42 results about "Anesthesia induction" patented technology

The invention discloses a compound propofol injection with analgesic and the related preparation method. The pH value to prepare the compound propofol injection is 5.0 to 9.5. The fat emulsion injection contains propofol which serves as intravenous anesthesia medicine, non-narcotic or narcotic analgesic, refined vegetable oil serving as oil-soluble diluent, phospholipids serving as emulsifier, glycerol serving as osmo-regulator, oleic acid or sodium oleate acting as emulsion stabilizer, and vitamin E. The produced fat emulsion injection has dual functions of anesthesia and analgesia as well as synergistic effect and can be directly used in anesthesia induction and maintenance and postoperative and ICU analgesia for the patients. The invention can reduce the pain of the injected part, and is convenient to use and controllable. Therefore the invention is a safe and effective compound intravenous anesthetic.

Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo. Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compositions are useful in a variety of applications. The compositions can be used therapeutically, for example, in the treatment of patients with narcolepsy, chronic schizophrenia, catatonic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, alcoholism, drug addiction and withdrawal, Parkinson's disease and other neuropharmacological illnesses, hypertension, ischemia, circulatory collapse, radiation exposure, cancer, and myocardial infarction. Other uses for the compositions include anesthesia induction, sedation, growth hormone production, heightened sexual desire, anorectic effects, euphoria, smooth muscle relaxation, muscle mass production, and sleep, including rapid eye movement sleep. In a still further embodiment, the oligomers and polymers may be used to produce absence seizures.

The invention discloses a finger lock type anaesthetic mask, which belongs to the field of medical appliances. The finger lock type anaesthetic mask is characterized by consisting of an air cushion, a mask body, an air inlet, an inflating valve and finger lock type devices, the finger lock type devices are located on two sides of the mask body, are close to the air cushion, are closely connected with the mask body, and are mainly used for providing effective exertion support for the thumbs and the thenars of an operator in a mask pressurizing oxygen feeding operation process, the finger lock type anaesthetic mask is a semi-opened arc-shaped structure or a hollow opened structure capable of holding the thumbs or a columnar structure, and anti-skidding grains are designed on the surface of the anaesthetic mask. When the mask is in pressurizing oxygen feeding during anesthesia induction, an original mask fastening operation method is not changed, the finger lock type devices on the two sides of the mask body provide the effective exertion support for the thumbs and the thenars of the operator, the problem that both hands of the operator slip and the mask cannot be fastened tightly due to deficiency of effective exertion points in a mask fastening process is avoided, air leakage is reduced, and the possibility of meionectic blood is also reduced.

The invention discloses a pharmaceutical composition containing a non-narcotic analgesic or a narcotic analgesic and pharmaceutically acceptable salts thereof and fospropofol disodium. The non-narcotic analgesic is nefopam hydrochloride or nefopam. The narcotic analgesic is selected from fentanyl, remifentanil, alfentanil and sufentanil. The pharmaceutical composition can be directly used for clinic comprising anesthesia induction, maintenance of anesthesia, post operation or ICU analgesia, and the like. The pharmaceutical composition has functions of analgesia and sedation. Through addition or synergistic effects of medicines, the pharmaceutical effects are enhanced, the dosage is reduced, untoward effects in pain treatment is prevented and relieved, the number of times of administration by an anesthetist is reduced, and therefore an anesthesia induction process is more convenient and an ideal anesthesia effect can be achieved.

The invention belongs to the technical field of small animal anesthesia and relates to a simple economical small animal inhalation anesthesia machine which comprises a gas steel bottle, a gas adjusting valve, a three-way pipe I, a gas flow meter I, a gas flow meter II, an isoflurane gas volatilization bottle, a three-way pipe II, an adjustable three-way pipe, an anaesthetic mask, an animal body constant temperature system, an anesthesia induction box and a gas recycling bottle. The gas steel bottle is connected with the gas adjusting valve, the three-way pipe I, the gas flow meter I, the gas flow meter II, the isoflurane gas volatilization bottle, the three-way pipe II, the adjustable three-way pipe, the anaesthetic mask, the animal body constant temperature system, the anesthesia induction box and the gas recycling bottle in sequence. Using results show that the simple economical small animal inhalation anesthesia machine is simple and reasonable in structure, various parts are fixed and combined in a coordinating mode, small animals can be subjected to anesthesia control in short time or long time, accurate anesthesia depth is guaranteed, safety is good, after operation, the morbidity and the mortality of the small animals are low, and the operation success rate is high.

The invention discloses a simple novel anesthesia machine for an experiment. The simple novel anesthesia machine comprises an oxygenation pump, and further comprises a centrifugal tube with a liquid anesthetic, wherein the oxygenation pump is respectively communicated with a first gas flowmeter and a second gas flowmeter; the first gas flowmeter is communicated with the centrifugal tube through a centrifugal tube gas-intake duct; the second gas flowmeter is communicated with a tee joint; the tee joint is communicated with the centrifugal tube through a centrifugal tube discharge duct; the tee joint is further communicated with an anesthesia induction box or a respiration anesthesia box through an anesthesia duct. The simple novel anesthesia machine for the experiment disclosed by the invention has the advantages of being high in structural strength, stable in structure, safe, reliable, easy to control of concentration, cheap, fine and the like.

The invention discloses an anesthesia induction and wakening method. According to the method, a computer system is utilized for controlling the anaesthesia induction and wakening process of a patientto ensure the life safety of the patient. Anaesthesia medicines are slowly and constantly injected through pumping through BIS monitoring or Narcotrend monitoring, non-invasive continuous arterial blood pressure monitoring or invasive arterial blood pressure monitoring and neuromuscular monitoring, the brain electrical activity of the patient is constantly monitored, the process of air way pipe inserting and air way pipe pulling is completed under blood pressure and neuromuscular conditions to reduce blood flowing mechanical fluctuation of the patient, and the risk of inserting the pipe againafter the patient is waked up when the pipe is pulled out is reduced. Objective technical support is provided for the developing of an anaesthesia induction and wakening interval method and system.

The invention discloses an anesthesia induction oxygen inhalation mask fixing frame and an operation and using method thereof. The anesthesia induction oxygen inhalation mask fixing frame is characterized in that the rear upper end of a base is provided with an under frame, the under frame is provided with a main support, the main support is arranged on the under frame by a lower adjusting shaft, the upper end of the main support is provided with an auxiliary support, the auxiliary support is arranged on the main support by a middle adjusting shaft, the upper end of the auxiliary support is provided with a connecting frame, the connecting frame is arranged on the auxiliary support by an upper adjusting shaft, the upper end of the connecting frame is provided with a universal joint, the upper end of the universal joint is provided with a center fixing clamp, and the middle part of the center fixing clamp is provided with a U-shaped tension spring. U-shaped fixing clamps can be fixedly arranged on transverse rods which are arranged at two sides of an operating bed during using, an outlet of an oxygen inhalation tube is put into the center fixing clamp for being fixed, the main support and the auxiliary support can be moved, and the height and the position can be optionally adjusted by utilizing folding and stretching of the main support and the auxiliary support and rotating of the universal joint.

The invention discloses a pharmaceutical composition containing propofol and opioid analgesics and a use thereof. The pharmaceutical composition comprises pharmaceutically acceptable carriers, propofol as a first active component and opioid analgesics as second active components selected from fentanyl, remifentanil, sufentanil and alfentanil. The pharmaceutical composition containing propofol and opioid analgesics utilizes the combination of narcotic analgesics and a narcotic sedative, has effects of analgesia and sedation, reduces the frequency of drug administration carried out by an analgesist, makes an anesthesia induction process more convenient, obviously reduces an incidence rate and the severity of the propofol injection pain, and reduces adverse reactions of monotherapy.

The invention discloses a novel clinical composite anaesthetic. The anaesthetic is an injection or powder using an anti-oxidant and a conventional clinical anaesthetic as active components. According to the invention, combined usage of the anti-oxidant and the conventional clinical anaesthetic can substantially decrease a desired clinical dosage during individual usage of the conventional clinical anaesthetic without influencing anesthetic effects, so side effects of the anaesthetic, especially damage of the anaesthetic to important internal organs like the brain, the heart and the kidney, are reduced, the problems of a great usage amount and great side effects of the conventional clinical anaesthetic are overcome, discomfort of a patient in the process of treatment can be substantially reduced, and the risk of cognitive disorder of the patient caused by usage of a great amount of the anaesthetic is lowered down. The composite anaesthetic provided by the invention has the advantages of a small usage amount, safety and high efficiency and is applicable to clinical anesthesia induction and (or) maintenance of medication related to anesthesia induction of an operation and anaesthesia in an operation.

The invention discloses an etomidate composition for injection. The etomidate composition is characterized by comprising a) etomidate, b) solutol HS 15 and any phospholipid, c) oil for injection and d) a pharmacy acceptable auxiliary material. The invention further discloses a preparation method for the etomidate composition for injection. According to the invention, the particle diameter of the etomidate composition for injection is less than 100 nm, the appearance is transparent, the pH value is 5 to 8, and the composition can be preserved at room temperature, cannot cause hemolysis, can be supplied for injection dosing, and is used of anesthesia induction and maintenance.

The invention relates to a compound propofol water-based injection for dogs, a preparing method thereof and application, and belongs to the technical field of veterinary medicine preparation. The compound propofol water-based injection is suitable for immobilizing and narcotizing dogs. The injection uses propofol and xylazine hydrochloride as active components, and a carrier acceptable pharmaceutically is added. The compound propofol water-based injection has hypnosis, calming and abirritation functions and can achieve the effect of anesthesia induction or anesthesia maintenance through one-time injection delivery, and the anesthesia process is more convenient; dosage of all single drugs is reduced, and a good anesthesia effect is achieved with the minimum side effect. The injection is stable in quality and suitable for subcutaneous, muscle and intravenous injection, and pain is avoided in the injection process. A fat emulsion carrier applied the most extensively is abandoned from the preparation, a water-based solution is prepared, microorganism growth can be limited, the injection can be sucked for multiple times, and the problem of medicine waste of a propofol fat emulsion preparation is avoided.

The invention discloses a compound anesthetic for a rat and a preparation method thereof and belongs to the field of preparation and application of animal compound anesthetics. The invention discloses the compound anesthetic for the rat for the first time. The compound anesthetic comprises dexmedetomidine, midazolam, oxycodone, a buffer solution and water for injection. The invention further discloses the preparation method of the compound anesthetic for the rat. The preparation method comprises the following steps: dissolving the above components in the water for injection; diluting; filtering; pilling in an ampoule bottle; and sterilizing to obtain. The compound anesthetic for the rat disclosed by the invention is quick in anesthesia induction, long in anesthesia maintenance time, good in antalgic and sedative effects and stable in revival, and the main influence on physiological and biochemical indexes of the rat is within the physiological range tolerance. The compound anesthetic is simple to operate and can be used for complex or long-term operations of the rat.

The invention belongs to veterinary medicine preparation technology and provides a compound anesthetic for cats and a preparation method thereof. The compound anesthetic is formed by ketamine hydrochloride, dexmedetomidine, tramadol hydrochloride, pentobarbital sodium, sodium chloride, gelatin and water for injection. The ketamine hydrochloride, the dexmedetomidine, the tramadol hydrochloride, the pentobarbital sodium, the sodium chloride and the gelatin are dissolved in the water for injection in sequence, by means of 0.2 mole per litre of hydrochloric acid solution, potential of hydrogen (PH) is adjusted to 7.8, the water for injection is added again, after dilution and filtering, the obtained solution is poured into an ampoule bottle, and after sterilization, the compound anesthetic for the cats can be obtained. The compound anesthetic is rapid in anesthesia induction, good in anesthetic effects, safe and effective in the process of anesthesia, slight in influence on normal physiological and biochemical indexes, small in toxic and side effects, and the cats can revive stably, and the preparation method is simple and feasible.

The invention discloses a pharmaceutical composition having abirritation and sedation, which comprises alfentanil and fospropofol disodium, wherein the weight ratio of alfentanil and fospropofol disodium is 1: (100 to 2500). The pharmaceutical composition is used in a form of a conventional medicine preparation, and a preferential medicament form is injection. By combining narcotic analgesic and narcotic sedative, better abirritation and better sedation can be realized, and times for applying medicine can be reduced, so that the anesthesia induction process is more convenient.

The invention discloses a target area adjustable type batch animal ionizing radiation local irradiation fixing and shielding device. The device comprises an animal fixing part and a ray shielding part, wherein the animal fixing part comprises an animal anesthesia fixing table, and the ray shielding part comprises a ray shielding table; an anesthesia induction box and a batch animal fixing box arearranged on the table top of the animal anesthesia fixing table; a transverse adjusting and controlling shielding device, an up-down adjusting and controlling shielding device and a transverse-longitudinal scale division plate are arranged on the table top of the ray shielding table; the transverse adjusting and controlling shielding device blocks redundant rays in the horizontal direction, and afirst gap with the adjustable size and position in the direction perpendicular to the ground is exposed; the up-down adjusting and controlling shielding device blocks redundant rays in the direction parallel to the ground, and a second gap with the adjustable size and position in the direction parallel to the ground is exposed; a rectangular area, namely an irradiation field, is formed at the intersection of the two gaps; through stepped connection, leakage caused when the rays pass through the transverse arrangement position of a shielding block is blocked, and incomplete blocking is avoided;and the position and area of the irradiation area are flexible, adjustable and accurate in irradiation.

The invention discloses an anesthesia device with a concentration adjusting function and an adjusting method thereof. The problems can be solved that on the premise that a filtering tank is additionally arranged for filtering anaesthetic gas, a patient can use an existing anesthesia device, the whole structure is complex, and a whole set of device occupies a large area; the inside of the existingdevice after use is inconvenient to clean, when the existing anesthesia device adjusts the concentration of the anaesthetic gas, the concentration of the anesthetic gas is adjusted by adopting a modethat an anesthesia induction box and the flowing speed of oxygen entering the anesthesia induction box cooperate with each other, the mode is extremely complex, and the concentration adjusting resultis quite inaccurate. The anesthesia device comprises a bracket, an evaporation tank and a concentration adjusting box, a medicine chamber is formed in the bracket, a liquid inlet is formed in the topof the medicine chamber, and a hydraulic telescoping pushing plate with the inner diameter adapting to that of the inside of the medicine chamber is installed in the medicine chamber; the hydraulic telescoping pushing plate is connected with a hydraulic pump at the bottom of the hydraulic telescoping pushing plate, and the evaporation tank is fixedly installed on the bracket.