48 results about "Ringer's solution" patented technology

The invention provides taxol freeze dried micro emulsion used for injection and a preparation method thereof. The freeze dried micro emulsion comprises taxol in effective dosage as the drug and pharmaceutic adjuvant such as oil phase, an emulsifier, an assistant emulsifier, a pH regulator, isotonic regulator and a freeze dried protective agent. The preparation method comprises the following steps: weighing the emulsifier in the amount according to the prescription, after evenly stirring the assistant emulsifier and oil for injection, adding the taxol into the mixed liquor and stirring for complete dissolution, then adding water for injection, completely stirring, obtaining taxol micro emulsion after regulating the pH value, further adding the freeze dried protective agent, and obtaining the freeze dried micro emulsion after vacuum freeze drying. Micro emulsion can be rapidly recovered by using physiologically compatible solution such as normal saline, glucose solution or Ringer's solution for dilution before use. The freeze dried micro emulsion and the preparation method are characterized in that through the further freeze drying technique to the taxol micro emulsion, the stability and the efficacy of the taxol are obviously enhanced, and the toxic and side effects are greatly reduced; especially, the freeze-drying method realizes very good protection function to the micro emulsion and avoids effusion of drug, thereby breaking through a new prospect for the establishment of stable dose pattern of a taxol micro emulsion drug loaded system and long-term preservation thereof. The preparation method for the freeze dried micro emulsion has the advantages of simple preparation technique, no organic solvent and low cost, therefore, the invention is suitable for industrialized mass production.

The present invention relates to a device for injecting a liquid medicine such as a Ringer's solution, and more particularly, to a device for regulating the amount of liquid medicine to be injected. According to the present invention, there is provided with a device for regulating the flow rate of a liquid medicine on a flow path of the liquid medicine, comprising an inflow passage for allowing the liquid medicine to be introduced therethrough; a discharge passage for allowing the liquid medicine to be discharged therethrough; a space for storing the liquid medicine introduced through the inflow passage therein; a capillary unit placed between the space and the discharge passage and having at least two capillaries and a plurality of outlets formed on the side of the discharge passage to correspond to the respective capillaries; and a discharge amount regulating valve that is placed between the capillary unit and the discharge passage and is movable to change the number of capillaries communicating with the discharge passage.

Disclosed is a Ringer solution infusion controlling apparatus which enables the infused amount and infusion state of a Ringer solution to be easily monitored by an administrator and which automatically blocks infusion of the Ringer solution when the infusion of the Ringer solution is completed. The Ringer solution infusion controlling apparatus includes a body coupled to a chamber receiving a Ringer's solution from a Ringer bottle in which the Ringer's solution is stored and ejecting the Ringer's solution in a state in which the Ringer's solution is maintained at a constant level by first coupling means, a sensing ball provided in the chamber and floating on the Ringer's solution, and elevating according to the level of the Ringer's solution in the chamber, an elevation sensor installed in the body and sensing elevation of the sensing ball, a Ringer's solution transfer blocking unit installed in the body and having a Ringer hose passing therethrough, the Ringer hose allowing the Ringer's solution ejected from the chamber to be transferred, and blocking transfer of the Ringer's solution by compressing the Ringer hose when it is detected by the elevation sensor that the sensing ball deviates from a predetermined range, and a wireless transmitter installed in the body and wirelessly transmitting a Ringer's solution transfer blocking signal to a nurse's room when the transfer of the Ringer's solution is blocked by the Ringer's solution transfer blocking unit.

This invention prevents the danger of falling of body temperature by making the blood temperature similar to the body temperature in the injection of Ringer's solution fluid or blood transfusion, and also alleviates the patient's pain and improves the speed at which Ringer's solution fluid or blood enters the body. The warming device is much cheaper than previously released products, and small and light in weight, and allows blood or solution fluids to flow most effectively by allowing sufficient time for heat transfer as a pack type. The operation is convenient and sanitary in its single usage only. The inventive purpose has the methods of utilizing the temperature sensor in adjusting temperature by utilizing them PTC heating element's resistance specialty against the temperature as well as temperature sensor.

The invention provides a flushing fluid for surgery, which comprises solute and solvent, wherein the solute is one or two selected from cellulose glycollic ether, carboxymethyl chitosan or carboxymethyl chitosan, the solvent being water for injection, physiological saline solution, sodium chloride flushing fluid, mannitol flushing fluid, glucose flushing fluid, chlorhexidine flushing fluid, gentamicin physiological saline flushing fluid, active iodine flushing fluid, benzalkonium bromide flushing fluid, aminoacetic acid flushing fluid, metronidazole flushing fluid or physiological equilibrium liquid comprising phosphates cushioning liquid, NaHCO3, sodium gluconate and mannitol.

An eyelid scrub composition comprising polyhexamethylene biguanide (PHMB), 1,2-hexanediol, 1,2-octanediol, and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5. The composition can further comprise moisturizers and foam stabilizers. The composition can be combined with a fabric pad for use as an eyelid scrub, where the fabric pad is pre-moistened with the composition and packaged for use. The composition may be applied to the eyelid scrub and rubbed to induce foaming. The composition is produced by preparing a modified Ringer's solution and adding 1,2-hexanediol, 1,2-octanediol, and an effective amount of one or more pH stabilizing surfactants. The mixture is then heated and allowed to cool before polyhexamethylene biguanide is added.

Disclosed are a method for producing a frozen pharmaceutical composition prepared from cultured human mesenchymal stem cells and a pharmaceutical composition containing human mesenchymal stem cells. This method is a method for producing a frozen pharmaceutical composition containing human mesenchymal stem cells, which comprises the following steps in this order: (a) adding trypsin to human mesenchymal stem cells in a culture vessel to detach the cells from the surface of the culture vessel; (b) adding a bicarbonate Ringer's solution containing human serum albumin to the detached cells to terminate the reaction with trypsin, and washing the cells with the bicarbonate Ringer's solution containing human serum albumin; (c) suspending the cells in a bicarbonate Ringer's solution containing human serum albumin and dimethyl sulfoxide; (d) putting the resulting suspension in a container which allows freezing of what is contained therein, and sealing the container; and (e) freezing the suspension put in the container.

The invention discloses a preparation method of an alginate porous material having a three-dimensional gradient pore structure. Sodium alginate or oxidized sodium alginate, which is above 100,000 in relative molecular mass, is taken as a solute, and de-ionized water, distilled water, normal saline, injection water or a Ringer's solution is used as a solvent, so that the structure with interior represented in a honeycombed form is prepared by freezing and forming in a special forming mould through a temperature gradient formed in a perpendicular direction and by conducting a cross-linking reaction; the material comprises a plurality of pores, and from lower surface to upper surface, the diameters of the various pore are in gradient change from large to small, wherein the diameter of the pores in the upper surface is 5-70 [mu]M and the diameter of the pores in the lower surface is 50-200 [mu]M; every two adjuvant pores mutually communicate; and the porous material has a skin bionic structure. The preparation method disclosed by the invention is simple and easy to control and is low in preparation cost; and the prepared product (the porous material) is good and stable in quality and good in water absorbing property, biodegradability and biocompatibility, and the product has the skin bionic structure.

The disclosed invention relates to a heating apparatus having a PCB-type heater capable of allowing the temperature of Ringer's solution or blood which is introduced into a blood vessel, when transfusing a blood thereto, to be equal to that of the human body to thereby provide an accurate resistance value. The present invention comprises 1. A heating apparatus according to an embodiment of the invention comprises a body including a first connecting portion having a tube which is connected to the first connection portion and receives a fluid supplied from an instillation room, a path having the shape of a spiral screw thread to enable the fluid to flow and a second connecting portion for supplying the fluid flowing through the path to an injection syringe; an inner cover inserted into the body and fixedly attached thereto in a prescribed adhesive manner for preventing the fluid from flowing out; a middle cover for closely fixing the body and the inner cover against each other; a PCB-type heater inserted into the inside of the top and bottom surfaces of the middle cover for heating the fluid flowing through the path so that the fluid is maintained at a prescribed temperature; a bottom case having a box portion to receive the body having the heater and the middle cover coupled thereto; and a upper case coupled to the bottom case.

The invention relates to a pharmaceutical composition of ondansetron hydrochloride and dexamethasone, and particularly relates to a combined application package comprising an ondansetron hydrochloride injection and an injection containing dexamethasone. When the combined application package is in use, the ondansetron hydrochloride injection and the injection containing dexamethasone are co-dissolved in normal saline, a Ringer's solution, 5% glucose injection and the like for intravenous infusion, so that a curative effect of stopping vomit can be increased.

The invention discloses a high survival rate loach drug spawning technology, and relates to an artificial spawning technology. The technology concretely comprises the following steps: fixing a spawning period, fixing male and female ratio, preparing and spraying drug soup, performing prevention before spawning and injecting odinagogue; the time is 15 to 20 hours; water temperature is fixed to be 20 to 25 DEG C; loaches are wrapped through towels; 0.1 to 0.2 milliliters of chorionic gonadotropin and Ringer's solution blending agent is injected to each loach, wherein the chorionic gonadotropin occupies 75 percent, and the Ringer's solution blending agent occupies 25 percent. The technology has the characteristics that the loaches absorb the drug soup before delivery, so that the quality of seminal fluid and egg is improved, prevention mixture properly protects the loaches, the survival amount of produced loach fries is high, the yield is high, the method is unique and simple and has good effect, and breeding with the technology is easy to promote for households.

The invention discloses a nano lotus fiber / alginate porous material and a preparation method thereof and belongs to the fields of preparation of the porous materials and processing and utilization of sodium alginate. The porous material is prepared from 0.02wt%-0.08wt% of nano lotus fibers, 1wt%-20wt% of oxidized sodium alginate, 0.6wt%-10wt% of carboxymethyl chitosan and the balance of solvent, wherein the solvent is one selected from deionized water, distilled water, normal saline, water for injection and ringer's solution. The nano lotus fiber / alginate porous material is obtained by crosslinking at a temperature in the range of 20 to 50 DEG C with nano lotus fibers as a reinforcer, the oxidized sodium alginate a base material and the carboxymethyl chitosan as a crosslinking agent. The prepared nano lotus fiber / alginate porous material is capable of degrading a biomaterial in short time, relatively low in cost, convenient to use, and non-toxic and antibacterial to a human body, and has excellent water-absorbing quality, biodegradability and biocompatibility.

The invention discloses a preparation method of a cellular reticular alginate porous material used as an artificial skin. The preparation method comprises: by taking sodium alginate or oxidized sodium alginate of which the relative molecular mass is more than or equal to 100000 as a solute, and deionized water, distilled water, normal saline, injection water or ringer's solution as a solvent, performing freeze forming by forming a vertical temperature gradient in a special forming mold, and performing crosslinking reaction to obtain a porous material, wherein the inside of the porous material is cellular, the porous material comprises a plurality of pores, the pore diameters of the pores change from big to small in gradient from the lower surface to the upper surface, the pore diameters of the pores on the upper surface are 5-70 mu m, the pore diameters of the pores on the lower surface are 50-200 mu m, and every two adjacent pores are communicated with each other and have skin bionic structures. The preparation method disclosed by the invention is simple, is easy to control and is low in manufacturing cost, and the prepared product is good and stable in quality, has a skin bionic structure, and has good hygroscopicity, biodegradability and biocompatibility.

The invention discloses a liver preservation solution which contains the following components in per 100ml: 7-8g of 1,6-fructose diphosptate, 1-2g of glutathione, 2-3g of allopurinol, 0.3-0.5g of traditional Chinese medicine ligustrazine, 8-12mg of traditional Chinese medicine anisodamine and the balance of Ringer's solution added to 100ml. Proved by a large number of experiments, the liver preservation solution has a statistical meaning compared with an experiment contrast group, and two treatment groups (a group of the invention and an American UW treatment group) do not have the statistical meaning. The invention provides an excellent guarantee for long-acting liver preservation, has simple prescription and saves production and inspection cost for production and clinical application.

Disclosed herein is a system for monitoring the injection of Ringer's solution. The monitoring system of the present invention includes a status detection device for measuring the weight of Ringer's solution, converting the weight information of the Ringer's solution into a data signal, and transmitting the data signal. A first line interface device receives the data signal from the status detection device, performs data conversion with respect to the data signal to allow identifier information required to identify the status detection device to be included in the data signal, and outputs the converted data to the communication line. A second line interface device receives the data signal through the communication line, and outputs the data signal to a remote monitoring device. The remote monitoring device decodes the data signal and outputs weight data of the Ringer's solution according to the identifier information.

The invention discloses a Ptychidio jordani sperm cryopreservation method, which comprises four steps, namely semen collection, semen dilution, sperm cryopreservation, and sperm thawing. The semen ofPtychidio jordani is collected through an artificial abdomen squeezing manner, is then mixed with a diluent, and is mixed with an antifreeze agent to obtain a sperm preservation solution, with the diluent being one of a D-17 diluent, a Hank's solution and a Ringer's solution for fish, and the antifreeze agent being one of methanol, dimethyl sulfoxide and dimethyl sulfoxide; then the sperm preservation solution is injected into a cryopreservation tube, and the tube is immersed into liquid nitrogen for long-term storage; when to be in use, the cryopreservation tube containing the sperm preservation solution is taken out of the liquid nitrogen, and then immediately thaw in a water bath with a temperature of 37 DEG C, and the obtained Ptychidio jordani sperms are used for artificial insemination. The method can store the sperms of the Ptychidio jordani for long time and ensures the survival rates of sperms after thawing and resuscitation.

The invention discloses a biological adhesive which is characterized in that the adhesive comprises two parts which are solute and solvent; the solute is an azide benzoylate acidylated biomacromolecule compound; the solvent can be water, water for injection, normal saline, washing liquor of Ringer solution, washing liquor of mannitol, washing liquor of dextrose, washing liquor of chlorhexidine, washing liquor of gentamicin normal saline, washing liquor of glycin, washing liquor of metronidazole or physiologic balance solution; the weight percentage concentration of the azide benzoylate acidylated biomacromolecule compound in the biological adhesive is 0.1 percent to 20 percent. When in use, the biological adhesive needs to be solidified by using ultraviolet irradiation. The biological adhesive of the invention can be used for bonding active physiological tissues, wadding and patching physiological channels, sealing surface of wound to stanch bleeding, bonding physiological materials with non-physiological materials as well as bonding non-physiological materials, with short clotting time.

A device for measuring a flow rate of Ringer's solution includes a key input unit including a number input key through which a user can make an input each time when a drip drips in a drip chamber; a power supply unit for supplying power; an oscillation circuit for oscillating a signal having a preset frequency; a display unit for quantitatively outputting a calculated flow rate of Ringer's solution; and a control unit for calculating an elapsed time when the input is made through the number input key of the key input unit for a preset number of times, calculating the number of drips per an hour using the preset number of times and the calculated elapsed time, acquiring a quantitative flow rate of Ringer's solution by multiplying a preset volume of each drip and the calculated number of drips, and outputting the acquired flow rate to the display unit.

The invention discloses a preparation method of an artificial skin bracket material. According to the preparation method disclosed by the invention, a mixture of carboxymethyl chitosan and sodium alginate or oxidation sodium alginate in the mass ratio of the carboxymethyl chitosan to the sodium alginate or the oxidation sodium alginate being 1:2 as a solute; distilled water, a Ringer's solution or the like is used as a solvent. In a special shaping die, temperature gradient freeze shaping in the perpendicular direction is performed, so that the artificial skin bracket material of which the inner part adopts a comby porous structure is obtained; from a lower surface to an upper surface, the hole diameters of holes are respectively and gradually decreased in a gradient gradual change manner, wherein the hole diameter of the upper surface is 5-70 [mu]m, and the hole diameter of the lower surface is 50-200 [mu]m, every two adjacent holes are perforated, and the artificial skin bracket material is a porous material adopting a skin bionic structure. The preparation technology is simple and easy to control, the preparation cost is low, and the prepared products are good in quality and stable in quality and adopt skin simulation structures. The artificial skin bracket material has favorable water absorbing property, biodegradability, biocompatibility, antibacterial function, antivirus function and anticoagulated blood function.

The present invention relates to a device for injecting a liquid medicine such as a Ringer's solution, and more particularly, to a device for regulating the amount of liquid medicine to be injected. According to the present invention, there is provided with a device for regulating the flow rate of a liquid medicine on a flow path of the liquid medicine, comprising an inflow passage for allowing the liquid medicine to be introduced therethrough; a discharge passage for allowing the liquid medicine to be discharged therethrough; a space for storing the liquid medicine introduced through the inflow passage therein; a capillary unit placed between the space and the discharge passage and having at least two capillaries and a plurality of outlets formed on the side of the discharge passage to correspond to the respective capillaries; and a discharge amount regulating valve that is placed between the capillary unit and the discharge passage and is movable to change the number of capillaries communicating with the discharge passage.

The invention relates to an artificial spawning induction technology, in particular to a family loach breeding artificial spawning induction technology. The family loach breeding artificial spawning induction technology comprises the steps of determination of the spawning induction time, determination of the proportion of females and males, preparation and spraying of liquid medicine, prophylaxis before spawning induction and injection of oxytocic, wherein the time is 15-20 hours, the water temperature is determined at 20-25 DEG C, loaches are wrapped with towels, 0.1-0.2 ml of chorionic gonadotropin and a Ringer's solution mixture is injected into each loach, the chorionic gonadotropin accounts for 75%, and the Ringer's solution mixture accounts for 25%. The family loach breeding artificial spawning induction technology has the advantages that the loaches absorb the liquid medicine before spawning, the quality of seminal fluid and eggs is improved, the loaches are better protected through a prophylaxis mixture, and delivered loaches are high in survival rate and high in yield. The family loach breeding artificial spawning induction technology is unique, simple, good in effect and suitable for being popularized in families for breeding.

The invention discloses a preparation method of an artificial skin bracket material. According to the preparation method disclosed by the invention, a mixture of carboxymethyl chitosan and sodium alginate or oxidation sodium alginate in the mass ratio of the carboxymethyl chitosan to the sodium alginate or the oxidation sodium alginate being 1:2 as a solute; distilled water, a Ringer's solution or the like is used as a solvent. In a special shaping die, temperature gradient freeze shaping in the perpendicular direction is performed, so that the artificial skin bracket material of which the inner part adopts a comby porous structure is obtained; from a lower surface to an upper surface, the hole diameters of holes are respectively and gradually decreased in a gradient gradual change manner, wherein the hole diameter of the upper surface is 5-70 [mu]m, and the hole diameter of the lower surface is 50-200 [mu]m, every two adjacent holes are perforated, and the artificial skin bracket material is a porous material adopting a skin bionic structure. The preparation technology is simple and easy to control, the preparation cost is low, and the prepared products are good in quality and stable in quality and adopt skin simulation structures. The artificial skin bracket material has favorable water absorbing property, biodegradability, biocompatibility, antibacterial function, antivirus function and anticoagulated blood function.

The invention relates to a pharmaceutical composition containing containing tropisetron hydrochloride and dexamethasone sodium phosphate, and particularly relates to a combined application package containing a tropisetron hydrochloride injection and a dexamethasone sodium phosphate injection. When the combined application package is in use, the tropisetron hydrochloride injection and the dexamethasone sodium phosphate injection are co-dissolved in normal saline, a Ringer's solution, 5% glucose injection, a fructose solution and the like for intravenous infusion, so that a curative effect of stopping vomit can be increased.

The invention relates to an autologous collagen injection combined with clostridium botulinum, and belongs to the technical field of medical cosmetology. The autologous collagen injection is prepared from the following raw materials of fibroblasts, collagen, a Ringer's solution I, a glucose solution and the clostridium botulinum, wherein the mass volume ratio of the fibroblasts to the collagen to the Ringer's solution I to the glucose solution to the clostridium botulinum is 10g: (5ml to 20ml): (10ml to 30ml): (5 mcg to 20 mcg). According to the technical scheme, autologous fibroblasts are separated, the collagen is secreted through the fibroblasts, rejection reaction of a human body can be reduced after the collagen is used as the autologous collagen injection, the clostridium botulinum is combined with the autologous collagen injection, muscles of wrinkles caused by the clostridium botulinum are paralyzed, the muscles are not shrunk, and meanwhile, the fibroblasts and other active ingredients in the injection are utilized, so that the tissue compatibility in a body is ensured, and the wrinkle removing effect is improved.

Disclosed are a method for producing a frozen pharmaceutical composition prepared from cultured human mesenchymal stem cells and a pharmaceutical composition containing human mesenchymal stem cells. This method is a method for producing a frozen pharmaceutical composition containing human mesenchymal stem cells, which comprises the following steps in this order: (a) adding trypsin to human mesenchymal stem cells in a culture vessel to detach the cells from the surface of the culture vessel; (b) adding a bicarbonate Ringer's solution containing human serum albumin to the detached cells to terminate the reaction with trypsin, and washing the cells with the bicarbonate Ringer's solution containing human serum albumin; (c) suspending the cells in a bicarbonate Ringer's solution containing human serum albumin and dimethyl sulfoxide; (d) putting the resulting suspension in a container which allows freezing of what is contained therein, and sealing the container; and (e) freezing the suspension put in the container.

The invention discloses a procypris merus sperm cryopreservation method. The method comprises four steps of seminal fluid collection, seminal fluid dilution, sperm cryopreservation and sperm unfreezing, procypris merus seminal fluid is collected by adopting an artificial abdominal extrusion method, then the seminal fluid is mixed with a diluent, the mixture is mixed with antifreezing liquid, and sperm preservation liquid is obtained, and the diluent is any one of D-15 diluent, Hank's liquid and Ringer's Solution for fishes, wherein the antifreeze agent is any one of methanol, dimethyl sulfoxide and glycerol; the sperm preservation liquid is injected into a cryopreservation tube, and the cryopreservation tube immersed into liquid nitrogen for long-term preservation; when the sperm preservation liquid is taken, the cryopreservation tube filled with the sperm preservation liquid is taken out of the liquid nitrogen and then immediately placed in a water bath kettle at the temperature of 27DEG C or 37 DEG C or 47 DEG C to be unfrozen, and then obtained procypris merus sperms are used for artificial insemination. The method can preserve the procypris merus sperms for a long time, and the survival rate of the thawed and recovered sperms is high.

The drug induced labor method for loach with a high survival rate involves an artificial induced labor technology, which specifically includes the following steps: determination of the induced labor period→determination of the male and female ratio→preparation and spraying of medicinal soup→prevention before induced labor→injection of oxytocic agent: the time is 15-20 When the water temperature is determined at 20-25°C, wrap the loach with a towel, and inject 0.1-0.2 ml of a mixture of chorionic gonadotropin and Ringer's solution, of which chorionic gonadotropin accounts for 75%, and Ringer's solution Mixture accounted for 25%. The characteristics of the present invention: the loach absorbs the medicinal soup before birth, improves the quality of semen and eggs, and the preventive mixture can better protect the loach, and the produced loach seedlings have a high survival rate and a large output. Promote farming at home.

The invention discloses a nanometer lotus fiber / sodium alginate porous material and a preparation method thereof, belonging to the field of preparation of porous materials and processing and utilization of sodium alginate. The porous material is composed of 0.02% to 0.08% by weight of nanometer lotus fiber, 1% to 20% of oxidized sodium alginate, 0.6% to 10% of carboxymethyl chitosan, and the balance of solvent, wherein, The solvent is selected from one of deionized water, distilled water, physiological saline, water for injection or Ringer's solution. The present invention selects nanometer lotus fiber as the reinforcing body, oxidized sodium alginate as the base material, and carboxymethyl chitosan as the crosslinking agent. agent, and cross-link at a temperature of 20°C to 50°C to obtain a nanometer lotus fiber / sodium alginate porous material. The nanometer lotus fiber / sodium alginate porous material prepared by the present invention is a biodegradable biomaterial in a short period of time, has low cost, is convenient to use, is non-toxic to the human body, is antibacterial, and has good water absorption, biodegradability and biological properties. compatibility.

A medium for culturing Balantidium ctenopharyngodoni in vitro, method for preparing the medium and method for culture in vitro are provided, which belongs to technical field of in vitro culture of intestinal protozoa. The formulation of the culture medium includes: 100 ml of Ringer's solution, 0.5 g of yeast extract, 1.0 g of proteose peptone, 3-6 ml of fetal bovine serum, 6-10 ml of horse serum, 300-500 μl of Bacillus licheniformis suspension, 200-300 mg of aseptic starch. Culture steps include: inoculating collected Balantidium ctenopharyngodoni into a prepared medium, filling with nitrogen and sealing, culturing at 15° C. for 48-72 hours, then transferring to another fresh medium, cycling back and forth, proliferating the Balantidium ctenopharyngodoni continuously. Balantidium ctenopharyngodoni are capable of achieving cell division and proliferation in the culture medium, and lays foundation for the physiological and experimental ecology research of the Balantidium ctenopharyngodoni.