39 results about "Iron supplementation" patented technology

The invention relates to the technical field of hemodialysis monitoring, and provides a hemodialysis on-line monitoring system and method, and the system comprises a data acquisition module which is used for collecting blood physiological parameters in a dialysis pipeline in real time; the blood component analysis module is connected with a blood loop of the dialysis machine and is used for detecting serum iron, ferritin and ferritin saturation indexes on line; and the data processing module is used for calculating the risk index of anemia, evaluating the iron utilization rate, constructing a model for measuring the iron deficiency erythropoiesis trend according to the collected and analyzed data, and training and optimizing the model. According to the method, individual parameters of patients are fused, personalized calculation is performed for iron metabolism rates and dialysis parameters of different patients, and data such as iron content, blood flow and dialysis fluid volume are acquired online in real time, so that iron concentration and infusion rate are accurately matched with real-time iron metabolism requirements of the patients, and anemia of the patients in the dialysis process is reduced.

The invention belongs to the technical field of food, and discloses a red date polysaccharide-iron compound and a preparation method thereof, and the compound comprises the following components by weight: 1-5 parts of red date polysaccharide; 5-20 parts by weight of a complexing agent; 15-30 parts by weight of a ferric iron compound; 5-15 parts by weight of alkali; and 200 to 300 parts by weight of deionized water. The red date polysaccharide-iron compound prepared by the invention has good dissolution performance, high stability and good solubility, and compared with a traditional iron supplementing agent, the red date polysaccharide-iron compound is more easily absorbed by an organism. In addition, the red date polysaccharide-iron compound has antioxidant activity in vitro. The preparation process is simple, the raw materials are rich in source, and the traditional Chinese medicine composition can be used for preventing or treating iron-deficiency anemia and provides a new choice for a novel iron supplementing agent.

This invention relates to the field of biomedical technology, providing a phosphorylated peptide iron chelate of Yanbian cattle hemoglobin, its preparation method, and its applications. The Yanbian cattle hemoglobin phosphorylated peptide iron chelate is prepared from Yanbian cattle blood through enzymatic hydrolysis, phosphorylation, and iron chelation. Specifically, the phosphorylation step actively introduces strongly negatively charged phosphate groups into the Yanbian cattle hemoglobin peptide chain, serving as new and stronger metal ion coordination sites, thereby specifically enhancing its chelating ability for ferrous ions and the stability of the complex. The Yanbian cattle hemoglobin phosphorylated peptide iron chelate possesses high iron content and good gastrointestinal stability, showing broad application prospects in the preparation of a new generation of highly efficient and low-irritant iron supplements.

The application relates to the technical field of sialic acid application, in particular to application of sialic acid in promoting iron absorption of iron supplement agents. It is found for the first time that sialic acid with a daily intake of 0.8-3.5 mg / kg and ferrous iron with a daily intake of 0.2-0.5 mg / kg can promote the absorption of ferrous iron by human bodies. More specifically, the application claims an iron supplement agent containing ferrous iron drugs and sialic acid. The iron supplement agent provided by the application promotes iron supplement by compounding sialic acid and ferrous iron drugs, thereby improving the bioavailability of iron, regulating immunity, promoting intestinal health and achieving various biological activities while supplementing iron.

In an iron (II) citrate monohydrate, identified by the formula FeC6H6O7-H2O ( Ferrous citrate monohydrate or iron citrate (II) monohydrate), obtained according to a particular production method, citric acid and elemental iron are bound in a molecular complex where the iron is agglomerated in the citrate which moves to a cyclic form and the iron is bound to the O groups of the carboxylic groups 1 and 3 through ionic bonds, forming two enantiomers, D and L (R and S), both perfectly water-soluble and highly assimilable by the human body. Formula (L) & Formula (D). With a different absorption mechanism from traditional iron molecules, said iron citrate monohydrate is usable in pharmaceutical and / or nutraceutical and / or food compositions, in particular in the treatment and prevention of iron deficiency anemias and in general of all diseases and disorders associated with iron deficiency. The effectiveness is proven by several examples.

The utility model discloses a tabletting device for iron supplementing agent ferrous sulfate tablets, which belongs to the technical field of iron supplementing agent ferrous sulfate tablet production and comprises a base, a supporting rod is fixedly connected to the top of the base, a tray is fixedly connected to the top end of the supporting rod, a discharge port is formed in one side of the bottom of the tray, and a feeding port is formed in the other side of the bottom of the tray. The outer ring of the tray is fixedly connected with two fixing plates, the fixing plates are fixedly connected with tabletting assemblies, the tabletting assemblies are used for extruding ferrous sulfate raw materials into tablets, a forming cover movably arranged in the tray in a sleeved mode is arranged below the tabletting assemblies, the center of the forming cover is fixedly connected with a fixing shaft, and the fixing shaft is fixedly connected with the fixing plate. The top end of the fixing shaft is fixedly connected with a gear column. According to the utility model, not only are rapid tabletting and discharging convenient, but also the forming hole is filled conveniently, the tabletting quality of each time is ensured, and the whole equipment is simple, clear, convenient to overhaul and maintain and beneficial to enterprise use.

The invention relates to the technical field of functional supplements, in particular to composite microspheres for regulating and controlling iron metabolism and a preparation method and application of the composite microspheres. The targeted delivery type tea-iron composite microsphere comprises an inner core containing a ferrous compound and theabrownin, the inner core is sequentially coated with sodium alginate and chitosan from inside to outside, so that the double-shell microsphere is formed; the surfaces of the double-shell microspheres are also coated with a theabrownin-probiotic metabolite composite membrane. The invention provides the tea-iron composite microsphere capable of realizing targeted delivery, effective release and synergistic interaction of iron element and tea active ingredients are realized through the design of a special structure, the immune function is remarkably enhanced while iron metabolism is regulated and controlled, the problems of low absorption efficiency, strong gastrointestinal tract irritation and the like of a traditional iron agent are effectively solved, and the tea-iron composite microsphere has a good application prospect. Therefore, a brand new solution is provided for improving intestinal health and enhancing body immunity.

The present invention belongs to the technical field of starch hydrogel materials, and discloses a starch gel material based on 4D printing technology and its preparation method and application, the preparation method comprising the following steps: (1) gelatinizing a mixture of carboxyl starch and water, and adding an iron source to obtain a uniform mixture; (2) transferring the mixture to the barrel of a 3D printer, and printing and shaping through hot extrusion 3D, obtaining a 3D printed sample and performing 4D printing stimulation; the 4D printing stimulation is an alkali liquor stimulation, and the pH of the alkali liquor is 8-12; (3) the 4D printed sample is immediately frozen, and then vacuum freeze-dried to obtain a starch gel material. The present invention applies hot extrusion 4D printing technology to the preparation of a starch-based mineral supplement for the first time, which can suppress the release of iron ions in the stomach and achieve efficient iron supplementation. The present invention has simple process, is environmentally friendly, and is easy to repeat and mass-produce.

The invention provides iron binding peptides based on tuna blood combined meat. The amino acid sequences of some polypeptides are SEQ ID NO: 1-6. The polypeptide provided by the invention can be used for preparing a product for treating iron-deficiency anemia. According to the tuna red meat hematopoietin provided by the invention, an organic iron compound with high bioavailability is formed through the chelation of specific polypeptide iron ions in preparation of a blood replenishing product, so that the absorption efficiency of intestinal tracts on iron is remarkably improved. A carrier formed by the polypeptide can protect iron ions from being damaged by gastric acid, and the iron ions are delivered to an absorption part in a targeted mode, so that the hemoglobin synthesis efficiency is improved by 40% or above. The natural polypeptide ligand disclosed by the invention avoids gastrointestinal irritation of a traditional iron supplementing agent, and is not interfered by absorption of dietary factors such as phytic acid and tannin. The tuna processing by-product is used as the raw material to prepare the functional blood-enriching peptide, so that high-value utilization of fishery resources is realized, and an eco-friendly new iron-enriching source is provided.

The invention relates to the technical field of functional feed additive development, in particular to a feed formula and a process for improving yellow tripe of fattening sheep, a novel selenium-porphyrin complex is used for resisting oxidation, an extract rich in beta-glucan and mannan oligosaccharide is used for regulating immunity and intestinal flora, a natural plant polyphenol compound is used for chelating heavy metals, and the feed has the effects of improving immunity and improving the yellow tripe of fattening sheep. The nano-scale montmorillonite and probiotic compound preparation can regulate intestinal tracts, the special amino acid chelated iron can supplement iron, and basic raw materials and other additives are added. The feed disclosed by the invention can efficiently improve the yellow tripe of the fattening sheep, and improves the growth performance and mutton quality of the fattening sheep by regulating nutrition metabolism, enhancing immunity, improving intestinal health, improving oxidation resistance and reducing the incidence rate of the yellow tripe, so that a synergistic effect is provided for farmers.

The present invention generally relates to treatment of iron-related conditions with iron carbohydrate complexes. One aspect of the invention is a method of treatment of iron-related conditions with a single unit dosage of at least about 0.6 grams of elemental iron via an iron carbohydrate complex. The method generally employs iron carbohydrate complexes with nearly neutral pH, physiological osmolarity, and stable and non-immunogenic carbohydrate components so as to rapidly administer high single unit doses of iron intravenously to patients in need thereof.

The present application provides compounds and methods for iron supplement therapy.

The invention discloses beet root powder for supplementing iron and a preparation method thereof, the beet root powder comprises red beet powder and compound vitamins, and the compound vitamins comprise vitamin C, vitamin E, nicotinamide, vitamin A, D-calcium pantothenate, vitamin B1, vitamin B6, vitamin B2, vitamin D3, vitamin B12, folic acid and maltodextrin. The invention further discloses a preparation method of the beet root powder for supplementing iron. According to the beet root powder for supplementing iron and the preparation method thereof, the prepared beet root powder for supplementing iron is composed of the red beet powder and the compound vitamins, so that the iron supplementing effect of the beet root powder is guaranteed, the whole preparation process is simple and convenient, and the preparation efficiency is improved.

Subject matter of the present invention is iron supplementation for treatment and / or prophylaxis of an affective disorder and / or post-traumatic stress disorder (PTSD) and / or serotonin-dependent diseases in a human patient in need thereof. Subject matter of the present invention is in particular iron supplementation for treatment and / or prophylaxis of depression, in particular of a major depressive disorder (MDD) in a human patient in need thereof.

The present application relates to a kind of intestinal absorption hemin, belong to biological medicine technical field, the intestinal absorption hemin, including hemin and gamma-cyclodextrin;The molar ratio of hemin and cyclodextrin is 1:2;The preparation method of the intestinal absorption hemin, comprising the following steps: (1) hemin is mixed with ammonia water, to obtain hemin solution;Cyclodextrin is mixed with water, to obtain cyclodextrin aqueous solution;(2) the hemin solution is mixed with the cyclodextrin aqueous solution, to obtain mixed solution;(3) the mixed solution is stirred, and dried for 5h, to obtain intestinal absorption hemin.The intestinal absorption hemin prepared in the present application has the advantages of water solubility and stability, high bioavailability after gastrointestinal digestion, and can be used as a raw material for preparing nutritional fortifier for iron supplementation.

The invention discloses a lentinan-ferrous complex for improving intestinal flora and oxidative stress as well as a preparation method and application of the lentinan-ferrous complex, and belongs to the technical field of functional foods and medicines. The preparation method comprises the following steps: dissolving lentinan and trisodium citrate in water in proportion, heating to 50-55 DEG C under the protection of nitrogen, slowly dropwise adding a FeSO4 solution, simultaneously maintaining the pH value to be 8-9 by using a NaOH solution, reacting, centrifuging the reaction solution, precipitating with alcohol, washing, and drying to obtain the lentinan. The prepared complex can significantly improve the stability of ferrous ions, and the bioavailability of the complex in a rat body is superior to that of ferrous sulfate and ferrous glycinate. More importantly, the complex has multiple effects of supplementing iron, regulating intestinal flora (such as reducing F / B value), increasing the yield of short-chain fatty acid and relieving oxidative stress and inflammatory response, and can be used for developing a novel iron supplementing preparation with an intestinal microenvironment improving function.

The invention discloses a nano iron oxide and colla corii asini synergistic blood replenishing nutrition formula and a preparation method thereof. The formula comprises the following components: 0.5-3% of surface functionalized nano iron oxide, 0.5-3% of colla corii asini and the balance of water. 30-50% of a donkey-hide gelatin matrix; 0.5 to 2.5% of vitamin C or a vitamin C derivative; 2-7% of plant polysaccharide; 0.5-3% of a licorice extract; 40-55% of ice syrup; the preparation method comprises the following steps: dissolving the donkey-hide gelatin matrix, adding the premixed nano iron oxide and vitamin C derivative, carrying out ultrasonic dispersion, sequentially adding other components, and carrying out homogenization treatment. According to the invention, sodium citrate or gelatin-coated nano iron oxide is used as a high-efficiency iron source and is matched with the blood replenishing effect of donkey-hide gelatin to realize function synergy; the bioavailability of iron is remarkably improved through the compatibility of vitamin C and polysaccharide; the nutritional powder has the advantages of traditional nourishing and modern nutritional supplement, and can be prepared into various dosage forms such as paste and soft sweets. In addition, the in-vitro absorption rate is 1.8-2.5 times of that of a traditional iron agent, the gastrointestinal irritation is remarkably reduced, and the iron-containing compound preparation is particularly suitable for nutrition intervention of people suffering from iron-deficiency anemia.

The present invention discloses a heme iron – glycine chelated iron supplement preparation, belonging to the technical field of nutritional and pharmaceutical preparations. The preparation employs a four-source composite of heme iron, glycine chelated iron, ferrous gluconate, and ferrous lactate, enabling iron supplementation via heme receptor absorption, amino acid chelation pathways, and ionic diffusion. This design overcomes the limitations of single iron sources, including gastrointestinal irritation and low absorption of inorganic iron, dietary inhibition of conventional organic iron, and the high cost or slow onset of novel iron sources. The four iron sources act synergistically to reduce free iron ions and integrate multiple absorption pathways. As a result, gastrointestinal irritation is minimized, and the inhibitory effects of phytic acid, oxalic acid, and tannins are reduced, enabling stable and efficient intestinal absorption. The preparation achieves non-irritating, highly bioavailable, and sustained iron supplementation.

1. The name of the product under this design: Pectin iron supplement packaging bottle. 2. Purpose of this design product: used for packaging pectin iron supplements. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The invention discloses ruddy heme iron red ginseng and donkey-hide gelatin nutritional milk powder and a preparation method thereof, and belongs to the technical field of milk powder, the ruddy heme iron red ginseng and donkey-hide gelatin nutritional milk powder comprises the following components in parts by mass: a wet process part: 420-455 parts of whole milk powder, 306-345 parts of dried skim milk, 185-205 parts of isomaltooligosaccharide (type 50) powder, 35-40 parts of polydextrose, 11.5-14.5 parts of a milk powder nutrition enhancer III, 0.3-0.5 part of compound L-carnitine, and 0.1-0.3 part of heme chloride; according to the ruddy heme iron red ginseng and donkey-hide gelatin nutritional milk powder and the preparation method thereof, the heme chloride is adopted as an iron source, the bioavailability of the red heme iron red ginseng and donkey-hide gelatin nutritional milk powder is remarkably higher than that of ferrous sulfate used in traditional iron-supplementing milk powder, meanwhile, through beta-cyclodextrin embedding treatment, the fishy smell problem of an iron agent is solved, gastrointestinal tract stimulation is avoided, and L-sodium ascorbate is matched, so that the nutrition of the milk powder is improved. And the iron absorption rate can be further improved.

The invention discloses a recombinant adeno-associated virus, a construction method thereof and application of a composition of the recombinant adeno-associated virus in treating acute myelogenous leukemia. The composition comprises the recombinant adeno-associated virus and a vein iron supplement agent, and the recombinant adeno-associated virus takes an adeno-associated virus as a vector and comprises an AML specific promoter NM and miR30-shGBA (miGBA). Under the combined action of the recombinant adeno-associated virus and the vein iron supplementing agent, acute myelogenous leukemia cell OH is induced to be remarkably increased, miGBA is continuously expressed, and lysosomal storage disorder and ferroptosis of cells are caused. The composition based on the recombinant adeno-associated virus and the vein iron supplement can be used for preparing a novel acute myelogenous leukemia treatment reagent.

The invention belongs to the field of bioanalytical chemistry and drug metabolism research, and discloses a typing quantitative detection method for different forms of iron in serum, which comprises the following steps: S1, mixing a to-be-detected serum sample with an inorganic chlorine salt solution, placing in an ultrafiltration centrifuge tube, standing, centrifuging, and taking filtrate as non-transferrin binding iron NTBI; s2, a weak acid solution of inorganic chlorine salt is added into the filter residues obtained in S1, centrifugation is conducted, and filtrate serves as transferrin binding iron TBI; s3, a mixed solution of a reducing agent solution and an inorganic chlorine salt solution is added into the filter residues obtained in the S2, centrifugation is conducted, and filtrate serves as drug binding iron DI; and S4, respectively measuring absorbance of the NTBI, TBI and DI parts by adopting a spectrophotometric method, and converting the concentration by combining a standard curve, so as to obtain the content of the NTBI, TBI and DI in the serum sample to be detected. The method realizes high-selectivity separation and accurate quantification of three different forms of iron, and is suitable for intravenous iron agent in-vivo behavior research and analysis of iron metabolism related mechanisms.

The invention provides application of ferritin in a feed additive, and belongs to the technical field of feed preparation. The feed additive is prepared by constructing recombinant bacillus subtilis for expressing deacetylated nereis ferritin, expressing the deacetylated nereis ferritin, carrying out ultrasonic splitting on thalli and carrying out spray drying on a splitting solution. Compared with unmutated nereis ferritin, the amount of binding iron of the deacetylated nereis ferritin is increased by 44.62%. The serum iron content of piglets fed with the deacetylated nereis ferritin feed additive is 2.51 mu g / mL, the health rate is 98%, the serum iron content and the health rate are both higher than those of a glycine iron and non-mutated nereis ferritin feed additive group, the feed conversion ratio is 1.70: 1, and the serum iron content and the health rate are lower than those of the glycine iron and the non-mutated nereis ferritin feed additive group. The deacetylated nereis ferritin feed additive has a good iron supplementing effect on piglets, and can improve the health condition of the piglets, promote the growth of the piglets and effectively increase the breeding benefits.

The invention relates to a composite peptide nutritional composition as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composite peptide nutritional composition comprises a hematopoietic function regulating system (such as cattle spleen peptide, blood protein polypeptide and salmon hydrolyzed protein peptide), an iron metabolism balance regulating system (concentrated hawthorn clear juice) and a nutrition absorption promoting system (endothelium corneum gigeriae galli peptide and pericarpium citri reticulatae powder) which have a synergistic effect. The traditional Chinese medicine composition does not contain an exogenous iron agent, and aims to improve malnutrition caused by chronic hemolytic diseases such as thalassemia. The uniformity and the stability of the product are guaranteed through a specific proportioning and a staged mixing preparation process. Animal experiments show that the composition can significantly improve hemoglobin and red blood cell count of beta-thalassemia model mice, effectively control serum iron and liver iron accumulation levels of the mice, show unique advantages of efficient hematopoiesis and low iron accumulation, and has broad application prospects. And a new nutrition support scheme is provided for improving anemia and abnormal iron metabolism conditions caused by chronic hemolysis.

The present invention provides a method for preparing an iron supplement preparation and an iron supplement preparation. The method for preparing the iron supplement preparation of the present invention comprises step (i), preparing a gold nanoparticle solution having a gold nanoparticle concentration of 200 to 1000 μg / mL and an iron solution having an iron concentration of 3 to 50 mg / mL; and step (ii), mixing the gold nanoparticle solution and the iron solution in a volume ratio of 1 to 10:10 to 30. According to the present invention, the side effects of existing oral iron supplement preparations on intestinal flora can be overcome, inflammation can be reduced, and more efficient and safe iron supplementation can be achieved.

The invention relates to a preparation method of iron supplement medicine ferrous succinate with low high iron content, succinic acid and ferrous sulfate heptahydrate are used as raw materials to generate ferrous succinate, the high iron content of the raw material ferrous sulfate is controlled, the oxygen content of water for reaction is controlled in the reaction process, and meanwhile, the process conditions are controlled, so that the iron supplement medicine ferrous succinate with low high iron content is obtained. And finally obtaining the ferrous succinate with the high iron content of less than 0.2%. The synthesis method is simple, conditions are easy to control, the production safety is high, the product yield is high, and ferrous succinate with very low high iron content can be obtained.

The invention discloses a nano iron oxide composition and application thereof in improvement of iron-deficiency fatigue, and the composition comprises the following components in parts by mass: 0.5-5 parts of nano iron oxide; 2-10 parts of ascorbic acid; 5-15 parts of small molecule peptide; 5 to 15 parts of oligosaccharide; 10 to 30 parts of gelatin; the particle size of the nano iron oxide is 3-10nm, and the surface of the nano iron oxide is coated with sodium citrate or chitosan. Fe < 3 + > is reduced into Fe < 2 + > which is easy to absorb through ascorbic acid, the small molecule peptide promotes iron transport, the oligosaccharide prolongs the residence time of intestinal tracts, and the gelatin and other carriers improve the taste, so that a multi-mechanism synergistic interaction system is formed; the hemoglobin level can be increased by 28% and is obviously superior to 12% of a traditional iron agent, and side effects such as gastrointestinal irritation are avoided; the product can be prepared into various dosage forms such as soft sweets, decoction pieces and the like, has the advantages of high absorptivity, good safety, strong palatability and the like, and is suitable for nutrition intervention of iron-deficiency fatigue crowds such as women, old people and the like; the raw materials are easy to obtain, the process is simple, and the industrial prospect is good.

1. The name of the design product: Pectin iron supplement packaging box. 2. The use of the design product: used for packaging pectin iron supplement. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective drawing.

This invention discloses a CS-SA bilayer microcapsule, its preparation method, and its application in encapsulating tuna protein peptides for chelated iron, belonging to the field of pharmaceutical technology. First, using tuna minced meat as raw material, tuna protein peptides for chelated iron are prepared through complex enzymatic hydrolysis and chelation reaction. Then, using sodium alginate as the wall material, single-layer microcapsules are prepared using a sharp-pore-coagulation method. Finally, using chitosan as the outer wall material, CS-SA bilayer microcapsules are prepared through electrostatic layer-by-layer self-assembly. The CS-SA bilayer microcapsules prepared by this invention have a dense structure, uniform particle size, and an encapsulation efficiency of up to 45.0%. They exhibit excellent sustained-release performance in simulated gastrointestinal fluid, with release stability significantly superior to single-layer microcapsules and commercially available iron supplements. This invention realizes the high-value utilization of tuna processing byproducts and provides a new approach for the development of iron supplements.

Subject matter of the present invention is supplementation for treatment and / or prophylaxis of a neurodevelopmental or psychiatric disorder in a human patient in need thereof, wherein said patient suffers from a neurodevelopmental or psychiatric disorder selected from the group comprising attention deficit hyperactivity disorder (ADHD), attention deficit disorder (ADD), impulse control disorder and learning disorder and wherein said iron supplementation is selected from the group comprising an intravenous iron supplementation, parenteral iron supplementation, oral iron supplementation, intraaerterial iron supplementation or intramuscular iron supplementation, preferably an intravenous iron supplementation.