15 results about "Tissue Compatibility" patented technology

This invention discloses an interlocking bone tissue repair scaffold, assembled from several notched links connected in an interlocking manner. The notches in one link allow passage through the notches in another link, but not through the remaining main body of the other link. The links are 3D printed from calcium phosphate ceramic powder. The porosity of the final assembled chain can be flexibly controlled by adjusting the shape, size, thickness, and combination of links of different sizes, allowing for precise customization according to specific application scenarios. This scaffold structure is flexible and adjustable, adaptable to different implantation areas, significantly expanding the product's applicability. After implantation, it creates a microenvironment more closely aligned with human tissue growth patterns, optimizing local tissue compatibility and providing excellent conditions for cell adhesion, retention, and proliferation, effectively improving the scaffold's biocompatibility and clinical application efficacy.

The invention relates to a degradable manganous-manganic oxide-tannic acid-polymer composite modified artificial dura mater and preparation thereof, and belongs to the technical field of biological materials. According to the modified artificial dura mater, a spongy collagen biological membrane scaffold beneficial to cell growth and new dura mater tissue generation is provided for a dura mater defect part, and the modified artificial dura mater with good tissue compatibility and degradability is prepared by introducing carboxymethyl chitosan and manganous-manganic oxide / tannic acid. The novel composite artificial dura mater can effectively reduce intracranial infection and leakage of cerebrospinal fluid. The modified artificial dura mater loaded with the antioxidant manganous-manganic oxide / tannic acid nano-composite can effectively remove free radicals in the brain, and the composite modified artificial dura mater has anti-inflammatory and antibacterial functions and can be adhered to the surface of the dura mater after absorbing tissue exudate, water, buffer solution and the like. And can be tightly attached to the dura mater without suturing, and can exert antibacterial and anti-inflammatory activity for a long time.

The application discloses a preparation method of a fluorescent self-healing injectable hydrogel and application thereof. A biocompatible fluorescent small molecule is anchored on a polysaccharide macromolecular chain through an EDC / NHS coupling reaction, and then in-situ cross-linking is carried out through a dynamic imine bond under physiological conditions to prepare a fluorescent self-healing injectable hydrogel. The fluorescent self-healing injectable hydrogel has self-healing, injectability, shape adaptability, biodegradability, cell compatibility, tissue compatibility and outstanding fluorescence effect, and can be used for non-destructive, in-situ and real-time detection, thereby providing a new strategy for synthesizing a polysaccharide-based fluorescent self-healing injectable hydrogel under mild conditions, and simultaneously providing a new idea for establishing a system model of an in-situ real-time monitoring biomedical platform of minimally invasive interventional treatment technology.

The invention belongs to the technical field of polymer biomedical materials, and particularly relates to an eyeball sclera external implantation hydrogel as well as a preparation method and application thereof. The invention provides a self-expandable hydrogel which is prepared by using methyl methacrylate, N-vinyl pyrrolidone and methacryloyloxyethyl trimethyl ammonium chloride as monomer raw materials through cross-linking of N, N-bis (acryloyl) cystamine, and the hydrogel is used for a rabbit pore-derived retinal detachment model. According to the material, the operation time is greatly shortened, the operation difficulty is reduced, meanwhile, the purposes of minimally invasive implantation, self-expansion, no need of suture and retina restoration are achieved, the material has good histocompatibility, and the material fills the technical blank of sclera buckle belt materials in hole-derived retina detachment treatment and has good application prospects. A novel diagnosis and treatment material which is safe, reliable and high in adaptability is provided for clinic, and a new solution is injected for precise treatment of related diseases.

The application discloses an artificial fascia which is a composite material with a five-layer structure and is composed of fat stem cell-loaded amniotic membrane, PRP gel and polyurethane film; the five-layer structure material is in sequence of fat stem cell-loaded amniotic membrane, PRP gel, polyurethane film, PRP gel and fat stem cell-loaded amniotic membrane; the fat stem cell-loaded amniotic membrane is acellular amniotic membrane paved with fat stem cells and is prepared by the following method: inoculating fat stem cells on the acellular amniotic membrane and growing for 7-14 days to obtain the fat stem cell-loaded amniotic membrane. The application further discloses a preparation method of the artificial fascia and application of the artificial fascia in preparation of a biological patch for treating hernia or in preparation of a mesh for treating pelvic organ prolapse. The artificial fascia has high tensile strength, good tissue compatibility, good immune function and degradability, is a biological composite material with excellent performance, can be used for treating hernia and pelvic organ prolapse and has great application potential.

The patent discloses a kind of lotus leaf base compositions for preventing and treating pet dog obesity, which is made of the following raw medicinal materials by weight: lotus leaf base 5-10 parts, egg yolk lecithin 50-100 parts, beta-sitosterol 10-20 parts, and sodium alginate 10-20 parts. The lotus leaf base is first encapsulated in liposomes with egg yolk lecithin and beta-sitosterol as the lipid film, and then the prepared lotus leaf base liposomes are wrapped with sodium alginate. Compared with the traditional method, the lotus leaf base composition provided by the present application not only provides double-layer protection and sustained-release effect for lotus leaf base absorption, but also provides targeted delivery effect for lotus leaf base. In addition, it can also reduce the absorption of cholesterol by pet dogs. The lotus leaf base composition prepared by the present application has good compatibility with pet dog tissues, can maintain bioavailability for a long time, and has excellent preventive and therapeutic effects on pet dog obesity.

The invention discloses a flexible closed-loop self-powered vagus nerve stimulation system for treating drug-resistant epilepsy. The system comprises a spiral electrode, a flexible friction nanometer generator and a flexible controller. According to the implantable vagus nerve stimulation system, the flexible material and the self-powered technology are adopted, effective stimulation on the vagus nerve is achieved, the tissue compatibility of the implantable vagus nerve stimulation system is remarkably improved, and secondary injury to a patient caused by battery replacement in an operation is avoided.

The invention belongs to the technical field of biomedical instruments, and particularly relates to a device for detecting and intervening fundus retinopathy, which comprises an external energy transmitting device and a multifunctional integrated flexible corneal contact lens, and is characterized in that energy is provided for a biological light adjusting unit in the multifunctional integrated flexible corneal contact lens through the external energy transmitting device; according to the multifunctional integrated flexible corneal contact lens, the LED patch is integrated, and non-invasive intervention and treatment on the retina are achieved through the biological light adjusting technology. The receiving coil and the ERG electrode adopt a parting paper-cut structural design, so that the tensile property of the ERG electrode and the overall flexibility and structural consistency of the device are improved. The closed-loop management of'detection-treatment 'of retinal diseases is successfully realized, the device has more excellent histocompatibility, wearing comfort and large-scale production feasibility, and an innovative solution is provided for diagnosis and treatment of fundus diseases.

A novel ultra-thin neural implant (1) is provided that is based on a cellulose thin film (4) featuring an array (2) of electrodes (3). Due to the use of cellulose as the base material, the implant (1) can be safely handled during a micro-surgery, despite its high softness and conformability. Such an implant (1) may be useful in numerous applications ranging from electrical stimulation in neural prostheses, electro-stimulated regeneration of neural tissue to accurate recording of nerve signals. The robustness of the implant (1) results from a woven fabric (5) that is integrated in the cellulose carrier thin film (4). Several approaches for enhancing the tissue compatibility of the implant (1) are also provided.

This invention belongs to the field of medical materials technology, specifically referring to a drug-loaded porous magnesium alloy bone scaffold and its preparation method. The drug-loaded porous magnesium alloy bone scaffold is composed of the following raw materials in parts by weight: 55 parts magnesium alloy, 6-10 parts corrosion inhibitor, 1 part drug-loaded gel, 2-4 parts antibacterial bone-promoting agent, and 3 parts gelatin. This invention achieves sustained drug release by fabricating magnesium alloy into microtubes and filling the interior with a drug-loaded hydrogel; gelatin is sprayed onto the surface and adhered through Mg-N coordination bonds, bonded to the corrosion inhibitor, and hot-pressed. The components form an interpenetrating network with the gelatin to enhance bonding and react with the magnesium alloy to form a protective film; simultaneously, Ca... 2+ The process initiates cross-linking of sodium alginate, forming a stable anti-corrosion barrier. Finally, an antibacterial and bone-promoting mixture containing modified chitosan and thermosensitive polymer is sprayed on. Through complexation reaction and temperature control, the bone-promoting components are evenly dispersed around the implant, improving tissue compatibility.

The utility model relates to the technical field of medical instruments, and discloses a hydrogel ejaculation tube stent which comprises an imbedding tube, two adjacent stent tubes are arranged in the imbedding tube and located at the head position, the stent tubes are designed to be hollow cylinders and are made of gamma-polyglutamic acid hydrogel, and the gamma-polyglutamic acid hydrogel is arranged in the imbedding tube. A push rod is arranged in the imbedding pipe in a sliding mode, a gasket is fixedly arranged at the head end of the push rod, and the tail end of the push rod is arranged outside the imbedding pipe and provided with an auxiliary rod in a threaded mode; the stent tube made of the special pH-sensitive hydrogel can absorb water to swell in a hydrophilic manner, can keep a certain shape and volume, has corresponding chemical reaction to environmental pH, is not easy to fall off, has better tissue compatibility, does not irritate mucous membrane tissues, and can be used for treating the mucous membrane. The ejaculation tube can be supported and prevented from being obstructed again.

The invention relates to the technical field of medical materials, and particularly discloses a high-strength anti-fatigue non-absorbent suture which comprises an inner core with the diameter being 200-300 microns, a transition layer with the thickness being 30-80 microns and a surface functional layer with the thickness being 10-20 microns. The inner core is made of polyarylester and polycaprolactone; the transition layer is a mixture of a polyvinyl alcohol-polyethylene glycol copolymer, amino-terminated polydimethylsiloxane and hydroxypropyl trimethyl ammonium chloride chitosan; the surface functional layer is prepared from sulfonated chitosan and a functional additive; furthermore, in the transition layer, the weight ratio of the polyvinyl alcohol-polyethylene glycol copolymer to the amino-terminated polydimethylsiloxane to the hydroxypropyl trimethyl ammonium chloride chitosan is 10: (1-4): (3-6). The high-strength anti-fatigue non-absorbent suture has the advantages of being high in strength, good in anti-fatigue performance, good in histocompatibility and the like, and can meet the long-term use requirement of a complex clinical repair scene.

The application discloses an anti-migration biodegradable composite esophageal stent and a manufacturing method thereof. The composite esophageal stent comprises, from inside to outside, a hydrogel film inner layer, a middle layer reinforcing body and a fiber film outer layer. The circumferential surface of the outer surface of both ends of the fiber film outer layer is provided with a suction cup. The hydrogel film inner layer, the middle layer reinforcing body, the fiber film outer layer and the suction cup are all made of biodegradable materials. The middle layer reinforcing body is composed of negative Poisson's ratio variable units with auxetic properties. The fiber film has a drug loading function. The hydrogel film inner layer, the middle layer reinforcing body and the fiber film outer layer are all made by 3D printing. The composite esophageal stent can effectively change its deformation and improve the tissue compatibility of the composite esophageal stent. The composite esophageal stent can move up and down with the esophagus of a patient to maintain good biological adhesion. The composite esophageal stent can be degraded and absorbed in the human body or discharged out of the body within a certain period of time, and does not need to be taken out by a secondary operation.

The invention provides a soft tissue filling method for facial contour remodeling, and relates to the technical field of medical cosmetology. According to the method, a personalized filling model is established through preoperative 3D scanning, and the volume defect amount of a target area is quantified; a three-phase composite filling material composed of cross-linked hyaluronic acid microspheres, PLGA nanofibers, recombinant human collagen and an antioxidant is prepared, and the length of the PLGA fibers is adapted according to the filling level; a layered progressive and fan-shaped fixed-point injection mode is adopted, and parameters are monitored and adjusted in real time in combination with ultrasound; after injection, dynamic shaping is guided through static pressing and muscle movement, and standardized postoperative care is matched. According to the method, the defects that in the prior art, filling materials are stiff, uneven in distribution, short in effect maintaining time and high in adverse reaction rate are overcome, the filling outline is natural and harmonious, tissue compatibility is excellent, the effect can be maintained for 20-24 months, the adverse reaction occurrence rate is only 3.3%, and the method is suitable for outline optimization of multiple parts such as apple muscles, temples and chin.

The invention relates to the technical field of three-tube type arc-shaped after-loading source applicator, in particular to a three-tube type arc-shaped after-loading source applicator for cervical cancer eccentric tumors, which aims at solving the problems of fuzzy nuclear magnetic development and tube position fixation of plastic materials, and is characterized in that outer enclosures with spiral development tubes are arranged on the outer walls of a uterine cavity tube and a dome tube; the internal air cavity is used for inducing magnetic sensitive artifacts in the MRI to improve the visibility of the target region; a pure titanium developing ring is pre-buried in a conical sealing area at the pipe end, and dual-mode coordinate registration is achieved in combination with a CT highlight signal. The push plate is of a double-layer structure, the locking shaft mechanism fixes the position of the uterine cavity tube, the split frame slides through the distance adjusting groove to adjust the distance between the dome tubes, the threaded push tube controls the extension length, and the traction spring restrains deflection. Tungsten alloy foils are annularly arranged in the shielding groove to absorb backward radiation and assist the contact block to improve histocompatibility. According to the invention, the bottleneck of development and structure adjustment is broken through, and precise hardware support is provided for individualized radiotherapy.