289 results about "Tissue Compatibility" patented technology

An implantable stimulation electrode for use with an implantable tissue stimulator, especially a pacemaker, a defibrillator, a bone stimulator or a neurostimulator includes a metal base body, optionally one or more intermediate layers disposed on the base body and a coating covering the base body and, optionally, intermediate layers in order to increase tissue compatibility. The coating should prevent tissue irritations after implantation and more particularly increase the stimulus threshold associated therewith, have very high biocompatibility and also has an anti-inflammatory effect. An increase in tissue compatibility is achieved by virtue of the fact that the coating has a polysaccharide layer made of hyaluronic acid and/or hyaluronic acid derivatives.

The invention relates to a hydroxyapatite coating magnesium alloy medical implantation material and a preparation method thereof. The hydroxyapatite coating magnesium alloy medical implantation material is characterized in that: the surface of a magnesium alloy substrate is attached with a hydroxyapatite coating layer. The preparation method of the hydroxyapatite coating magnesium alloy medical implant material can adopt the bionic solution growing method, the ion beam deposition method, the coating and sintering process, the plasma spray method, the discharge plasma sintering method or the electrophoresis deposition method. The magnesium alloy material with the hydroxyapatite coating structure which is provided by the invention can effectively slow down the degradation rate of the magnesium alloy; at the same time, the coating layer can not only have great tissue compatibility, but can also be conductive to connective tissue attachment and the growth of the bone tissues, improve the bone healing rate and shorten the healing time.

The invention discloses a chitosan/polylysine in-situ gel and a preparation method thereof. The gel is an in-situ gel prepared from 1-5.5 percent by weight of sulfhydrylization chitosan and 0.1- 3.2 percent by weight of maleimide polylysine. The preparation method comprises the following steps of synthetizing the polylysine containing maleimide double bonds, and preparing a maleimide polylysine solution by taking a PBS (phosphate buffer solution) as a solvent; preparing a sulfhydrylization chitosan solution by taking the PBS as a solvent; and uniformly mixing the two solutions under the condition of physiological pH value to obtain the in-situ gel. The invention has the advantages that the preparation process is simple, and the prepared in-situ gel simulates the components, the structure and the functional characteristics of polysaccharide/polypeptide of a natural extracellular substrate, helps to increase histocompatibility of a material, promotes cell adhesion growth and has wide application prospects in the fields of tissue engineering and drug release.

The present invention discloses one kind of cell culturing rack material and its preparation process. The cell culturing rack material is prepared with silk as main material, and through degumming, dissolving, purifying and drying to form fimbrin; dissolving together with collagen or gelatin in the same kind of solvent; high voltage electrostatic spinning to obtain 3D netted nanometer fiber non-woven felt of fimbrin base material, collagen, gelatin, etc. and final organic alcohol treatment. The cell culturing rack material has average fiber diameter smaller than 100 nm, average pore size of 1.0-5.0 microns and porosity of 70-90%. Test shows that the nanometer fiber material has no toxicity, no irritation, no sensibilization, excellent tissue compatibility and perforated pore structure, and may be used as cell culturing rack material for repairing human body tissue.

The invention discloses a Zn-Sr series zinc alloy as well as a preparation method and application of the Zn-Sr series zinc alloy. The zinc alloy comprises Zn and Sr, wherein the mass percent of Sr in the zinc alloy ranges from 0% to 10%, but is not equal to 0. The zinc alloy also comprises trace elements including Si, P, Li, Ag, Sn and at least one selected from rare earth elements, wherein the mass percent of the trace elements ranges from 0% to 3%, but is not equal to 0. The mechanical property of the Zn-Sr series zinc alloy disclosed by the invention meets the requirements for strength and toughness of a medical implant material, is nontoxic and favorable in tissue compatibility and blood compatibility, can be degraded by using body fluid and can be applied to preparation of medical implants; and the dissolved metal ions can be absorbed and utilized by living bodies to promote bone growth or can be discharged out of bodies through metabolism.

The invention discloses a Zn-Ca series zinc alloy as well as a preparation method and application of the Zn-Ca series zinc alloy. The zinc alloy comprises Zn and Ca, wherein the mass percent of Ca in the zinc alloy ranges from 0% to 30%, but is not equal to 0. The zinc alloy also comprises trace elements including Si, P, Li, Ag, Sn and at least one selected from rare earth elements, wherein the mass percent of the trace elements ranges from 0% to 3%, but is not equal to 0. The mechanical property of the Zn-Ca series zinc alloy disclosed by the invention meets the requirements for strength and toughness of a medical implant material, is nontoxic and favorable in tissue compatibility and blood compatibility, can be degraded by using body fluid and can be applied to preparation of medical implants; and the dissolved metal ions can be absorbed and utilized by living bodies to promote bone growth or can be discharged out of bodies through metabolism.

Hydroxyapatite is treated by a combination of nitridation and the application of bone morphogenetic protein to improve the tissue compatibility and affinity of the hydroxyapatite, rendering the hydroxyapatite more useful as a material for biomedical implants.

The invention relates to a bio-derived material with high tissue compatibility and long acting anti-infection. The bio-derived material comprises the components of a cell-free matrix and absorbable anti-infective nanometer particles, wherein the amount of the absorbable anti-infective nanometer particles implanted into the cell-free matrix have the range of 100-1000 micrograms/cm<3> according to the content of the inorganic antibacterial agent. A preparation method of the bio-derived material comprises the following steps of: (1) preparing absorbable inorganic antibacterial agent nanometer particles; (2) carrying out cell-free modifying treatment on the bio-derived material; and (3) constructing a nanometer-modified bio-derived material by using a self-assembly technology. The bio-derivedmaterial has the advantages of directly contacting an abdominal cavity, long acting anti-infection, high tissue compatibility and strong ability to promote cell proliferation and can be used for contaminated wounds or infected wounds and the like; after implanted in vivo, the inorganic antibacterial nanometer particles burst a medicament within a short period (not more than 2 h) to quickly realize effective concentration so that the duration time of the effective blood concentration reaches 2 weeks to 3 months or even longer; and the invention has favorable application potential in the rehabilitation treatment of various tissue organs.

The invention relates to an ophthalmic medical appliance and a manufacture method of the ophthalmic medical appliance, in particularly to a biomembrane material strip belt for a high-myopia posterior scleral reinforcement surgery. Base materials of the biomembrane material strip belt have a wide resource, the biomembrane material strip belt is blue after the treatment, the manufactured blue biomembrane material strip belt has good visuality and cannot easily get lost in the implantation process; the hardness and the elasticity are proper, the adaptability is good, the implantation is easy, and the biomembrane material strip belt is easily pasted, sewed and fixed with a receptor sclera; after the implantation into the human body, the toxicity is low, the mechanical strength is high, the tissue compatibility is good, the degradation resistance capability is high, and the calcification is not easy to occur; and the whole body of the biomembrane material strip belt is in a fusiform shape, the thickness is 0.15 to 0.45mm, the side part is an inclined surface, the middle section is widest, the middle section is gradually narrowed in arc-shaped transition respectively towards the left end and the right end, the length is 30 to 60mm, the width of the middle section is 10 to 16mm, the width of the left and the right end is 2 to 3mm, through the special shape design of the strip belt, the venae vorticosae can be prevented from being pressed, the reinforcement range is enlarged, the inclined surface of the side part is in 30 to 45 degrees, the marking at the positive surface and the opposite surface is realized, and the twisting turning is not easy to cause during the implantation.

The invention discloses a method for preparing an anticoagulant vascular stent, which comprises the following steps of: A, depositing a plasma-polymerized allyl amine functional film on the surface of the vascular stent by using a pulse plasma polymerization method; B, preparing heparin sodium mixed solution; and C, precipitating heparin sodium, namely soaking the vascular stent on which the plasma-polymerized allyl amine functional film is deposited prepared in the step A into the heparin sodium mixed solution prepared in the step B, reacting at the temperature of between 4 and 20 DEG C for 12 to 48 hours, and after the reaction, fully rinsing by using distilled water, and drying to obtain the anticoagulant vascular stent. The vascular stent prepared by the method has the advantages of high binding force between an anticoagulant film layer on the surface of the vascular stent and the vascular stent, and excellent tissue compatibility and blood compatibility.

The invention belongs to the field of medicine and high-polymer materials, and discloses a method for preparing small-diameter artificial blood vessels on the basis of nanotechnologies. The method includes steps of dissolving, by weight, 8% of fibroin and 5% of polycaprolactone in hexafluoroisopropanol to obtain spinning liquor; manufacturing the nano-fiber blood vessels with the wall thicknesses of 130-170 micrometers on cylindrical rod-shaped receiving screens with the diameters of 1-1.2mm by means of electrospinning by the aid of electrospinning technologies. Compared with the prior art, the method has the advantages that requirements of tissue engineering on high tissue compatibility, high porosity, plasticity and degradability can be met owing to the electrospinning technologies, vascular stents can be modified by cell activity factors (mechanical growth factors) and medicine (heparin) with anticoagulant activity, and accordingly shortcomings of technological complexity and poor tissue compatibility of existing cell-modified vascular stents can be overcome by the aid of the method.

The invention discloses a gelatin-chitosan/montmorillonite drug carried microsphere and a preparation method thereof. The drug carried microsphere is prepared by the following steps: dissolving the hydrophilic drug in the gelatin water solution, adding montmorillonite suspended water solution, carrying out intercalation reaction to obtain solution A; dissolving the chitosan in the acetic acid water solution, stirring and dissolving to obtain solution B; stirring and emulsifying liquid paraffin wax and span-80 to obtain C; adding solution B into solution A, carrying out intercalation reaction, adding C, stirring, standing, dropwise adding glutaric dialdehyde water solution, crosslinking and curing, adding isopropyl alcohol and stirring, removing supernate after standing and delaminating, vacuum filtrating to remove liquid; and washing with anhydrous ether and isopropyl alcohol in sequence, and drying to obtain the microsphere. The drug carried microsphere in the invention has good tissue compatibility, low toxicity or no toxicity, and is a drug carried material with excellent performance. The method in the invention can reduce the dosage of chemical crosslinking agent, lower the toxity of the microsphere, dramatically lower the rate of drug release, and further improve slowly controlled release ability of the drugs.

The invention provides an acellular dermal matrix guided tissue regeneration membrane material as well as a preparation method and application thereof, and relates to the technical field of medical biological materials. The preparation method provided by the invention comprises the following steps: pretreating, removing an epidermal layer, preparing a loose surface, stabilizing, performing the accellular treatment, washing, and sterilizing. A membrane material prepared by the method provided by the invention adopts fish skin as a raw material and has a three-dimensional space framework structure, and comprises a compact surface formed by a biological substrate membrane and a collagen loose surface formed by a dermal scaffold. By adopting the membrane material provided by the invention, therisk of the existing tissue restoration material in carrying and propagating the human-animal viruses can be avoided, the cell components can be completely removed, the immunogenicity is low, the clearance of the collagen fibers is increased, a corium layer structure is reserved, the tissue compatibility is good, the mechanical shielding effect is good, and the generation of new bones can be facilitated; and when used for restoring and treating the bone deficiency of an oral implantation operation, the material is digestible, and the second operation and the injury of the membrane material topatients can be effectively avoided.

The invention relates to a chitosan biofilm polypropylene mesh and a preparation method thereof. According to the invention, a polypropylene mesh is processed by using waterless ethanol and deionized water; the polypropylene mesh is modified by using 1.0 to 5.0% of a chitosan film forming solution through a process of biofilm forming, such that a chitosan biofilm polypropylene mesh is obtained. The method of the invention is simple and operable. No toxic or harmful reagent is included. No adverse effect is brought to subsequent applications of the medical mesh. According to the invention, the polypropylene mesh has a high porosity, peripheral tissue can well contact and grow on the polypropylene mesh, such that the anti-stretching property of a repaired part is enhanced; also, chitosan has a good biocompatibility, such that complications such as polypropylene mesh erosion, exposure and tissue adhesion at an implantation position are effectively reduced. The chitosan biofilm polypropylene mesh is especially suitable for clinical women pelvic reconstructive surgery. With the chitosan biofilm polypropylene mesh, histocompatibility of the polypropylene materials in pelvic reconstructive operations is improved, and pelvic reconstruction postoperative complications are reduced.

The invention relates to a loaded drug sustained release composite tissue repairing material and a preparation method thereof. The repairing material comprises a material having a three dimensional structure, porosity, and permeability, a drug or a drug loading medium. The repairing material can sustained release loaded drugs. Moreover, the release curve is controllable. The tissue compatibility and host-material immune reaction type of the repairing material are not changed. The repairing material is biocompatible, nontoxic, and harmless. The biological functions and special functions of the repairing material are enhanced, and the clinical application prospect is good.

A post operation adhesion proof carboxymethyl chitin membrane characterizing in containing carboxymethyl chitin and cross linking agent or chitosan is provided. The weight ratio of carboxymethyl chitin with cross linking agent is 100:0.1í½0.5, while the weight ratio of carboxymethyl chitin with chitosan is 100:10í½1000. The preparing process: carboxy methylating chitin to carboxymethyl chitin, combining with cross linking agent or chitosan to prepare carboxy methylating chitin water soluble collagen solution or acid solution, preparing to carboxy methylating chitin dry membrane, flushing and drying. The adhesion proof membrane provided by the invention has favorable tissue compatibility, favorable adhesion with body wound surface, rapid degradation rate, in addition, the degradation product can be absorbed and utilized by body without adverse reaction.

The invention discloses a nano silver-porcine acellular dermal matrix (PADM) biological dressing and a preparation method thereof. The biological dressing comprises PADM and nano-silver particles assembled on the PADM, wherein, the content of the nano-silver particles is 435.66-447.66 mu g/g, and the particle size of the nano-silver particles is 55-75nm. The preparation method of the biological dressing comprises the following steps: (1) reducing silver nitrate with trisodium citrate to prepare nano silver solution; (2) carrying out gradient dehydration with alcohol and ultrasonic treatment on the PADM; and (3) placing the treated PADM obtained from the step (2) in the nano silver solution for self-assembly, thus finally obtaining the nano silver-PADM biological dressing. The biological dressing obtained in the invention has the advantages of strong antibacterial property, high biological safety and good tissue compatibility; and simultaneously, the process is simple, and the use is convenient.

The invention provides a preparation method of an ocular surface biofilm, which uses animal pericardium, intestinal membrane and adipose omentum as raw materials through degreasing, decellularization, multi-directional antigen removal, epoxy fixation, curved surface molding, surface Modification, cobalt-60γ-ray irradiation sterilization and other process steps. The ocular surface biofilm obtained by the method of the present invention has a curved surface similar to that of the eyeball, can be close to the eyeball, has no antigenicity, good histocompatibility, can participate in the healing process of ocular surface wounds, and is beneficial to wound healing; Good air permeability and bacterial filtration can play a good role in the protection and treatment of the ocular surface; it has good strength, can be pasted and sewed, and is easy to use. In addition, through the surface modification of drug sustained release, it can also be made into a therapeutic ocular surface biofilm that can release anti-infective drugs slowly.