1,2,3-Triazole derivative as well as synthesis and application thereof

Abstract

The invention discloses a 1,2,3-triazole derivative and a synthesis method thereof. S,N-Substituted internal olefin and aryl diazonium salt are used as initial raw materials, copper salt is used as acatalyst, and cyclization is performed in the presence of alkali and an oxidizing agent in an organic solvent to obtain 1,2,3-triazole derivative. By designing the substrate configuration, 1,2,3-triazole derivative with potential biological activity is simply and conveniently synthesized. The method has the advantages of accessible raw materials, wide substrate range, mild synthesis reaction conditions and high reaction product yield, is simple to operate, and has diversified functional groups.

Description

technical field [0001] The invention belongs to the technical field of chemical organic synthesis, and relates to a 1,2,3-triazole derivative and a synthesis method thereof. technical background [0002] 1,2,3-triazole compounds are an important class of heterocyclic compounds. Due to their unique chemical properties and biological activities, they have been widely used in many fields such as medicine, materials and biology. In medicinal chemistry, they have 1 , Compounds with 2,3-triazole skeleton structure exhibit various biological activities such as anti-virus, anti-cancer, anti-bacteria and anti-tuberculosis. At present, there are mainly three methods for the synthesis of 1,2,3-triazole compounds: 1) Transition metal-catalyzed 1,3-dipolar cycloaddition reaction of organic azides and alkynes (Angew. Chem. Int. Ed.2002,41,2596); 2) 1,3-dipolar cycloaddition reaction of organic azides and ketones catalyzed by small organic molecules (Angew.Chem.Int.Ed.2014,53,10420);3 ) ...

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Problems solved by technology

However, the synthesis of 1,2,3-triazole compounds by cyclization of S,N-substituted internal alkenes with aryl diazonium salts has not been reported yet.

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