572 results about "Elimination reaction" patented technology

The present invention relates to the preparation of hyperstable Y-type RE molecular sieve for the catalytic cracking of heavy oil and containnig vanadium resisting component. The preparation uses NaY-type molecular sieve as main material and chemical aluminum-eliminating complex containing oxalic acid and/or oxalate and its mixture and through introducing RE ion in the late stage of chemical aluminum elimination reaction to from RE precipitate and hydrothermal treatment to realize hyperstabilizing and introduce RE ion and independent phase Re oxide. The formed precipitate RE precursor includes RE oxalate. Compared with conventional REY, REHY and REUSY, the molecular sieve preparing process is simple and high in RE utilization, and has homogeneously distributed aluminum, more secondary pores high hydrothermal stability, high activity and high vanadium contamination resisting capacity.

A method for making an object, wherein the object comprises a material including a functional group and a metal compound or acid that causes an elimination reaction on irradiation with a laser, to form a reaction product of contrasting colour, comprises directing a laser beam on to the areas of the object to be marked. For example, by using a carbohydrate and a metal salt, effective marking can be achieved on the coating of a pill or other edible material.

The invention relates to the field of polypeptides, in particular to a method for preparing semaglutide. The method has the advantages that Fmoc-Lys (Alloc)-OH protection amino acid is used as a raw material, de-protection is carried out by the aid of selected Pd (PPh3) 4, accordingly, operation procedures are simple, only 1-2 times of simple elimination reaction operation are required, each elimination reaction operation is carried out for 10-30 min, side reaction is prevented, the operation procedures are safe, and enlarged production can be facilitated; Boc-His (Boc)-OH. DCHA and Boc-His (Trt)-OH are used as raw materials in the procedures, and accordingly His racemization risks can be reduced to the greatest extent; special fragments are coupled, and accordingly the synthesis efficiency can be improved.

A method for marking an object, wherein the object comprises a material including a functional group and a metal compound or acid that causes an elimination reaction on irradiation with a laser, to form a reaction product of contrasting colour, comprises directing a laser beam on to the areas of the object to be marked. For example, by using a carbohydrate and a metal salt, effective marking can be achieved on the coating of a pill or other edible material.

The invention provides a method to prepare a compound method, including the steps: ethylbenzene and capryl chloride make Friedel-Crafts reaction to generate p-capryl chloroethylbenzene; convert capryl chloroethylbenzene under the action of sodium iodide into p-capryl iodoethylbenzene; p-capryl iodoethylbenzene and acetylamino diethyl malonate condense under the action of alkali to generate 2-(p-capryl phenethyl)-2-acetylamino diethyl malonate; or p-capryl iodoethylbenzene makes elimination reaction under the action of alkali to generate p-capryl styrene, which together with acetylamino diethyl malonate condenses under the action of alkali into 2-(p-capryl phenethyl)-2- acetylamino diethyl malonate; a compound is reduced into 2-[4-(1-hydroxyoctyl) phenethyl-]2- acetylamino propylene alcohol; the other coumpound makes hydrogenolysis to obtain 2-(p-octyl phenethyl)-acetylamino propylene alcohol; make alkali hydrolyzation and then acidifies them into salt, so as to obtain it. It also provides a method to prepare intermediate in the above preparing course.

The invention discloses a preparation method of 16alpha-hydroxyprednisolone, which comprises the following steps: by using a compound I prednisone acetate as an initial raw material, carrying out esterification reaction, reduction reaction, elimination reaction, oxidation reaction and hydrolysis reaction to obtain the end product VI 11beta,16alpha,17alpha,21-tetrahydroxyprogsteroid-1,4-diene-3,20-dione, i.e. 16alpha-hydroxyprednisolone. By using the cheaper initial raw material, the method has the advantages of shorter reaction steps, feasible reaction steps, higher yield and higher economy and safety for production, and is more suitable for industrial production. The method avoids using the traditional virulent product for bis-hydroxy oxidation, enhances the reaction safety and operability, simplifies the multiple protection and deprotection operation steps, greatly shortens the synthesis route, lowers the production cost, basically prevents the three-site carbonyl groups from being simultaneously reduced in the reduction process, greatly reduces the side reactions, and enhances the yield and quality of the reduction reaction.

A method for marking an object, wherein the object comprises a material including a functional group and a metal compound or acid that causes an elimination reaction on irradiation with a laser, to form a reaction product of contrasting colour, comprises directing a laser beam on to the areas of the object to be marked For example, by using a carbohydrate and a metal salt, effective marking can be achieved on the coating of a pill or other edible material.

The invention relates to a preparation method of a steroid hormone medicinal intermediate, in particular to a preparation method for a betamethasone intermediate or its analogue. The betamethasone intermediate or its analogue is prepared from a compound I by means of elimination reaction, methylation reaction, cyano-group substitution reaction, siloxy protective reaction, intramolecular nucleophilic substitution reaction and esterification reaction. The method provided by the invention has the characteristics of cheap raw materials, and high and stable yield. The reaction route is as the following, wherein R1 is Cl or Br, and R is H or hydrocarbonyl of C1-C10.

The invention discloses a method for synthesizing vinylene carbonate, and the method mainly comprises the following steps: (1) chlorine gas is introduced into the raw material of ethylene carbonate in ultraviolet light condition, thus synthesizing chlor-ethylene carbonate; (2) taking mixture of ester, ether and hydrocarbon as the organic solvent, the chlor-ethylene carbonate which is obtained in the step (1) produces elimination reaction with triethylamine, thus eliminating hydrogen chloride and generating the vinylene carbonate; and (3) the mixed product obtained in the step (2) is distilled and purified after filtration. By adopting the mixed solvent of ester, ether and hydrocarbon, the reaction product is easily isolated from triethylamine hydrochloride, thus increasing the yield and the production efficiency; and BHT can be used as a polymerization inhibitor in the reaction process, thus controlling the polymerization of the vinylene carbonate effectively and increasing the yield.

A production process for alpha-olefins making use of elimination reaction of a primary alcohol or an ether is characterized by use of an alumina catalyst in the presence of an amine. The production process for alpha-olefins according to the present invention can yield an alpha-olefin at a high proportion with respect to the entire olefin products and can maintain the reactivity of the catalyst and selectivity of the products for a prolonged time. In the process, unreacted material and ether intermediate byproduct produced in the process can be used in the reaction with the same catalyst. This allows industrially and environmentally favorable production process of alpha-olefins.

The invention discloses a fluoradene derivative and a preparation method thereof. The preparation method comprises the following steps of: introducing fluoradene rings into compounds, namely carbazole, hexyl carbazole, triphenylamine and hexyl triindole; and catalyzing intramolecular carbon-hydrogen bond activation and hydrogen halide elimination reaction through palladium and efficiently constructing a carbon ring or a heterocyclic compound, particularly constructing the carbon ring with a novel structure. The invention aims to synthesize and characterize a fluoradene structural unit-containing large-tension cyclic compound; and the novel fluoradene structural unit-containing compound is expected to be used in the field of organic photoelectric materials.

The present invention is directed to the use of alkyl (meth)acrylate polymers or copolymers of the formula (I)

In-Poly-(E)_y  (I)

as cold flow improvers in biodiesel fuel (or bio-fuel) and biodiesel compositions incorporating said polymers or copolymers, obtained by nitroxyl mediated controlled free radical polymerization,

• wherein
• In is the initiator fragment starting the polymerization reaction;
• E is an end group bearing at least one stable free nitroxyl radical, which is bound via an oxygen atom to the polymer or copolymer; or a group which results from a substitution or elimination reaction of the attached stable free nitroxyl radical;

Poly is any polymer or copolymer formed from ethylenically unsaturated monomer(s); and

• y is a number 1 or greater than 1 indicating the average number of end groups E attached to Poly.

Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.

The invention relates to a preparation method of vinylene carbonate. In the preparation method, monochloroethylene carbonate directly contacts with excessive triethylamine in the protection of inert gas for reaction, and no solvent is involved. In the preparation method of the present invention, triethylamine has two functions: the first one is that triethylamine is used as a dehydrochlorination reagent to participate in elimination reaction; the second one is that triethylamine is used as a solvent of dehydrochlorination reaction. The vinylene carbonate prepared by the preparation method of the invention has a yield of up to 93%, is easy to separate and purify, and has purity of up to more than 99%. The preparation method of the invention does not involve any other reaction solvent, and realizes full contact reaction of monochloroethylene carbonate with triethylamine; therefore, compared with traditional method, the preparation method of the invention is high in reaction speed, high in product yield, and suitable for large-scale industrial production. The vinylene carbonate prepared by the preparation method of the invention is applicable to various fields.

The invention discloses a preparation method of triamcinolone acetonide. A compound I prednisone acetate which is taken as a starting material is subjected to a primary elimination reaction, an oxidation reaction, a condensation reaction, a reduction reaction, a secondary elimination reaction, a hydrolysis reaction, an epoxidation reaction and a fluorination reaction, so that an end-product IX, 9-fluoro-11beta, 21-dihydroxyl-16a,17-[(1-methyl ethylidene) bi(oxo)]-pregnen steroid-1,4-diene-3, 20-diketone, namely triamcinolone acetonide, is obtained. The preparation method of the triamcinolone acetonide has the advantages that a relatively cheap starting raw material is adopted, each reaction step can be relatively easily realized, and yield is relatively high, so that production is more economic and safer, and the triamcinolone acetonide is more applicable to industrial production; a multi-step protection and deprotection operation is simplified, a synthetic route is greatly shortened, and production cost is reduced; possibility that a three-position carbonyl group is reduced in a reduction process is almost zero, so that side effects are greatly reduced, and yield and quality of the reduction reaction are improved.

The present invention discloses a gas-solid radial reactor of moving bed for chemical industry and petroleum processing industry, and is characterized by that the lower portion of inner not of said reactor is equipped with a skirt, and the external surface of said skirt is inclined from top to bottom along the direction from inner net toward outer net, its upper edge is connected with inner net, and its lower edge is connected with internal surface of closure head of the bottom, and the radial position of the lower edge is positioned in internal side of radial position of catalyst outlet pipe, and the external surface of said skirt is generally made into circular truncated cone side face or frustum side face. Said invention can effectively reduce or eliminate flow dead zone of catalyst inthe reactor, at the same time the structure of said skirt is simple, and easy to implement. It is specially applicable to hydrocarbon conversion reaction and catforming reaction.

The invention discloses a near-infrared photo-thermal dye based on aza-fluoro borane, preparation and application. The photo-thermal dye comprises an electron-donating group containing lone pair electrons and a basic aza-fluoro borane skeleton. The near-infrared photo-thermal dye based on aza-fluoro borane is prepared through steps as follows: (1), ketene synthesis: ketene is prepared from aldehyde ketone by an addition-elimination reaction under the alkaline condition; (2), an addition reaction of ketene and nitromethane; (3), a cyclization reaction; (4), a coordination reaction: a product obtained in the step (3) coordinates with boron difluoride, and a target product is obtained. The photo-thermal dye can be applied to the technical fields of photodynamic therapy and photo-thermal therapy under the guidance of photo-thermal imaging and photo-acoustic imaging, bio-marker and detection and the like.

The invention provides a method for continuously preparing vinylene carbonate by a tubular reactor. The method includes using chlorosulfuric acid and ethylene carbonate as raw materials to be synthesized into chloroethylene carbonate in the tubular reactor under the action of initiator, rectifying the chloroethylene carbonate and subjecting the rectified chloroethylene carbonate to elimination reaction with trimethylamine in the tubular reactor with existence of organic solvent and generating the vinylene carbonate. By the method for continuously preparing vinylene carbonate by the tubular reactor, existing intermittent production methods are changed, reaction speed is greatly increased, reaction period is reduced, yield is increased and productivity can be effectively improved.

Process for preparing nitriles by reacting N-alkylcarboxamides (RCO—NHR¹) or ammonium salts of carboxylic acids (RCOO—NH₃R¹⁺) or carboxylic acids in the presence of alkylamines or ammonium salts (RCOOH+NH²R¹, RCOOH+NH₃R¹⁺), respectively, R being an arbitrarily substituted linear or branched C₁-C₁₂-alkyl radical, a C₃-C₁₂ cycloalkyl radical or an alkenyl, alkynyl or aryl or heteroaryl radical and R¹ being an arbitrary substituted, linear or branched C₂-C₁ alkyl radical, a C₃-C₁₂ cycloalkyl radical or an alkenyl or alkynyl radical, with phosphonic anhydrides in the presence of an optional base in an organic solvent at a temperature in the range from −30 to 180° C. In advantageous embodiments, the phosphonic anhydride is a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide of the formula (I)

The invention belongs to the technical field of organic synthesis. The synthesis method firstly provided by the invention takes benzyl-4-oxopiperidine as a starting material, and the starting materialis subjected to Grignard reaction, elimination reaction, hydrogenation reduction reaction and chiral resolution in sequence to successfully obtain a target product (R)-3-phenylpiperidine or/ and (S)-3-phenylpiperidine. The synthesis method sencondly provided by the invention takes the same starting raw material for Grignard reaction, organic silicon reagent is used for removing a hydroxide radical, and benzyl is removed by catalytic hydrogenation reaction; finally, the chiral resolution is carried out to obtain a target product. The (S)-3-phenylpiperidine can be synthesized according to the synthesis method. (S)-3-p-aminosalicylic phenylpiperidine can be synthesized according to the third aspect; or according to the fourth aspect, (S)-3-p-bromophenyl piperidine is synthesized to serve asthe key intermediate for preparing the niraparib. According to the synthesis method for (R)-3-phenylpiperidine or/ and (S)-3-phenylpiperidine and the synthesis method for chiral intermediate of niraparib, production cost is obviously lowered, and the synthesis methods are favorable for the large-scale industrial production of a niraparib medicine.

The invention discloses a preparation method of apixaban.The method comprises the steps that paranitroaniline serves as the raw material, paranitroaniline and delta-valerolactone are subjected to amidation ring-opening, substituting and ring-closing reactions under the action of AlMe3, and a compound 8 is obtained; the compound 8 is subjected to alpha-position dichloro substituting and condensation-elimination reactions, and a compound 7 is obtained; the compound 7 and a compound 6 are subjected to [3+2] cyclization-elimination and nitro reduction, and a compound 4 is obtained; the compound 4 sequentially reacts with delta-valerolactone and ammonium chloride under the action of AlMe3, and a compound 3 is obtained; the compound 3 is subjected to substituting and ring closing, and apixaban is obtained.According to the preparation method of apixaban, paranitroaniline and delta-valerolactone which are low in price are adopted to serve as the raw materials, operation of the whole route is simple, conditions of each reaction are mild, and the synthesizing method is easy to operate, high in yield and purity and suitable for industrial production.