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Liquid medicine composition of Ramosetron

The technology of a liquid medicine, ramosetron, is applied in the field of nasal spray preparation, ramosetron nasal drug delivery system or composition and its preparation, which can solve the problem of low bioavailability, high economic burden on patients, and oral tablet To solve the problems of slow onset of drug and other problems, achieve high bioavailability, solve delayed vomiting, and avoid the effects of liver first-pass effect

Active Publication Date: 2012-07-11
韩斌 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Intravenous injection of injection requires a specific environment and is limited to use in hospitals, and patients have to bear certain pain and high economic burden; oral tablets need to be taken a certain time in advance before treatment due to their slow onset of action, and their bioavailability is low

Method used

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  • Liquid medicine composition of Ramosetron
  • Liquid medicine composition of Ramosetron
  • Liquid medicine composition of Ramosetron

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: ramosetron hydrochloride liquid composition

[0050] Name of raw material Dosage Ramosetron Hydrochloride 300mg Polyvinylpyrrolidone 0.5g laurocapram 0.5g Propylene Glycol 1.0g Ethylparaben 0.1g water up to 100g

[0051] Preparation method: add the above-mentioned amount of ramosetron hydrochloride, polyvinylpyrrolidone, azone, propylene glycol, and ethylparaben into an appropriate amount of distilled water and stir well to completely dissolve them, and finally add distilled water to 100ml to obtain the liquid of the present invention combination. The obtained solution is divided into spray pumps or metered drop pumps to obtain sprays or drops that can be administered nasally.

Embodiment 2

[0052] Embodiment 2: Ramosetron Hydrochloride Nasal Spray

[0053] Name of raw material Dosage Ramosetron Hydrochloride 600mg Hydroxypropyl-β-cyclodextrin 2.5g Mannitol 0.5g polyethylene glycol 400 1.0g Ethylparaben 0.1g water up to 100g

[0054] Preparation method: Add the above-mentioned amount of ramosetron hydrochloride, hydroxypropyl-β-cyclodextrin, mannitol, and ethylparaben into appropriate amount of distilled water and stir well to dissolve them all, then add the above-mentioned polyethylene glycol 400, Finally, add distilled water to 100 g to obtain the liquid composition of the present invention. The obtained solution is divided into spray pumps or metered drop pumps to obtain sprays or drops that can be administered nasally.

Embodiment 3

[0055] Embodiment 3: Ramosetron Hydrochloride Nasal Spray

[0056] Name of raw material Dosage Ramosetron Hydrochloride 600mg Methyl-β-cyclodextrin 5.0g Mannitol 0.5g polyvinyl alcohol 0.5g Ethylparaben 0.1g water up to 100g

[0057] Preparation method: Add the above amount of ramosetron hydrochloride, methyl-β-cyclodextrin, mannitol, polyvinyl alcohol, and ethylparaben into an appropriate amount of distilled water and stir well to dissolve them all, and finally add distilled water to 100g , to obtain the liquid composition of the present invention. The obtained solution is divided into spray pumps or metered drop pumps to obtain sprays or drops that can be administered nasally.

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PUM

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Abstract

The invention relates to a liquid medicine composition of Ramosetron. According to the invention, the liquid medicine composition comprises a curing and / or preventing effective quantity of Ramosetron or pharmaceutically acceptable salt, absorption enhancer and water thereof. The liquid medicine composition of the Ramosetron, provided by the invention, has the advantages as shown in the specification.

Description

field of invention [0001] The invention relates to a liquid pharmaceutical composition of antiemetic drug ramosetron, which can be used as a nasal cavity spray preparation. The invention also relates to a nasal cavity drug delivery system or composition of ramosetron and a preparation method thereof. Specifically, the nasal cavity delivery system of the present invention comprises ramosetron hydrochloride or its free base or other pharmaceutically acceptable salts of ramosetron, absorption enhancers, and optional osmotic pressure regulators, preservatives, solvents or other medical supplements. Background technique [0002] With the increase in the incidence of tumors, the antiemetic drug market is also rising and expanding. The antiemetic drugs currently used in adjuvant tumor therapy are 5-hydroxytryptamine receptor antagonists, which occupy an absolute dominant position in the market, and their combined market share is as high as 98% in China. [0003] Since 1987, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4184A61K47/32A61K47/40A61P1/08
Inventor 韩斌高纪理
Owner 韩斌
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