7 results about "Magnetosome" patented technology

The invention discloses a magnetosome targeted driven neural signal read-write polymeric membrane as well as a preparation method and application thereof. The polymeric membrane has a layered composite structure and sequentially comprises a base layer made of a biocompatible composite material, a magnetic response targeting layer containing a targeting modified magnetosome, an electrode functional layer containing a polypyrrole-doped patterned electrode array and a polymeric protective layer from bottom to top, the preparation method comprises the steps of base layer film forming, PEG coating of magnetosomes and coupling modification of acetylcholine receptors, magnetic response targeting layer construction, ink-jet printing of an electrode array and hot-pressing compounding of a protective layer. The polymeric membrane can be attached to the body surface in a non-invasive mode, targeted enrichment of a signal area is achieved through magnetosomes under driving of an external magnetic field, neurotransmitter signals are captured through surface receptor specificity of the polymeric membrane, high-precision reading and writing of neuroelectric signals can be completed with the help of an electrode array, and the application range is wide. And safe, accurate and bidirectional neural information interaction is realized.

The invention relates to a preparation method of coupling magnetic beads for microbial collection, which adopts SPDP (N-succinimido-3-(2-pyridine dithio) propionate) as a cross-linking agent to realize directional fixation of recombinant protein A-Cys on magnetosome, and then the recombinant protein A-Cys can be coupled with an antibody to form the coupling magnetic beads for microbial collection with specific antigen binding. The coupling magnetic bead for microbial collection prepared by the preparation method provided by the invention can be efficiently coupled with different types of antibodies, and has a relatively wide application prospect.

The application discloses a method for fixing and magnetically separating arsenic in water by using biological mineralization, and comprises the following steps: S1, liquid medium preparation: dissolving 60% (volume) sodium lactate solution, sodium nitrate, potassium dihydrogen phosphate, magnesium sulfate heptahydrate and yeast extract in deionized water according to proportions, adjusting the pH of the medium solution to 6.9-7.0, and performing high-pressure sterilization after being divided into small portions; S2, inoculating bacteria liquid into the sterilized medium to perform amplification culture; S3, preparing a standard arsenic solution; S4, preparing iron citrate and ferrous chloride solutions; S5, MSR-1 biological control mineralization synthesis of magnetosomes; S6, MSR-1 induced bivalent iron precipitation for arsenic removal; and S7, magnetic separation of bacteria-iron-arsenic mixture. The method realizes the fixation and separation of arsenic in water, retains the advantages of low cost and environmental friendliness of the biological mineralization for repairing contaminated water, and overcomes the disadvantages of low repair efficiency and potential pollution caused by the inability to recycle.

The invention relates to a vascular implantable brain-computer interface polymeric membrane material based on magnetosome targeted delivery as well as a preparation method and application of the vascular implantable brain-computer interface polymeric membrane material. The polymeric membrane material comprises a flexible polymeric basement membrane, a biocompatible coating and amination modified magnetosomes loaded on the surface of the coating, the basement membrane is composed of a blend of polycaprolactone and gelatin, and graphene nanosheets are dispersed in the basement membrane; the biocompatible coating is a compound of chitosan and hyaluronic acid; and the magnetosome is loaded on the surface of the coating through electrostatic interaction after amination treatment. The preparation method comprises the following steps: forming a basement membrane, constructing a biocompatible coating, and modifying and compounding the magnetosome. The vascular implantable brain-computer interface polymeric membrane material based on magnetosome targeted delivery can be used in a vascular implantable brain-computer interface targeted delivery system, delivery is carried out through a degradable packaging carrier in a vascular intervention mode, and targeted positioning of a brain target area is achieved under the action of an external magnetic field.

The application discloses a soil directional reinforcement method and control system based on magnetosome modified microorganisms, relates to the technical field of soil reinforcement, and endows the microorganisms with magnetic responsiveness through a magnetosome modification technology, realizes remote non-contact directional migration of the microorganisms in combination with magnetic navigation control, and enables the microorganisms to be accurately distributed in a target reinforcement area according to a preset path, effectively solving the problems of uncontrollable migration of the microorganisms and uneven reinforcement, and fully retaining the mineralization activity of the microorganisms in cooperation with mild conditions during the magnetosome modification and activity monitoring, thereby improving the reinforcement efficiency and reducing engineering cost, and the magnetic field parameters can be flexibly adjusted through programming, are suitable for different soil, reinforcement depth and path requirements, are suitable for various geotechnical engineering scenes such as foundation treatment and slope reinforcement, provide an efficient solution for directional reinforcement under complex geological conditions, and have remarkable application value and popularization prospect.

A method to control or change the polarization of at least one macrophage associated with a tumor or pathological site (TAM), from being predominantly a TAM with either no polarization (M0) or a polarization i (Mi) before at least one step of the method, to a predominant polarization j (Mj), by associating at least one TAM with a nanoparticle, preferentially a magnetosome, 10 and by exposing the assembly to a radiation, where Mi=Mi and Mj=M2 or Mi=M2 and Mj'M1.

The invention discloses a magnetosome-based GPC3 thermal dissociation aptamer composite magnetic bead, and relates to the technical field of biological medicines. The magnetosome-based GPC3 thermal dissociation aptamer composite magnetic bead comprises a temperature-sensitive thermal dissociation aptamer for specifically recognizing GPC3 protein, a magnetosome and a bifunctional reagent. The invention further provides a preparation method and application of the GPC3 thermal dissociation aptamer composite magnetic bead based on the magnetosome. The magnetosome-based GPC3 thermal dissociation aptamer composite magnetic bead prepared by the method provided by the invention can be specifically bound with GPC3 at 37 DEG C and dissociated with GPC3 at 46 DEG C, so that effective release of drugs in magnetocaloric therapy is realized, and the problem that a thermal dissociation aptamer capable of being specifically bound with GPC3 protein is lacked in the prior art is effectively solved.