38 results about "Iron supplement" patented technology

The invention relates to the technical field of small-molecule donkey-hide gelatin peptides, and provides a small-molecule donkey-hide gelatin peptide with iron ion chelating ability and application thereof, the molecular weight of the small-molecule donkey-hide gelatin peptide is smaller than 1000 Da, and the small-molecule donkey-hide gelatin peptide has the iron ion chelating ability. The iron chelation rate of the small-molecule donkey-hide gelatin peptide reaches 95%, and the small-molecule donkey-hide gelatin peptide has good solubility in in-vitro gastrointestinal digestion simulation and can be applied to the fields of iron supplements, nutrition fortified foods and the like.

Methods of increasing systemic iron availability in a human subject using plant-derived ferritin-bound iron are provided. In certain embodiments, ferritin-bound iron is orally administered in an amount effective to produce sustained systemic iron exposure characterized by measurable serum iron levels at least 24 hours after administration. In some embodiments, administration produces a delayed peak serum iron concentration and provides controlled systemic iron delivery relative to conventional iron supplements. In certain embodiments, administration of ferritin-bound iron results in a reduced hepcidin response relative to ferrous sulfate, thereby facilitating improved iron utilization. The ferritin-bound iron may be absorbed through receptor-mediated uptake mechanisms that provide controlled intracellular iron release and sustained systemic availability. The methods are useful for increasing systemic iron availability and for treating or preventing iron deficiency and iron deficiency anemia in human subjects.

The present application relates to a milk-derived phosphorylated peptide with the activity of improving intestinal iron absorption and its application in the preparation of iron supplements. The sequence of the milk-derived phosphorylated peptide is EESITRINKKIE, and the glutamic acid at the amino terminal of the sequence is connected with 1-3 phosphoserines. The milk-derived phosphorylated peptide can be combined with Fe 2+ Specifically bound, strong iron chelating ability, and can significantly improve the iron transport amount in the Caco-2 small intestinal epithelial cell model, thereby having good activity of improving intestinal iron absorption, and can be widely applied in the fields of drugs, health care products or food.

This invention relates to the field of biomedical technology, providing a phosphorylated peptide iron chelate of Yanbian cattle hemoglobin, its preparation method, and its applications. The Yanbian cattle hemoglobin phosphorylated peptide iron chelate is prepared from Yanbian cattle blood through enzymatic hydrolysis, phosphorylation, and iron chelation. Specifically, the phosphorylation step actively introduces strongly negatively charged phosphate groups into the Yanbian cattle hemoglobin peptide chain, serving as new and stronger metal ion coordination sites, thereby specifically enhancing its chelating ability for ferrous ions and the stability of the complex. The Yanbian cattle hemoglobin phosphorylated peptide iron chelate possesses high iron content and good gastrointestinal stability, showing broad application prospects in the preparation of a new generation of highly efficient and low-irritant iron supplements.

The application relates to the technical field of sialic acid application, in particular to application of sialic acid in promoting iron absorption of iron supplement agents. It is found for the first time that sialic acid with a daily intake of 0.8-3.5 mg / kg and ferrous iron with a daily intake of 0.2-0.5 mg / kg can promote the absorption of ferrous iron by human bodies. More specifically, the application claims an iron supplement agent containing ferrous iron drugs and sialic acid. The iron supplement agent provided by the application promotes iron supplement by compounding sialic acid and ferrous iron drugs, thereby improving the bioavailability of iron, regulating immunity, promoting intestinal health and achieving various biological activities while supplementing iron.

The utility model discloses a tabletting device for iron supplementing agent ferrous sulfate tablets, which belongs to the technical field of iron supplementing agent ferrous sulfate tablet production and comprises a base, a supporting rod is fixedly connected to the top of the base, a tray is fixedly connected to the top end of the supporting rod, a discharge port is formed in one side of the bottom of the tray, and a feeding port is formed in the other side of the bottom of the tray. The outer ring of the tray is fixedly connected with two fixing plates, the fixing plates are fixedly connected with tabletting assemblies, the tabletting assemblies are used for extruding ferrous sulfate raw materials into tablets, a forming cover movably arranged in the tray in a sleeved mode is arranged below the tabletting assemblies, the center of the forming cover is fixedly connected with a fixing shaft, and the fixing shaft is fixedly connected with the fixing plate. The top end of the fixing shaft is fixedly connected with a gear column. According to the utility model, not only are rapid tabletting and discharging convenient, but also the forming hole is filled conveniently, the tabletting quality of each time is ensured, and the whole equipment is simple, clear, convenient to overhaul and maintain and beneficial to enterprise use.

DEPCT67 What was revealed was a plant-derived iron supplement in particle form, containing iron in the specified amount. At least 40 mg per 100 g of dry weight of the substance, and of which at least 50% by volume of the additive. It has an apparent diameter of less than 500 micrometers;

The disclosure is directed to a method of replenishing a subject's iron, ferritin, and / or hemoglobin level. The method includes orally administering elemental metal iron to the subject; and orally administering a source of nitrate anion to the subject.

The invention provides iron binding peptides based on tuna blood combined meat. The amino acid sequences of some polypeptides are SEQ ID NO: 1-6. The polypeptide provided by the invention can be used for preparing a product for treating iron-deficiency anemia. According to the tuna red meat hematopoietin provided by the invention, an organic iron compound with high bioavailability is formed through the chelation of specific polypeptide iron ions in preparation of a blood replenishing product, so that the absorption efficiency of intestinal tracts on iron is remarkably improved. A carrier formed by the polypeptide can protect iron ions from being damaged by gastric acid, and the iron ions are delivered to an absorption part in a targeted mode, so that the hemoglobin synthesis efficiency is improved by 40% or above. The natural polypeptide ligand disclosed by the invention avoids gastrointestinal irritation of a traditional iron supplementing agent, and is not interfered by absorption of dietary factors such as phytic acid and tannin. The tuna processing by-product is used as the raw material to prepare the functional blood-enriching peptide, so that high-value utilization of fishery resources is realized, and an eco-friendly new iron-enriching source is provided.

The invention discloses an easy-to-absorb iron-supplementing carrier capable of reducing inflammation and preparation and application thereof.The iron-supplementing carrier is prepared by packaging a self-prepared citrus polysaccharide iron compound into sodium alginate / chitosan hydrogel pellets, and experiments prove that the iron-supplementing carrier is successfully positioned and released, the content of RBC and HGB in blood is remarkably increased, and the effect of reducing inflammation is achieved. The recovery of iron-deficiency anemia is effectively promoted; meanwhile, it is found that the content of a proinflammatory factor TNF-alpha in serum is reduced, the content of an anti-inflammatory factor IL-10 is remarkably increased, and the occurrence of inflammation is effectively reduced.

The invention discloses beet root powder for supplementing iron and a preparation method thereof, the beet root powder comprises red beet powder and compound vitamins, and the compound vitamins comprise vitamin C, vitamin E, nicotinamide, vitamin A, D-calcium pantothenate, vitamin B1, vitamin B6, vitamin B2, vitamin D3, vitamin B12, folic acid and maltodextrin. The invention further discloses a preparation method of the beet root powder for supplementing iron. According to the beet root powder for supplementing iron and the preparation method thereof, the prepared beet root powder for supplementing iron is composed of the red beet powder and the compound vitamins, so that the iron supplementing effect of the beet root powder is guaranteed, the whole preparation process is simple and convenient, and the preparation efficiency is improved.

The present invention discloses the use of a composition for preparing an iron-supplementing preparation. The composition comprises cornus officinalis and / or a cornus officinalis extract, and mangosteen and / or a mangosteen extract. By combining the active ingredients, the present invention provides a composition that can promote the body's absorption of iron by promoting intestinal iron absorption and / or inhibiting hepcidin, thereby providing an iron-supplementing effect. The composition can further be used to treat functional iron deficiency and other indications, providing a more effective preparation for improving iron deficiency. Furthermore, the preparation prepared using the composition also has the effects of regulating physical constitution, replenishing deficiency and invigorating qi, and regulating the body's health.

This invention relates to the field of microbial technology, specifically disclosing a strain of *Lactobacillus paracasei* BL23 that promotes iron absorption and its applications. The preservation number of *Lactobacillus paracasei* BL23 is CGMCC No. 32468. Experimental verification shows that this strain has the ability to reduce ferric iron to ferrous iron, and that specific reducing epitopes exist on the cell surface, enabling it to secrete siderophores. This strain utilizes siderophore secretion and Fe... 3＋ It reduces iron absorption through a dual mechanism and has strong strain specificity, enabling it to independently improve iron deficiency anemia without relying on exogenous iron supplements, thus providing a novel probiotic resource for the prevention and treatment of iron deficiency anemia.

The invention discloses a lentinan-ferrous complex for improving intestinal flora and oxidative stress as well as a preparation method and application of the lentinan-ferrous complex, and belongs to the technical field of functional foods and medicines. The preparation method comprises the following steps: dissolving lentinan and trisodium citrate in water in proportion, heating to 50-55 DEG C under the protection of nitrogen, slowly dropwise adding a FeSO4 solution, simultaneously maintaining the pH value to be 8-9 by using a NaOH solution, reacting, centrifuging the reaction solution, precipitating with alcohol, washing, and drying to obtain the lentinan. The prepared complex can significantly improve the stability of ferrous ions, and the bioavailability of the complex in a rat body is superior to that of ferrous sulfate and ferrous glycinate. More importantly, the complex has multiple effects of supplementing iron, regulating intestinal flora (such as reducing F / B value), increasing the yield of short-chain fatty acid and relieving oxidative stress and inflammatory response, and can be used for developing a novel iron supplementing preparation with an intestinal microenvironment improving function.

The invention relates to the technical field of peptide extraction, in particular to sipunculus nudus peptide and an extraction method and application thereof. According to the specific technical scheme, the method comprises the following steps: 1) crushing a sipunculus nudus raw material, adding water, adding sodium hydrogen sulfite and ascorbic acid, and stirring and soaking for 10-15 minutes; 2) grinding the soaked raw materials, and adjusting the pH value of the slurry to be alkaline; (3) adding alkali enzyme into the slurry, carrying out microwave enzymolysis for 45-50 minutes, adding papaya peptidase B, continuously carrying out microwave enzymolysis for 45-50 minutes, heating, inactivating, cooling, carrying out centrifugal filtration, and collecting filtrate; and 4) sequentially carrying out microfiltration, ultrafiltration and sodium filtration on the obtained filtrate to obtain the product. Microwave radiation is adopted for assisting enzymolysis, energy can be provided for an enzymolysis system, the temperature needed by enzymolysis can be maintained, the enzymolysis efficiency is greatly improved, the prepared sipunculus nudus peptide can stabilize iron ions, a safe and efficient iron supplementing preparation can be developed, meanwhile, reproductive function decline caused by obesity can be comprehensively repaired, the advantage of multi-dimensional conditioning is achieved, and the sipunculus nudus peptide has a good application prospect. And the method is suitable for metabolism-related reproductive disorder treatment.

The present invention discloses a heme iron – glycine chelated iron supplement preparation, belonging to the technical field of nutritional and pharmaceutical preparations. The preparation employs a four-source composite of heme iron, glycine chelated iron, ferrous gluconate, and ferrous lactate, enabling iron supplementation via heme receptor absorption, amino acid chelation pathways, and ionic diffusion. This design overcomes the limitations of single iron sources, including gastrointestinal irritation and low absorption of inorganic iron, dietary inhibition of conventional organic iron, and the high cost or slow onset of novel iron sources. The four iron sources act synergistically to reduce free iron ions and integrate multiple absorption pathways. As a result, gastrointestinal irritation is minimized, and the inhibitory effects of phytic acid, oxalic acid, and tannins are reduced, enabling stable and efficient intestinal absorption. The preparation achieves non-irritating, highly bioavailable, and sustained iron supplementation.

The invention relates to the technical field of fertilizers, in particular to a humic acid-containing medium trace element fertilizer for improving poor growth of blueberries and a preparation method of the humic acid-containing medium trace element fertilizer. According to the fertilizer, potassium fulvate and citric acid are used as main complexing frameworks, and an internal and external gradient release structure is formed by adopting a fractional iron supplementing process: the mass ratio of stable complexing iron to weak complexing iron is (8-19): 1, so that quick-acting and long-acting combination is realized. According to the formula, polydopamine nanoparticles are introduced and modified to form a core-shell structure, so that flocculation and pipeline scaling induced by calcium and magnesium ions in hard water are effectively prevented. Zinc, manganese, magnesium and boron cooperate to promote chlorophyll synthesis. Field trials show that the SPAD value of leaves is increased by 21-35%, available iron in soil is increased to 7.6 mg / kg, the irrigation uniformity coefficient reaches 94.6%, and poor growth of blueberries is remarkably improved.

1. The name of the product under this design: Pectin iron supplement packaging bottle. 2. Purpose of this design product: used for packaging pectin iron supplements. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention is related to a novel pharmaceutical product containing iron and meglumine. In certain embodiments, the present invention is related to a novel injectable dosage form comprising ferric meglumine as a parenteral iron supplement to treat iron deficiency anemia. In certain embodiments, the present invention is related to a novel oral dosage form comprising ferric meglumine as iron supplement and / or phosphate binder.

The application provides an iron supplement tabletting candy and a preparation method thereof, and the iron supplement tabletting candy comprises the following components in parts by weight: sorbitol 48-53 parts, hemoglobin peptide 35-40 parts, needle cherry fruit powder 4.1-4.8 parts, hemin chloride 1.2-1.5 parts, L-ascorbic acid 1.5-3.0 parts, and magnesium stearate 3.4-3.8 parts. The tabletting candy and the preparation method improve the viscosity of the mixture by using hemoglobin peptide in the preparation of the hemin tabletting candy, and the flowability and compressibility of the material can be improved by adding the flow agent powder in batches and premixing the material except part of the magnesium stearate and the hemoglobin peptide.

The invention relates to the technical field of peptide iron chelation processing, in particular to a preparation method of a phycocyanin polypeptide-ferrous chelate, which comprises the following steps: taking phycocyanin freeze-dried powder as a raw material, and carrying out enzymolysis by adopting protease combined with ultrasound to obtain phycocyanin polypeptide; dissolving with pure water to obtain phycocyanin polypeptide, adding ascorbic acid, and heating in a water bath; centrifuging a chelation reaction solution, taking supernate, adding ethanol, standing, centrifuging again, collecting precipitate, and performing vacuum freeze drying to obtain phycocyanin polypeptide-ferrous chelate powder; the phycocyanin polypeptide-ferrous chelate prepared by the invention has higher iron content, shows more excellent stability in the process of simulating gastrointestinal digestion in vitro compared with inorganic iron salt, further has triple functions of supplementing iron, resisting oxidation and supplementing essential amino acids, is prepared from food-grade raw materials, is safe in process and low in cost, and is suitable for industrial production. A low-cost and high-efficiency scheme is provided for IDA intervention, and the method can be widely applied to development of foods, medicines and health-care products.

The invention relates to the technical field of food fortification, in particular to a whey protein-tannic acid-ferrous ion compound and a preparation method thereof. According to the compound, whey protein serves as a carrier, the whey protein is modified through tannic acid, ferrous ions are introduced on the basis, and the stable iron supplement is formed. According to the compound, the stability and bioavailability of ferrous iron can be remarkably improved, the defects of an existing iron supplement in the aspects of cost, stability and side effects are overcome, and oxidative conversion of iron in gastrointestinal tracts is effectively prevented. The preparation method is simple, mild in process condition and easy for industrial production, and has a wide application prospect.

The present invention provides a method for preparing an iron supplement preparation and an iron supplement preparation. The method for preparing the iron supplement preparation of the present invention comprises step (i), preparing a gold nanoparticle solution having a gold nanoparticle concentration of 200 to 1000 μg / mL and an iron solution having an iron concentration of 3 to 50 mg / mL; and step (ii), mixing the gold nanoparticle solution and the iron solution in a volume ratio of 1 to 10:10 to 30. According to the present invention, the side effects of existing oral iron supplement preparations on intestinal flora can be overcome, inflammation can be reduced, and more efficient and safe iron supplementation can be achieved.

This invention provides a glycosylated peptide chelated iron pyrophosphate supplement, its preparation method, and its application. The raw materials for preparing the glycosylated peptide chelated iron pyrophosphate supplement include glycosylated peptides, iron pyrophosphate, and a solubilizer. The glycosylated peptide is a β-glucan-grafted casein phosphopeptide, and the solubilizer is sodium pyrophosphate. The glycosylated peptide chelated iron pyrophosphate supplement of this invention exhibits good water solubility, color stability over a wide pH range, coexistence with nutrients such as vitamin C and oils, high iron loading capacity, good stability in gastric juice, sustained iron release in simulated intestinal fluid, and high iron absorption and utilization rate, significantly improving anemia in iron-deficiency anemia mice. The excellent absorption performance and superior physicochemical properties of the glycosylated peptide chelated iron pyrophosphate supplement of this invention make it a potential candidate for widespread application in the iron supplement market.

The invention relates to a preparation method of iron supplement medicine ferrous succinate with low high iron content, succinic acid and ferrous sulfate heptahydrate are used as raw materials to generate ferrous succinate, the high iron content of the raw material ferrous sulfate is controlled, the oxygen content of water for reaction is controlled in the reaction process, and meanwhile, the process conditions are controlled, so that the iron supplement medicine ferrous succinate with low high iron content is obtained. And finally obtaining the ferrous succinate with the high iron content of less than 0.2%. The synthesis method is simple, conditions are easy to control, the production safety is high, the product yield is high, and ferrous succinate with very low high iron content can be obtained.

The invention discloses a composite food-grade nano iron oxide particle for iron supplement coloring and a preparation method thereof, the nano iron oxide core with the particle size of 3-8nm is prepared by using food-grade ferric chloride and ferrous sulfate as raw materials through an alkaline coprecipitation method, and sodium citrate and gelatin are used for surface modification to obtain the composite food-grade nano iron oxide particle. And embedding with food-grade polysaccharides such as fructo-oligosaccharide to form stable composite particles. The iron content of the obtained product is greater than or equal to 65%, the absolute value of Zeta potential is greater than or equal to 25mV, the product can be stably dispersed for more than 30 days in a pH range of 3-8, the CIELAB chromaticity parameters are as follows: the L value is 28-35, the a value is 10-15 and the b value is 5-8, and the product has the coloring property required by dark food and excellent iron bioavailability; by accurately controlling the particle size and the surface characteristics, the problems that a traditional iron supplementing agent is low in absorptivity and a coloring agent is single in function are solved; the product is suitable for deep-color health-care food such as donkey-hide gelatin cakes and black sesame pills, and can achieve the dual effects of nutrient enrichment and appearance improvement.

1. The name of the design product: Pectin iron supplement packaging box. 2. The use of the design product: used for packaging pectin iron supplement. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective drawing.

This invention belongs to the field of bioactive peptide preparation, specifically relating to an iron chelating peptide, its preparation method, and its application in the preparation of iron supplements. This study used soybean protein as raw material and screened four iron chelating peptides—EDEPFNLRSR, EDEPFNLR, DDLELKKIR, and EEQPLEVR—through enzymatic hydrolysis, purification, identification, and molecular docking techniques. Using a Caco-2 small intestinal epithelial cell model, it was found that all of the above iron chelating peptides significantly promoted iron transport and absorption, and significantly promoted Fe2+ absorption. 2+ Retention in the Caco-2 cell monolayer. The novel iron chelating peptides screened from soybean protein hydrolysates in this invention hold promise as a safe and effective iron supplement.

This invention discloses a CS-SA bilayer microcapsule, its preparation method, and its application in encapsulating tuna protein peptides for chelated iron, belonging to the field of pharmaceutical technology. First, using tuna minced meat as raw material, tuna protein peptides for chelated iron are prepared through complex enzymatic hydrolysis and chelation reaction. Then, using sodium alginate as the wall material, single-layer microcapsules are prepared using a sharp-pore-coagulation method. Finally, using chitosan as the outer wall material, CS-SA bilayer microcapsules are prepared through electrostatic layer-by-layer self-assembly. The CS-SA bilayer microcapsules prepared by this invention have a dense structure, uniform particle size, and an encapsulation efficiency of up to 45.0%. They exhibit excellent sustained-release performance in simulated gastrointestinal fluid, with release stability significantly superior to single-layer microcapsules and commercially available iron supplements. This invention realizes the high-value utilization of tuna processing byproducts and provides a new approach for the development of iron supplements.

[Problem] To provide an iron supplement free from bad taste (metallic taste), which is a drawback of iron agents, and free from side effects such as nausea, vomiting, and constipation, and that has excellent storage stability (oxidation resistance). [Solution] The present invention provides an iron supplement containing a magnesium hydroxide-based solid solution represented by formula (1): (Mg)1-x-y(Fe2+)x(M2+)y(OH)2-nz(An-)z. (In the formula, M2+ represents at least one selected from Zn, Mn, Cu, and Co, An- represents at least one of organic acid ion moieties, x, y and z are in the respective ranges: 0 < x < 0.3, preferably 0.01 ≤ x ≤ 0.2, 0 ≤ y < 0.2, preferably 0 ≤ y ≤ 0.1, and 0 ≤ z < 0.1, preferably 0.001 ≤ z ≤ 0.005, and n represents zero or an integer in the range of 0-4.)