16 results about "Nitrostyrol" patented technology

To provide a method for preparing oligonucleotides that can improve yields and purities of target phosphorodiamidate morpholino oligomers and reduce 4-nitrostyrene adduct impurities.SOLUTION: The process comprises: (a) converting a compound of Formula X-1 into a compound of Formula X-2: where R10 is a residue of an oligonucleotide (e.g., a phosphorodiamidate morpholino oligomer); R11 is an amine protecting group; wherein the compound of Formula X-1 is not bound to a solid support; and (b) optionally removing protecting groups in the compound of Formula X-2 to obtain the olignucleotide.SELECTED DRAWING: None

A biphenylthiourea carboxylic acid metal organic framework crystal material and a preparation method and application thereof.The material has the following chemical formula: {[Zn4O(L)3]·DMF·H2O} n , wherein L is a 6-thio-6,7-dihydro-5H-dibenzo[d,f][1,3]diazepine-3,9-dicarboxylate divalent anion, and n is a degree of polymerization.The metal organic framework crystal material of the present application is synthesized by a solvothermal method, is simple to operate, has low cost, high yield, and is easy to mass industrial production.The prepared metal organic framework crystal material has a high specific surface area (a BET specific surface area of 594 m 2 / g), and an adsorption amount of CO2 of 46.0 cm 3 / g at 1 atm and 273 K.The biphenylthiourea carboxylic acid metal organic framework crystal material of the present application can efficiently catalyze a Friedel-Crafts alkylation reaction of substituted indole and substituted trans-nitrostyrene to generate an indole 3-substituted derivative, and can also efficiently catalyze a Michael addition reaction of diethyl malonate and substituted trans-nitrostyrene, both of which have mild conditions, and the catalyst can be recycled with almost no activity loss, and are good heterogeneous catalysts.

The invention provides indole C3-O functionalized derivatives as well as a preparation method and insecticidal and antibacterial application thereof, and relates to the technical field of pesticide development. The indole C3-O functionalized derivative provided by the invention has a structure of a general formula (1), is prepared through a free radical cyclization reaction catalyzed by N-heterocyclic carbene (NHC), does not need a transition metal catalyst, and efficiently constructs a C3-site oxygen functional group by taking o-nitroalkyne or cis-o-nitrostyrene and aldehyde as raw materials through multi-step series conversion in an inert atmosphere. The method has the advantages of being high in atom economy, good in functional group compatibility, easy and convenient to operate, environmentally friendly and the like. The obtained derivative shows remarkable activity in prevention and treatment of various agricultural diseases and insect pests such as rice sheath blight disease, aflatoxin and brown planthopper, can be prepared into various pesticide preparations, has the characteristics of broad spectrum, high efficiency and low toxicity, and is suitable for development of green pesticides.

The invention relates to a pyrrolo [2, 1-b] quinazoline-9 (1H)-ketone derivative and application thereof. The invention discloses a method for synthesizing pyrrolo [2, 1-b] quinazoline-9 (1H)-ketone based on cyclization reaction of 2-(phenylethynyl) quinazoline-4 (3H)-ketone and nitrostyrene and application of the pyrrolo [2, 1-b] quinazoline-9 (1H)-ketone, and belongs to the field of organic synthetic chemistry and medicinal chemistry. The synthesis method is realized through a 3 + 2 cyclization reaction of 2-(phenylethynyl) quinazoline-4 (3H)-ketone and nitrostyrene under base catalysis, the reaction condition is mild, the yield is good, and large-scale preparation is easy. The newly synthesized compound has obvious proliferation inhibition activity on various tumor cells such as gastric cancer, liver cancer, breast cancer, lung cancer, colon cancer, cervical cancer and the like, and can be used as a lead compound of an anti-tumor drug for preparing a novel anti-tumor drug.

The invention discloses a cyclohexadiene derivative as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: carrying out allylic mike addition-cyclization reaction on raw materials containing a 2-(2-chloro-1-phenylethylene) malononitrile derivative and a nitrostyrene derivative in a molar ratio of 1: (1-2) in the presence of an organic solvent and a chiral catalyst at the temperature of-55 DEG C to-65 DEG C for 4-6 days to obtain the cyclohexadiene derivative, the chemical structural formula is shown in the specification, wherein R1 is selected from hydrogen, fluorine, chlorine, bromine, trifluoromethyl, methyl or methoxyl; and / or R2 is selected from hydrogen, fluorine, chlorine, bromine, trifluoromethyl, methyl or methoxyl. The method has the advantages of simple operation, cheap raw materials, green and mild reaction conditions, high yield and purity of more than 97%; the chiral cyclohexadiene derivative especially has a relatively good antibacterial effect on bacillus subtilis.

The invention discloses application of a nitrostyrolene compound in prevention and / or control of pathogenic microorganisms and a medicine, further discloses a pharmaceutical preparation containing the nitrostyrolene compound, and relates to the technical field of pharmaceutical chemistry. The compound has a good application prospect in the aspects of preventing and treating agricultural pathogenic fungi, agricultural pathogenic bacteria and agricultural pathogenic nematodes, and is expected to be developed into a novel antibacterial or nematode-killing active ingredient of a medicinal preparation.

The invention relates to a crosslinked polystyrene dielectric film as well as a preparation method and application thereof. The preparation method of the crosslinked polystyrene dielectric film comprises the following steps: S1, mixing styrene, divinyl benzene, nitrostyrene, a thermal initiator and a solvent to obtain a mixed solution, and then carrying out prepolymerization reaction to obtain a prepolymer solution; s2, mixing the prepolymer solution with a photoinitiator, then performing blade coating to form a film, and performing photo-crosslinking to obtain the crosslinked polystyrene dielectric film, in the step S1, the mass ratio of styrene to nitrostyrene is 100: (5-25). The crosslinked polystyrene dielectric film prepared by the preparation method not only has glass transition temperature, but also has high dielectric constant and breakdown strength, and is very suitable for preparing polymer film capacitors, especially high-temperature-resistant polymer film capacitors.

A method for preparing oligonucleotides is disclosed. The method includes: (a) converting a compound having formula X-1 into a compound having formula X-2: wherein R 10 These are residues of oligonucleotides (e.g., phosphorylated diamine morpholine oligomers); R 11 The protecting group is an amine; wherein the compound having formula X-1 is not bound to a solid support; and; (b) optionally, the protecting group in the compound having formula X-2 is removed to obtain the oligonucleotide. The synthetic method described herein is advantageous in many respects, including but not limited to improving the yield and purity of the target phosphoryldiamine morpholino oligomer while reducing 4-nitrostyrene adduct impurities.

This invention discloses a method for synthesizing pyrrole compounds using solid acid catalysis. The method is as follows: in the presence of a carbon-based solid acid catalyst, β-nitrostyrene compounds represented by formula (1), acetyl acetate represented by formula (2), and primary amine represented by formula (3) are reacted in a solvent in a one-pot reaction. After the reaction is completed, the reaction solution is post-treated to obtain polysubstituted pyrrole compounds represented by formula (4). In the preparation of polysubstituted pyrrole compounds by this invention, the reaction can proceed smoothly under carbon-based solid acid catalysis without the need for other additives, making it safe, environmentally friendly, and with mild reaction conditions. The reaction formulas are as follows: in formulas (1) to (4), substituent R1 is H, C1-C5 straight-chain or branched alkyl or alkoxy, halogen, nitro, etc.; substituent R2 is C1-C10 straight-chain or branched alkyl, C5-C6 cycloalkyl, benzyl, etc.; substituent R3 is selected from C1-C5 straight-chain or branched alkyl, phenyl, benzyl, or substituted benzyl.

This application discloses a palladium-based bimetallic catalyst supported on cellulose nanocrystals, its preparation method, and its application. The catalyst includes a cellulose nanocrystal support and an active component supported on the surface of the support. The active component comprises palladium nanoparticles and an auxiliary metal element. The auxiliary metal element is selected from at least one of iron, cobalt, copper, gold, silver, tin, or nickel. The content of the cellulose nanocrystal support is 90–93 wt%. The content of the active component is 7–10 wt%. The content of palladium in the active component is 6–8 wt%. The content of the auxiliary metal element in the active component is 0.1–2 wt%. When the above-mentioned palladium-based bimetallic catalyst supported on cellulose nanocrystals is used for the selective hydrogenation reaction of the C=C bond in 3-nitrostyrene, the selectivity for 3-ethylnitrobenzene reaches 90%–100%.

The invention relates to the technical field of chemistry, and discloses a beta-bromo-beta-nitrostyrene compound as well as a preparation method and application thereof. The beta-bromo-beta-nitrostyrene compound is a compound as shown in a formula I or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitrogen oxide, a hydrate, a solvate and a pharmaceutically acceptable salt of the compound as shown in the formula I. In the formula I, R is a mono-substituent group or a multi-substituent group at any position of a benzene ring; r is selected from at least one of H, halogen, alkyl, alkoxy, halogenated alkyl or halogenated alkoxy; x is oxygen, and n is 0 or 1. The compound can effectively inhibit the growth of plant pathogenic fungi.

The invention provides a method for preparing amino styrene through selective hydrogenation of nitrostyrene. The method is carried out by using a PtNP / Fe2O3-sheet catalyst under the condition that a solvent contains a certain amount of water. The preparation method of the catalyst comprises the following steps: preparing Fe2O3 nanosheets by a hydrothermal method, preparing Pt nanoparticles by a sol-gel method, loading PtNP on the surface of Fe2O3 by an excessive impregnation method, and roasting to obtain the catalyst. The invention indicates that water can influence the selectivity of nitro hydrogenation, when a solvent contains 10% of water, the selectivity of the catalyst for catalyzing nitrostyrene into amino styrene exceeds 98%, and the activity is maintained at a relatively high level. The solvent system of ethanol and 10% water can also improve the selectivity of the PtNP / FeOx for catalyzing nitro hydrogenation, which is simply prepared by the coprecipitation method.

The invention relates to a direct fluoroalkylation method of a 3-methyl-4-nitro-5-styryl isoxazole compound, which comprises the following steps: taking substituted 3-methyl-4-nitro-5-styryl isoxazole and sodium fluoroalkyl sulfinate as raw materials, carrying out selective free radical addition under the action of a photocatalyst, nitrogen atmosphere and LED (light-emitting diode) blue light irradiation, and carrying out direct fluoroalkylation on the 3-methyl-4-nitro-5-styryl isoxazole compound to obtain the 3-methyl-4-nitro-5-styryl isoxazole compound. And directly carrying out 1, 6-fluoroalkylation to generate the 5-(fluoroalkyl-2-phenylpropyl)-3-methyl-4-nitroisoxazole product, namely the 5-(fluoroalkyl-2-phenylpropyl)-3-methyl-4-nitroisoxazole. The raw materials are easy to prepare, and the photocatalysis method is green, simple and convenient.

This invention belongs to the field of eumelanin biopolymers, and particularly relates to a method for preparing 5,6-dihydroxyindoline, comprising the following steps: dissolving 3,4-dibenzyloxybenzaldehyde in a reaction solvent, adding a brominating reagent, and reacting to obtain 3,4-dibenzyloxy-6-bromobenzaldehyde; mixing the obtained 3,4-dibenzyloxy-6-bromobenzaldehyde with ammonium formate and nitromethane, and stirring and heating, followed by a condensation reaction to obtain 3,4-dibenzyloxy-6-bromo-β-nitrostyrene; and subjecting the obtained 3,4-dibenzyloxy-6-bromo-β-nitrostyrene to hydrogenation reduction, cyclization, and debenzylation reactions in the presence of a catalyst, cuprous halide, and alkali, using water as the reaction solvent, to obtain the target product. The synthesis method of this invention has the advantages of readily available raw materials, good reaction selectivity, good yield, mild reaction conditions, easy product separation, and environmental friendliness, making it suitable for industrial production.

This invention discloses an iron-catalyzed method for the hydroxylation of alkenes. The method includes the following steps: in a solvent, using nitrostyrene compounds and alkenes as substrates, peroxides as oxidants, iron as catalysts, and amino acids and their derivatives as ligands, the hydroxylation of alkenes is catalyzed to generate alkenylated alcohols. This method can synthesize alkenylated alcohols in one step, is simple, and utilizes widely available and inexpensive catalysts and oxidants. The reaction conditions are mild and highly selective. It uses 1-2 equivalents of olefin substrates, exhibiting good functional group compatibility and a wide range of substrate applicability. Drug molecules and their derivatives are compatible, achieving the hydroxylation of alkenes. Under optimized reaction conditions, the yield of the target product after separation can reach 86%.

The present application relates to a kind of methods for improving the activity and selectivity of nitrostyrene hydrogenation catalyst Pt / SnO2-Sb2O3.The catalyst Pt / SnO2-Sb2O3 is reduced in 10% H2-N2 mixed gas or high-purity hydrogen at 50~250 ℃ for 1~5h, and then heat-treated in air atmosphere at 80~150 ℃ for 2~132h or placed at room temperature for 15~120 days, and then reduced in 10% H2-N2 mixed gas or high-purity hydrogen at 50~100 ℃ for 1~5h, and then selectively hydrogenated in anhydrous ethanol to prepare aminostyrene from nitrostyrene.The selectivity of aminostyrene reaches 95% when nitrostyrene is completely converted.The above scheme significantly improves the activity of catalyst Pt / SnO2-Sb2O3, and solves the problem of reducing the selectivity of aminostyrene during the storage process.