The invention discloses a 105 DEG C low-smoke zero-halogen flame-retardant ethylene-propylene-diene monomer cable material and a preparation method thereof. The cable material is prepared from the following raw materials in parts by weight: 75-95 parts of ethylene-propylene-diene monomer, 30-40 parts of SG-4 type PVC resin, 10-15 parts of PBT resin, 1-2 parts of antiager DM, 1-2 parts of antiager RD, 2-3 parts of zinc oxide, 3-6 parts of titanium dioxide, 4-8 parts of microcrystalline wax, 10-15 parts of aluminium hydroxide, 5-10 parts of molybdenum trioxide, 8-12 parts of zinc borate, 1-2 parts of promoter TMTD, 2-3 parts of stearic acid, 15-20 parts of fumed silica, 10-15 parts of ultrafine powdered steatile, 10-15 parts of nanometer potter's clay, 1-2 parts of dehydroacetic acid, 5-10 parts of acetyl triethyl citrate, 4-8 parts of tributyl citrate, 2-3 parts of sulphur and 3-5 parts of a composite filler. The cable material of the invention is excellent in flame retardation effect, extremely less in smoke generating amount during combustion, none in generated toxic gas, none in generated corrosive gas, completely environment-friendly, good in high-temperature resistance, usable at 105 DEG C for a long time without deformation or scorch, capable of normally transmitting signals or electric energy, and durable.