT) with an aliphatic diol or an aliphatic triol or an ether or an ester thereof. These cosmetic compositions or the respective combinations show a significant antimicrobial effect on microorganisms.

The invention discloses an antibacterial peptide fragment intercepted from a mined fly IDGF4 protein and application of the antibacterial peptide fragment in preparation of antibacterial drugs. According to the invention, oligopeptide fragments at different parts in the collected fly IDGF4 protein are screened, three candidate peptides are obtained through chemical synthesis, the antibacterial performance of the candidate peptides is systematically evaluated, antibacterial experiment results show that the oligopeptide with the amino acid sequence shown as SEQ ID No.2 can effectively inhibit the growth of salmonella and staphylococcus aureus under the concentration of 1mg / mL, and the oligopeptide with the amino acid sequence shown as SEQ ID No.2 can effectively inhibit the growth of salmonella and staphylococcus aureus under the concentration of 1mg / mL. The antibacterial effect of the peptide is confirmed in inhibition zone experiments, enzyme-labeled turbidimetry and growth curve monitoring, and the peptide shows stable and remarkable antibacterial activity, which indicates that the peptide can be used as a novel antibacterial molecule. The invention provides a new candidate sequence for developing the antibacterial peptide with high efficiency and low drug resistance risk, and has application potential in the aspect of preparing clinical antibacterial drugs.

The present disclosure relates to the field of antimicrobial compositions. More particularly, it concerns the use of a composition as an antimicrobial agent, the composition comprising ingredients selected from the group consisting of: (i) nona-2,6-dien-1-ol in combination with at least one ingredient selected from the group consisting of 3-neopentylpyridine, 2-methylhexan-3-one oxime, terpineol and 2-isopropyl-5-methylphenol; (ii) gamma-dodecalactone in combination with at least one ingredient selected from the group consisting of 1-Methyl-4-(1-methylethenyl)-cyclohexene, 4-Methoxybenzaldehyde, and 1,3-Benzodioxole-5-carbaldehyde; (iii) (Z)-3,7-Dimethyl-2,6-octadien-1-ol and gamma-dodecalactone; (iv) cis-4(Isopropyl)cyclohexanemethanol and 4-Methoxybenzaldehyde; and (v) 1,3-Benzodioxole-5-carbaldehyde and 4-Methoxybenzaldehyde, wherein the ingredients are present in an amount sufficient to provide an antimicrobial effect. The composition and its use for the preparation of antimicrobially active perfuming compositions and consumer products are also objects of the disclosure.

Disclosed herein are lipid nanoparticles that demonstrate effective antimicrobial effects. An example lipid nanoparticle includes an unsaturated monoglyceride, a saturated monoglyceride, and a glycerol behenate. Also disclosed herein are microfluidic methods of making the lipid nanoparticles, pharmaceutical compositions that include the lipid nanoparticles, methods of modulating a microorganism's activity, and methods of promoting beneficial health effects in an animal.

This invention discloses a silver-carbon quantum dot composite nanomaterial loaded with an antimicrobial peptide, comprising silver-carbon quantum dots (AgCQDs) and an antimicrobial peptide CKKII14. The antimicrobial peptide CKKII14 is loaded onto the silver-carbon quantum dots (AgCQDs) via Ag-S bonds, and its serial number is CIKKIIKKIIKKII-NH2. This silver-carbon quantum dot composite nanomaterial loaded with the antimicrobial peptide enhances the antimicrobial properties of the peptide, exhibiting significant antimicrobial effects against *Escherichia coli* and *Staphylococcus aureus*. The optimal inhibitory concentration (MIC) against *Escherichia coli* reaches 3 µg / mL, and against *Staphylococcus aureus* reaches 5 µg / mL.

The invention discloses an antibacterial peptide GV-16 and application of the antibacterial peptide GV-16 in preparation of antibacterial drugs, and belongs to the technical field of biological medicines. The amino acid sequence of the antibacterial peptide GV-16 is as shown in SEQ ID NO. 2. The antibacterial peptide GV-16 provided by the invention has an efficient killing capability on various gram negative / positive bacteria, and the cytotoxicity is greatly reduced while the antibacterial activity is effectively retained. Meanwhile, the antibacterial peptide GV-16 can also generate a synergistic antibacterial effect with various antibiotics, and has remarkable application values in the aspects of improving the curative effect, overcoming the drug resistance of the antibiotics, reducing the dosage, delaying the generation of the drug resistance, dealing with complex infection and the like. The invention provides a promising candidate material resource for developing high-efficiency and low-toxicity antibacterial drugs, also provides a high-efficiency, safe and sustainable solution for developing a novel combination therapy and coping with global drug resistance crisis, and has important clinical application value and industrialization potential.

The present inventive concept relates to an antimicrobial coating composition, and more specifically, to an antimicrobial coating composition whose components have excellent solubility in the composition and which may be prevented from discoloring, and at the same time, exhibits excellent antimicrobial effects, and a method of producing an antimicrobial product using the same.

The antimicrobial composition comprises a mixture or a reaction product of at least turmeric extract (TME), japonica extract (SJE) and Azithromycin (AZM), wherein the ratio of the mass of turmeric extract (TME) to the mass of japonica extract (SJE), mT\n.: msjE is in the range from 1 : 10 to 10: 1, and wherein the ratio of the sum of the masses of turmeric extract (TME) and japonica extract (SJE) to the mass of Azithromycin (AZM), (mTME + mSJE) : mAZM is in the range from 1 : 10 to 10: 1. The composition has an excellent antimicrobial effect. It can be embedded in products or placed on their surfaces and prevents or impedes the settling of microorganisms.

The present invention provides multifunctional particulates that release one or more functional compounds in response to environmental triggers and whose external surface modification imparts secondary functionalities to a selected coating composition. For example, disclosed are hydrophobic particles having a smart release mechanism for anticorrosion compounds that release the anticorrosion compounds upon exposure to the local pH changes induced by corrosion processes. Formulations are disclosed for multifunctional smart particles having antimicrobial effects and protections as well.

The present invention relates to an antimicrobial composition for a plant culture medium, which has high physicochemical stability, so that active ingredients remain without being destroyed during a high-temperature and high-pressure sterilization process, thereby exhibiting an excellent antimicrobial effect, has no phytotoxicity, can be easily added to a plant medium, and has high convenience of long-term use without a problem of corroding a plant tissue culture container made of polycarbonate, thereby being able to be effectively used to prevent contamination of microorganisms with respect to a plant tissue culture medium or a nutrient solution for hydroponics.

Novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation are described herein. Methods and devices disclosed herein utilize a synergistic combination of two or more antiseptic agents to reduce contact time, enhance antimicrobial effects, and reduce the likelihood of allergy and other side effects from the antiseptic agents in subjects. In one embodiment, devices include a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

The invention relates to a device (1) with a surface (2) and an antimicrobial agent (3) for inhibiting microbial growth on the surface (2), wherein the antimicrobial agent (3) comprises a plastic (5) in which an antimicrobial component (4) is embedded, the antimicrobial component (4) being electrically conductive and at least partially exposed to the outside of the surface (2). To enhance the antimicrobial effect, it is proposed that the antimicrobial component (4) causes the antimicrobial agent (3) to be electrically conductive, wherein the device (1) has electrical connections (7) configured to conduct an electric current through the antimicrobial agent (3) to heat the surface (2).

The present disclosure relates to compositions and methods for combinatorial assessment of nanoscale droplets, as specifically exemplified by massively parallel assessment of spatially-directed (while agnostic as to precise droplet content) combinations of droplets harboring distinct and independently identifiable microbial types and / or chemical compounds or mixtures. More particularly, the disclosure relates to a platform and methodologies for identifying advantageous (including synergistic, additive, etc.) microbial interactions and / or chemical compound or mixture interactions with microbes in a manner that allows for binary, trinary, etc. combinatorial assessments to be performed across a range of many discrete input types of microbes (e.g., 6-16 or more discrete input microbial types), to an extent capable of approaching comprehensive sampling and measurement of microbial community combinations from a selected panel of microbial inputs, optionally also in the presence of chemical compounds or mixtures (e.g., test compounds or mixtures for antimicrobial effect).

The invention discloses a fibrous membrane loaded with infinite coordination polymer nanoparticles and a preparation method and application thereof, the fibrous membrane loaded with infinite coordination polymer nanoparticles comprises a nanofiber scaffold fused with polycaprolactone (PCL) and sericin Se, and curcumin-copper ICP loaded on the nanofiber scaffold. Accurate pH response release is shown, in an early infected / inflammatory wound (acidic microenvironment), curcumin Cur and Cu < 2 + > are released through rapid dissociation of curcumin-copper ICP, curcumin Cur clears ROS (reactive oxygen species) and inhibits inflammation, and Cu < 2 + > has a synergistic antimicrobial effect. Along with the transition of the wound to a neutral healing stage, the structure of the curcumin-copper ICP is re-stabilized, and the release rate is obviously slowed down. In the stage, low-dose curcumin Cur maintains the anti-inflammatory / anti-oxidation effect, and slow Cu < 2 + > release promotes angiogenesis. The intelligent controlled release provides a reference for designing an environmentally responsive drug delivery system.

The present application provides a hydrogel-plasma generator-integrated patch capable of supporting reactive species and / or useful substances. More specifically, the present application provides a hydrogel-plasma generator-integrated patch capable of supporting reactive species and / or useful substances, which is used by being attached to the skin and simultaneously treat skin diseases and / or wounds while exhibiting synergistic antimicrobial effects and controlled release of useful substances.

A novel recombinant antimicrobial multidomain polypeptide in an aggregated and functional format is provided. The antimicrobial multidomain polypeptide comprises at least three peptidic domains: a) a non-enzymatic antimicrobial peptidic domain from mammal's immune system, b) a bacterial binding peptidic domain which interacts with the bacterial cell wall or membrane, and c) an enzymatic antimicrobial peptidic domain from mammal's immune system. The antimicrobial multidomain polypeptide exhibits a broad-spectrum antimicrobial effect and is produced in an efficient production system, i.e in form of inclusion bodies.

A puck is made of a porous resilient material and is held in a housing to comprise a cable swipe cassette. The puck holds fluid in the porous material, and there is a bore through the puck. A cable is routed through the bore so that when the cable is pulled through the bore the exterior surface of the cable is wetted with the fluid. The fluid can have an antimicrobial effect so as to disinfect the cable.

Provided in the present invention are a Bacillus strain, a biocontrol inoculant prepared by the Bacillus strain, and the use thereof. The Bacillus strain provided by the present invention is Bacillus subtilis and is named ZZ-1, is preserved in the preservation authority: the China General Microbiological Culture Collection Center at the preservation address: Institute of Microbiology, Chinese Academy of Sciences, No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and is assigned with the accession number CGMCC No. 31374 on 19 July 2024. The Bacillus strain ZZ-1 of the present invention, regardless of being in the form of live bacterial cells, a supernatant or a cell lysate, has certain antimicrobial effects on various pathogenic fungi. The Bacillus strain ZZ-1 has strong living ability, has a wide application range in terms of nutrient sources, temperature, humidity and pH value, has no pathogenicity to fruits and vegetables, and has relatively good tolerance to broad-spectrum fungicides.

This invention belongs to the field of biocontrol technology of plant endophytic fungi and their metabolites, specifically relating to a growth-promoting and disease-resistant fermentation broth of a gentian endophytic fungus, its preparation method, and its application. The fermentation broth of this invention is prepared by activating and fermenting the endophytic fungus *Trichoderma* sp. 3711 from gentian. Antibacterial and growth-promoting experiments have demonstrated that the fermentation broth of this invention has significant broad-spectrum antimicrobial effects against plant pathogens and promotes plant (especially crop) growth. Furthermore, the preparation method of the fermentation broth based on *Trichoderma* sp. 3711 isolated from gentian is simple, inexpensive, and has good economic value and broad market prospects.

The present invention refers to a combination of enzymes that presents antimicrobial features. Specifically, the combination of the invention comprises an endolysin and a glucose oxidase. Surprisingly, the combination of the invention presents a synergistic antimicrobial effect that is useful for the control of food borne pathogens, such as Listeria monocytogenes.