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Method for preparing anticoagulant vascular stent

A vascular stent and anti-coagulation technology, which is applied in the field of preparation of medical vascular stents, can solve the problems of poor anti-coagulation effect and easy shedding of biological macromolecules, and achieve strong anti-coagulation function, excellent anti-coagulation function, blood good compatibility

Inactive Publication Date: 2010-12-29
CHENGDU SOUTHWEST JIAOTONG UNIV SCI & TECH GARDEN MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biomacromolecules that play an anticoagulant role are easy to fall off, and the anticoagulant effect is poor

Method used

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  • Method for preparing anticoagulant vascular stent
  • Method for preparing anticoagulant vascular stent
  • Method for preparing anticoagulant vascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A preparation method of an anticoagulant vascular stent, the method is:

[0040] A. Deposition of plasma-polymerized allylamine functional film

[0041] A1 sputtering cleaning: ultrasonic cleaning with acetone and ethanol in sequence; then put it into a vacuum chamber of 0.5Pa, with a flow rate of 15sccm (sccm is converted into the amount of milliliters at 25°C and 1 atmospheric pressure per minute) Argon gas, set the RF power to 80W, the negative bias of the stent to -50V, and perform sputter cleaning for 10 minutes;

[0042] A2 Plasma Coating: After sputtering and cleaning, the vacuum degree of the vacuum chamber is set to 1Pa again, and argon gas is introduced as a carrier gas. The flow rate of argon gas is 4.5 sccm, and allylamine is used as a reaction gas. The working pressure is 5Pa, the negative bias of the vascular stent is -20V, the pulse duty ratio is 10%, and the time is 25 minutes, that is, the plasma-polymerized allylamine functional film with a film thick...

Embodiment 2

[0048] A preparation method of an anticoagulant vascular stent, the method is:

[0049] A. Deposition of plasma-polymerized allylamine functional film

[0050] A1 sputtering cleaning: ultrasonic cleaning with acetone and ethanol in sequence; then put it into a vacuum chamber of 2Pa, pass in argon gas with a flow rate of 20sccm, set the radio frequency power to 120W, and the negative bias of the stent to -100V for 30 minute sputter cleaning;

[0051] A2 Plasma Coating: After sputtering and cleaning, the vacuum degree of the vacuum chamber is set to 2Pa again, and the flow rate of 20 sccm is introduced as argon as a carrier gas and allylamine as a reaction gas. The RF power is 100W and the working pressure is 20Pa. 1. The negative bias voltage of the vascular stent is -100V, the pulse duty ratio is 100%, and the time is 90 minutes, that is, the plasma-polymerized allylamine functional film with a film thickness of 150 nm is coated on the vascular stent.

[0052] B. Prepare hep...

Embodiment 3

[0057] A preparation method of an anticoagulant vascular stent, the method is:

[0058] A. Deposition of plasma-polymerized allylamine functional film

[0059] A1 sputtering cleaning: ultrasonic cleaning with acetone and ethanol in sequence; then put it into a vacuum chamber of 1Pa, pass in argon gas with a flow rate of 18sccm, set the radio frequency power to 100W, and the negative bias of the stent to -75V for 20 minute sputter cleaning;

[0060] A2 Plasma Coating: After sputtering and cleaning, the vacuum degree of the vacuum chamber is set to 1.5 Pa again, and argon gas as a carrier gas with a flow rate of 15 sccm and allylamine as a reaction gas are fed in. The radio frequency power is 50W and the working pressure is 15Pa, the negative bias of the vascular stent is -60V, the pulse duty ratio is 50%, and the time is 45 minutes, that is, the plasma-polymerized allylamine functional film with a film thickness of 100nm is coated on the vascular stent.

[0061] B. Prepare he...

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Abstract

The invention discloses a method for preparing an anticoagulant vascular stent, which comprises the following steps of: A, depositing a plasma-polymerized allyl amine functional film on the surface of the vascular stent by using a pulse plasma polymerization method; B, preparing heparin sodium mixed solution; and C, precipitating heparin sodium, namely soaking the vascular stent on which the plasma-polymerized allyl amine functional film is deposited prepared in the step A into the heparin sodium mixed solution prepared in the step B, reacting at the temperature of between 4 and 20 DEG C for 12 to 48 hours, and after the reaction, fully rinsing by using distilled water, and drying to obtain the anticoagulant vascular stent. The vascular stent prepared by the method has the advantages of high binding force between an anticoagulant film layer on the surface of the vascular stent and the vascular stent, and excellent tissue compatibility and blood compatibility.

Description

technical field [0001] The invention relates to a preparation method of a medical vascular stent, in particular to a preparation method of a vascular stent. Background technique [0002] Cardiovascular stents made of medical stainless steel, titanium, tantalum, nickel-titanium alloy or cobalt-based alloy have been widely used in clinical treatment. In 2006, more than 3 million people in the world had implanted various vascular stents. When a vascular stent is implanted in the human body, blood coagulation will occur, and the existence of blood coagulation will directly lead to stenosis or even blockage of the lumen, which will seriously affect the health of patients and even endanger their lives. Improving the anticoagulant property of vascular stents is the key to solve this problem. The most effective method is to modify the surface of the stent material to improve the anticoagulant property of the stent by improving the surface composition, structure and properties of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/10A61L31/10
Inventor 王进王晓娜黄楠罗日方杨志禄
Owner CHENGDU SOUTHWEST JIAOTONG UNIV SCI & TECH GARDEN MANAGEMENT
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