21 results about "P-Nitroaniline" patented technology

The invention relates to an atestin diterpenoid compound as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The preparation method of the atestin diterpenoid compound comprises the following steps: S1, taking commercially available paranitroaniline 1a as a raw material to obtain an intermediate 2a; carrying out amide condensation and reduction on the intermediate 2a and corresponding amine to obtain intermediates 4a-4c; s2, taking commercially available m-nitrophenol 1d as a raw material to obtain an intermediate 3d; s3, taking commercially available 1-(t-butyloxycarbonyl) piperidine-3-carboxylic acid 1e as a raw material to obtain an intermediate 3e; s4, taking a compound J10 separated from a natural plant sea lacquer as a raw material to obtain compounds HXY1-6; and S5, taking a compound J12 separated from a natural plant sea lacquer as a raw material to obtain compounds HXY7-23. The invention aims to explore a preferable compound with a novel structure, better activity and high safety through structural optimization of a natural product, and provides support for research and development of a novel sEH inhibitor and an anti-AD drug.

The present application relates to the technical field of medicine, and provides a potency calibration method of haena polysaccharide.The present application adopts p-nitroaniline colorimetric method to test the haena polysaccharide activity curve, wherein the abscissa of the haena polysaccharide activity curve is the reciprocal of the weight of haena polysaccharide, and the ordinate is the logarithm of the residual activity unit of FVIII; the weight of haena polysaccharide for inhibiting the iFXase (endogenous factor X enzyme) activity of 1 IU FVIII is taken as 1 potency unit, and the potency of haena polysaccharide is obtained according to the haena polysaccharide activity curve.The potency calibration method provided by the present application can accurately calibrate the anticoagulant activity intensity of haena polysaccharide, and has important significance in aspects of guaranteeing drug efficacy, drug safety and quality control.

The invention provides a preparation method of 2-chloro-4-nitro-6-bromoaniline and a diazonium salt of the 2-chloro-4-nitro-6-bromoaniline. The preparation method of 2-chloro-4-nitro-6-bromoaniline comprises the following steps: a chlorination step: carrying out a chlorination reaction on paranitroaniline to obtain a chlorination reaction product, and carrying out post-treatment on the chlorination reaction product to obtain a 2-chloro-4-nitroaniline product; wherein the water content of the 2-chloro-4-nitroaniline product is 60% or below; and a bromination step: mixing the 2-chloro-4-nitroaniline product with sulfuric acid to obtain a sulfuric acid slurry, and carrying out a bromination reaction on the sulfuric acid slurry and a brominating agent to obtain a 2-chloro-4-nitro-6-bromoaniline reaction solution. The 2-chloro-4-nitroaniline is prepared by taking paranitroaniline as an initial raw material through chlorination reaction and post-treatment, and then the sulfuric acid is taken as a solvent to penetrate through the subsequent reaction, so that the separation process is simplified, the production cost is reduced, and waste and pollution are reduced.

The present application relates to papermaking technical field, especially to a kind of anti-myopia yellow light absorption dye preparation method and myopia protection paper.The present application discloses a kind of anti-myopia yellow light absorption dye preparation method, dye preparation is diazotized to p-nitroaniline, coupled with 2-(2-hydroxy-5-sulfonic acid group phenyl) benzotriazole, salting-out, then with zinc sulfate, sodium sulfide complex azo dye-zinc sulfide complex is obtained.The protection paper is made by 3D printing texture forming and multiple composite function layer, mixed dye, 3D printing net form paper is made of pulp;Coated with bottom layer composite fluid, spray nano-silicon dioxide to obtain first-stage processing paper;Pretreatment dye coating, crosslinking to obtain secondary processing paper;Hot-pressing copolymerization fiber membrane and fumigation are obtained.The paper can prevent myopia, and is suitable for writing and printing.

The utility model discloses a feeding device for paranitroaniline production. The feeding device comprises a mixing tank body, when p-nitroaniline production feeding is carried out and a feeding cover on the left side needs to be opened, a pressing block is pressed towards the inner side, the pressing block drives a connecting plate and a sliding block to move towards the inner side along a sliding rail, the connecting plate drives a moving column to move towards the inner side, the moving column drives an inserting column to move towards the inner side, and the inserting column moves towards the inner side to extrude a reset spring; when an inserting column moves towards the inner side to an inserting hole to lose contact, a handle is held to pull up the feeding cover on the left side to open the feeding cover, after materials needing to be added are poured into the feeding box, a driving motor is started to drive a spiral conveying blade to rotate to convey the materials into the mixing tank body, and then paranitroaniline can be produced and processed; therefore, the charging device has the advantage of facilitating charging for paranitroaniline production, charging for paranitroaniline production can be automatically carried out, the blockage condition is avoided, and the paranitroaniline production time is shortened.

The invention discloses a method for synthesizing N, N '-dialkyl p-phenylenediamine as shown in a formula (I) or a mixture thereof and an anti-aging agent mixture produced by adopting the method. Comprising the following steps: adding a raw material A selected from paranitroaniline and p-phenylenediamine, a raw material B selected from a compound as shown in a formula (II), a compound as shown in a formula (III) and cyclohexanone, and a catalyst into a reaction device, and carrying out hydrogenation reaction under a hydrogen condition to obtain N, N '-dialkyl p-phenylenediamine as shown in a formula (I) or a mixture thereof, wherein the raw material A and the raw material B are fed in a liquid form; in the formula (I), the formula (II) and the formula (III), R1, R2, R3 and R4 are respectively and independently H or C1-C6 alkyl, or-CHR1R2 and-CHR3R4 are independently cyclohexyl. According to the method disclosed by the invention, high-selectivity and low-cost production of the N, N '-dialkyl p-phenylenediamine can be realized, and the reaction conditions are milder and more controllable. (I) (II) (III)

The utility model relates to the field of nitroaniline, and discloses a drying machine for paranitroaniline production, which comprises a frame, a placing box is fixedly mounted at the top of the frame, a connecting box is fixedly mounted on the left side of the placing box, and a heating box is fixedly mounted on the left side of the connecting box. A heating assembly for heating nitroaniline is arranged in the heating box, and a rotating assembly for stirring nitroaniline is arranged in the placing box. Through mutual cooperation of the electric heating wire, the conveying pipe and the fan, when nitroaniline is placed in the placing box, the electric heating wire can be electrified, when the electric heating wire reaches enough temperature, the fan can be started at the moment, the fan can extract outside air into the heating box, and the nitroaniline can be heated in the heating box. And then hot air in the heating box can enter a conveying pipe, the conveying pipe conveys heat of the hot air into the containing box, and therefore nitroaniline in the containing box can be dried.

The invention relates to the technical field of synthesis of organic compounds, and particularly discloses a synthesis process of paranitroaniline. The synthesis process comprises the following steps: (1) preparing strong ammonia water with the concentration of 38-42% by using an ammonia water preparation unit; (2) adding p-nitrochlorobenzene, stronger ammonia water and an auxiliary agent into the reaction kettle, and then carrying out heat preservation reaction for 14-16 hours under the conditions that the temperature is 150-170 DEG C and the pressure is 5.6-6.2 MPa; the auxiliary agent comprises modified cyclodextrin and trehalose; and (3) transferring the material in the reaction kettle into a water washing kettle after pressure relief, carrying out water washing stirring for 1-2 hours, and carrying out centrifugal separation on the material liquid after water washing to obtain p-nitroaniline. According to the synthesis process disclosed by the invention, the problem of balance between main reaction efficiency and side reaction inhibition is solved from a reaction mechanism level through compounding and synergy of the modified cyclodextrin and the trehalose, and finally, high yield and high purity in the paranitroaniline synthesis process are synchronously achieved.

The application discloses N-o-tolyl-N'-(1-methyl-2-benzyl) ethyl p-phenylenediamine and a preparation method and application thereof. The product is prepared from p-chloronitrobenzene and 2-methylaniline through a nucleophilic substitution reaction to obtain N-o-tolyl p-nitroaniline, and then the N-o-tolyl p-nitroaniline and benzylacetone are subjected to a catalytic reduction reaction under high temperature and high pressure conditions to obtain the final product. The product has excellent ozone protection effect and anti-crack performance, and can obviously improve the red discoloration phenomenon of the tire side caused by the migration of the antioxidant.

The utility model discloses a blanking structure for paranitroaniline processing, which comprises a placing plate, the top of the placing plate is fixedly connected with a support frame, the top of the support frame is fixedly connected with a circular plate, the top of the circular plate is fixedly connected with a stock bin, the left side of the placing plate is fixedly connected with a reinforcing frame, and the top of the placing plate is provided with a stirring mechanism. A discharging mechanism is arranged on the left side of the containing plate. By using the stirring mechanism, nitroaniline in the stock bin can be stirred and scattered, by using the discharging mechanism, discharged nitroaniline can be more uniform, and the problem that when nitroaniline is discharged, due to the fact that the nitroaniline has high hygroscopicity, moisture in air can be easily absorbed, and the nitroaniline cannot be uniformly discharged is solved. The problems that the physical state of materials is changed, the caking phenomenon often occurs, the uniformity of discharging is seriously disturbed, and the proportioning accuracy of nitroaniline and other raw materials is badly affected due to non-uniform discharging are solved, and the discharging device has the advantage of being convenient to discharge.

This invention relates to the field of catalytic hydrogenation technology, and provides a fixed-bed continuous catalytic hydrogenation system for preparing p-phenylenediamine. The method includes: Step A, p-nitroaniline and solvent are mixed in a material mixing device in advance according to a certain proportion to obtain a p-nitroaniline solution, and then the p-nitroaniline solution and hydrogen are preheated separately in preheaters; Step B, the preheated reaction material is mixed in a gas-liquid mixer and then enters a fixed-bed reactor pre-loaded with a multilayer catalyst, where a catalytic hydrogenation reaction occurs to generate the product material; Step C, the product material is separated by a gas-liquid separator to obtain p-phenylenediamine solution and hydrogen gas, the p-phenylenediamine solution is post-treated to obtain p-phenylenediamine, and the solvent is recovered and reused. This invention effectively overcomes the pain point of the existing batch catalytic hydrogenation process, which has a single-batch reaction time of 4-14 hours, and achieves a significant reduction in the reaction time of continuous catalytic hydrogenation; it can also effectively ensure product selectivity, easy product separation, good safety, significantly reduced cost, and easy industrial application.

The application relates to the technical field of organic compound synthesis, and particularly discloses a synthesis process of p-nitroaniline. The synthesis process of p-nitroaniline comprises the following steps: (1) preparing concentrated ammonia water with a concentration of 38%-42% by using an ammonia water preparation unit; (2) adding p-nitrochlorobenzene, concentrated ammonia water and an additive into a reaction kettle, and then carrying out heat preservation reaction under the condition of 150-170 DEG C and 5.6-6.2 MPa for 14-16 h; the additive comprises modified cyclodextrin and trehalose; (3) after pressure relief, the materials in the reaction kettle are transferred into a water washing kettle to carry out water washing and stirring for 1-2 h, and the material liquid after water washing is subjected to centrifugal separation to obtain p-nitroaniline. According to the synthesis process, the modified cyclodextrin and the trehalose are compounded and synergized, the balance problem of the main reaction efficiency and the side reaction inhibition is solved from the reaction mechanism level, and finally the high yield and the high purity in the synthesis process of p-nitroaniline are simultaneously achieved.

A method for purifying p-nitroaniline and application thereof, comprising the following steps: (1) dissolving: adding p-nitroaniline into an oxygen-containing polar solvent, and stirring until completely dissolved; (2) filtering: adding a filter aid into the above solution, and filtering, wherein the filter cake is tar impurities in the p-nitroaniline and the filter aid, and the filtrate is the purified p-nitroaniline solution; (3) post-treatment: adding water to the purified p-nitroaniline solution to perform rectification, wherein the solvent is collected at the top of the column, and is recycled and reused; the suspension of water and p-nitroaniline is collected at the bottom of the column, and is filtered, wherein the filter cake is the purified p-nitroaniline, and the filtrate is water, which is recycled and reused. The p-nitroaniline treated by the method has a bright yellow appearance, a small odor and no pungent smell, and can be directly used for catalytic hydrogenation reaction, especially the reaction of a noble metal catalyst, so that the catalyst can be continuously recycled, and the product quality meets the standards.

The invention discloses a multichannel fluorescent probe compound based on pyrone functionalization. The compound is synthesized through the steps of diazotization, cyclization, condensation and the like of raw materials such as paranitroaniline, furaldehyde, 2-hydroxy-1-naphthaldehyde and the like. Q3 has high selective recognition capability on Cu, and in a DMSO / HEPES buffer solution, Cu can enable fluorescence of a probe solution to be quenched, ultraviolet absorption to be subjected to red shift and the color to be changed from light green to yellow, so that fluorescence and naked eye detection are realized; the formed Q3-Cu complex can specifically recognize CN, so that fluorescence recovery, ultraviolet absorption blue shift and turning of color back to light green are caused, and Cu and CN can be continuously detected. The probe can be used for Cu / CN fluorescence imaging in living cells, detection of Cu residues in traditional Chinese medicinal materials and preparation of Cu / CN detection test paper, and has the characteristics of high sensitivity, strong anti-interference performance, quick response and the like.

The present application relates to the technical field of organic synthesis, in particular to a preparation method of N-(4-nitrophenyl)-4-nitrobenzamide, which comprises the following steps: S1, dissolving p-nitrobenzoyl chloride in an inert compound solvent under the condition of inert gas; the inert compound solvent comprises an aprotic main solvent and a weak polar cosolvent; S2, controlling the temperature and slowly adding part of p-nitroaniline in the system of step S1 to form a seed reaction liquid after mixing; S3, slowly adding the remaining part of p-nitroaniline in the seed reaction liquid of step S2 and heating and incubating for reaction; S4, after the reaction is completed, N-(4-nitrophenyl)-4-nitrobenzamide is obtained through post-treatment. In the preparation process, no additional catalyst is needed, the side reaction can be effectively inhibited, the safety and stability of the production process are ensured, the product yield and purity are significantly improved, and the method is more suitable for industrial application.

The utility model relates to the technical field of nitroaniline, and discloses a continuous amination reaction device of p-nitroaniline, which comprises a reaction kettle, a motor is arranged on the side wall of the reaction kettle, a rotating shaft is rotatably connected in the reaction kettle, the output end of the motor is connected with the rotating shaft, a cleaning assembly is arranged in the reaction kettle, and the cleaning assembly is connected with the rotating shaft. A first stirring blade is fixedly connected to the side wall of the rotating shaft, a second stirring blade is fixedly connected to the side wall of the rotating shaft, and a filtering assembly is arranged on the side wall of the reaction kettle; the cleaning assembly comprises a connecting frame. According to the reaction kettle, water is pumped from the water tank to the connecting pipe and the conveying pipe through the fixed pipe by starting the water pump and is sprayed out through the spray head, and meanwhile, the motor is started to drive the rotating shaft, so that the connecting frame and the cleaning brush on the side wall of the connecting frame clean the inner wall of the reaction kettle under the cooperation of the telescopic rod and the spring, and the stirring blade I and the stirring blade II are also cleaned in water when the rotating shaft rotates; the problems that the cleaning mode is single and comprehensive cleaning is difficult are solved.

The invention relates to the technical field of chemical production and discloses a preparation device and process applied to paranitroaniline production, the preparation device applied to paranitroaniline production comprises a base, a shell assembly and an inner container assembly, the shell assembly and the inner container assembly are fixedly installed at the top of the base, and the inner container assembly is arranged in the shell assembly; the inner container assembly comprises a corrosion-resistant inner container fixedly installed at the top of the base, the inner wall of the corrosion-resistant inner container is rotationally connected with a stirring shaft, a heat transfer mechanism is arranged in the corrosion-resistant inner container, and through the arranged extension assembly, the stirring shaft is rotated anticlockwise at the moment when heat is released violently in the initial stage of the reaction, and the heat transfer mechanism is arranged in the corrosion-resistant inner container; the stirring shaft drives the driving frame to rotate through the connecting rod, and the driving frame drives the extension bag to unfold and pulls the fixing frame; after the extension bag is unfolded, the heat dissipation area is obviously enlarged, a large amount of heat generated by reaction can be effectively dissipated, local overheating is avoided, and the product quality and the production safety are guaranteed.

This invention relates to the field of chemical production technology and discloses a preparation apparatus and process for the production of p-nitroaniline. The preparation apparatus includes a base, an outer shell assembly and an inner liner assembly fixedly mounted on top of the base. The inner liner assembly is disposed inside the outer shell assembly and includes a corrosion-resistant inner liner fixedly mounted on top of the base. A stirring shaft is rotatably connected to the inner wall of the corrosion-resistant inner liner. A heat transfer mechanism is provided inside the corrosion-resistant inner liner. Through an extension component, during the initial stage of the reaction, when the reaction is intensely exothermic, rotating the stirring shaft counterclockwise causes the stirring shaft to drive a drive frame to rotate via a connecting rod. The drive frame then causes the extension liner to expand and pull the fixed frame. After the extension liner expands, the heat dissipation area significantly increases, effectively dissipating the large amount of heat generated by the reaction, avoiding localized overheating, and ensuring product quality and production safety.

The invention provides synthesis of a coumarin fluorescent probe and a method for detecting paranitroaniline by the coumarin fluorescent probe, and belongs to the field of fluorescent molecular probes, the synthesis method of the coumarin fluorescent probe comprises the following steps: weighing 7-amino-4-methylcoumarin and ethyoxyl salicylaldehyde, mixing, dissolving with absolute ethyl alcohol, stirring and reacting for set time under the condition of constant-temperature water bath, filtering, washing, and drying to obtain the coumarin fluorescent probe. Cooling and filtering to precipitate a red crystal, namely the coumarin fluorescent probe. The coumarin Schiff base fluorescent probe A5 is synthesized through a heating condensation reflux method, the crystal structure of the coumarin fluorescent probe A5 is successfully analyzed through X-ray single crystal diffraction, the molecular configuration and substituent connection sites of the coumarin fluorescent probe A5 are clarified, and a structural basis is provided for functional design of the probe. The optimal excitation wavelength of the A5 probe is 340 nm, the maximum emission wavelength is 440 nm, and the dependence of the emission wavelength on the excitation wavelength is low. The fluorescence intensity of the A5 probe is kept stable within the pH value range of 3-10, and the A5 probe is suitable for detection of natural water and weakly acidic / alkaline industrial wastewater.

The present application relates to the technical field of biological chemical industry, especially to a kind of p-nitrophenylamine hydrophobic hapten and its preparation method and application.The present application is based on p-nitrophenylamine, by introducing polar atom (F, N or O) from spacer arm to adjust the hydrophobicity of target material.Then, hapten is coupled with carrier protein, and the immunogenicity of artificial antigen is evaluated.The present application explores the influence of the change of hapten hydrophobicity on immunogenicity, which provides theoretical support for rational design of hapten on one hand, and provides material basis for preparation of high-affinity antibody of p-nitrophenylamine on the other hand.The present application provides a new idea for rational design of small molecule compound hapten and preparation of high-affinity antibody.