32 results about "Tissue Compatibility" patented technology

The invention belongs to the technical field of biomedical functional dyes and probes, and relates to a fluorescent probe, in particular to a cyclodextrin-based near-infrared fluorescent probe, which is a conjugate formed by coating a fluorescent molecule with cyclodextrin. According to the near-infrared fluorescent probe disclosed by the invention, cyclodextrin is nested on a carbon chain of a fluorescent molecule, so that the water solubility, histocompatibility and safety are improved, the fluorescence lifetime is prolonged, the light stability is improved, and rapid transmission and response of ureters, lymphatic vessels and lymph nodes in vivo are realized; the method can be used for NIR-I and NIR-II imaging; a near-infrared fluorescence probe with targeting property can be formed by marking various tumor targeting molecules, so that accurate targeting fluorescence imaging of different types of tumors such as urogenital tumors, head and neck cancers, breast cancers and cervical cancers and metastatic lymph nodes in NIR-I and NIR-II windows is realized, and the near-infrared fluorescence probe can be applied to fluorescence imaging navigation in clinical operations.

The invention provides a double-layer wound dressing with gradient adhesive power and a preparation process thereof, the dressing comprises a wound contact layer A and a functional support layer B, the layer A is a chitosan / epsilon-polylysine nanofiber membrane prepared by electrostatic spinning, a composite antibacterial agent is loaded, and mild antibacterial and histocompatibility are realized; the layer B is oxidized sodium carboxymethyl cellulose-polyvinyl alcohol cross-linked hydrogel, the pore diameter is in gradient distribution, pH response type microcapsules are embedded, and repair factors can be directionally released according to wound microenvironment alkalinity. The gradient adhesive force constructed by the dressing gives consideration to wound fitness and external fixity. The preparation technology comprises the steps of electrostatic spinning film forming, gradient aperture construction through three-stage freeze drying, plasma activation interface and pulsed electric field auxiliary lamination compounding, and precise regulation and control of the material structure and function are achieved. According to the dressing, through gradient adhesive force design, targeted release and an antibacterial system, the hemostatic efficiency is remarkably improved, wound healing is promoted, secondary injury is reduced, and the dressing has outstanding clinical application value.

Disclosed in the present invention is the use of a mesenchymal-stem-cell-derived intracellular nanovesicle in neuroprotection. Compared to a small extracellular vesicle with exosomes as the main component, the small intracellular nanovesicle of the present invention has a smaller particle size, a narrower particle size distribution range, and greater stability at different temperatures, and has good tissue compatibility. The small intracellular nanovesicle of the present invention can better ameliorate nerve injury or neurodegenerative diseases such as optic nerve injury, ischemic stroke and Alzheimer's disease, and has very good application and research value in the field of pharmaceuticals.

This invention discloses an interlocking bone tissue repair scaffold, assembled from several notched links connected in an interlocking manner. The notches in one link allow passage through the notches in another link, but not through the remaining main body of the other link. The links are 3D printed from calcium phosphate ceramic powder. The porosity of the final assembled chain can be flexibly controlled by adjusting the shape, size, thickness, and combination of links of different sizes, allowing for precise customization according to specific application scenarios. This scaffold structure is flexible and adjustable, adaptable to different implantation areas, significantly expanding the product's applicability. After implantation, it creates a microenvironment more closely aligned with human tissue growth patterns, optimizing local tissue compatibility and providing excellent conditions for cell adhesion, retention, and proliferation, effectively improving the scaffold's biocompatibility and clinical application efficacy.

The invention discloses hydrogel loaded with repair-promoting and antioxidant peptides as well as a preparation method and application of the hydrogel, and belongs to the technical field of preparation of medical materials. According to the preparation method, firstly, polypeptide with the amino acid sequence of CEYWVKWCGEKGPAGERG is synthesized, and the polypeptide has antioxidant activity and cell proliferation promoting activity and has good structural stability and enzymatic degradation resistance; and loading the polypeptide into the hyaluronic acid hydrogel to obtain the hyaluronic acid hydrogel. The prepared hydrogel loaded with the repair-promoting and antioxidant peptide has excellent injectable performance and cornea spreadability, can enhance the retention of the polypeptide on the ocular surface, effectively solves the technical problem of high administration frequency of the existing preparation, has good cell and tissue compatibility, and has no adverse reaction in vivo.

The invention relates to a degradable manganous-manganic oxide-tannic acid-polymer composite modified artificial dura mater and preparation thereof, and belongs to the technical field of biological materials. According to the modified artificial dura mater, a spongy collagen biological membrane scaffold beneficial to cell growth and new dura mater tissue generation is provided for a dura mater defect part, and the modified artificial dura mater with good tissue compatibility and degradability is prepared by introducing carboxymethyl chitosan and manganous-manganic oxide / tannic acid. The novel composite artificial dura mater can effectively reduce intracranial infection and leakage of cerebrospinal fluid. The modified artificial dura mater loaded with the antioxidant manganous-manganic oxide / tannic acid nano-composite can effectively remove free radicals in the brain, and the composite modified artificial dura mater has anti-inflammatory and antibacterial functions and can be adhered to the surface of the dura mater after absorbing tissue exudate, water, buffer solution and the like. And can be tightly attached to the dura mater without suturing, and can exert antibacterial and anti-inflammatory activity for a long time.

The utility model discloses an anti-tissue-deformation antibacterial impedance cardiogram electrode slice, which relates to the technical field of medical instruments and comprises a metal connecting buckle, a composite hydrogel layer is adhered to the bottom of the metal connecting buckle, an electric conductor is arranged at the edge of the bottom of the metal connecting buckle, and the metal connecting buckle is connected with the composite hydrogel layer. The upper surface of the bottom of the metal connecting buckle is bonded with a release film, the edge of the release film is provided with a fabric electrode, the composite hydrogel layer is composed of TCP and iodine nanosheets, the iodine nanosheets are uniformly embedded in the TCP, and the size of a single iodine nanosheet is at the nanoscale. The antibacterial impedance cardiogram electrode plate capable of resisting tissue deformation is wide in antibacterial spectrum, high in antibacterial capacity, capable of being repeatedly used, capable of reducing resource waste, high in tissue viscosity and shaping capacity, capable of solving the problem that the electrode plate is prone to falling off in the impedance cardiogram detection process, high in tissue compatibility, high in reliability and good in anti-bacterial effect. The problem of medical viscose-related skin injury of part of examinees is solved.

The application discloses a preparation method of a fluorescent self-healing injectable hydrogel and application thereof. A biocompatible fluorescent small molecule is anchored on a polysaccharide macromolecular chain through an EDC / NHS coupling reaction, and then in-situ cross-linking is carried out through a dynamic imine bond under physiological conditions to prepare a fluorescent self-healing injectable hydrogel. The fluorescent self-healing injectable hydrogel has self-healing, injectability, shape adaptability, biodegradability, cell compatibility, tissue compatibility and outstanding fluorescence effect, and can be used for non-destructive, in-situ and real-time detection, thereby providing a new strategy for synthesizing a polysaccharide-based fluorescent self-healing injectable hydrogel under mild conditions, and simultaneously providing a new idea for establishing a system model of an in-situ real-time monitoring biomedical platform of minimally invasive interventional treatment technology.

The invention belongs to the technical field of polymer biomedical materials, and particularly relates to an eyeball sclera external implantation hydrogel as well as a preparation method and application thereof. The invention provides a self-expandable hydrogel which is prepared by using methyl methacrylate, N-vinyl pyrrolidone and methacryloyloxyethyl trimethyl ammonium chloride as monomer raw materials through cross-linking of N, N-bis (acryloyl) cystamine, and the hydrogel is used for a rabbit pore-derived retinal detachment model. According to the material, the operation time is greatly shortened, the operation difficulty is reduced, meanwhile, the purposes of minimally invasive implantation, self-expansion, no need of suture and retina restoration are achieved, the material has good histocompatibility, and the material fills the technical blank of sclera buckle belt materials in hole-derived retina detachment treatment and has good application prospects. A novel diagnosis and treatment material which is safe, reliable and high in adaptability is provided for clinic, and a new solution is injected for precise treatment of related diseases.

The application discloses an artificial fascia which is a composite material with a five-layer structure and is composed of fat stem cell-loaded amniotic membrane, PRP gel and polyurethane film; the five-layer structure material is in sequence of fat stem cell-loaded amniotic membrane, PRP gel, polyurethane film, PRP gel and fat stem cell-loaded amniotic membrane; the fat stem cell-loaded amniotic membrane is acellular amniotic membrane paved with fat stem cells and is prepared by the following method: inoculating fat stem cells on the acellular amniotic membrane and growing for 7-14 days to obtain the fat stem cell-loaded amniotic membrane. The application further discloses a preparation method of the artificial fascia and application of the artificial fascia in preparation of a biological patch for treating hernia or in preparation of a mesh for treating pelvic organ prolapse. The artificial fascia has high tensile strength, good tissue compatibility, good immune function and degradability, is a biological composite material with excellent performance, can be used for treating hernia and pelvic organ prolapse and has great application potential.

The patent discloses a kind of lotus leaf base compositions for preventing and treating pet dog obesity, which is made of the following raw medicinal materials by weight: lotus leaf base 5-10 parts, egg yolk lecithin 50-100 parts, beta-sitosterol 10-20 parts, and sodium alginate 10-20 parts. The lotus leaf base is first encapsulated in liposomes with egg yolk lecithin and beta-sitosterol as the lipid film, and then the prepared lotus leaf base liposomes are wrapped with sodium alginate. Compared with the traditional method, the lotus leaf base composition provided by the present application not only provides double-layer protection and sustained-release effect for lotus leaf base absorption, but also provides targeted delivery effect for lotus leaf base. In addition, it can also reduce the absorption of cholesterol by pet dogs. The lotus leaf base composition prepared by the present application has good compatibility with pet dog tissues, can maintain bioavailability for a long time, and has excellent preventive and therapeutic effects on pet dog obesity.

The present invention discloses a biomimetic nanomaterial, its preparation method, and application. The biomimetic nanomaterial comprises a degradable two-dimensional nanomaterial, a biomimetic biocoating with anti-nonspecific adhesion function bound to the two-dimensional nanomaterial, and a dendritic cationic polymer end-modified with alkyne groups, which is loaded onto the biomimetic biocoating. The biomimetic nanomaterial has the advantages of good tissue compatibility, systemic intravenous administration, high biosafety, simple operation, low cost, minimal toxicity and side effects, and good material stability.

The invention discloses a preparation method of a terminal sterilized collagen implant product, which is characterized in that a phosphoric acid buffer solution system and a collagen stock solution are mixed according to a mass ratio of 1: (1-9) at 2-20 DEG C and then freeze-dried, the stability of a collagen structure is maintained while the implant is physically and chemically close to a physiological environment, and functional additives are reasonably compatible, so that the terminal sterilized collagen implant product is prepared. Wherein the additive comprises 0.3% of lidocaine hydrochloride and 1.0%-5.0% of glycerol, the stability and histocompatibility of the product are improved, the clinical applicability of the product is enhanced, the phosphate buffer solution and the collagen stock solution are mixed and then freeze-dried, and it can be ensured that the final freeze-dried sponge is in an ideal neutral state after being dissolved without any chemical modification step. Therefore, the residual risk caused by introduction of chemical reagents is thoroughly avoided, the biological safety and the clinical application reliability of the product are remarkably improved, meanwhile, the key functional characteristics of collagen are guaranteed, and the collagen has a wide application prospect in the aspects of tissue engineering, drug delivery systems, cell culture and cosmetics.

The present invention discloses an insulin-like growth factor-1-linker polypeptide-collagen, and the linker polypeptide has an amino acid sequence as shown in SEQ ID No.1. The N-terminus of the linker polypeptide designed and synthesized by the present invention simulates the IGF-1 receptor structure, can be combined with IGF-1, and the C-terminus of the linker polypeptide is rich in lysine residues, which can be covalently cross-linked to collagen by transglutaminase, prolonging the attachment time of IGF-1 in the endometrium, and effectively promoting endometrial thickening and endometrial damage repair. A protein solution for promoting endometrial damage repair provided by the present invention can form a stable repair microenvironment on the surface of the endometrium, promote the recovery of the number of endometrial glands with intrauterine adhesions, reduce the proportion of fibrosis, and promote the thickening of thin endometrium, with the advantages of high tissue compatibility, simple preparation, obvious improvement effect, no potential toxic effects on cells, and good clinical application prospects.

The invention belongs to the technical field of medical materials, and particularly relates to a drug-loaded porous magnesium alloy bone scaffold and a preparation method thereof.The drug-loaded porous magnesium alloy bone scaffold is prepared from, by mass, 55 parts of magnesium alloy, 6-10 parts of corrosion-resistant matter, 1 part of drug-loaded gel, 2-4 parts of antibacterial bone promoting matter and 3 parts of gelatin; the magnesium alloy is made into a micro tube, and the micro tube is filled with the drug-loaded hydrogel to realize drug sustained release; gelatin is sprayed on the surface, corrosion-resistant materials are attached through Mg-N coordinate bonds, hot pressing is carried out, and components of the corrosion-resistant materials and the gelatin form an interpenetrating network to enhance combination and react with the magnesium alloy to form a protective film. Meanwhile, Ca < 2 + > initiates crosslinking of sodium alginate to form a stable corrosion-resistant barrier; and finally, an antibacterial bone-promoting mixed solution containing modified chitosan and a temperature-sensitive polymer is sprayed, bone-promoting components are uniformly dispersed around the implant through a complex reaction and temperature control, and tissue compatibility is improved.

The present invention relates to a chitosan / polycaprolactone composite microsphere gel, which has increased hydrophilicity and water absorption compared with the existing microsphere gel, has better tissue compatibility, and the prepared microsphere particle size distribution is narrower. It comprises chitosan / polycaprolactone composite microspheres and carboxymethyl cellulose (CMC) hydrogel, wherein the polycaprolactone microspheres are uniformly dispersed in the carboxymethyl cellulose (CMC) hydrogel, the chitosan / polycaprolactone composite is a molten blend of chitosan and polycaprolactone, and the chitosan / polycaprolactone composite microsphere gel is an injectable implant.

The invention discloses a flexible closed-loop self-powered vagus nerve stimulation system for treating drug-resistant epilepsy. The system comprises a spiral electrode, a flexible friction nanometer generator and a flexible controller. According to the implantable vagus nerve stimulation system, the flexible material and the self-powered technology are adopted, effective stimulation on the vagus nerve is achieved, the tissue compatibility of the implantable vagus nerve stimulation system is remarkably improved, and secondary injury to a patient caused by battery replacement in an operation is avoided.

The invention provides an antibacterial nickel-titanium alloy bone tissue engineering scaffold as well as a preparation method and application thereof. The preparation method comprises the following steps: polishing a nickel-titanium alloy sheet; carrying out acid etching treatment on the nickel-titanium alloy sheet subjected to the polishing treatment; then adopting glutaraldehyde crosslinking to introduce a chitosan coating; and introducing a sodium alginate coating and a chitosan quaternary ammonium salt coating to prepare the antibacterial nickel-titanium alloy bone tissue engineering scaffold. According to the antibacterial nickel-titanium alloy bone tissue engineering scaffold, the chitosan quaternary ammonium salt coating is formed on the surface of the nickel-titanium alloy in a layer-by-layer self-assembly mode, the tissue compatibility of the nickel-titanium alloy can be effectively improved, the antibacterial activity is good, the osteogenic activity of osteoblasts can be enhanced, proliferation of the osteoblasts is facilitated, and the bone tissue engineering scaffold has a good application prospect. And the material can be widely applied to bone substitute materials.

The invention belongs to the technical field of biomedical instruments, and particularly relates to a device for detecting and intervening fundus retinopathy, which comprises an external energy transmitting device and a multifunctional integrated flexible corneal contact lens, and is characterized in that energy is provided for a biological light adjusting unit in the multifunctional integrated flexible corneal contact lens through the external energy transmitting device; according to the multifunctional integrated flexible corneal contact lens, the LED patch is integrated, and non-invasive intervention and treatment on the retina are achieved through the biological light adjusting technology. The receiving coil and the ERG electrode adopt a parting paper-cut structural design, so that the tensile property of the ERG electrode and the overall flexibility and structural consistency of the device are improved. The closed-loop management of'detection-treatment 'of retinal diseases is successfully realized, the device has more excellent histocompatibility, wearing comfort and large-scale production feasibility, and an innovative solution is provided for diagnosis and treatment of fundus diseases.

A novel ultra-thin neural implant (1) is provided that is based on a cellulose thin film (4) featuring an array (2) of electrodes (3). Due to the use of cellulose as the base material, the implant (1) can be safely handled during a micro-surgery, despite its high softness and conformability. Such an implant (1) may be useful in numerous applications ranging from electrical stimulation in neural prostheses, electro-stimulated regeneration of neural tissue to accurate recording of nerve signals. The robustness of the implant (1) results from a woven fabric (5) that is integrated in the cellulose carrier thin film (4). Several approaches for enhancing the tissue compatibility of the implant (1) are also provided.

This invention belongs to the field of medical materials technology, specifically referring to a drug-loaded porous magnesium alloy bone scaffold and its preparation method. The drug-loaded porous magnesium alloy bone scaffold is composed of the following raw materials in parts by weight: 55 parts magnesium alloy, 6-10 parts corrosion inhibitor, 1 part drug-loaded gel, 2-4 parts antibacterial bone-promoting agent, and 3 parts gelatin. This invention achieves sustained drug release by fabricating magnesium alloy into microtubes and filling the interior with a drug-loaded hydrogel; gelatin is sprayed onto the surface and adhered through Mg-N coordination bonds, bonded to the corrosion inhibitor, and hot-pressed. The components form an interpenetrating network with the gelatin to enhance bonding and react with the magnesium alloy to form a protective film; simultaneously, Ca... 2+ The process initiates cross-linking of sodium alginate, forming a stable anti-corrosion barrier. Finally, an antibacterial and bone-promoting mixture containing modified chitosan and thermosensitive polymer is sprayed on. Through complexation reaction and temperature control, the bone-promoting components are evenly dispersed around the implant, improving tissue compatibility.

The invention discloses an exosome based on a stem cell source for tissue repair, and belongs to the technical field of biological materials. Aiming at the limitation of the traditional skin tissue repair means and the problems of poor stability, low delivery efficiency and the like of stem cell-derived exosomes in application, the human umbilical cord mesenchymal stem cells are extracted through a tissue block adherence method and are cultured and subcultured, and the exosomes are extracted through multi-step centrifugation; the preparation method comprises the following steps: preparing methyl diphenyl sulfide functionalized polycysteine modified polyethylene glycol-fucoidin gel by adopting a multi-step chemical reaction, and compounding the methyl diphenyl sulfide functionalized polycysteine modified polyethylene glycol-fucoidin gel with exosome to form a gel-loaded mesenchymal stem cell exosome composite material; the composite material is applied to skin wound repair. The gel carrier protects the exosome through interaction of physical embedding and chemical, regulates and controls the release rate of the exosome, and reduces the administration frequency; the fucoidin, polyethylene glycol and other components in the gel carrier have a synergistic effect, so that the compatibility of the material and tissues is enhanced, the inflammatory reaction is relieved, and the exosome structure is protected.

The invention relates to the field of biomedical materials, in particular to a novel zinc ion cross-linked hydrogel, which is prepared by the following steps: preparing a hyaluronic acid solution with the oxidation degree of 40%, then preparing a chitosan solution, violently stirring and mixing the two solutions according to the volume ratio of 2: 8 under the acidic condition, and standing and reacting at 37 DEG C for 3-5 minutes. The material is constructed based on chemical crosslinking of oxidized hyaluronic acid and chitosan, zinc ions are introduced to form a metal coordination network, and the material is endowed with good structural stability, drug loading performance and biological activity. The hydrogel can effectively load and slowly release antibacterial and antifungal drugs, and has good local tissue compatibility while inhibiting pathogenic microorganisms. Experiments on cell and tissue levels prove that the hydrogel can induce activation of a mitochondrial autophagy pathway, further regulate oxidative stress and improve mitochondrial membrane potential, so that the hydrogel shows enhanced tissue repair and anti-recurrence effects in urinary system infection treatment.

The invention provides a method and a device for predicting bonding between a protein fragment and a major histocompatibility complex (MHC). The method for predicting the bonding of the peer-MHC comprises the following steps of: selecting the peer-MHC; a peptide sequence and an MHC sequence are obtained. According to the peptide sequence and the MHC sequence, at least one Protein Data Bank, PDB is obtained by at least one Protein Data Bank prediction model. Obtaining at least one structure combination pointer by at least one structure combination simulation tool according to the protein structure file; a human leukocyte antigen (HLA) type corresponding to a peptide sequence and a corresponding MHC sequence is obtained by using a human leukocyte antigen (MHC) sequence as an antigen sequence of a human leukocyte antigen (HLA). Obtaining at least one affinity index by at least one affinity analysis model according to the peptide sequence and the HLA type; the input structure combines the pointer and the affinity pointer to a machine learning model to obtain an integrated score.

The utility model relates to the technical field of medical instruments, and discloses a hydrogel ejaculation tube stent which comprises an imbedding tube, two adjacent stent tubes are arranged in the imbedding tube and located at the head position, the stent tubes are designed to be hollow cylinders and are made of gamma-polyglutamic acid hydrogel, and the gamma-polyglutamic acid hydrogel is arranged in the imbedding tube. A push rod is arranged in the imbedding pipe in a sliding mode, a gasket is fixedly arranged at the head end of the push rod, and the tail end of the push rod is arranged outside the imbedding pipe and provided with an auxiliary rod in a threaded mode; the stent tube made of the special pH-sensitive hydrogel can absorb water to swell in a hydrophilic manner, can keep a certain shape and volume, has corresponding chemical reaction to environmental pH, is not easy to fall off, has better tissue compatibility, does not irritate mucous membrane tissues, and can be used for treating the mucous membrane. The ejaculation tube can be supported and prevented from being obstructed again.

The invention relates to the technical field of medical materials, and particularly discloses a high-strength anti-fatigue non-absorbent suture which comprises an inner core with the diameter being 200-300 microns, a transition layer with the thickness being 30-80 microns and a surface functional layer with the thickness being 10-20 microns. The inner core is made of polyarylester and polycaprolactone; the transition layer is a mixture of a polyvinyl alcohol-polyethylene glycol copolymer, amino-terminated polydimethylsiloxane and hydroxypropyl trimethyl ammonium chloride chitosan; the surface functional layer is prepared from sulfonated chitosan and a functional additive; furthermore, in the transition layer, the weight ratio of the polyvinyl alcohol-polyethylene glycol copolymer to the amino-terminated polydimethylsiloxane to the hydroxypropyl trimethyl ammonium chloride chitosan is 10: (1-4): (3-6). The high-strength anti-fatigue non-absorbent suture has the advantages of being high in strength, good in anti-fatigue performance, good in histocompatibility and the like, and can meet the long-term use requirement of a complex clinical repair scene.

Bioresorbable zinc-based (i.e., Zn-based) wound closure devices are provided. The Zn-based wound closure devices include Zn and at least one primary alloying element (i.e., Cr, V and / or Zr). The Zn-based wound closure devices are biocompatible with good mechanical strength and tissue compatibility. The Zn-based wound closure devices are safe and easy to use during surgical operations and provide shorter recovery and healing time with less chance of clinical complications. Typical applications for Zn-based wound closure devices include skin wound closure, muscular, vascular, and neuronal anastomosis, as well as GI anastomosis and other tissue or organ anastomosis. The Zn-based wound closure devices can be used for treatment of the above applications for pediatric patients.

Embodiments of the present invention provide a skin grafting stent and an implantation system, relating to the technical field of medical devices. The skin grafting stent provided by the embodiments of the present invention includes a stent body and a xenogeneic dermal membrane. The stent body is in a cylindrical shape. The xenogeneic dermal membrane is coated on the outer peripheral surface of the stent body. When the skin grafting stent is implanted into the esophagus, the stent body covers and fixes the xenogeneic dermal membrane on the ESD postoperative wound surface. The basement membrane in the xenogeneic dermal membrane can enable cells to regenerate rapidly, promote the epithelialization of the esophageal wall, and has better tissue compatibility compared with the existing stent used alone, playing a stronger role in reducing the inflammatory response and promoting tissue reconstruction, and effectively improving the problem of postoperative stenosis after ESD.

The application discloses an anti-migration biodegradable composite esophageal stent and a manufacturing method thereof. The composite esophageal stent comprises, from inside to outside, a hydrogel film inner layer, a middle layer reinforcing body and a fiber film outer layer. The circumferential surface of the outer surface of both ends of the fiber film outer layer is provided with a suction cup. The hydrogel film inner layer, the middle layer reinforcing body, the fiber film outer layer and the suction cup are all made of biodegradable materials. The middle layer reinforcing body is composed of negative Poisson's ratio variable units with auxetic properties. The fiber film has a drug loading function. The hydrogel film inner layer, the middle layer reinforcing body and the fiber film outer layer are all made by 3D printing. The composite esophageal stent can effectively change its deformation and improve the tissue compatibility of the composite esophageal stent. The composite esophageal stent can move up and down with the esophagus of a patient to maintain good biological adhesion. The composite esophageal stent can be degraded and absorbed in the human body or discharged out of the body within a certain period of time, and does not need to be taken out by a secondary operation.

The invention provides a soft tissue filling method for facial contour remodeling, and relates to the technical field of medical cosmetology. According to the method, a personalized filling model is established through preoperative 3D scanning, and the volume defect amount of a target area is quantified; a three-phase composite filling material composed of cross-linked hyaluronic acid microspheres, PLGA nanofibers, recombinant human collagen and an antioxidant is prepared, and the length of the PLGA fibers is adapted according to the filling level; a layered progressive and fan-shaped fixed-point injection mode is adopted, and parameters are monitored and adjusted in real time in combination with ultrasound; after injection, dynamic shaping is guided through static pressing and muscle movement, and standardized postoperative care is matched. According to the method, the defects that in the prior art, filling materials are stiff, uneven in distribution, short in effect maintaining time and high in adverse reaction rate are overcome, the filling outline is natural and harmonious, tissue compatibility is excellent, the effect can be maintained for 20-24 months, the adverse reaction occurrence rate is only 3.3%, and the method is suitable for outline optimization of multiple parts such as apple muscles, temples and chin.