104 results about "Anisodamine" patented technology

The invention discloses a medicament formula for relieving pain caused by infusion medicament and preventing phlebitis. The medicament formula can be used for relieving pain caused by intravenous supplementing potassium, infusion mannitol, azithromycin, fructose diphosphate sodium and chemotherapeutic medicaments, and can be used for effectively preventing and treating extravasation phlebitis caused by long-term use of a remaining needle, infusion of vein high-nutrition medicaments, infusion of chemotherapeutic medicaments, infusion extravasation and the like. According to the medicament formula, 20-35ng of anisodamine, 6-13ml of lidocaine, 15-26mg of dexamethasone and 4-6ml of glycerin are arranged in a sterile kidney basin, sterile gauze is coated above a puncture part after being uniformly wetted, and an external preservative film is wound on the gauze. The medicinal formula has the advantages of continually and efficiently relieving local pain caused by infusion medicaments, and effectively preventing and treating local inflammation, swelling pain and stripped cable change caused by infusion.

The invention relates to bis-[6-oxa-(2-carboxylbenzenesulfonyl-butanedioic acid 1,4 monoester-4)-beta-cyclodextrin, a preparation method and application thereof as chiral selective agent in high performance capillary electrophoresis (HPCE), namely being prepared into a chiral electrophoresis column and a mobile phase chiral additive for detachment of chiral substances. The molecular formula of the bis-[6-oxa-(2-carboxylbenzenesulfonyl-butanedioic acid 1,4 monoester-4)-beta-cyclodextrin is determined to be C64H84O49S2; beta-CD-B2 is used as the HPCE mobile phase chiral additive to separate chiral substances of phenylglycinol, anisodamine, isoprenaline and propafenone to realize baseline separation; beta-CD-B2 is used for preparing a chiral HPCE column to separate chlortrimeton, bupivacaine, procaine, atenolol, anisodamine, propafenone, lobeline and other chiral substances to realize the baseline separation. Therefore, a novel HPCE quantitative measurement method for a single enantiomerof various chiral substances can be established.

A medicine in the form of powder for treating sore and ulcer is proportionally prepared from Chinese gall, gentamycin, metronidazole, and anisodamine and zinc gluconate through baking Chinese gall, proportionally mixing it with others, grinding, sieving, sterilizing and packing.

A veterinary medicine for treating the disease in digestive tract of animal and fowl is prepared from acetylmethaquine, anisodamine hydrochloride, sodium salicylate, and 4 Chinese-medicinal materials including pink plumepoppy herb, coptis root, etc.

The invention discloses a liver preservation solution which contains the following components in per 100ml: 7-8g of 1,6-fructose diphosptate, 1-2g of glutathione, 2-3g of allopurinol, 0.3-0.5g of traditional Chinese medicine ligustrazine, 8-12mg of traditional Chinese medicine anisodamine and the balance of Ringer's solution added to 100ml. Proved by a large number of experiments, the liver preservation solution has a statistical meaning compared with an experiment contrast group, and two treatment groups (a group of the invention and an American UW treatment group) do not have the statistical meaning. The invention provides an excellent guarantee for long-acting liver preservation, has simple prescription and saves production and inspection cost for production and clinical application.

The invention relates to an eyedrop, and particularly relates to an eyedrop for reducing intraocular pressure and treating glaucoma and a preparation method thereof. The eyedrop is prepared by the following raw material drugs by weight: 160-230 parts by weight of ginkgo leaves, 160-230 parts of cassia seeds, 160-230 parts of honeysuckle, 160-230 parts of chrysanthemum morifolium, 100-160 parts ofbutterflybush flowers, 100-160 parts of medlar, 100-160 parts of inula flowers, 40-60 parts of safflowers, 1-3 parts of musk, 0.5-1.5 parts of anisodamine, and 0.5-1.5 parts of borneol. The raw material drugs of the invention are prepared, are directly applied to eyes in a form of an eyedrop, and have fast effect, a good treatment course, no pain, a high cure rate, and no side effect.

The invention provides an anisodamine production method which comprises the following steps: S1, taking belladonna coarse powder, adding 25% to 28% concentration of ammonia for soaking for 15-20min; S2, adding diethoxymethane for percolation, extracting the percolation liquid with 2% sulfuric acid; S3, adding chloroform for cleaning, adding the ammonia to adjust pH to 9, adding carbon tetrachloride for extraction; S4, adding water for washing carbon tetrachloride layer, and adding anhydrous sodium sulfate into chloroform layer for drying; S5, filtering and recovering the chloroform, adding anhydrous benzene for dissolution, and precipitating crystal; and S6, adding benzene for washing, drying at 55-60 DEG C to obtain anisodamine. The anisodamine production method improves the collection rate and collection purity of the anisodamine, the purity reaches 98%, and the process parameters are optimized.

The invention relates to an improved mustard plaster applied on an acupuncture point for intervention treatment of a chronic obstructive pulmonary disease and a preparation method and an application thereof, belonging to the technical field of treatment through combination of traditional Chinese medicine and Western medicine. The medicament for intervention treatment of the chronic obstructive pulmonary disease is characterized by comprising the following raw materials in parts by weight: 1-2 parts of manchurian wildginger, 1-1.5 parts of white mustard seed, 1-1.5 parts of gansui root, 0.5-1.5 parts of rhizoma corydalis, 0.2-0.6 part of cassia bark, 0.2-0.6 part of flos caryophyllata, 0.1-0.3 part of Szechuan pepper, 0.1-0.2 part of borneol, 0.003-0.005 part of anisodamine, 0.003-0.005 part of chlorpheniramine and 3-5 parts of fresh ginger juice. Compared with the prior art, the medicament provided by the invention has the following advantages: combining the traditional Chinese medicine with the Western medicine, respectively playing the effects, treating both manifestation and root cause of the disease, being convenient for administration, being fast in onset of action and having small side effects. The medicament can effectively reduce airway hyperresponsiveness, control occurrence and development of the condition of the disease and alleviate clinical symptoms.

The present invention relates to a kind of chemical mixture and its application. The chemical mixture of five components including acetaminophen, ABOB, anisodamine, dexamethasone and pseudoephedrine hydrochloride is used in the medicinal treatment of cold with excellent effect, no bad reaction, and no side effect.

The invention relates to an externally-used drug used for treating leucoderma skin disease, in particular to compound skin cream for treating leucoderma. The cream comprises, by weight, 0.20-0.50% of anisodamine, 0.10-0.50% of quercetin and 0.10-0.15% of betamethasone, the cream further comprises, by weight, 1.50-3.00% of dimethyl sulfoxide and 0.05-0.10% of 8-methoxypsoralen, and the cream further comprises oil phase raw materials, namely 15.00-25.00% of albolene, 8.00-15.00% of liquid paraffin, 5.00-9.00% of glycerin monostearate and 5.00-9.00% of octadecanol, and water phase raw materials, namely 0.50-1.20% of lauryl sodium sulfate, 5.00-10.00% of glycerinum, 0.05-0.10% of ethylparaben and 5.00-10.00% of propylene glycol; the cream further comprises 1.00-2.50% of hydrochloric acid and purified water, and the pH value ranges from 5.5 to 6.5. According to the compound skin cream for treating leucoderma, the formula is reasonable, the technique is feasible, and the cream has the advantages of being great in stability, good in effect and free of irritation.

The invention relates to a medicine for treating chilblain. The medicine is prepared by taking pearl cream, Vaseline, starch, talcum powder or distilled water as a substrate and preparing following raw medicines into an ointment or liquid according to mass percentage: 0.1-5% of anisodamine and 0.1-5% of nitrendipine. With the adoption of the medicine for treating the chilblain, the anisodamine is taken as a blood vessel active medicine and has an expansion functions on arterioles, venule and blood capillaries, so that microcirculation can be improved; the nitrendipine is used as a calcium ion antagonist and has a selective expansion function on the venule of the peripheral blood vessels; and the anisodamine and nitrendipine are combined to have obvious improvement on blood supply of a chilblain part, so as to have the effect of preventing and treating the chilblain.

The invention discloses a wet compressing preparation with the functions of resisting skin flap infection and promoting healing and the application thereof. The wet compressing preparation with the functions of resisting skin flap infection and promoting healing is characterized in that the raw materials comprise ligustrazine, anisodamine and normal saline, and the weight proportion of the ligustrazine, the anisodamine and the normal saline is 25-35:5-15:15-20; the preparation method of the wet compressing preparation comprises the steps that according to the weight proportion, the ligustrazine, the anisodamine and the normal saline are placed upside down in small square gauze after being mixed and dissolved thoroughly, and accordingly the wet compressing preparation is obtained. The wet compressing preparation has the advantages of enabling affected part microcirculation to be reestablished or improved, promoting blood circulation, increasing fibroblast cells, being conductive to forming wound surface growth factors, promoting growth of granulation tissue, enabling wound surfaces to be healed gradually, avoiding surgery, and relieving the pain of a patient.

The invention discloses a topical drug composite, and the formula comprises: by weight, 15-20 parts of rhizoma coptidis, 15-50 parts of radix scutellariae, 20-30 parts of lithospermum, 15-25 parts of safflower carthamus, 15-20 parts of myrrh, 15-50 parts of raw rhubarb, 50-100 parts of pseudo-ginseng, 15-50 parts of polygonum cuspidatum, 40-70 parts of zinc oxide, 0.8 part of anisodamine, 150 parts of borneol and 320-380 parts of sesame oil. The invention further discloses application of the topical drug composite in the preparation of drugs treating skin injury which comprises skin burn, skin scald, skin ambustion, skin lesions caused by radiation and chemotherapy, bedsore, and skin fester caused by other reasons.

The invention provides a method for simultaneously carrying out chiral separation analysis on anisodamine, atenolol and metoprolol, which comprises the following steps: putting an anisodamine sample, an atenolol sample and a metoprolol sample in a sample cell of a capillary electrophoresis electrochemistry luminescence detection hyphenated instrument and applying an injection voltage to make the samples enter a capillary of the instrument; applying a separation voltage to make the samples carry out electrophoretic separation in the capillary, wherein the capillary is filled with separation solution comprising carboxymethyl-beta-cyclodextrin and the pH value of the separation solution is between 3.0 and 6.0; and making the separated samples enter a detection cell of the instrument and applying a detection voltage to carry out detection, wherein the detection cell is filled with detection solution comprising tris (bipyridine) ruthenium and the pH value of the detection solution is between 6.0 and 9.0. Compared with the prior art, the method for carrying out chiral separation analysis, which is provided by the invention, has the advantages of less reagent use, lower detection cost, higher separation efficiency and higher detection sensitivity.

The invention discloses a separation method of anisodamine and enantiomers thereof. The anisodamine can be separated from a racanisodamine standard substance purchased from Nanjing Ze Lang Biotechnology Co., Ltd. The structural formulas of the anisodamine are represnted by formula I to formula IV shown in the description. The method is a capillary electrophoresis method, and is characterized in that an electrophoretic buffer solution contains a chiral resolving agent, and the chiral resolving agent is selected from sulfobutyl ether-beta-cyclodextrin, and / or a sulfobutyl ether-beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin mixture; and 2, the separation voltage is -8 to -18 kV.

The invention provides application of a radix physochlainae extract in preparation of drugs for preventing and treating myopia. Effective compositions such as anisodamine, scopolamine and scopoletin in the radix physochlainae extract are obtained through tests, the purpose of preventing and treating myopia can be achieved, and the defect that clinical application cannot be achieved due to potential side effects caused by long-term single use of anticholinergic drugs can be effectively overcome. The radix physochlainae extract has a remarkable treatment effect on myopia, is high in safety, andis expected to be popularized and applied clinically. Experiments prove that the radix physochlainae extract can be used for improving myopia by regulating scleral fibrous layers and retinal pigment cells, influencing expression of matrix metalloproteinase 2, matrix metalloproteinase inhibitor 2 and the like, regulating spasm of ciliary muscles and the like. The invention also provides a composition. The composition comprises effective components of the radix physochlainae extract; and the composition provides a new way for preventing and treating myopia.

The invention relates the preparing method for stopping smoking drug with anisodamine. The nicotine reacts with acetylcholine to produce specificity association. The more the nicotine is, the more the acetylcholine is. The anisodamine can effectively oppose the acetylcholine. The anisodamine can also remove free radical, protect cell, accelerate microcirculation flow ratio, and protect body. 5-50mg anisodamine can be mixed with 5% dextrose or 5% dextrose salt solution or 10% dextrose to intravenous inject or intramuscular inject or oral administration. One course of treatment is 10-14 days.

The invention discloses a method for separating anisodamine and / or tropic acid mixed enantiomer. The method has the advantages that the anisodamine and tropic acid enantiomers can be respectively separated from a racemization anisodamine and tropic acid mixture; the structural formula is shown in formulas I to VI; the formulas I to VI are shown in the description. The method is a capillary electrophoresis method, and comprises the following steps that (1) an electrophoresis buffer solution contains a chiral resolution agent, and the chiral resolution agent is selected from a mixture of sulfobutyl-beta-cyclodextrin, and / or sulfobutyl-beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin; (2) the separation voltage is -8kV to -18kV.

The complementary gain pain-killing medicine consists of vitamin B6, anisodamine and Tiapride. The medicine has outstand curative effect on vascular headache and excellent curative effect on the sciatica, trigeminal neuralgia and dizziness syndromes. The medicine features that it can regulate the biochemical change of vascular headache, block the conductance of pain sensation impulsion, improve microcirculation and eliminate sickness caused the prostaglandin and arachidonic acid evolution process to result in lasting pain-killing effect. The medicine has simple preparation process, is safe, non-toxic and low in cost, and may be used widely in treating vascular headache, sciatica, trigeminal neuralgia, dizziness syndromes, etc.

The invention discloses a method for increasing the content of tropane alkaloid in atropa belladonna. The gene expression quantity of a TAs alkaloid synthesis pathway is effectively increased by expressing a gene rolC or rolB in the atropa belladonna, and the content of hyoscyamine and anisodamine in the atropa belladonna is increased, but variation influence is caused on plant phenotype; and thegene rolC or rolB expressed by H6H-p tissue localization does not influence plant phenotypic growth while the alkaloid content is increased. By selective control of the gene rolC or rolB, a foundationis laid for further cultivating a high-alkaloid-yield atropa belladonna strain in the medicinal field of the atropa belladonna, and a new method is provided for further developing TAs alkaloid gene engineering metabolism research of the atropa belladonna.

The present invention discloses a freezing stem preparation of the anisodamine and a preparation method, which is produced by concentrated preparation, carbon adsorption, crude filtration, dilution, intermediate good measurement, refined filtration, filling, half compression and plugging, freezing and drying with the active component of the nisodamine, the salt formation agent, the acid regulator, the isoosmotic adjusting agent, the excipient or the water for the injection.

The invention discloses a western medicine composition for preventing and treating scalds. The western medicine composition is prepared from, by weight, 1-15 parts of antibiotic, 1-7 parts of anisodamine, 2-10 parts of corticosteroid medicine, 20-50 parts of superoxide dismutase, 1-7 parts of metronidazole, 2-10 parts of vitamin B and 4-20 parts of vitamin E. The raw materials are easy to obtain, the western medicine composition is low in cost and easy to prepare, has the functions of relieving pain, diminishing inflammation and promoting tissue regeneration, and is remarkable in effect and short in effective time, scalds can be cured generally within one week, skin can recover, no scars or side effects are generated, and pain of long-time treatment is avoided.

The present disclosure relates to a paper deacidification agent composition and a deacidification method for acidified paper. The composition comprises alkaloid, a soluble tetraborate and a solvent, wherein the alkaloid comprises one or more of scopolamine, hyoscyamine, demethylated hyoscyamine and anisodamine. The paper deacidification agent composition can complex with alum in the acidified paper so as to prevent the aluminum ion water from separating out acids, and can form alkali residues on the papers so as to moderate the secondary acidification of the paper; the influences on the appearances and colors of the paper are not great; besides the deacidification, the folding resistance and tensile strength of the paper are strengthened; and the pH values of the paper after the deacidification is 7 to 8.5, thereby effectively prolonging the paper life of paintings and calligraphies.

The invention provides a capsule which is used for the CT examination of intestine air angiography. The capsule is aerogenes drug capsule and muscle loosening drug capsule. An intestinal sol lorica is adopted as a lorica by the aerogenes capsule and citrate acid and sodium bicarbonate are used as the drug core of the capsule. The intestinal sol lorica is adopted as a lorica by the muscle loosening drug capsule and anisodamine is adopted as the drug core of the capsule. The invention is an oral capsule. The lorica is an enteric-coated capsule, resists the acid environment in a stomach, dissolves in the alkaline environment of an intestine and releases the contained drug. The capsule which is used for the CT examination of intestine air angiography has the advantages of reasonable drug configuration, convenient use, stable aerogenesis, no side effect, long service life, good relaxation of the intestinal cavity, good angiography effect and clear image, and is beneficial to the observation of CT inspection on the normal structure and the lesion of the intestine and is provided with good effect in the X ray inspection of gastrointestinal double-contrast barium examination.

The invention discloses a topical drug composite, and the formula comprises: by weight, 15-20 parts of rhizoma coptidis, 15-50 parts of radix scutellariae, 20-30 parts of lithospermum, 15-25 parts of safflower carthamus, 15-20 parts of myrrh, 15-50 parts of raw rhubarb, 50-100 parts of pseudo-ginseng, 15-50 parts of polygonum cuspidatum, 40-70 parts of zinc oxide, 0.8 part of anisodamine, 150 parts of borneol and 320-380 parts of sesame oil. The invention further discloses application of the topical drug composite in the preparation of drugs treating skin injury which comprises skin burn, skin scald, skin ambustion, skin lesions caused by radiation and chemotherapy, bedsore, and skin fester caused by other reasons.

The invention relates to the field of medicine, and in particular relates to a haemorrhoids paste and a preparation method thereof. The haemorrhoids paste can be used for shortening the cure course and comprises the following ingredients in parts by weight: 100-200 parts of badger fat, 1.5-4 parts of borneol, 1-3 parts of water, 0.1-0.4 parts of ammonium glycyrrhetate, 0.8-1.5 parts of vitamin B1, 0.8-1.5 parts of vitamin B2, 0.05-0.15 parts of vitamin B6 and 0.05-0.25 parts of anisodamine; the badger fat is molten within 40-60 DEG C; the molten badger fat is filtered; the borneol is added into the filtered badger fat so as to form a first mixture after the borneol is completely molten; ammonium glycyrrhetate, vitamin B1, vitamin B2, vitamin B6, and anisodamine are added into the 1-3 parts of water to be mixed and prepared into a first mixture solution; and the first mixture solution and the first mixture are mixed and uniformly stirred so as to form the haemorrhoids paste provided by the invention.

The invention relates to a composite florfenicol injection and a preparation method thereof. The injection comprises the following components in part by weight: 6 to 15 parts of florfenicol, 1 to 5 parts of olaquindox, 1 to 5 parts of trimethoprim, 0.03 to 0.05 part of anisodamine hydrochloride, 75 to 80 parts of organic solvent and 4 to 8 parts of water for injection, wherein the organic solvent is a solution obtained by mixing N,N-dimethylformamide, alpha-pyrrolidone and benzyl alcohol in the weight part ratio of 3-5:3-5:1-2. In the preparation method, raw materials are dissolved in the water for injection in turn. The composite florfenicol in the components has a scientific formula, is screened through a large number of experiments, has stable property as proved by animal experiments and has long medicament action time, small local stimulation effect, remarkable treating effect and wide market prospect.

The invention discloses application of atropa-belladonna ornithine decarboxylase to cultivating high-yield hyoscyamine and anisodamine atropa-belladonna varieties. The amino acid sequence coded by theatropa-belladonna ornithine decarboxylase is shown as SEQ ID NO.12, and as the ornithine decarboxylase is over expressed in atropa belladonna, rooting of the atropa belladonna can be improved, and the content of putrescine, N-methyl putrescine and TAs in plants can be increased; by researching AbODC, functions of the AbODC in polyamine and tropane-alkaloid biosynthesis are definite, understandingof biosynthetic pathways of tropane alkaloids can be deepened, and the AbODC has important theoretical value; related results of researching also indicate that the AbODC has the important applicationvalue in the aspects of improving the TAs biosynthetic pathways with a metabolic engineering technology and increasing the TAs content.

Disclosed is an oral antidiarrheal powder for treating diarrhea occurring on infants, which is composed by the method that 2.5 portions to 3.12 portions of indomethacin, 1 portion to 1.25 portions of anisodamine, 2.5 portions to 3.12 portions of chlorpromazine and 992.51 portions to 994 portions of glucose powder are well mixed to reach enough amount together with the glucose powder with the equivalently increasing method, and are split charged in each packet for 1000 mg. Based on the modern medical theories, the invention is a compound oral administration preparation, which has the advantages of scientific and reasonable composing prescriptions,stable formulation,convenient using in clinic, definite pharmacological effects, fast symptom controlling, short course of treatment, little side-effect, sweet taste, small taken dosage, convenience and safety, and thus the invention is a safe and effective auxiliary therapy reagent for treating various diarrheas occurring on infants, particularly the diarrheas in spring and autumn. With low price, fast effect, short treatment cycle and good therapeutic effect whether for the infectious diarrhea or the non-infectious diarrhea, the invention is an effective preparation for treating diarrhea in clinic.

The invention relates to application of anisodamine or a pharmaceutically acceptable salt thereof in preparation of a cell glycocalyx protective agent, in particular to application of the anisodamineor the pharmaceutically acceptable salt thereof serving as the cell glycocalyx protective agent in recovery and protection of cell glycocalyx and cell adhesion. The application of the anisodamine or the pharmaceutically acceptable salt thereof in preparation of the cell glycocalyx protective agent also has the effect of protecting endothelial cell structures and functions.