140results about How to "Synthetic reaction conditions are mild" patented technology

The invention discloses a full chemical synthesis method for mangiferin aglycones. In a process of full chemical synthesis, the mangiferin aglycones are prepared from 3,4-methyl dihydroxybenzoate serving as an initiative raw material through six chemical reactions and steps. The synthetic process of the full chemical synthesis of the mangiferin aglycones has the advantages of short synthetic routes, mild condition of a synthetic reaction and high yield, and can be used for large-scale production.

The invention provides a formula and a preparation method of a cationic polymer. The raw material formula of the cationic polymer comprises the following components in part by weight: water 5-50, acetone 3-25, amine 5-30, aldehyde 5-40, alkaline regulator 3-12 and acidic regulator 5-20. In the method, a water soluble cationic polymer is prepared from aldehyde, acetone and amine by a nucleophilic addition reaction, an aldol condensation reaction and a Michael addition reaction in the presence of acid and alkali catalysts in turn and by a two-step feeding process. The method has the advantages that: the raw material cost is low, the synthesis process is simple and easy to implement; the preparation conditions are mild and safe; and the obtained product has high cation content and has high decolorizing and flocculating effects on anionic dye waste water.

The invention discloses a method for synthesizing an alpha-beta unsaturated acetyenic ketone compound through carbonylation. The method is to take iodo arene, a terminal acetylene compound and carbon monoxide as reactants and activated carbon loaded palladium as a catalyst, to control the reaction temperature to be between 80 and 140 DEG C and the pressure of the carbon monoxide to be between 0.5 and 3.0 MPa in the presence of a catalyst accelerator and a reaction solvent, and to react for 1 to 4 hours to obtain products. The method can realize separation of the catalyst and the products after the reaction is over, and can reuse the catalyst and maintain the activity of the catalyst unchanged; and the selectivity is more than 99 percent, and the conversion rate is more than 90 percent. The method has good industrial application prospect.

The invention discloses a method for synthesizing a quindoline derivative by visible light catalysis. The method uses metal salt to synthesize the quindoline derivative through photocatalysis. According to the invention, extra photosensitizer is not required, cheap transition metal salt and secondary amine enable in-situ coordination to generate a compound which is taken as a photocatalyst, oxygen in air is taken as a terminal oxidizing agent, so that oxidation coupling of secondary amine and an indole derivative can be realized through a photochemical method, and the quindoline derivative enables one-step synthesis. The whole synthesis reaction has the advantages of mild condition, high efficiency, simple operation and atom economy.

The invention discloses a preparation method for increasing the synthetic yield of 1,1,3-trichloroacetone, and belongs to the technical field of organic synthesis. The method comprises the steps that a load type amine catalyst is prepared, a certain amount of ultra pure acetone is added into a reactor, the load type amine catalyst is slowly added in a stirring state, after the load type amine catalyst and ultra pure acetone are fully mixed to be uniform, temperature is increased, the temperature inside the reactor is controlled to be at 25 DEG C to 30 DGE C, chlorine starts to be introduced into the reactor under the stirring condition, after chlorine introduction is finished, the reaction temperature is controlled to be constant, stirring and thermal reacting continue to be conducted for 2 h, and then 1,1,3-trichloroacetone is obtained. According to the preparation method, the load type amine catalyst is used, the contact area with reactant is increased, the selectivity of 1,1,3-trichloroacetone is improved, and the yield of 1,1,3-trichloroacetone is further increased. According to the load type amine catalyst, load in a covalent bond connection mode is firm, and the catalyst can be recycled multiple times.

The invention belongs to the field of a photoelectric material and specifically relates to an organic electroluminescence material. The structural formula of the material is as defined in the specification, wherein R is a C1-C20 alkoxy group. The organic electroluminescence material has high LUMO energy level and low HOMO energy level and is beneficial to blue shift of emission wavelength of the material. The material also has high phosphorescence quantum efficiency and good dissolving property and processability. The invention also provides a preparation method of the organic electroluminescence material and an application of the organic electroluminescence material in an organic electroluminescent device.

The invention belongs to the field of bio-medicinal materials, and discloses a tetraphenylethylene-labeled responsive quaternized polyvinyl alcohol, and a preparation method and an application thereof. The tetraphenylethylene-labeled responsive quaternized polyvinyl alcohol has a structural formula represented by formula (I). The preparation method comprises the following steps: dissolving PVA inan organic solvent, adding an activator CDI to activate the PVA, adding DEEDA, performing a reaction, and carryin gout impurity removal, precipitation, purification and drying to obtain PVA-DEEDA; anddissolving the PVA-DEEDA in the organic solvent, adding TPE-CH2Br, heating and reacting the obtained solution, precipitating the obtained solution, and purifying and drying the obtained precipitate to obtain PVA-TPE. The material disclosed in the invention simultaneously has temperature, pH response and AIE fluorescence property, and the prepared polymer belongs to a quaternary ammonium salt polymeric antibacterial agent, has a superior antibacterial property, is safe and nontoxic, has a stable antibacterial property, and can realize in-situ bacterium killing and imaging.

The invention discloses an amphiphilic polysaccharide derivative containing cholesterol and phytolectin group as well as a preparation method and application of the amphiphilic polysaccharide derivative. According to the invention, firstly, an amphiphilic polysaccharide derivative containing cholesterol and a phytolectin group is synthesized; and further an insulin-loaded amphiphilic polysaccharide derivative nanoparticle with glucose responsiveness is synthesized. The capability of combining free glucose molecules in the surrounding environment of the phytolectin group in the nanoparticle ishigher than that of combining glucose groups on polysaccharide chains, so that the chain segments of the amphiphilic polysaccharide derivative become loose, the size of the nanoparticles is increased,insulin is released, and intelligent regulation and control are realized. The preparation conditions of the amphiphilic polysaccharide derivative and the nanoparticle are mild, the used raw materialsare safe, and the activity of specific binding of phytolectin to glucose molecules and the structural stability and biological activity of insulin are maintained. The amphiphilic nanoparticle for intelligently regulating and controlling insulin release prepared by the invention is expected to be used as an insulin delivery carrier, and can intelligently regulate and control insulin release according to the change of the blood glucose level in the body of a diabetes patient, so that the amphiphilic nanoparticle has a certain application prospect in the aspect of diabetes treatment.

The invention discloses a synthesis method of a 3-(2-cyanovinyl)indole derivative. An indole derivative cheap, easy to obtain and having structural diversity is used as a raw material and performs continuous Friedel-Crafts reaction/elimination reaction with 3-dimethylamino acrylonitrile in the presence of acid, and the 3-(2-cyanovinyl)indole derivative is synthesized. Compared with a reported 3-(2-cyanovinyl)indole derivative synthesis method, the raw material is cheap, easy to obtain and low in toxicity, operation is easy and simple, the reaction conditions are mild, and the efficiency is high.

The invention discloses a method for preparing an aniline derivative through visible light catalysis of acyl migration. The method comprises the following step: (1) adding enamine and alcohol into an organic solvent to obtain a solution A; (2) adding a photosensitizer into the solution A to obtain a solution B; and (3) in an air or oxygen atmosphere, irradiating the solution B with visible light to obtain a 1,2-acyl migrated aniline derivative. An acyl functional group in a substrate undergoes a 1,2-migration reaction under visible light catalysis; acyl-substituted, ester-substituted, arylamino-substituted and alkyl-substituted quaternary carbon compounds are synthesized at one step through a photochemical method, the whole synthesis reaction is mild in condition, operation is easy, and atom economy is realized; oxygen in the air is converted into an oxygen-containing functional group; and LED (Light-Emitting Diode) blue light or green light is taken as a visible light source, and operation is easy.

The invention discloses a synthesis method of an indole derivative with wide bioactivity. The method includes: taking a simple pyrrole derivative and a beta-chloroketone derivative as the raw materials, using a palladium salt as the catalyst, adding an oxidant and an additive, and under an alkaline condition, carrying out Domino pyrrole alkenylation-Diels-Alder cycloaddition-dehydro-aromatization reaction to synthesize the indole derivative. Compared with the reported indole derivative synthesis method, the method provided by the invention has the advantages of easily available raw materials, simple operation, wide application range, and mild synthesis reaction conditions.

The invention provides a silane hybrid quaternary ammonium salt modified polyisocyanate curing agent and a preparation method thereof. The preparation method includes the steps that by mass, 1.0-3.0%of alkylol amine, 2.0-4.0% of silane coupling agent and 90-94% of polyisocyanate react under the protection of the nitrogen atmosphere at the temperature of 40-60 DEG C till the NCO content of the system reaches a theoretical value, 0.05-0.5% of polymerization inhibitor is added, and thus a silane hybrid polyisocyanate curing agent containing tertiary amine is prepared; and then 2.0-4.0% of sultone is added to react with the silane hybrid polyisocyanate curing agent containing tertiary amine until the sultone is completely consumed, and cooling and discharging are conducted. By adopting the sultone hydrophilic modifier with strong hydrophilicity, the prepared curing agent can be dispersed in water, is low in viscosity and environment-friendly, and has the characteristics of excellent scratch resistance, transparency, storage stability and the like.

The invention belongs to the field of photoelectric materials, and in particular relates to a blue ray organic electroluminescent material with the structural formula shown as P, wherein R is hydrogen atom or C1-C20 alkyl. The blue ray organic electroluminescent material has higher LUMO (lowest unoccupied molecular orbital) energy level and lower HOMO (highest occupied molecular orbital) energy level, is conducive to blue shift of material luminescent wavelength, and also has higher phosphorescence quantum efficiency and better dissolution properties and processing properties. The invention also provides a preparation method of the blue ray organic electroluminescent material and application of the blue ray organic electroluminescent material in organic electroluminescent devices.

The invention discloses a thieno[3,4-b]indole derivative and a synthesis method thereof. The preparation method comprises the following steps: by taking 4-alkylthio-4-((2-(phenyl ethynyl)aryl)amino)butyl-3-ene-2-one as a raw material, catalyzing a self-cyclization reaction of 4-alkylthio-4-((2-(phenyl ethynyl)aryl)amino)butyl-3-ene-2-one with an oxidizing agent by catalyzing with a cheap metal toconstruct the thieno[3,4-b] indole derivative in one step, wherein the obtained thieno[3,4-b] indole derivative is widely applied to the fields of photoelectric materials, medicines and the like. Themethod of the invention has characteristics of cheap metal catalysis, elemental sulfur oxidation, easily available raw materials, simple operation, high efficiency, wide substrate adaptability and diversified functional groups.

The invention belongs to the field of photoelectric materials, and in particular relates to a blue ray organic electroluminescent material with the structural formula shown as P, wherein R is hydrogen atom or C1-C20 alkyl. The blue ray organic electroluminescent material has higher LUMO (lowest unoccupied molecular orbital) energy level and lower HOMO (highest occupied molecular orbital) energy level, is conducive to blue shift of material luminescent wavelength, and also has higher phosphorescence quantum efficiency and better dissolution properties and processing properties. The invention also provides a preparation method of the blue ray organic electroluminescent material and application of the blue ray organic electroluminescent material in organic electroluminescent devices.

The invention discloses a pyrimidotriazole-indole compound having a general formula as shown in I (shown in the description). The invention also provides a preparation method and application of the above compound. An in vitro BRD4 enzymatic activity inhibition test proves that the pyrimidotriazole-indole compound has potential inhibition effects on various tumor cells by inhibiting the enzymatic activity of BRD4, and can be used as a lead compound for antitumor drug preparation. In addition, a preparation method of the compound, provided by the present invention, has the advantages of mild reaction conditions, simple operation and high yield.

The invention relates to a synthetic method of 2-mercaptobenzimidazole allyl sulfide. The synthetic method comprises the following steps: adding 1-2 parts by mass of 2-mercaptobenzimidazole and 3-5 parts by mass of organic solvent to a reaction kettle under the protection of nitrogen, and magnetically stirring till the 2-mercaptobenzimidazole is fully and uniformly dissolved; then adding 4-5 parts by mass of 26% potassium hydroxide solution to the reaction kettle, afterwards, rapidly adding 0.1-0.2 part of phase transfer catalyst, and magnetically stirring so as to uniformize the phase transfer catalyst; dropwise adding 1-3 parts of halogenated hydrocarbon, stirring and reacting for 3 hours at a room temperature; and filtering, drying, collecting a product, further recrystallizing and purifying by using acetone so as to obtain the product. The synthetic method has the advantages that synthetic reaction conditions are relatively mild, the yield of the 2-mercaptobenzimidazole alkene thio-propenyl ether obtained by a phase transfer method is relatively high, the technology is simple, excessive aftertreatment is not needed, and the follow-up testing of the experiment is easily satisfied.

The invention discloses a synthetic method of polysubstituted benzoic acid. Benzoic acid which is simple and easy to obtain and aziridine which is easy to prepare are used as raw materials, synthesisof polysubstituted benzoic acid is achieved in one step, and the obtained polysubstituted benzoic acid can be further converted into a functional product. The method has the advantages of easily available raw materials, simple operation, mild synthesis reaction conditions, high reaction efficiency, and diversity of functional groups.

The invention belongs to the field of photoelectric materials, and specifically relates to a blue light organic electroluminescent material. A structural formula (P) is shown in the description. In the formula, R represents alkoxy of C1-C20. The blue light organic electroluminescent material has a relatively high LUMO energy level and relatively low HOMO energy level, is beneficial to blue shift of luminescent wavelengths of the material. The blue light organic electroluminescent material also has relatively high fluorescence quantum efficiency, relatively good solubility and processability. The invention also provides a preparation method of the blue light organic electroluminescent material, and an application of the blue light organic electroluminescent material in an organic electroluminescent device.

The invention discloses a composite ion exchanger, which comprises a layered sulfide material containing a [Sn3S7]n<2n-> anion skeleton and a polymer, and a preparation method thereof. The method comprises the following steps: mixing a sulfide material containing a [Sn3S7]n<2n-> anion layered skeleton and a polymer, and heating to obtain a mixed solution; and adding the mixed solution into water in a dropwise manner, condensing into balls, cleaning, and drying to obtain the composite ion exchanger. The preparation method has the advantages of simplicity, easiness in operation, cheap and easilyavailable raw materials, low cost, good adsorption effect and the like. The composite ion exchanger has the advantages of rapid kinetic response, high adsorption capacity, high selectivity, wide pH activity range and easiness in elution when adsorbing Cs<+> and/or Sr<2+> ions, and has important significance for recovering high-radioactivity elements in a water environment and treating radioactivepollution.

The invention relates to the field of agricultural functional materials, and discloses a preparation method of a sunshade net with a self-cleaning function. The preparation method comprises the following steps: dissolving soluble zinc salt, sodium citrate, sodium acetate, soluble copper salt and silver nitrate in ethylene glycol to prepare a solution, adding a titanium source, keeping the temperature at 150-250 DEG C for 8-16 hours, cooling to the room temperature after the reaction is finished, separating out a solid product, washing, and calcining at 400-600 DEG C for 2-5 hours to obtain a composite titanium dioxide photocatalyst; wherein the molar ratio of the soluble zinc salt to the sodium citrate to the sodium acetate to the soluble copper salt to the silver nitrate to the titanium source is (10-20): (1-3): (25-40): (0.5-2): (0.5-2): (30-60); uniformly mixing polyethylene particles and the composite titanium dioxide photocatalyst according to a mass ratio of (100-200): 1, and adding the mixture into a wire drawing machine for wire drawing to obtain self-cleaning polymer fibers; and weaving the self-cleaning polymer fibers into the sunshade net with a self-cleaning function ina visible light area by a net weaving machine.

The invention discloses high-temperature-resistant polycarbonate and a preparation method thereof. According to the preparation method, a dihydric phenol monomer containing imide groups is synthesized by virtue of reaction between binary anhydride and aminophenol, and high-temperature-resistant polycarbonate is prepared from the dihydric phenol monomer containing the imide groups and diphenyl carbonate by virtue of melting ester exchange. The glass-transition temperature of high-temperature-resistant polycarbonate prepared by virtue of the preparation method exceeds 250 DEG C, meanwhile, and high-temperature-resistant polycarbonate has high transparency and is applicable to high-temperature-resistant transparent plastic components such as airplane plastic components, automobile lamps and high-temperature medical instruments.