31 results about "Ferroporphyrin" patented technology

The invention belongs to the technical field of bioactive peptides, and discloses a white snakehead oligopeptide as well as a preparation method and application thereof. The white snakehead oligopeptide is selected from one of oligopeptides with amino acid sequences as shown in SEQ ID NO.1-8. The invention further discloses a preparation method of the white snakehead oligopeptide. The polypeptide provided by the invention has a relatively high ferrous / zinc absorption rate to a human body, has a certain function of treating iron-deficiency anemia and zinc deficiency, and has a good application prospect in mineral (iron / zinc) supplements, functional foods and health-care products.

The application discloses a method for synthesizing tervalent tetraaryl iron porphyrin from pyrrole, aromatic aldehyde and ferrous salt, which comprises the following steps: adding anhydrous aluminum chloride, aromatic aldehyde, pyrrole and ferrous salt into DMF under stirring, and then heating and refluxing the reaction mixture for 0.5 hours under nitrogen; removing the nitrogen and continuing to heat the reaction mixture for a certain time; stopping the reaction; cooling the reaction mixture; and placing the reaction mixture at 273K overnight; and finally filtering the reaction mixture to obtain the iron porphyrin.

The application relates to the technical field of sialic acid application, in particular to application of sialic acid in promoting iron absorption of iron supplement agents. It is found for the first time that sialic acid with a daily intake of 0.8-3.5 mg / kg and ferrous iron with a daily intake of 0.2-0.5 mg / kg can promote the absorption of ferrous iron by human bodies. More specifically, the application claims an iron supplement agent containing ferrous iron drugs and sialic acid. The iron supplement agent provided by the application promotes iron supplement by compounding sialic acid and ferrous iron drugs, thereby improving the bioavailability of iron, regulating immunity, promoting intestinal health and achieving various biological activities while supplementing iron.

There is provided a method for producing ferrous sulphate and phosphoric acid comprising treating ferrous phosphate with sulphuric acid for obtaining ferrous sulphate and phosphoric acid. Additionally, there is provided a use of sulphuric acid for treating ferrous phosphate for obtaining ferrous sulphate and phosphoric acid.

In an iron (II) citrate monohydrate, identified by the formula FeC6H6O7-H2O ( Ferrous citrate monohydrate or iron citrate (II) monohydrate), obtained according to a particular production method, citric acid and elemental iron are bound in a molecular complex where the iron is agglomerated in the citrate which moves to a cyclic form and the iron is bound to the O groups of the carboxylic groups 1 and 3 through ionic bonds, forming two enantiomers, D and L (R and S), both perfectly water-soluble and highly assimilable by the human body. Formula (L) & Formula (D). With a different absorption mechanism from traditional iron molecules, said iron citrate monohydrate is usable in pharmaceutical and / or nutraceutical and / or food compositions, in particular in the treatment and prevention of iron deficiency anemias and in general of all diseases and disorders associated with iron deficiency. The effectiveness is proven by several examples.

The utility model discloses a pneumatic stirring device for preparing ferrous chloride, and relates to the technical field of ferrous chloride preparation. The device comprises a tank body, the top of the tank body is fixedly provided with a top cover through bolts, the bottom of the tank body is fixedly connected with an inclined filter pipe, one side of the filter pipe is fixedly communicated with a horizontal discharge pipe, the bottom of the filter pipe is open and is in threaded connection with a bottom cover, and the top of the bottom cover is fixedly connected with a supporting column. A filter cylinder is fixedly connected to the top of the supporting column, a gap is formed between the filter cylinder and the inner wall of the filter pipe, and a limiting ring is fixedly connected to the top of the filter cylinder and makes contact with the inner wall of the filter pipe. According to the utility model, the filter cartridge is taken down by taking down the bottom cover, so that iron powder which is not completely reacted can be conveniently recycled and reused, and meanwhile, during discharging, the stirring shaft drives the movable shaft to rotate, and the movable shaft stirs in the filter cartridge, so that the filter cartridge is prevented from being blocked, and the discharging efficiency is improved.

A method for preparing magnetic amino-functionalized biochar and its application are disclosed, relating to the field of biochar preparation technology. The method involves dissolving ferrous chloride dihydrate, ferric chloride dihydrate, and ammonia in deoxygenated water, stirring until homogeneous, then adding amino-functionalized biochar. After thorough stirring, the product is collected by magnetic adsorption and finally washed to obtain magnetic amino-functionalized biochar. The magnetic amino-functionalized biochar is used for removing chromium from water. This invention provides a method for preparing magnetic amino-functionalized biochar and its application.

The application discloses a method for preparing pure chromium trichloride and ferrous chloride by using low-silicon ferrochrome, and comprises the following steps: an acid leaching step: crushing ferrochrome raw materials with silicon content less than 1% to 1-5mm, adding hydrochloric acid for step-by-step leaching to obtain a leaching solution; a purification step: diluting the leaching solution to a total content of Cr and Fe of 20-80g / L, adding a purifying agent for stirring, standing and filtering to obtain a purified solution; a concentration step: performing negative pressure vacuum concentration on the purified solution, filtering most of sodium chloride when the concentration is 1 / 4-1 / 3 of the original volume, then adding components according to the content of chromium and iron in the filtrate and continuing to concentrate, cooling and crystallizing, and drying to obtain pure chromium trichloride and ferrous chloride. The application significantly improves the filtering performance in the purification process, reduces the loss of chromium and iron elements and the use cost of the purifying agent, and overcomes the problems of battery charge-discharge efficiency reduction and ion membrane blockage caused by the high silicon ion concentration in the electrolyte solution.

A composition and method for capturing and releasing cells containing CD44 antigen, comprising cholesterol-aptamers, silver nanoparticle-modified aptamers, and bleomycin-ferrous ion complexes, exhibits higher biocompatibility and stability, facilitating the formation of a biointerface for the efficient capture and release of mesenchymal stem cells. Applying the composition of this invention to the electrochemical detection of cell capture and release offers advantages such as mild reaction conditions, simplicity, speed, and sensitivity, making it easy to integrate with other automated reaction interfaces for commercial development. Furthermore, it can be combined with electrochemical biochip sensor arrays to achieve even more convenient capture, detection, and release of mesenchymal stem cells.

The application discloses a kind of phosphorus-free pre-film agent, which is composed of the following components with mass percentage: N-lauroyl sarcosine 12-18%, zinc salt 15-20%, ferrous salt 7-10%, acrylic acid-itaconic acid copolymer 5-9% and soft water 50-60%. The application also discloses a preparation method of the above-mentioned phosphorus-free pre-film agent and a method for pre-film treatment in circulating cooling water system. The pre-film agent can effectively avoid the problem that traditional phosphorus-containing pre-film agent easily causes water eutrophication. The circulating water after pre-film does not contain phosphorus and can be recycled. Therefore, the pre-film agent does not need to be discharged after pre-film is completed and can be directly transferred to normal operation, thereby saving water resources and cleaning pre-film cost. The pre-film agent has good synergistic effect among components, and forms an organic-inorganic composite film interwoven on the metal surface. The composite film has the characteristics of rapid film formation, compactness, smoothness, uniformity, stable adhesion and strong corrosion resistance.

The invention provides a method for recycling and regenerating chlorosuccinimide, and belongs to the technical field of resource recycling. The method comprises the following steps: decoloring the mother liquor after reaction, adding sulfide to enable metal palladium to form palladium sulfide precipitate, performing chlorination reaction on filtrate, ferrous chloride and phosphorus oxychloride, and performing extraction and back extraction to obtain chlorosuccinimide, so that the chlorosuccinimide is recycled and regenerated. The result of the embodiment shows that the melting point of the chlorosuccinimide obtained by the method disclosed by the invention is consistent with a literature value.

The invention relates to a nano preparation based on a ferrous phosphide nano structure and a preparation method and application thereof, and belongs to the technical field of medical nano materials. In order to solve the problems that in the prior art, the curative effect of CDT is limited, the single therapy effect is poor, and effective imaging guidance lacks, the invention provides a nano preparation based on a ferrous phosphide nanostructure, the nano preparation comprises a core layer, a modification layer and a functional layer, the core layer is a hydrophobic ferrous phosphide nanostructure, the modification layer is a PTMP-PMAA polymer, and the functional layer is glucose oxidase. The nano preparation disclosed by the invention induces tumor apoptosis by increasing the ROS level through multiple synergy of chemical kinetics therapy, hunger therapy and photothermal therapy, so that the tumor treatment effect is remarkably improved; the system also has the advantages of precise dual-mode imaging and biological safety, can precisely position the tumor boundary, monitors the distribution and treatment process of the preparation in the tumor, provides a reliable basis for the selection of treatment opportunities, and shows important application prospects in the field of precise tumor treatment.

The invention discloses an enhanced colorimetric method for rapidly and selectively detecting glutathione and a kit thereof, and belongs to the technical field of biochemical detection. The method comprises the following steps: preparing a prussian blue solution, a Turnish blue solution, a ferrous chloride solution or a ferric chloride solution as a nano-enzyme catalysis solution; mixing the catalytic solution with an ABTS solution and a hydrogen peroxide solution according to a specific proportion to form a blank reaction solution; adding a glutathione-containing to-be-detected sample into the solution to carry out a chromogenic reaction; and determining the content of glutathione by determining the absorbance difference between the blank and the reaction solution to be detected in a specific wavelength range. The method is mainly used for rapid, selective and quantitative detection of glutathione in the fields of food, medicine and biological analysis.

The invention discloses application of NAC in preparation of a medicine for treating temporomandibular joint disorder, and particularly discloses application of the medicine in effectively improving TMD joint tissue oxidation resistance, inhibiting inflammation level, promoting extracellular matrix secretion and inhibiting iron (ferrous) ions and lipid peroxides so as to improve cartilage injury, relieve pain in a condylar process region and improve osteoarthritis. As a clinical common medicine, NAC is low in cost, high in availability, excellent in cell and tissue safety and high in practicability. The medicine can be safely applied to TMD treatment by means of condyle local injection or condyle region skin application (microneedle) and the like, has important significance in clinical medication of TMD, and has good medication value and application prospect.

The application relates to the technical field of water treatment, and discloses an iron-based coordination assembly as well as a preparation method and application thereof. The iron-based coordination assembly comprises ferrous ions as central ions, and perfluoroalkyl sulfonic acid and / or perfluoroalkyl carboxylic acid with a perfluorinated carbon chain having 7 or 8 carbon atoms as ligand compounds; and the iron-based coordination assembly forms an active catalytic system in an aqueous solution with a pH value of 4.0-5.0. The iron-based coordination assembly provided by the application retains the active 3d electron configuration of Fe 2+ , and effectively breaks the dense hydration layer around Fe 2+ by using the extremely strong hydrophobic effect of the carbon-fluorine chain of the ligand compound, so that a hydrophobic microenvironment rich in NO2 ‑ is constructed at the active site, thereby greatly optimizing the electron transfer path, and successfully solving the key bottleneck of slow reaction rate and low mass transfer efficiency in the traditional Fe 2+ nitrite reduction technology.

The invention relates to the technical field of biological medicines, in particular to application of a ferrous ion compound in preparation of a medicine for treating perianal diseases and the medicine. The comprehensive effect of the ferrous ion compound in treatment of perianal inflammation and the like is remarkably superior to the treatment effect of existing positive drugs and high or low-concentration ferrous ions, and in a domestic rabbit model, the remarkable comprehensive effects of resisting inflammation, improving perianal circulation, inhibiting bacteria and promoting tissue repair can be achieved.

This invention discloses a chromogenic solution and kit for visual colorimetric detection of free ferrous protoporphyrin in cells. The chromogenic solution consists of reagents A, B, and C: Reagent A is prepared with deionized water and contains NaCl, Proclin 300, and glycerol; Reagent B is prepared with an acetate-sodium acetate buffer at pH 4.0 and contains glycerol, Triton X-100, β-cyclodextrin, disodium EDTA, citric acid, ethanol, and 3,3',5,5'-tetramethylbenzidine; Reagent C is prepared with an acetate-sodium acetate buffer at pH 4.0 and contains 2.0-4.0% hydrogen peroxide and 35.0-50.0% ethanol. The chromogenic solution of this invention has a lower background value and can detect the content of free ferrous protoporphyrin in cells within 10 minutes by visual colorimetry, with a detection limit as low as 10 nmol / L. The chromogenic stability is maintained for 12 hours, making it suitable for rapid assessment of cellular pathological conditions.

This invention discloses a novel application of undecanoic acid in inducing ferroptosis in laryngeal cancer cells and in the preparation of anti-laryngeal cancer drugs. For the first time, it was discovered that the known compound undecanoic acid can specifically target the mitochondria of laryngeal cancer cells, inducing mitochondrial structural damage and dysfunction. This, in turn, activates the ferroptosis pathway through multiple mechanisms, including increasing intracellular ferrous ion accumulation, increasing lipid peroxide levels, downregulating GPX4 / SLC7A11 expression, and upregulating ACSL4 expression, thereby effectively inhibiting the proliferation of laryngeal cancer cells. Based on this mechanism, this invention provides a pharmaceutical composition with undecanoic acid as the active ingredient, and its combined application with platinum-based drugs (such as cisplatin). This combined treatment exhibits a significant synergistic effect, particularly overcoming the platinum resistance of laryngeal cancer cells. This invention provides a novel drug selection and combination therapy strategy for the treatment and prevention of laryngeal cancer and precancerous lesions.

The application discloses a method for fixing and magnetically separating arsenic in water by using biological mineralization, and comprises the following steps: S1, liquid medium preparation: dissolving 60% (volume) sodium lactate solution, sodium nitrate, potassium dihydrogen phosphate, magnesium sulfate heptahydrate and yeast extract in deionized water according to proportions, adjusting the pH of the medium solution to 6.9-7.0, and performing high-pressure sterilization after being divided into small portions; S2, inoculating bacteria liquid into the sterilized medium to perform amplification culture; S3, preparing a standard arsenic solution; S4, preparing iron citrate and ferrous chloride solutions; S5, MSR-1 biological control mineralization synthesis of magnetosomes; S6, MSR-1 induced bivalent iron precipitation for arsenic removal; and S7, magnetic separation of bacteria-iron-arsenic mixture. The method realizes the fixation and separation of arsenic in water, retains the advantages of low cost and environmental friendliness of the biological mineralization for repairing contaminated water, and overcomes the disadvantages of low repair efficiency and potential pollution caused by the inability to recycle.

The application discloses a preparation method of glycine ferrous without obvious iron smell in a liquid agent product, and relates to the technical field of food or health product processing. The method comprises the following steps: preparing a first solution by hot water swelling of gamma-cyclodextrin; preparing a second solution by adding glycine ferrous and vitamin C or citric acid into the first solution after cooling; preparing a third solution by dissolving soluble soybean polysaccharide or pectin in water and then adding malt dextrin; and then slowly adding the second solution into the third solution, and then performing high-pressure homogenization and spray drying. Through the synergistic effect of gamma-cyclodextrin inclusion, acidic auxiliary protection and double embedding of a film forming agent, the prepared glycine ferrous is clear and free of precipitation in hot water, has no obvious iron smell, and has a significantly improved absorption rate, and is particularly suitable for liquid dosage forms such as oral liquids.

The invention belongs to the technical field of analysis and detection, and discloses a method for analyzing ferrous ions in a sample and application of the method. The invention particularly relates to a method for analyzing spatial distribution and content of ferrous ions in biological tissues. The method is characterized by comprising the following steps: 1) applying a ferrous ion probe reagent to selectively generate ferrous coordination compound ions with ferrous ions in a sample; (2) detecting the generated ferrous coordination compound ions by adopting a mass spectrum imaging technology; and (3) carrying out qualitative, quantitative and positioning analysis on spatial distribution of ferrous ions (Fe < 2 + >) in the sample by utilizing the collected ion characteristic information of the ferrous coordination compound. The invention further provides specific application of the method in in-vivo and in-vitro analysis.

This disclosure provides ferric phosphate, its preparation method, and its application. The preparation method includes the following steps: (1) mixing ferrous salt, phosphorus source, and solvent to obtain a mixed salt solution, and freezing the mixed solution to obtain a frozen mixed salt solution; (2) placing the frozen mixed salt solution in a reflux device, controlling the reflux of hydrogen peroxide solution between the reflux device and the reaction device, controlling the concentration of hydrogen peroxide in the system to carry out the reaction, until the frozen mixed salt solution is completely dissolved; (3) adjusting the pH in the system to carry out an aging reaction, and separating the solid and liquid to obtain the ferric phosphate. In this disclosure, the solution containing ferrous salt and phosphorus source is frozen in advance, and hydrogen peroxide is controlled to flow through the frozen mixed salt solution. By controlling the concentration and flow rate of hydrogen peroxide, the reaction can be carried out slowly, so that the iron and phosphorus elements in the prepared ferric phosphate precursor are evenly distributed and have few surface defects.

The application discloses a preparation method of ferrous phosphate octahydrate, which comprises the following steps: 1) preparing ferrous sulfate solution and phosphorus source solution, protecting by inert gas, adding the ferrous sulfate solution and the phosphorus source solution into a surfactant bottom solution, stirring, adding alkali solution until the pH of the reaction system is 2.5-4.0, stirring for the first-stage reaction, and performing suction filtration to obtain a filter cake; 2) slurring the filter cake according to the original solid content to obtain a reaction solution, protecting by inert gas, heating to 40-50 DEG C, adding alkali solution to adjust the pH of the solution to 4.5-6.0, stirring for the second-stage reaction, performing suction filtration, washing, and drying to obtain the ferrous phosphate octahydrate. The application controls the coprecipitation reaction by using stage temperature and segmented pH value, and performs solid-liquid separation by suction filtration under low pH value, so that the particle size, morphology and purity of the crystal can be controlled. After the first-stage reaction is completed, the slurry is subjected to the first suction filtration, and impurity elements such as Mg and Mn which are easy to precipitate in the system under high pH value are removed.

The application discloses an up-conversion nano drug delivery system for inducing a high-efficiency ferroptosis effect to target and kill brain glioma and a preparation method thereof, and belongs to the field of biological medicines. The method comprises the following steps: preparing up-conversion nanoparticles by using a modified thermal decomposition method; wrapping the up-conversion nanoparticles with mesoporous silica and connecting hydrophilic enzymes through electrostatic adsorption; and loading hydrophobic chemotherapeutic drugs by using a thin film hydration method to obtain an up-conversion nano composite drug delivery system. The composite drug delivery system uses the photoreduction of the up-conversion nanoparticles to enhance the content of ferrous ions, combines with glucose oxidase to enhance the Fenton reaction, mediates a high-efficiency ferroptosis effect, and targets and kills brain glioma cells. The application provides a new idea for the future clinical treatment of brain glioma and has a good application prospect.

This utility model relates to the field of ferrous chloride production technology, and in particular to a purification device for ferrous chloride production. It includes a housing, with partitions fixedly connected to the top of both sides of the inner cavity of the housing. A linear motor is bolted to the top of the inner cavity of the housing, and a bracket is bolted to the moving end of the linear motor. An electromagnet is bolted to the bottom of the bracket. This utility model, through the cooperation of an electric push rod, a housing, a filter membrane, a drain valve, a support plate, a drive motor, and a rinsing pipe, has the advantage of rinsing function. When the surface of the filter membrane needs to be cleaned, an external controller controls the electric push rod to operate. The output end of the electric push rod drives the housing to move to the left. The housing extends to the left side of the housing through a rectangular hole. Then, an external water supply pipe delivers clean water to the telescopic pipe. The clean water is sprayed onto the surface of the filter membrane through the rinsing pipe, thereby cleaning it.

The application provides a preparation method of azodicarbonamide, which comprises the following steps: step (1), mixing biurea, a ferrous compound catalyst and water according to a certain proportion to prepare a biurea suspension; step (2), adjusting the pH value of the biurea suspension prepared in step (1) to 2-6, and heating the biurea suspension with the pH value of 2-6 to 50-100 DEG C to obtain a second suspension; step (3), slowly dropping hydrogen peroxide solution into the second suspension obtained in step (2) to react for a certain time to obtain solid azodicarbonamide; and step (4), separating and washing the solid azodicarbonamide prepared in step (3), so that azodicarbonamide is obtained. In the application, hydrogen peroxide is used as an oxidant, a ferrous compound is used as a catalyst, and the ferrous compound and hydrogen peroxide are reacted, so that biurea can be efficiently oxidized to obtain azodicarbonamide, there is no risk of harmful gas leakage, no waste salt is generated, the preparation process is clean and green.

The present disclosure belongs to the technical field of biomedicine, and specifically relates to an iron ion carrier, a preparation method therefor and the use thereof. The present disclosure has the following advantages: the iron ion carrier can have good binding activity with both ferric ions and ferrous ions, has low cytotoxicity, and has a long in-vivo drug half-life.

Complex molecular units of ferrous bis-citrate monot art rate stable over time, which has optimal bioavailability, are obtained through a particular and simple synthesis method, and have the following structural formula M: STRUCTURAL FORMULA M Through a polymerization method, such complex molecular units of iron bis-citrate monotartrate form the monomers of a cyclic polymer structure having the following structural formula P: STRUCTURAL FORMULA P where the iron content per each mole of substance is equal to 50. 20% (w / w), and where the same iron has the dual role of bridging the two acids which move in a cyclic form and binding to the 0- groups of the carboxylic groups by means of dative covalent bonds, resulting in both intramolecular and intermolecular bonds. Such a cyclic polymer structure is usable in pharmaceutical, food, and / or nutraceutical composit ions, in particular in the treatment and prevention of iron deficiency anemias and, in general, all diseases or disorders associated with iron deficiency.

The invention discloses an intelligent suspension conveying device for ferrous lactate filling, and relates to the technical field of liquid medicine conveying. The intelligent suspension conveying device for ferrous lactate filling comprises a filling machine and a mounting frame, and a suspension conveying belt driven by a servo motor is assembled on the side face of the mounting frame; and the liquid medicine containing tank is assembled on the hanging conveying belt, and the top of the liquid medicine containing tank is rotationally connected with a cover plate driven by a micro motor. According to the intelligent suspension conveying device for ferrous lactate filling, a servo motor is started to drive a suspension conveying belt to move, so that a liquid medicine containing tank is driven to rapidly move, and a first rotating rod, a toothed rod, a gear, a first hydraulic bin, a first elastic telescopic rod, an extrusion block, a first arc-shaped rod, a second hydraulic bin, a first stress rod, a first spring, a hydraulic hose and a third hydraulic bin are matched; and the two sealing gaskets move in opposite directions, so that a gap between the two cover plates can be sealed, and the possibility that liquid medicine is splashed out is reduced.

This invention discloses a bergamot effervescent tablet based on microencapsulation technology and its preparation method, relating to the field of solid beverage technology. The invention comprises, based on a total feed weight of 100 kg, the following components: bergamot extract; 3 kg; anhydrous citric acid; 18 kg; sodium bicarbonate; 15 kg; dextrin; 45 kg; gum arabic; 0.6 kg; tragacanth gum; 0.15 kg; taurine; 1.58 kg; zinc gluconate; 0.75 kg; zinc citrate; 0.25 kg; calcium gluconate; 0.25 kg; ascorbic acid C; 0.1 kg; ferrous gluconate; 0.11 kg; thiamine hydrochloride; 0.058 kg; riboflavin; 0.03 kg; pyridoxine hydrochloride; 0.02 kg; cyanocobalamin; 0.001 kg; folic acid; 0.001 kg; isomaltitol; 15 kg; sucralose; 0.1 kg. The advantages are: through systematic screening of key factors such as the inclusion of aromatic oil components in bergamot extract, the ratio of acid-base disintegrants, the ratio of flavoring agents and food fortifiers, the type of fillers, the preparation method of acid-base particles, and the tableting process parameters.