Pharmaceutical composition containing tropisetron hydrochloride and dexamethasone sodium phosphate

A kind of technology of dexamethasone sodium phosphate and tropisetron hydrochloride, applied in the field of medicine

Inactive Publication Date: 2013-11-20
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, direct use of tropisetron hydrochloride and dexamethasone still has many side effects, such as constipation, headache, dizziness, vertigo, abdominal pain, glucocorticoid syndrome, etc.

Method used

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  • Pharmaceutical composition containing tropisetron hydrochloride and dexamethasone sodium phosphate
  • Pharmaceutical composition containing tropisetron hydrochloride and dexamethasone sodium phosphate
  • Pharmaceutical composition containing tropisetron hydrochloride and dexamethasone sodium phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of tropisetron hydrochloride freeze-dried powder for injection

[0036] prescription:

[0037]

[0038] Preparation Process:

[0039] (1) First add 2800ml of water for injection into the container, and control the temperature at 10°C to 20°C;

[0040] (2) Add 105g glycine, stir to dissolve completely;

[0041] (3) Add 7g of tropisetron hydrochloride (press C 17 h 20 N 2 o 2 meter), stir to dissolve completely, and adjust the pH to 4.9 with 1mol / L sodium hydroxide solution or 1mol / L hydrochloric acid solution;

[0042] (4) Add 0.7g of activated carbon for injection, add the remaining water for injection, set the volume to 3500ml, stir and absorb for 30 minutes;

[0043] (5) The solution is decarbonized by coarse filtration, coarsely filtered through a 0.45 μm cartridge filter, and then sterilized and filtered with a 0.22 μm microporous membrane until the visible foreign matter is qualified;

[0044] (6) Filling.

[0045] (7) Freeze dryi...

Embodiment 2

[0050] Example 2 Preparation of Tropisetron Hydrochloride Injection

[0051] prescription:

[0052]

[0053] Preparation Process:

[0054] (1) First add 5600ml of water for injection into the container, and control the temperature at 10°C to 20°C;

[0055] (2) Add tropisetron hydrochloride 7g (press C 17 h 20 N 2 o 2 meter), stir to dissolve completely, and adjust the pH to 5.0 with 1mol / L sodium hydroxide solution or 1mol / L hydrochloric acid solution;

[0056] (4) Add 1.4g of activated carbon for injection, add the remaining water for injection, set the volume to 7000ml, stir and absorb for 30 minutes;

[0057] (5) The solution is decarbonized by coarse filtration, coarsely filtered through a 0.45 μm cartridge filter, and then sterilized and filtered with a 0.22 μm microporous membrane until the visible foreign matter is qualified;

[0058] (6) Filling, sealing, and sterilization.

Embodiment 3

[0059] Example 3 Preparation of Dexamethasone Sodium Phosphate Injection

[0060] prescription:

[0061]

[0062] Preparation Process:

[0063] (1) Add 500ml of water for injection into the beaker, add 2g of sodium bisulfite and 300ml of propylene glycol, stir to dissolve, then add 1g of dexamethasone sodium phosphate, stir to completely dissolve, use 0.1mol / L hydrochloric acid solution or 0.1 mol / L sodium hydroxide solution to adjust the pH to 7.8, then add 0.5g of wetted medicinal charcoal, add water for injection to 1000ml, stir for 30 minutes, filter and decarbonize; fine filter with a 0.22μm microporous membrane, Filling, 1ml / bottle, sealing; autoclave at 121°C for 15 minutes, quickly spray to cool down, take out the cabinet, and naturally cool to room temperature.

[0064] (2) Add 500ml of water for injection into the beaker, add 2g of sodium bisulfite and 300ml of propylene glycol, stir to dissolve, then add 2g of dexamethasone sodium phosphate, stir to completel...

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing containing tropisetron hydrochloride and dexamethasone sodium phosphate, and particularly relates to a combined application package containing a tropisetron hydrochloride injection and a dexamethasone sodium phosphate injection. When the combined application package is in use, the tropisetron hydrochloride injection and the dexamethasone sodium phosphate injection are co-dissolved in normal saline, a Ringer's solution, 5% glucose injection, a fructose solution and the like for intravenous infusion, so that a curative effect of stopping vomit can be increased.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing tropisetron hydrochloride and dexamethasone sodium phosphate, in particular to a pharmaceutical combination application package composed of tropisetron hydrochloride injection and dexamethasone sodium phosphate injection The composition belongs to the technical field of medicine. Background technique [0002] Tropisetron hydrochloride is a highly efficient and highly selective competitive antagonist of peripheral neurons and central nervous system 5-hydroxytryptamine 3 (5-HT3) receptors. Certain substances, including some chemotherapeutic drugs, stimulate the release of serotonin from chromaffin-like cells in the visceral mucosa, which induces the gag reflex with nausea. Tropisetron hydrochloride inhibits the gag reflex mainly by selectively blocking the presynaptic 5-HT3 receptors of peripheral neurons. In addition, its antiemetic effect may also be related to the direct blockad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/661A61P1/08A61K31/46
Inventor 陶灵刚
Owner HAINAN LINGKANG PHARMA CO LTD
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