25 results about "Iron supplementation" patented technology

The invention belongs to the technical field of food, and discloses a red date polysaccharide-iron compound and a preparation method thereof, and the compound comprises the following components by weight: 1-5 parts of red date polysaccharide; 5-20 parts by weight of a complexing agent; 15-30 parts by weight of a ferric iron compound; 5-15 parts by weight of alkali; and 200 to 300 parts by weight of deionized water. The red date polysaccharide-iron compound prepared by the invention has good dissolution performance, high stability and good solubility, and compared with a traditional iron supplementing agent, the red date polysaccharide-iron compound is more easily absorbed by an organism. In addition, the red date polysaccharide-iron compound has antioxidant activity in vitro. The preparation process is simple, the raw materials are rich in source, and the traditional Chinese medicine composition can be used for preventing or treating iron-deficiency anemia and provides a new choice for a novel iron supplementing agent.

This invention relates to the field of biomedical technology, providing a phosphorylated peptide iron chelate of Yanbian cattle hemoglobin, its preparation method, and its applications. The Yanbian cattle hemoglobin phosphorylated peptide iron chelate is prepared from Yanbian cattle blood through enzymatic hydrolysis, phosphorylation, and iron chelation. Specifically, the phosphorylation step actively introduces strongly negatively charged phosphate groups into the Yanbian cattle hemoglobin peptide chain, serving as new and stronger metal ion coordination sites, thereby specifically enhancing its chelating ability for ferrous ions and the stability of the complex. The Yanbian cattle hemoglobin phosphorylated peptide iron chelate possesses high iron content and good gastrointestinal stability, showing broad application prospects in the preparation of a new generation of highly efficient and low-irritant iron supplements.

The application relates to the technical field of sialic acid application, in particular to application of sialic acid in promoting iron absorption of iron supplement agents. It is found for the first time that sialic acid with a daily intake of 0.8-3.5 mg / kg and ferrous iron with a daily intake of 0.2-0.5 mg / kg can promote the absorption of ferrous iron by human bodies. More specifically, the application claims an iron supplement agent containing ferrous iron drugs and sialic acid. The iron supplement agent provided by the application promotes iron supplement by compounding sialic acid and ferrous iron drugs, thereby improving the bioavailability of iron, regulating immunity, promoting intestinal health and achieving various biological activities while supplementing iron.

In an iron (II) citrate monohydrate, identified by the formula FeC6H6O7-H2O ( Ferrous citrate monohydrate or iron citrate (II) monohydrate), obtained according to a particular production method, citric acid and elemental iron are bound in a molecular complex where the iron is agglomerated in the citrate which moves to a cyclic form and the iron is bound to the O groups of the carboxylic groups 1 and 3 through ionic bonds, forming two enantiomers, D and L (R and S), both perfectly water-soluble and highly assimilable by the human body. Formula (L) & Formula (D). With a different absorption mechanism from traditional iron molecules, said iron citrate monohydrate is usable in pharmaceutical and / or nutraceutical and / or food compositions, in particular in the treatment and prevention of iron deficiency anemias and in general of all diseases and disorders associated with iron deficiency. The effectiveness is proven by several examples.

The utility model discloses a tabletting device for iron supplementing agent ferrous sulfate tablets, which belongs to the technical field of iron supplementing agent ferrous sulfate tablet production and comprises a base, a supporting rod is fixedly connected to the top of the base, a tray is fixedly connected to the top end of the supporting rod, a discharge port is formed in one side of the bottom of the tray, and a feeding port is formed in the other side of the bottom of the tray. The outer ring of the tray is fixedly connected with two fixing plates, the fixing plates are fixedly connected with tabletting assemblies, the tabletting assemblies are used for extruding ferrous sulfate raw materials into tablets, a forming cover movably arranged in the tray in a sleeved mode is arranged below the tabletting assemblies, the center of the forming cover is fixedly connected with a fixing shaft, and the fixing shaft is fixedly connected with the fixing plate. The top end of the fixing shaft is fixedly connected with a gear column. According to the utility model, not only are rapid tabletting and discharging convenient, but also the forming hole is filled conveniently, the tabletting quality of each time is ensured, and the whole equipment is simple, clear, convenient to overhaul and maintain and beneficial to enterprise use.

The invention relates to the technical field of functional supplements, in particular to composite microspheres for regulating and controlling iron metabolism and a preparation method and application of the composite microspheres. The targeted delivery type tea-iron composite microsphere comprises an inner core containing a ferrous compound and theabrownin, the inner core is sequentially coated with sodium alginate and chitosan from inside to outside, so that the double-shell microsphere is formed; the surfaces of the double-shell microspheres are also coated with a theabrownin-probiotic metabolite composite membrane. The invention provides the tea-iron composite microsphere capable of realizing targeted delivery, effective release and synergistic interaction of iron element and tea active ingredients are realized through the design of a special structure, the immune function is remarkably enhanced while iron metabolism is regulated and controlled, the problems of low absorption efficiency, strong gastrointestinal tract irritation and the like of a traditional iron agent are effectively solved, and the tea-iron composite microsphere has a good application prospect. Therefore, a brand new solution is provided for improving intestinal health and enhancing body immunity.

The present invention generally relates to treatment of iron-related conditions with iron carbohydrate complexes. One aspect of the invention is a method of treatment of iron-related conditions with a single unit dosage of at least about 0.6 grams of elemental iron via an iron carbohydrate complex. The method generally employs iron carbohydrate complexes with nearly neutral pH, physiological osmolarity, and stable and non-immunogenic carbohydrate components so as to rapidly administer high single unit doses of iron intravenously to patients in need thereof.

The invention discloses beet root powder for supplementing iron and a preparation method thereof, the beet root powder comprises red beet powder and compound vitamins, and the compound vitamins comprise vitamin C, vitamin E, nicotinamide, vitamin A, D-calcium pantothenate, vitamin B1, vitamin B6, vitamin B2, vitamin D3, vitamin B12, folic acid and maltodextrin. The invention further discloses a preparation method of the beet root powder for supplementing iron. According to the beet root powder for supplementing iron and the preparation method thereof, the prepared beet root powder for supplementing iron is composed of the red beet powder and the compound vitamins, so that the iron supplementing effect of the beet root powder is guaranteed, the whole preparation process is simple and convenient, and the preparation efficiency is improved.

Subject matter of the present invention is iron supplementation for treatment and / or prophylaxis of an affective disorder and / or post-traumatic stress disorder (PTSD) and / or serotonin-dependent diseases in a human patient in need thereof. Subject matter of the present invention is in particular iron supplementation for treatment and / or prophylaxis of depression, in particular of a major depressive disorder (MDD) in a human patient in need thereof.

The present application relates to a kind of intestinal absorption hemin, belong to biological medicine technical field, the intestinal absorption hemin, including hemin and gamma-cyclodextrin;The molar ratio of hemin and cyclodextrin is 1:2;The preparation method of the intestinal absorption hemin, comprising the following steps: (1) hemin is mixed with ammonia water, to obtain hemin solution;Cyclodextrin is mixed with water, to obtain cyclodextrin aqueous solution;(2) the hemin solution is mixed with the cyclodextrin aqueous solution, to obtain mixed solution;(3) the mixed solution is stirred, and dried for 5h, to obtain intestinal absorption hemin.The intestinal absorption hemin prepared in the present application has the advantages of water solubility and stability, high bioavailability after gastrointestinal digestion, and can be used as a raw material for preparing nutritional fortifier for iron supplementation.

The invention discloses a lentinan-ferrous complex for improving intestinal flora and oxidative stress as well as a preparation method and application of the lentinan-ferrous complex, and belongs to the technical field of functional foods and medicines. The preparation method comprises the following steps: dissolving lentinan and trisodium citrate in water in proportion, heating to 50-55 DEG C under the protection of nitrogen, slowly dropwise adding a FeSO4 solution, simultaneously maintaining the pH value to be 8-9 by using a NaOH solution, reacting, centrifuging the reaction solution, precipitating with alcohol, washing, and drying to obtain the lentinan. The prepared complex can significantly improve the stability of ferrous ions, and the bioavailability of the complex in a rat body is superior to that of ferrous sulfate and ferrous glycinate. More importantly, the complex has multiple effects of supplementing iron, regulating intestinal flora (such as reducing F / B value), increasing the yield of short-chain fatty acid and relieving oxidative stress and inflammatory response, and can be used for developing a novel iron supplementing preparation with an intestinal microenvironment improving function.

The present invention discloses a heme iron – glycine chelated iron supplement preparation, belonging to the technical field of nutritional and pharmaceutical preparations. The preparation employs a four-source composite of heme iron, glycine chelated iron, ferrous gluconate, and ferrous lactate, enabling iron supplementation via heme receptor absorption, amino acid chelation pathways, and ionic diffusion. This design overcomes the limitations of single iron sources, including gastrointestinal irritation and low absorption of inorganic iron, dietary inhibition of conventional organic iron, and the high cost or slow onset of novel iron sources. The four iron sources act synergistically to reduce free iron ions and integrate multiple absorption pathways. As a result, gastrointestinal irritation is minimized, and the inhibitory effects of phytic acid, oxalic acid, and tannins are reduced, enabling stable and efficient intestinal absorption. The preparation achieves non-irritating, highly bioavailable, and sustained iron supplementation.

The invention discloses ruddy heme iron red ginseng and donkey-hide gelatin nutritional milk powder and a preparation method thereof, and belongs to the technical field of milk powder, the ruddy heme iron red ginseng and donkey-hide gelatin nutritional milk powder comprises the following components in parts by mass: a wet process part: 420-455 parts of whole milk powder, 306-345 parts of dried skim milk, 185-205 parts of isomaltooligosaccharide (type 50) powder, 35-40 parts of polydextrose, 11.5-14.5 parts of a milk powder nutrition enhancer III, 0.3-0.5 part of compound L-carnitine, and 0.1-0.3 part of heme chloride; according to the ruddy heme iron red ginseng and donkey-hide gelatin nutritional milk powder and the preparation method thereof, the heme chloride is adopted as an iron source, the bioavailability of the red heme iron red ginseng and donkey-hide gelatin nutritional milk powder is remarkably higher than that of ferrous sulfate used in traditional iron-supplementing milk powder, meanwhile, through beta-cyclodextrin embedding treatment, the fishy smell problem of an iron agent is solved, gastrointestinal tract stimulation is avoided, and L-sodium ascorbate is matched, so that the nutrition of the milk powder is improved. And the iron absorption rate can be further improved.

The invention discloses a recombinant adeno-associated virus, a construction method thereof and application of a composition of the recombinant adeno-associated virus in treating acute myelogenous leukemia. The composition comprises the recombinant adeno-associated virus and a vein iron supplement agent, and the recombinant adeno-associated virus takes an adeno-associated virus as a vector and comprises an AML specific promoter NM and miR30-shGBA (miGBA). Under the combined action of the recombinant adeno-associated virus and the vein iron supplementing agent, acute myelogenous leukemia cell OH is induced to be remarkably increased, miGBA is continuously expressed, and lysosomal storage disorder and ferroptosis of cells are caused. The composition based on the recombinant adeno-associated virus and the vein iron supplement can be used for preparing a novel acute myelogenous leukemia treatment reagent.

The invention belongs to the field of bioanalytical chemistry and drug metabolism research, and discloses a typing quantitative detection method for different forms of iron in serum, which comprises the following steps: S1, mixing a to-be-detected serum sample with an inorganic chlorine salt solution, placing in an ultrafiltration centrifuge tube, standing, centrifuging, and taking filtrate as non-transferrin binding iron NTBI; s2, a weak acid solution of inorganic chlorine salt is added into the filter residues obtained in S1, centrifugation is conducted, and filtrate serves as transferrin binding iron TBI; s3, a mixed solution of a reducing agent solution and an inorganic chlorine salt solution is added into the filter residues obtained in the S2, centrifugation is conducted, and filtrate serves as drug binding iron DI; and S4, respectively measuring absorbance of the NTBI, TBI and DI parts by adopting a spectrophotometric method, and converting the concentration by combining a standard curve, so as to obtain the content of the NTBI, TBI and DI in the serum sample to be detected. The method realizes high-selectivity separation and accurate quantification of three different forms of iron, and is suitable for intravenous iron agent in-vivo behavior research and analysis of iron metabolism related mechanisms.

The invention relates to a composite peptide nutritional composition as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composite peptide nutritional composition comprises a hematopoietic function regulating system (such as cattle spleen peptide, blood protein polypeptide and salmon hydrolyzed protein peptide), an iron metabolism balance regulating system (concentrated hawthorn clear juice) and a nutrition absorption promoting system (endothelium corneum gigeriae galli peptide and pericarpium citri reticulatae powder) which have a synergistic effect. The traditional Chinese medicine composition does not contain an exogenous iron agent, and aims to improve malnutrition caused by chronic hemolytic diseases such as thalassemia. The uniformity and the stability of the product are guaranteed through a specific proportioning and a staged mixing preparation process. Animal experiments show that the composition can significantly improve hemoglobin and red blood cell count of beta-thalassemia model mice, effectively control serum iron and liver iron accumulation levels of the mice, show unique advantages of efficient hematopoiesis and low iron accumulation, and has broad application prospects. And a new nutrition support scheme is provided for improving anemia and abnormal iron metabolism conditions caused by chronic hemolysis.

1. The name of the design product: Pectin iron supplement packaging box. 2. The use of the design product: used for packaging pectin iron supplement. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective drawing.

This invention discloses a CS-SA bilayer microcapsule, its preparation method, and its application in encapsulating tuna protein peptides for chelated iron, belonging to the field of pharmaceutical technology. First, using tuna minced meat as raw material, tuna protein peptides for chelated iron are prepared through complex enzymatic hydrolysis and chelation reaction. Then, using sodium alginate as the wall material, single-layer microcapsules are prepared using a sharp-pore-coagulation method. Finally, using chitosan as the outer wall material, CS-SA bilayer microcapsules are prepared through electrostatic layer-by-layer self-assembly. The CS-SA bilayer microcapsules prepared by this invention have a dense structure, uniform particle size, and an encapsulation efficiency of up to 45.0%. They exhibit excellent sustained-release performance in simulated gastrointestinal fluid, with release stability significantly superior to single-layer microcapsules and commercially available iron supplements. This invention realizes the high-value utilization of tuna processing byproducts and provides a new approach for the development of iron supplements.

Subject matter of the present invention is supplementation for treatment and / or prophylaxis of a neurodevelopmental or psychiatric disorder in a human patient in need thereof, wherein said patient suffers from a neurodevelopmental or psychiatric disorder selected from the group comprising attention deficit hyperactivity disorder (ADHD), attention deficit disorder (ADD), impulse control disorder and learning disorder and wherein said iron supplementation is selected from the group comprising an intravenous iron supplementation, parenteral iron supplementation, oral iron supplementation, intraaerterial iron supplementation or intramuscular iron supplementation, preferably an intravenous iron supplementation.

The application relates to the fields of medical care informatics and precision medical technology, and discloses a precision medication system for hemodialysis patients based on multiple omics and big data, which comprises the following modules: a multi-source data acquisition module, which acquires multi-source heterogeneous data of patients and performs standardization and integration processing; a drug metabolism analysis module, which analyzes drug metabolism pathways and individual differences through multi-omics data, constructs a drug metabolism polymorphism model, and outputs gene metabolism capacity classification and biomarker risk labels; an initial medication decision module, which is used for constructing an initial medication decision model based on a federal optimization framework of momentum enhancement and robust aggregation mechanism, and outputting a personalized initial medication scheme for erythropoietin and intravenous iron agents; and a drug dose adjustment module, which is used for dynamically optimizing time nodes and dose adjustment opportunities of drug administration through an asynchronous federal reinforcement learning framework combined with a forward-looking parameter correction strategy. The application constructs an intelligent medication system with strong robustness and fine decision.

1. Name of the designed product: packaging set (iron supplement). 2. Use of the designed product: for product packaging. 3. Design points of the designed product: in the pattern. 4. Picture or photo best indicating the design points: front view of set 2. 5. The designed product is a thin product, omitting the left view, right view, top view, and bottom view of set 1. 6. Other circumstances needing explanation: The designed product is a set product, so it is used and sold as a set. Set 1 is an inner packaging bag, set 2 is an outer packaging box, and set 1 is packed into set 2 for sale and use.

The application provides a kind of iron-binding peptide based on tuna blood meat, wherein the amino acid sequence of some polypeptides is SEQ ID NO:1-6.The polypeptide provided by the application can be used to prepare a preparation for treating iron deficiency anemia.The tuna red meat blood peptide provided by the application can be used to prepare a blood supplement preparation, and through specific polypeptide iron ion chelation, a high-bioavailability organic iron complex is formed, which significantly improves the absorption efficiency of iron in the intestinal tract.The carrier formed by the polypeptide can protect iron ions from being destroyed by gastric acid and target delivery to the absorption site, so that the hemoglobin synthesis efficiency is increased by more than 40%.The natural polypeptide ligand of the application avoids the gastrointestinal irritation of traditional iron supplements and is not affected by dietary factors such as phytic acid and tannin absorption interference.Functional blood supplement peptides are prepared from tuna processing by-products, which not only realizes the high-value utilization of fishery resources, but also provides an ecological-friendly new source of iron supplement.

The utility model discloses a mixing device for iron supplement agent ferrous sulfate tablets, which belongs to the technical field of iron supplement agent ferrous sulfate tablets and comprises two support plates, rotating shafts are rotatably connected between the two support plates, a mixing cylinder is fixedly connected between the two rotating shafts, and the mixing cylinder is fixedly connected with the support plates. Wherein one supporting plate is fixedly connected with a driving motor used for driving the rotating shaft to rotate, a transmission assembly is rotationally arranged on the mixing barrel, the transmission assembly is movably sleeved with a lifting stirring assembly, and the transmission assembly drives the lifting stirring assembly to rotate to stir raw materials. The raw materials can be conveniently driven by the mixing cylinder to shake, and can be stirred in a reciprocating lifting manner, so that the stirring range is widened, and the raw materials can be more fully mixed.

The invention discloses a nutritional therapy-based functional potion for benefiting qi and nourishing blood and a preparation process thereof, and belongs to the technical field of functional foods.The preparation process comprises the following steps: preparing beta-cyclodextrin, ergothioneine and an iron source into an inclusion compound; the inclusion compound, the colloid, the red ginseng, the red date concentrated juice, the lemon concentrated juice and the like are added into a reaction container to form a synergistic effect mechanism of tonifying qi, generating blood and promoting absorption, and the traditional Chinese medicine composition has a more remarkable hematopoietic function improvement effect compared with a single iron agent or a traditional blood replenishing traditional Chinese medicine; the ergothioneine can remarkably promote absorption of iron, and the iron source and the ergothioneine are prepared into the inclusion compound, so that the stability of the ergothioneine and the iron is improved, the damage of gastric acid is avoided, and the bioavailability of the potion is improved; through synergistic compatibility of the active component of red ginseng and iron, the multiplication capacity of bone marrow stroma cells can be remarkably enhanced, and the qi and blood biochemical function of the body is improved; ginsenoside contained in the red ginseng has the effect of promoting hematopoiesis and can activate proliferation and differentiation of hematopoietic stem cells.

The present invention falls within the technical field of iron supplement preparation, and relates more particularly to a process for preparing and applying a supplement based on a polysaccharide-iron complex derived from Auricularia auricula-judae, intended to supplement iron, improve iron deficiency anemia and strengthen immunity, comprising the following steps: preparation of raw materials, selection of iron-rich Auricularia auricula-judae as raw material; culture and optimization, engineering modification of fermented and cultured Auricularia auricula-judae; screening and selection of Auricularia auricula-judae strains with a high iron content;The beneficial effects are as follows: by constructing gene expression vectors, transforming fungal cells, and screening and identifying transformants with high synthetic capacity, the level of expression of genes related to the generation and conversion of the iron element is increased, allowing the cultivation of Auricularia auricula-judae varieties containing higher levels of iron, in order to improve the yield and production efficiency of the polysaccharide-iron complex.