7305results about "Pharmaceutical packaging" patented technology

A drug supply apparatus that packages a drug with packaging paper that is conveyed from an upstream side to a downstream side, the packaging paper being folded in half with an opening on an upper side, the drug supply apparatus including: a nozzle that dispenses the drug into the packaging paper, the packaging paper including a sealed part, in which the nozzle includes: an insertion guidance piece that protrudes downward and positions a folded part of a lower end of the packaging paper in a state of being inserted in the packaging paper from the opening on the upper side, and a posture adjustment part that guides to inside of the packaging paper the drug, and causes the drug to stand while shifting the drug toward the sealed part side in the packaging paper, the posture adjustment part being provided on the downstream side of the insertion guidance piece.

A zwitterionic polymer coating with surface grafting crosslinking, its preparation method and application are disclosed, which relate to surface modification of biomedical materials, pipelines and other medical equipment, such as extracorporeal blood circulation devices, artificial blood vessels, catheters, endoscopes and other medical equipment, to provide functions such as anticoagulation and anti-biological adhesion. The disclosure constructs the zwitterionic polymer coating with simple process and excellent performance by simulating the structure of the blood vessel intima, having the surface micro-nano structure similar to the blood vessel intima, extremely low friction coefficient, soft elasticity and super hydrophilicity, realizing zero activation and zero adhesion of blood platelets, further providing the blood circulation effect of “blood undisturbed”, which is beneficial to avoiding the problems of thrombus of artificial blood vessels in vivo, various complications caused by clinical blood extracorporeal circulation and the like, and has great clinical application value.

The invention provides a medicine dispensing machine which comprises a frame, and a medicine bottle box for storing ampoule bottles and penicillin bottles, a liquid bag box for storing liquid bags and a suction and injection device hanging frame for conveying suction and injection devices are arranged in the frame. An ampoule bottle opening device for opening an ampoule bottle, a penicillin bottle cover opening device for opening a bottle cover of the penicillin bottle, a penicillin bottle liquid medicine mixing device for mixing and uniformly shaking liquid medicine injected into the ampoule bottle, and a marking device for marking a liquid bag injected with the mixed liquid medicine are arranged in the frame; the frame is internally provided with a sucking and injecting manipulator which is used for clamping a sucking and injecting device and sucking and injecting liquid medicine of an ampoule bottle into a penicillin bottle, all the devices are transferred through a transferring manipulator, full-automatic medicine dispensing is carried out, and the medicine dispensing efficiency is improved.

A support device for supporting a plurality of containers for pharmaceutical use to be handled in a processing line includes a plate having a plurality of first housing seats, wherein each first housing seat includes a first end edge defining an opening; and a base within each first housing seat, wherein the base includes at least one stacking element protruding above the first end edges of the first housing seats.

The present disclosure provides a medication dispensing system comprised of a medication dispensing device and a keyed and associated medication cartridge. The device includes a housing containing a cartridge carrier, designed with a specific connector to align with the medication cartridge. The device also includes an authentication mechanism that works in conjunction with an activator mechanism. When operated, the activator mechanism causes the cartridge carrier to move the medication cartridge between a stored position and a dispensing position, where it can be compressed to safely and efficiently dispense medication to a user.

A tamper evident seal structure for a vial septum or other cover having a housing including a sidewall terminating in oppositely disposed open and closed ends. A retainer is fixedly disposed within the housing and structured for retaining engagement with a portion of a vial, substantially adjacent the vial cover. The housing also includes a pressure member disposed within an interior thereof in attached, relation to the closed-end. The pressure member and the retainer are cooperatively disposed and structured to respectively exert pressure on the vial cover concurrent to retaining engagement with the vial. Tamper evident capabilities are at least partially defined by a detachment of a removable sidewall section from a remainder of said sidewall.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. The regulator assembly can include a valve configured to transition between a closed configuration and an opened configuration.

A holding device configured to support medical containers includes a supporting plate having a first surface, a second surface, a peripheral edge between the first surface and the second surface, and a plurality of openings through the supporting plate configured to receive the medical containers. The surfaces of the supporting plate include a peripheral lower portion extending inward from the peripheral edge; at least one upper portion enclosed by the peripheral lower portion; and at least one upwardly angled portion extending between the lower portion and the upper portion. The holding device further includes a plurality of chimneys protruding from the first surface and / or the second surface of the supporting plate at least partially enclosing the plurality of openings, such that the plurality of chimneys guide insertion of the medical containers into the plurality of openings.

The present invention relates to liquid pharmaceutical compositions of clonidine or its pharmaceutically acceptable salts thereof. Preferably, the liquid pharmaceutical compositions are suitable for oral administration, and are stable for extended periods of time. More specifically, stable liquid pharmaceutical compositions of clonidine at concentrations of 1 μg / mL or more are provided. The present invention further relates to stable oral liquid compositions of clonidine, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by clonidine.

A childproof pill container has a top lid, an upper lid, a box body, a bottom lid, and a childproof lock. The upper lid is movably mounted below the top lid and has a first through hole. The box body is mounted below the upper lid and has a second through hole. The bottom lid is mounted below the box body and has a third through hole. The childproof lock includes a rotatable member and an accessory. The rotatable member is mounted through the first through hole, the second through hole and the third through hole and contact the top lid. The rotatable member comprises a first block. The accessory comprises a first opening corresponding to the first block. When the first block is aligned with the first opening, the rotatable member can move upwardly to push the top lid, so the childproof pill container can be opened.

A vial adaptor can include a connector interface and / or a piercing member. The vial adaptor can include a regulator assembly. The regulator assembly can include a regulator base, a regulator nest coupled with the regulator base, and / or a storage chamber formed at least partially by one or both of the regulator base and regulator nest. The regulator assembly can include a cover connected to one or both of the regulator base and regulator nest and fitted around a radially outward portion of one or both of the regulator base and regulator nest. In some cases, the regular assembly includes a flexible enclosure connected to the regulator nest and configured to transition between a contracted configuration and an expanded configuration. In some cases, the flexible enclosure is inhibited from transitioning to the expanded configuration prior to removal or modification of the cover from the regulator assembly.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

The invention discloses an epoxy group modified zwitterionic polymer / heparin composite coating and a preparation method thereof. The preparation method comprises the following steps: firstly, constructing an amino-containing adhesion layer on the surface of a substrate by adopting a dip-coating method; then, the substrate is soaked in a mixed solution of the zwitterionic polymer and the heparin, and grafting of the zwitterionic polymer and the heparin on the surface of the medical material is completed through incubation. The coating provided by the invention has excellent hydrophilicity, can form a hydration layer, provides a physical barrier, and remarkably prevents adhesion and colonization of microorganisms. The inhibition rate of the coating on escherichia coli and staphylococcus aureus exceeds 99%, protein adhesion is remarkably reduced in an anti-protein adhesion experiment, and the coating is simple in strategy design, has a potential application prospect in the aspect of preventing blood contact catheter related infection and thrombosis, and has a wide application prospect. The complication occurrence rate and the medical care cost can be reduced.

A pill container has a body, at least one lid, and at least one elastic assembly. The body comprises a first wall, a second wall, and at least one compartment. The first wall and second wall are two opposite sides of the body. The compartment is located between the first wall and the second wall. The lid is pivotably mounted on the second wall of the body. The elastic assembly is located on the second wall, and has a flexural segment and a first protruding section. The first protruding section is located on the flexural segment and contacts the second wall. The first protruding section supports a space between the flexural segment of the elastic assembly and the body.

To provide systems and methods suitable for delivering a therapeutic agent to a target site.SOLUTION: The system comprises a container for holding the therapeutic agent, and a pressure source having pressurized fluid, where the pressure source is in selective fluid communication with at least a portion of the container. A catheter is placed in fluid communication with the container, and has a lumen sized for delivery of the therapeutic agent to a target site. A housing is configured to securely retain the container. The system further comprises a camera having a camera head coupled to the catheter, where the camera provides a visual image of the target site during the delivery of the therapeutic agent.SELECTED DRAWING: Figure 1

Systems and methods for the transfer of medical fluid are provided. A medical fluid transfer system may comprise a pump configured to transfer fluid through a tube assembly having a first connector configured to couple to a source container and a second connector configured to couple to a target container. The medical fluid transfer system may also comprise a destination sensor configured to output information about the target container. The medical fluid transfer system may further comprise a control system configured to operate the pump based on an operational setting associated with fluid volume; receive measurement data representing a measurement of the target container by the destination sensor, and adjust the operational setting based on an observed volume of fluid transferred to the target container.

A quick-fill pill organizer has a box, multiple retrieving covers, and a packaging cover. The box has multiple compartments. Each compartment has a retrieving opening and a packaging opening. The retrieving cover is mounted on the retrieving opening and corresponds to the compartment one-to-one such that the corresponding compartment connects to or is blocked from the outside. The packaging cover is mounted on the packaging openings such that all the compartments connect to or are blocked from the outside at the same time. When the retrieving openings are upward, the retrieving cover of the specific compartment can be opened. When the packaging openings are upward, the packaging cover can be opened or closed such that all of the compartments connect to or are blocked from outside at once.

A vial adaptor can include a connector interface and / or a piercing member. The vial adaptor can include a regulator assembly. The regulator assembly can include a regulator base, a regulator nest coupled with the regulator base, and / or a storage chamber formed at least partially by one or both of the regulator base and regulator nest. The regulator assembly can include a cover connected to one or both of the regulator base and regulator nest and fitted around a radially outward portion of one or both of the regulator base and regulator nest. In some cases, the regular assembly includes a flexible enclosure connected to the regulator nest and configured to transition between a contracted configuration and an expanded configuration. In some cases, the flexible enclosure is inhibited from transitioning to the expanded configuration prior to removal or modification of the cover from the regulator assembly.

The invention relates to the technical field of blocking medicine bottles, and particularly discloses a blocking medicine bottle and a preparation method thereof, aiming at the problems that the upper limit of the blocking performance of the existing blocking medicine bottle is low and the blocking performance is difficult to break through due to the fact that the blocking performance of the existing blocking medicine bottle is mostly realized through structural design. A bottle body of the blocking medicine bottle comprises an inner layer, a secondary inner layer, a middle layer, a secondary outer layer and an outer layer which are sequentially arranged in a covering mode. The inner layer comprises polyethylene; the secondary inner layer comprises an ethylene-methyl acrylate copolymer; the middle layer comprises an ethylene-vinyl alcohol copolymer, cyclic polyolefin and modified montmorillonite; the secondary outer layer comprises an ethylene-methyl acrylate copolymer; the outer layer comprises polyethylene, cyclic polyolefin and modified montmorillonite. The barrier medicine bottle is formed by compositing five layers of materials, the oxygen and water transmittance is low, the barrier property is high, and the barrier medicine bottle has great application value in packaging of medicine or food and the like.

A packaged, sealed container system for stable storage of a formulation of an oxygen-sensitive pharmaceutical compound, the packaged, sealed container system comprising a primary container including therein a formulation of an oxygen-sensitive pharmaceutical compound, a secondary outer container comprising a first flexible sheet layer, an opposing second flexible sheet layer, and a seal disposed along a common peripheral edge of the first and second flexible sheet layers, such that the primary container is disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. An oxygen scavenger is also disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. The oxygen scavenger is in fluid communication with the contents of the primary container.

The invention provides an anticoagulant coating for medical instruments, which can be used in the field of regenerative medical instruments. The prepared anticoagulant coating has short-term and long-term anticoagulant performance, and in addition, the thrombin responsive nanoparticles wrapped in the hydrogel coating can selectively release a factor Xa (FXa) inhibitor apixaban according to needs, so that thrombosis is inhibited in the middle stage of implantation. In-vitro and in-vivo experimental evidences show that after the material is implanted for a long time, an organized endodermis can be seen on the surface of the material, and the material has a special antithrombotic characteristic. The dynamic adjusting system has a multi-layer protection mechanism, and a new thought can be provided for designing the surface of a contact blood material adapting to environmental conditions.

The utility model provides a medicine dispensing device convenient to maintain, which comprises a box body, a medicine dispensing device and a medicine dispensing device, the feeding door is used for sealing the feeding opening, and the feeding door is movably connected to the box body; the rotating disc is provided with a fixing groove used for containing a medicine bottle, the rotating disc is rotationally connected with the box body, and the rotating disc corresponds to the feeding opening in position; the cover opening assembly is configured to open a cover of the medicine bottle; and the liquid extraction assembly is configured to extract the medicine in the medicine bottle. The medicine bottle extracting device has the advantages that different kinds of medicine bottles are placed in the fixing grooves respectively according to needs, the rotating plate is rotated to move the medicine bottles needing to be extracted to the uncovering assembly for uncovering operation, then the uncovered medicine bottles are moved to the liquid extracting assembly for liquid extraction, the operation of extracting multiple kinds of medicine in sequence can be conducted in sequence, and the working efficiency is improved. And the working efficiency is improved.

A medicine liquid transfer device includes a double-chamber syringe, a dispensing needle assembly, and a syringe needle sealing assembly. The medicine liquid transfer device features an exquisite structural design and easy assembly, enables fully-closed medicine preparation and transfer, and allows automatic or manual adjustment and balance of the air pressure inside the medicine container in use, thereby minimizing the risk of medicine leakage and providing an excellent leakproof effect, while having advantages of low cost, high convenience of use, and the like.

The invention belongs to the field of biological medicine, and particularly relates to application of recombinant III-type humanized collagen in an injection. The invention provides an injection, the injection comprises recombinant III-type humanized collagen, the amino acid sequence of the recombinant III-type humanized collagen comprises n repetitions of the sequence as shown in SEQ ID NO.1, n is an integer greater than or equal to 1, and when n is an integer greater than or equal to 2, the repetitions are directly connected; moreover, when the injection is applied in one application period, the total application amount of the recombinant III-type humanized collagen is less than or equal to 3640 mg / kg. The recombinant III-type humanized collagen has high-dose injection safety, and can be applied in a single high-dose manner or continuously applied to realize high-dose application in a total amount level.

The invention relates to the technical field of coating surface preparation, in particular to an anticoagulant coating based on novel tick-derived anticoagulant protein Qinghaenin and a preparation method of the anticoagulant coating. The functional layer of the anticoagulant coating comprises the following components: anticoagulant protein Qinghaenin or a functional peptide fragment Qinghaenin 167-192 of the anticoagulant protein Qinghaenin, wherein the amino acid sequence of the functional peptide fragment is as shown in SEQ ID NO. 2. The preparation method of the anticoagulant coating comprises the following steps: by using a polydopamine coating as a substrate layer, covalently grafting through an amido bond, immobilizing anticoagulant protein Qinghaenin capable of inhibiting FXII factor activation or a functional peptide fragment Qinghaenin 167-192 thereof on the surface of a medical polymer material, and successfully constructing a novel anticoagulant coating. Compared with an unmodified medical polymer material, the modified coating can significantly enhance the hydrophilic performance of the material and inhibit platelet adhesion and activation, finally effectively prolongs the in-vitro blood coagulation time, and shows excellent anticoagulation performance.