7 results about "Nitrostyrol" patented technology

A biphenylthiourea carboxylic acid metal organic framework crystal material and a preparation method and application thereof.The material has the following chemical formula: {[Zn4O(L)3]·DMF·H2O} n , wherein L is a 6-thio-6,7-dihydro-5H-dibenzo[d,f][1,3]diazepine-3,9-dicarboxylate divalent anion, and n is a degree of polymerization.The metal organic framework crystal material of the present application is synthesized by a solvothermal method, is simple to operate, has low cost, high yield, and is easy to mass industrial production.The prepared metal organic framework crystal material has a high specific surface area (a BET specific surface area of 594 m 2 / g), and an adsorption amount of CO2 of 46.0 cm 3 / g at 1 atm and 273 K.The biphenylthiourea carboxylic acid metal organic framework crystal material of the present application can efficiently catalyze a Friedel-Crafts alkylation reaction of substituted indole and substituted trans-nitrostyrene to generate an indole 3-substituted derivative, and can also efficiently catalyze a Michael addition reaction of diethyl malonate and substituted trans-nitrostyrene, both of which have mild conditions, and the catalyst can be recycled with almost no activity loss, and are good heterogeneous catalysts.

The invention provides indole C3-O functionalized derivatives as well as a preparation method and insecticidal and antibacterial application thereof, and relates to the technical field of pesticide development. The indole C3-O functionalized derivative provided by the invention has a structure of a general formula (1), is prepared through a free radical cyclization reaction catalyzed by N-heterocyclic carbene (NHC), does not need a transition metal catalyst, and efficiently constructs a C3-site oxygen functional group by taking o-nitroalkyne or cis-o-nitrostyrene and aldehyde as raw materials through multi-step series conversion in an inert atmosphere. The method has the advantages of being high in atom economy, good in functional group compatibility, easy and convenient to operate, environmentally friendly and the like. The obtained derivative shows remarkable activity in prevention and treatment of various agricultural diseases and insect pests such as rice sheath blight disease, aflatoxin and brown planthopper, can be prepared into various pesticide preparations, has the characteristics of broad spectrum, high efficiency and low toxicity, and is suitable for development of green pesticides.

The invention relates to a pyrrolo [2, 1-b] quinazoline-9 (1H)-ketone derivative and application thereof. The invention discloses a method for synthesizing pyrrolo [2, 1-b] quinazoline-9 (1H)-ketone based on cyclization reaction of 2-(phenylethynyl) quinazoline-4 (3H)-ketone and nitrostyrene and application of the pyrrolo [2, 1-b] quinazoline-9 (1H)-ketone, and belongs to the field of organic synthetic chemistry and medicinal chemistry. The synthesis method is realized through a 3 + 2 cyclization reaction of 2-(phenylethynyl) quinazoline-4 (3H)-ketone and nitrostyrene under base catalysis, the reaction condition is mild, the yield is good, and large-scale preparation is easy. The newly synthesized compound has obvious proliferation inhibition activity on various tumor cells such as gastric cancer, liver cancer, breast cancer, lung cancer, colon cancer, cervical cancer and the like, and can be used as a lead compound of an anti-tumor drug for preparing a novel anti-tumor drug.

The invention discloses application of a nitrostyrolene compound in prevention and / or control of pathogenic microorganisms and a medicine, further discloses a pharmaceutical preparation containing the nitrostyrolene compound, and relates to the technical field of pharmaceutical chemistry. The compound has a good application prospect in the aspects of preventing and treating agricultural pathogenic fungi, agricultural pathogenic bacteria and agricultural pathogenic nematodes, and is expected to be developed into a novel antibacterial or nematode-killing active ingredient of a medicinal preparation.

This invention discloses a method for synthesizing pyrrole compounds using solid acid catalysis. The method is as follows: in the presence of a carbon-based solid acid catalyst, β-nitrostyrene compounds represented by formula (1), acetyl acetate represented by formula (2), and primary amine represented by formula (3) are reacted in a solvent in a one-pot reaction. After the reaction is completed, the reaction solution is post-treated to obtain polysubstituted pyrrole compounds represented by formula (4). In the preparation of polysubstituted pyrrole compounds by this invention, the reaction can proceed smoothly under carbon-based solid acid catalysis without the need for other additives, making it safe, environmentally friendly, and with mild reaction conditions. The reaction formulas are as follows: in formulas (1) to (4), substituent R1 is H, C1-C5 straight-chain or branched alkyl or alkoxy, halogen, nitro, etc.; substituent R2 is C1-C10 straight-chain or branched alkyl, C5-C6 cycloalkyl, benzyl, etc.; substituent R3 is selected from C1-C5 straight-chain or branched alkyl, phenyl, benzyl, or substituted benzyl.

The invention relates to a direct fluoroalkylation method of a 3-methyl-4-nitro-5-styryl isoxazole compound, which comprises the following steps: taking substituted 3-methyl-4-nitro-5-styryl isoxazole and sodium fluoroalkyl sulfinate as raw materials, carrying out selective free radical addition under the action of a photocatalyst, nitrogen atmosphere and LED (light-emitting diode) blue light irradiation, and carrying out direct fluoroalkylation on the 3-methyl-4-nitro-5-styryl isoxazole compound to obtain the 3-methyl-4-nitro-5-styryl isoxazole compound. And directly carrying out 1, 6-fluoroalkylation to generate the 5-(fluoroalkyl-2-phenylpropyl)-3-methyl-4-nitroisoxazole product, namely the 5-(fluoroalkyl-2-phenylpropyl)-3-methyl-4-nitroisoxazole. The raw materials are easy to prepare, and the photocatalysis method is green, simple and convenient.

This invention discloses an iron-catalyzed method for the hydroxylation of alkenes. The method includes the following steps: in a solvent, using nitrostyrene compounds and alkenes as substrates, peroxides as oxidants, iron as catalysts, and amino acids and their derivatives as ligands, the hydroxylation of alkenes is catalyzed to generate alkenylated alcohols. This method can synthesize alkenylated alcohols in one step, is simple, and utilizes widely available and inexpensive catalysts and oxidants. The reaction conditions are mild and highly selective. It uses 1-2 equivalents of olefin substrates, exhibiting good functional group compatibility and a wide range of substrate applicability. Drug molecules and their derivatives are compatible, achieving the hydroxylation of alkenes. Under optimized reaction conditions, the yield of the target product after separation can reach 86%.