61 results about "Channel modulator" patented technology

The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition or a central nervous system traumatic injury comprising the administration to a subject of a potassium ion channel modulator in combination with a cyclooxygenase-2 selective inhibitor.

A wireless fading-channel demodulator using adaptive sub-array group antennas to combine beamforming and diversity gain, a signal receiving system and method for mobile communications using the wireless fading-channel demodulator. The wireless fading-channel demodulator eliminates interference signals arriving at different directions-of-arrival (DOAs) from undesired mobile stations (users) and provides strong immunity to fading. A high signal and interference-to-noise ratio SINR can be achieved even when the number of antennas is smaller than the number of mobile stations (users). The wireless fading channel modulator can be applied to any system receiving mobile communication information, such as a base station, a mobile station, etc.

The present invention is directed to compounds of Formula I:

that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compounds and pharmaceutical compositions of the invention. The present invention is still further directed to synthetic processes for producing the compounds of the invention.

Disclosed herein are substituted piperazine late Na⁺ channel modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

A vehicle door that may include a latch/window regulator module and rear and forward integrated channel/regulators, is disclosed. The rear integrated channel/regulator may include a glass run channel that is integral with a window regulator guide rail, and may also have a door latch assembly mounted to it. Other features may be integral with and extend from the rear integrated channel/regulator. The forward integrated channel/regulator may include a glass run channel that is integral with a window regulator guide rail, and may include an integral flange to which a cable drum and motor are mounted. The latch/window regulator module may be pre-assembled before being assembled into the vehicle door.

The invention belongs to the technical field of integrated circuits, in particular to a passive bandpass Delta-Sigma modulator based on a time-interleaved SAR (Synthetic Aperture Radar) ADC (Analog-to-Digital Converter). The passive bandpass Delta-Sigma modulator comprises a two-path time-interleaved SAR ADC; the overall structure of the passive bandpass Delta-Sigma modulator is a two-channel modulator structure; each path of structure includes a pair of differential noise shaping modules; a DAC (Digital-to-Analog Converter) array in each path of SAR ADC is an MOM capacitor which consists of 511 unit capacitors with 9-bit output accuracy; and the SAR ADC in each path of channel also includes a four-input comparator and a successive approximation logic circuit. Through adoption of the modulator disclosed by the invention, the passband is transferred from low frequency to quarter sampling frequency. In the analog-to-digital conversion of an application requiring a specific frequency band, the speed and power expenditure of a circuit are greatly reduced through adoption of the basic structure of SAR ADC and a passive filter structure.

Methods of using imidazo[1,2-α]pyridine ether compounds for modulating ion channel activity in a warm-blooded animal are disclosed.

The present invention provides 2-aryl or heteroaryl indole derivatives which are ASIC channel modulators, maceutical compositions containing such compounds, and methods of using them as therapeutic agents.

An optical channel regulator (46) is provided. The optical channel regulator (46) includes a tapped optical coupler (60) receiving an optical line carrying an optical signal. The tapped optical coupler (60) provides substantially all of the optical signal as an output. An electrically variable optical attenuator (64) receives the output of the tapped optical coupler (60) and attenuates the optical signal responsive to a feedback control signal. A second tapped optical coupler (66) receives an output of the attenuator (64). The second coupler (66) provides substantially all of the received optical signal as an output and provides a remaining portion of the optical signal as a tapped output. An optical detector (68) then receives the tapped output and provides an output signal representing the optical signal. A comparator (70) receives the output signal of the optical detector (68) and a reference signal. The comparator (70) compares the output signal and the reference signal and provides the feedback control signal to the attenuator (64) responsive to the comparison. As part of a multi-channel communication system, the regulator is used to adjust the levels of each channel for automatically maintaining channel balance and equalization.

A multi-channel regulator system includes serially connected PWM integrated circuits, each of which determines a PWM signal for a respective channel to operate therewith, and individually controls its operation mode according to whether or not an external clock is detected. Therefore, each channel will not be limited to operate under a constant mode and could become a master channel or a slave channel. Additionally, each of the PWM integrated circuits generates a phase shifted synchronous clock for its next channel during it is enabled, and thus all the channels operate in a synchronous but phase interleaving manner.

The invention discloses a device capable of receiving and sending various alarming messages and conducting acoustic code word communication, which comprises a channel modulator/demodulator, a channel coding/decoding module, a data coding/decoding module, an LCD (liquid crystal display) module, a microprocessor control module, a panel operating and displaying interface module, an analog voice/data voice conversion module, a digital alarming signal generator, a transmitter interface and an audio output interface. When a radiofrequency antenna receives an alarm and an alarm message, the channel modulator/demodulator conducts radiofrequency demodulation to the received signal firstly, then the channel coding/decoding module decodes the channel signal, the data coding/decoding module decodes the transmission data, and the LCD module displays the alarm and the alarm message. The device not only can receive alarms or alarming messages, but also can give an alarm or an alarm message, can display the specific content of the alarms or alarming messages by audio or characters, and also can be used for acoustic code communication in need.

The invention discloses a miniaturized Ka band single-channel modulator comprising a first waveguide microstrip conversion module, a second waveguide microstrip conversion module, a Ka band 0/pi modulator, a Ka band microstrip combiner and an aluminum shell, wherein the first waveguide microstrip conversion module, the second waveguide microstrip conversion module, the Ka band 0/pi modulator, and the Ka band microstrip combiner are packaged in the aluminum shell. The first waveguide microstrip conversion module and the second waveguide microstrip conversion module separately convert a Ka band difference signal transmitted by an antenna and a rectangular waveguide TE10 mode of the signal into a quasi TEM mode of a microstrip line, the Ka band 0/pi modulator realizes the phase modulation of the difference signal, and the Ka band microstrip combiner combines the Ka band with two paths of difference signals. The miniaturized Ka band single-channel modulator disclosed by the invention realizes a seamless connection with a waveguide feeder, improves the standing wave characteristic of ports, realizes miniaturization and light weight, and facilitates batch production.

The invention relates to a compound as a potassium channel modulator and preparation and application thereof. Specifically, the compound provided by the invention has a structure as shown in a formula A. The invention also discloses a preparation method of the compound and application of the compound as a potassium channel regulator. Formula A.

The invention relates to a method for the identification of a channel modulator, such as an agonist or antagonist, that interacts with one or more or LRRC8A, LRRC8B, LRRC8C, LRRC8D and/or LRRC8E and/or protein complexes thereof. The invention further relates to an isolated heteromeric protein complex comprising one or more or LRRC8A, LRRC8B, LRRC8C, LRRC8D and/or LRRC8E for use in such methods, in addition to kits suitable for carrying out such methods. The invention therefore relate preferably to the use of LRRC8 proteins and complexes thereof for the identification of VRAC (VSOAC) modulators.

The invention provides a compound as a selective sodium channel regulator, a synthesis method and a use method thereof, and particularly provides a compound as shown in a formula (I), a preparation method of the compound and application of the compound as the selective sodium channel regulator. The compounds exhibit excellent activity as sodium channel modulators.

The invention concerns pharmaceutical formulas designed for the treatment of diseases related to CFTR channel dysfunction, such as cystic fibrosis, asthma or diarrhoea. These formulas contain a molecule, coming in the form of a zwitterion at physiological pH, with the formula:

where X═N or P; Y═O or S;

• • R₁ to R₇ represent: —, H, or carbon chains, substituted or not, which may contain heteroatoms; except for betaine.

The disclosed embodiments relate to a system and method for processing digital communication signals. An exemplary system comprises a first input adapted to receive a first digital communication signal, a second input adapted to receive a second digital communication signal, an upconverter adapted to generate a multichannel digital signal that incorporates data corresponding to the first digital signal at a first frequency and data corresponding to the second digital signal at a second frequency, and a digital-to-analog converter adapted to convert the multichannel digital signal to a multichannel analog signal.