38 results about "Hyperthermic perfusion" patented technology

The invention discloses a temperature and pressure real-time monitoring and adjusting device used for a urogenital tract intraluminal surgery. The temperature and pressure real-time monitoring and adjusting device comprises a perfusion fluid inputting and adjusting system, a temperature and pressure monitoring system and a medical waste water and waste residue treatment system. The perfusion fluid inputting and adjusting system is used for mixing a perfusion fluid in an indoor-temperature perfusion fluid soft bag and a perfusion fluid in a preheating perfusion fluid soft bag, and inputting the mixture into an endoscope body by means of a perfusion pump; the temperature and pressure monitoring system is used for detecting temperature data and pressure data in a surgery area in real time by means of an optical-fiber-type temperature and pressure sensor, receiving a video signal collected by a video collecting system by means of an endoscope video signal receiving unit, and outputting the temperature data, the pressure data and the video signal to a display unit; the medical waste water and waste residue treatment system is used for separating medical waste water from medical waste residues, and conducting innocent treatment on the medical waste water. The temperature and pressure real-time monitoring and adjusting device is suitable for the urogenital tract intraluminal surgery, it can be guaranteed that the surgery is conducted at the proper temperature and pressure in the whole process, and operative complications are reduced or even avoided.

The invention discloses a plug-draining device in the tumor hyperthermic perfusion treatment. The device comprises a tank body, wherein a controller is arranged on the right side of the tank body; a separator is arranged at the center of the cavity of the tank body; a heat tank, a booster pump and a flowmeter are arranged on the upper surface of the separator; the heat tank is connected with the inlet of the booster pump through a pipeline, and the outlet of the booster pump is connected with the inlet of the flowmeter through a pipeline; a puncture outfit is arranged at the outlet of the flowmeter; a collection tank and a vacuum extractor are arranged at the bottom of the cavity of the tank body; the collection tank is connected with the inlet of the vacuum extractor through a pipeline. According to the plug-draining device in the tumor hyperthermic perfusion treatment, treatment liquid is heated to a certain temperature by the heat tank and is delivered into the first vacuum extractor through the booster pump, a bent plate in the first vacuum extractor is deformed when impacted, so that pressure fluctuation can be absorbed, and abdominal liquid backflow can be prevented; the puncture head is disposable, the inside of the main pipe is prevented from being polluted, and the device can be used repeatedly, so that certain medical-treatment resource can be saved.

The present invention relates to a body cavity thermal perfusion treatment device, including a water tank, a heating pipe, circulating pumps, circulating guide pipes, a heat exchanger and a water tank controller, wherein, the water tank, an external circulating pump, an external circulating guide pipe and the heat exchanger constitute an external circulating system, the heat exchanger, an internal circulating guide pipe, an internal circulating pump and the body cavity of the human constitute an internal circulating system, and the present invention is characterized in that a constant temperature water tank which is provided with a heater is arranged in the external circulating system. The external circulating pump in the constant temperature water tank is arranged at the lower part of the water tank, the water tank is arranged at the upper part of a shell body, the electric heating pipe is arranged in the water tank, and a water level gauge which is communicated with the water tank is arranged at the side surface of the shell body. The present invention adopts an industry control computer to regulate the electric heating pipe which is arranged in the constant temperature water tank by the water tank controller, so as to accurately control the temperature of the liquid in the water tank, and the precision of the control temperature can achieve plus or minus 0.1 DEG C during the constant temperature, thereby achieving the purpose of constant temperature thermal perfusion treatment.

The invention discloses a body cavity drainage tube. The body cavity drainage tube comprises a main drainage tube, and further comprises a branch drainage tube A and N branch drainage tubes B; one endof the main drainage tube is communicated with one ends of the branch drainage tube A and the branch drainage tubes B respectively; the other ends of the branch drainage tubes B are closed; one ends,communicated with the main drainage tube, of the branch drainage tubes B are connected to the end part surface of the one end of the main drainage tube; the end part of the one end of the branch drainage tube A is located at the middle-lower part of the end part surface of the main drainage tube; the end parts of the one ends of the branch drainage tubes B are located at the middle-upper part ofthe end part surface of the main drainage tube in an equal arc distance or equidistance manner; and N is a natural number greater than or equal to 2. The body cavity drainage tube claimed in the invention can replace a traditional tubular drainage tube or a spiral multi-channel drainage tube, and is designed to be a sector-shaped multi-channel drainage tube, so generated blood or a diffusate in the operation area is fully drained, and inflammatory adhesion is reduced; and the body cavity drainage tube also can be used as a body cavity hyperthermia perfusion drainage tube, so body cavity hyperthermic perfusion chemotherapy can be fully carried out in the body cavity.

A body position changing bed for hyperthermic perfusion chemotherapy effectively solves the problem of body position changing of a cancer patient in hyperthermic perfusion chemotherapy and comprises abed body. A bed board is arranged in the bed board and rotationally connected with the bed body, a medicine injection tube and a medicine return tube extend out from two sides of the bed board, and amedicine injection tank and a medicine return tank are arranged under two sides of the bed body. A circulating pump is arranged in the bed board, the medicine injection tube, the medicine injection tank and the circulating pump are communicated in the bed board through a pipeline, the medicine return tube, the medicine return tank and the circulating pump are communicated in the bed board througha pipeline, and reversing valves are arranged at the communication position of the medicine injection tube and the medicine injection tank and at the communication position of the medicine return tube and the medicine return tank respectively. The bed further comprises a driving device which controls direction changes of the reversing valves and rotation of the bed board on the bed body. The bedis ingenious in structure and convenient to use, automatic hyperthermic perfusion chemotherapy can be realized after equipment starting, frequent participation of medical personnel is avoided, and accordingly burden of the medical personnel is relieved.

The invention discloses an intraperitoneal hyperthermic perfusion chemotherapy instrument in operation, belonging to the technical field of medical instruments. The intraperitoneal hyperthermic perfusion chemotherapy instrument in operation comprises a heating device, a control device, a man-machine interaction device, a chemotherapy liquid collection bag, two adjustable speed peristaltic pumps, two T-junction dividers and a plurality of sensors, wherein the heating device comprises a heating plate and a heating bag, the heating plate and the heating bag are tightly stuck, the heating plate is connected with the control device to transfer heating temperature control information, and the inlet and the outlet of the heating bag are respectively provided with a temperature sensor. The invention has simple structure and convenient operation; the heating plate is utilized to carry out heat exchange so as to evenly heat, and the chemotherapy liquid is only sealed and circulated in the pipeline, which is clean and reliable; and the chemotherapy liquid collection bag can effectively collect and manage the chemotherapy liquid, and a DSP processor has precise temperature control and obvious curative effect.

The invention relates to an electric heating abdominal cavity hyperthermia perfusion treatment system. The electric heating abdominal cavity hyperthermia perfusion treatment system comprises a host device; the host device comprises a heating bin and a liquid medicine self-circulation module; a liquid medicine heating body is arranged in the heating bin; the liquid medicine heating body comprises a heating cup; the heating cup is of a double-layer structure and comprises a heating layer and a heat insulation layer arranged outside the heating layer in a sleeving mode; a cavity is formed between the heat insulation layer and the heating layer; a plurality of heating rods are inserted into the wall body of the heating layer and are used for heating the heating cup; a second liquid inlet hole and a second liquid outlet hole are formed in the two sides of the lower portion of the heat insulation layer respectively; the second liquid inlet hole is communicated with a liquid medicine conveying pump; and the second liquid outlet hole is communicated with the liquid medicine self-circulation module through a hose. The heating cup of the double-layer structure is adopted to heat liquid medicine; the structure is stable; furthermore, the contact area between the liquid medicine and the heating cup can be increased through a heating channel; the circulating liquid medicine is evenly heated; and the heating efficiency is improved.

The invention discloses a combined hyperthermic perfusion drainage tube set and belongs to the field of medical apparatuses and instruments. The hyperthermic perfusion drainage tube set is divided into a drainage tube set body and a temperature measurement set, wherein an outer set is directly fixed to the center of a heparin cap film by using a temperature measurement wire, a disposable sterile temperature measurement sensor is inserted into a drainage tube wall sheath during treatment, a heparin cap is fixed, an external connector is directly connected with a hyperthermic perfusion machine,and the set can be directly removed after treatment. The drainage tube set is provided with a special temperature measurement sensor drainage tube wall sheath channel, original in-vitro indirect temperature measurement is changed into in-vivo direct temperature measurement for hyperthermic perfusion of the body cavity, the precision of temperature measurement in the body cavity during treatment inthe body cavity is greatly improved, and especially the influence of outside environment temperature on temperature measurement is completely eradicated, so that medical workers accurately master temperature change of the body cavity. The combined hyperthermic perfusion drainage tube set is simple in whole structure, easy to manufacture, low in cost and convenient to popularize widely.

The invention provides a method for monitoring the temperature of a lesion area in real time through magnetic resonance and application thereof. The temperature average value of an ROI of an MRI temperature distribution diagram and a signal average value of a T2WI image are integrated to serve as judgment standards, and the situation that the temperature monitoring effect is affected due to the fact that calculation of the ROI temperature, the signal average value and the like is inaccurate due to the fact that a single temperature imaging parameter is easily affected by external factors is avoided. The method can be applied to real-time guidance of bladder cancer hyperthermia perfusion chemotherapy; the temperature change in the hyperthermia perfusion chemotherapy process is evaluated according to the ROI average signal intensity change condition, and whether hyperthermia perfusion chemotherapy damages normal tissues or not can be observed in real time by comparing the average value of the perfusion region temperature distribution diagram and the T2WI image ROI with an initial value.

The invention discloses an abdominal cavity hyperthermic perfusion chemotherapy device which comprises an abdominal pressure belt, an injector assembly and a bed body, wherein the injector assembly and the bed body are installed on the abdominal pressure belt. The injector assembly comprises an injection tube and an infusion tube, the infusion tube is mounted at the top of the injection tube, one side of the injection tube is connected with a liquid return tube, an inlet of the liquid injection tube is connected with a liquid storage tank, an outlet of the liquid return tube is connected with a waste liquid tank, a heating device is arranged on the infusion tube, and a metering pump is arranged on the infusion tube; the bed body comprises an arc-shaped bed board, a bed frame and a support, the arc-shaped bed board is arranged on the bed frame in a sliding mode, an arc-shaped rack is arranged at the bottom of the arc-shaped bed board, a servo motor is arranged on the bed frame, a rotating shaft of the servo motor is connected with a gear meshed with the arc-shaped rack, and the servo motor drives the gear to rotate and drives the arc-shaped bed board to swing back and forth. The bed frame is arranged on the support in a sliding mode, a driving piece is arranged on the support, and the driving piece drives the bed frame to linearly slide on the support in a reciprocating mode. According to the invention, the comfort and the chemotherapy effect of a patient in the chemotherapy process can be improved.

The invention relates to medical instruments, in particular to a dredging device for an abdominal cavity hyperthermia perfusion pipeline, which comprises a hyperthermia perfusion pipe used for communicating with the abdominal cavity of a patient to form a circulation loop; a flexible balloon which is arranged on the hot infusion tube; one end of the flexible balloon is connected with the hyperthermia perfusion tube, or the inlet end and the outlet end of the flexible balloon are both connected to the hyperthermia perfusion tube, and the flexible balloon is used for stretching out and drawing back or expanding so that the flow speed of fluid in the hyperthermia perfusion tube can be changed. According to the dredging device for the abdominal cavity hyperthermic perfusion pipeline, when the hyperthermic perfusion pipeline is blocked, the flexible balloon is stretched or expanded to enable the flow speed of fluid in the hyperthermic perfusion pipeline to change, and liquid in the balloon can drain residues of the blocked pipeline out of the pipeline, so that the effect of dredging the pipeline is achieved.

The present invention provides a control system and a control method of a device for a hyperthermic perfusion treatment. The control system comprises a variable-speed peristaltic pump, transfusion guide pipes and a heating tank body; the variable-speed peristaltic pump comprises a pump head and a driving device; the transfusion guide pipes comprises a first guide pipe and a second guide pipe; oneend of the first guide pipe and one end of the second guide pipe are arranged in the heating tank body in a sealed mode, and the pump head is connected on the first guide pipe or the second guide pipein a pressing manner; the driving device is used for receiving preset time-varying signals and controlling the pump head to rotate in a positive direction within a first preset time period accordingto the preset time-varying signals including direction time-varying signals to enable medicine liquid to enter an inner cavity of a human body from the heating tank body through the first guide pipe;and the driving device is used for controlling the pump head to rotate in an opposite direction in a second preset time period according to the preset time-varying signals to enable the medicine liquid to enter the inner cavity of the human body from the heating tank body through the second guide pipe. The control system can realize full heating of cavity walls and organs, enables the medicine liquid to flush rear sides of the organs, enables an area which is not fully heated originally under a winding-column eddy current to be fully heated, and improves a treatment effect on a patient.

The invention discloses a drug for intrapleural hyperthermic perfusion therapy, and is used for solving the therapy problem of cancerous hydrothorax. The drug is characterized by being prepared from the medicinal raw materials including rhizoma arisaematis, folium eucalypti, denseflower bulbophyllum herb, mussel, fragrant sarcococca herb, periostracum cicada, motherwort fruit, sweet clover, kaempferiae, fruits of polygonum orientale and sargassum fusiforme. Clinical experiments prove that the drug disclosed by the invention has good curative effect and higher safety for treating cancerous hydrothorax; and therefore, the drug is worthy of being clinically applied and popularized.

The invention provides an intraperitoneal hyperthermic perfusion catheter fixing device for ovarian cancer treatment, which comprises a support fixed on the abdomen of a human body, a plurality of guide tubes are arranged on the support, hose joints are arranged at the first ends of the guide tubes, each group of hose joints is connected with a group of catheters, a group of self-sealing components are arranged at the second ends of each group of guide tubes, each self-sealing component comprises a tube body and a sealing plug, the first end of the tube body is communicated with the guide tubes, a sealing opening is formed in the second end of the tube body, and the sealing plug is detachably sealed in the sealing opening; an extension section communicated with the lower end of the sealing opening is further arranged in the tube body, a group of sealing plates are further hinged to the inner side of the tube body, tension springs are arranged between the sealing plates and the inner wall of the tube body, and the sealing plates are promoted to be attached to the lower end of the extension section through the tension springs; and according to the intraperitoneal hyperthermic perfusion catheter fixing device, a self-sealing effect can be conveniently formed on a pipeline of the catheter, and in the intraperitoneal hyperthermic perfusion process, the possibility of seepage of liquid in the intraperitoneal cavity is reduced.

The disclosure discloses an abdominal cavity hyperthermia perfusion chemotherapy treatment system which comprises an input subsystem and an output subsystem. The input subsystem comprises a medicine storage bag, a first input pump, an input catheter, a second input pump and an abdominal cavity perfusion end; the medicine storage bag is connected to the first input pump, the first input pump is connected to the abdominal cavity perfusion end through the input catheter, and one end of the second input pump is connected to the input catheter; the output subsystem comprises an abdominal cavity drainage end, an output catheter, an output pump, a purification unit and a collection bag; the abdominal cavity drainage end is connected to the output pump through the output pipe, the output pump is connected to the purification unit, the purification unit is used for purifying perfusate flowing out of the peritoneal cavity, a first output end of the purification unit is connected to the collection bag, and a second output end of the purification unit is connected to the other end of the second input pump.

The invention belongs to the field of medicine and relates to a pharmaceutical combined solution with an anti-tumor effect, a pharmaceutical combination compound containing the pharmaceutical combinedsolution or a combination drug. The pharmaceutical combined solution, the pharmaceutical combination compound or the combination drug contains deuterium oxide, is utilized with methods of perfusion lavage, hyperthermic perfusion lavage, intravenous injection, arterial intervention injection, intrathecal injection, intratumoral and peritumoral injection and the like, is applied to oncotherapy andconvenient to use and has few toxic and side effects.

The invention relates to a bladder hyperthermic perfusion device and a dustproof lifting mechanism thereof. The dustproof lifting mechanism comprises a lifting assembly, a dustproof assembly and a lifting platform; the lifting assembly comprises a driving source, a driving shaft and a lifting block, the dustproof assembly comprises a lifting base, a dustproof belt, an upper rolling shaft and a lower rolling shaft, the driving shaft can be driven by the driving source to move, and the lifting block rises or falls in the lifting direction to drive the lifting platform to rise or fall, so that aheating can carried on the lifting platform rises or falls. Since the lifting platform is fixed on a mounting part of a mounting base, the mounting part is exposed out of a shell through a sliding groove in the shell; since the other end of the dustproof belt bypasses the upper rolling shaft, penetrates through the lifting base, bypasses the lower rolling shaft and then is fixed on the lifting base, the dustproof belt can always abut against the inner side wall of the shell, and in the rising or falling process, the dustproof belt can always cover the sliding groove to effectively prevent debris or dust from entering the shell.

The invention discloses an anhydrous peritoneal puncture technology, and belongs to the technical field of anhydrous peritoneal puncture. Compared with continuous peritoneal hyperthermia perfusion chemotherapy, peritoneal hyperthermia retention perfusion cisplatin chemotherapy has the characteristics of good curative effect, simple method, easiness in operation, small toxic and side effects, few complications and no need of utilizing a complex and expensive special circulating hyperthermia perfusion therapeutic machine. The technology can further screen different drugs for chemotherapy to carry out peritoneal hyperthermia fluid retention perfusion, and is worthy of further research and popularization.

The invention discloses a hyperthermic intraperitoneal perfusion drainage tube capable of being sealed at both ends. The middle of a main tube is sleeved with a latex sleeve with a length of 10-15 cm, the upper end and the lower end of the latex sleeve respectively connected with the outer wall of the main tube to be a whole, the outer wall of the latex sleeve in the range corresponding to the latex sleeve is provided with a plurality of air outlets communicating with an inflatable chamber and open in the latex sleeve and a main tube interlayer. A plurality of restraining rings can sleeve the latex sleeve. Compared with the prior art, the positions and the number of the restraining rings can be adjusted as required; after inflation, an annular bag is formed on the inner side of the abdominal wall to prevent the drainage tube from dropping out; an annular bag can also be formed on the outer side of the abdominal wall, the two annular bags clamp the abdominal wall in between, not only is the drainage tube prevented from dropping out, but also the abdominal cavity is sealed from the two ends, so that the abdominal cavity is insulated from the outside, hyperthermic perfusion liquid leakage is avoided, and infection around the drainage tube is reduced. The distance between the two annular bags can be adjusted according to fatness of different people.

The invention discloses a novel animal perfusion method. The method comprises the following steps: preheating a perfusion system; preparing the perfusion system by starting circulating water baths ofall components provided with a water jacket before an operation, ensuring that pipelines are clean, and replacing the pipelines when necessary; limiting the speed of perfusion liquid; performing vascular catheter insertion operation; and arranging the perfusion system. A model provided by the invention is a very useful tool for researching pathological processes and drug delivery mechanisms, migration / metastasis of circulating tumor cells into tumors, and interaction between an immune system and perfusion organs and tissues; interference caused by metabolic tissues such as liver, kidney, spleen and the like on experiments can be effectively avoided; and moreover, the invention provides a brand-new research approach with smaller interference for drug research and development, so that drug and tumor researchers can more intuitively know the action modes and effects of drugs on tumor tissues.

The invention provides a temperature monitoring system and method for a hyperthermic perfusion system. The system comprises a data monitoring module, and a control module, wherein the data monitoringmodule is used to monitor whether the temperature of a perfusion liquid of the hyperthermic perfusion system is abnormal or not; and the control module is used to stop liquid perfusion when the temperature of the perfusion liquid is abnormal. The temperature monitoring system and method for the hyperthermic perfusion system provided by the invention has the advantages that a large amount of manualoperation which is originally required is changed into automatic monitoring, so that the treatment efficiency is greatly improved.

The extracorporeal circulation hyperthermic perfusion therapeutic apparatus comprises a base, a disinfection cabinet, a control panel, a temperature sensor, a first liquid pump and a spiral stirring column, a transparent liquid storage box is connected to the inner side of a heat preservation sleeve box in a clamped mode, and the temperature sensor and the first liquid pump are fixed to the two sides of the inner bottom of the transparent liquid storage box respectively; and a second liquid pump is fixed to one inner wall of the transparent liquid storage box, and the spiral stirring column penetrates through the top cover and is rotationally connected to the inner side of the sleeve. According to the extracorporeal circulation hyperthermic perfusion therapeutic apparatus, therapeutic liquid with a certain temperature enters the abdominal cavity of the human body through the first connecting pipeline and the liquid conveying pipeline in sequence and then flows back into the transparent liquid storage tank through the backflow pipeline and the second connecting pipeline in sequence, the therapeutic liquid circularly flows in the abdominal cavity of the human body, and therefore the therapeutic effect is better; the heat-insulating sleeve box can move up and down under the telescopic action of the electric telescopic column, so that the heights of the heat-insulating sleeve box and the disinfection cabinet can be conveniently adjusted according to requirements.

A position bed for hyperthermic perfusion chemotherapy, which effectively solves the problem of position change for cancer patients during hyperthermic perfusion chemotherapy; it includes a bed body, a bed board is arranged in the bed body, the bed board and the bed body are rotatably connected, and the two sides of the bed board are respectively extended There are drug injection pipes and drug return pipes. There are drug injection boxes and drug return boxes on both sides of the bed body. There is a circulation pump inside the bed. The drug injection pipe, drug injection box and circulation pump are connected to the bed through pipelines The medicine return pipe, the medicine return box and the circulation pump are connected to the inside of the bed plate through the pipeline, and the connection between the medicine injection pipe and the medicine injection box, the medicine return pipe and the medicine return box are all equipped with a reversing valve, and a driving device is also included. The driving device controls the reversing of the reversing valve and the rotation of the bed board on the bed body; the invention has an ingenious structure and is easy to use. After starting the device, automatic thermoperfusion chemotherapy can be realized without excessive participation of medical staff, reducing the burden on medical staff.

The invention relates to a hyperthermic perfusion chemotherapy apparatus based on the Bluetooth technology. In the apparatus, a puncture catheter comprises a catheter body and an inflation catheter, wherein a liquid outlet end of the catheter body is wrapped with an inflatable balloon, the inflatable balloon is in ventilation connection with the inflation catheter, the inflation catheter extends toward a liquid inlet end of the catheter body, and is connected with a medical air pump, the inflatable balloon is provided with a micro temperature sensor for detecting an intracavity temperature, and a Bluetooth temperature module is arranged at the free end of the catheter body. The invention provides the hyperthermic perfusion chemotherapy apparatus based on the Bluetooth technology. Accordingto the apparatus, a temperature in the body cavity can be measured in real time, the temperature data are reliable, no additional harm to a patient is caused, the body temperature in the body cavitycan be monitored and adjusted in real time, a compressed tissue near the liquid outlet end of the catheter body is pushed away after the inflatable balloon is inflated, the micro temperature sensor isarranged on the inflatable balloon, the micro temperature sensor is pushed away from the catheter body after the inflatable balloon is inflated, and thereby the interference of liquid heat in the catheter body to temperature measurement of the micro temperature sensor is eliminated.