The invention relates to an externally-used drug used for treating leucoderma skin disease, in particular to compound skin cream for treating leucoderma. The cream comprises, by weight, 0.20-0.50% of anisodamine, 0.10-0.50% of quercetin and 0.10-0.15% of betamethasone, the cream further comprises, by weight, 1.50-3.00% of dimethyl sulfoxide and 0.05-0.10% of 8-methoxypsoralen, and the cream further comprises oil phase raw materials, namely 15.00-25.00% of albolene, 8.00-15.00% of liquid paraffin, 5.00-9.00% of glycerin monostearate and 5.00-9.00% of octadecanol, and water phase raw materials, namely 0.50-1.20% of lauryl sodium sulfate, 5.00-10.00% of glycerinum, 0.05-0.10% of ethylparaben and 5.00-10.00% of propylene glycol; the cream further comprises 1.00-2.50% of hydrochloric acid and purified water, and the pH value ranges from 5.5 to 6.5. According to the compound skin cream for treating leucoderma, the formula is reasonable, the technique is feasible, and the cream has the advantages of being great in stability, good in effect and free of irritation.