187 results about "Blood component" patented technology

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

The invention belongs to the technical field of medical treatment, and discloses a preparation process for accurately regulating and controlling the component proportion of a blood product. The process comprises the following steps: blood collection and pretreatment; blood components are accurately separated; performing real-time component detection; intelligent regulation and control and closed-loop feedback are realized; and optimizing a finished product and monitoring quality. According to the preparation process capable of accurately regulating and controlling the component proportion of the blood product, by integrating AI intelligent control, microfluid separation, real-time sensor detection, dynamic feedback regulation and control and other technologies, high-precision, automatic and intelligent blending of blood components is achieved. The AI intelligent optimization algorithm is adopted, the composition proportion is dynamically adjusted, and the precision error of a finished product is reduced to be within + / -1% from traditional + / -5%. Intelligent feedback closed-loop control avoids deviation caused by human intervention, and the consistency is improved. In the traditional centrifugal separation, parameters need to be manually adjusted, and the separation efficiency is low, while the micro-fluid centrifugal technology is adopted in the method, efficient separation can be completed within 5-10 minutes, and the overall productivity is improved by 30%-50%.

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

The invention discloses a continuous domain bound state sensor based on a composite prism all-dielectric metasurface, which is composed of periodically arranged unit structures, and each unit structure comprises a barium fluoride substrate layer and a group of silicon structure layers stacked on the barium fluoride substrate layer; the silicon structure layer comprises two first composite prisms arranged along a main diagonal line and two second composite prisms arranged along an auxiliary diagonal line, and the main diagonal line and the auxiliary diagonal line are in a crossed state; the tips of the two first composite prisms and the tips of the two second composite prisms are arranged in opposite directions, and the first composite prisms and the second composite prisms are of asymmetric structures; when polarized light is vertically incident, the resonance response of the ring dipole is excited, and two Fano formants are formed; the sensor has ultrahigh sensitivity and quality factor in a middle-infrared band, and can be applied to gas sensing and detection of various components of blood.

A method comprising: detecting a start of a donation process; in response to detecting the start of the donation process, providing an output; determining an amount of time remaining for the donation process; updating the output in response to detecting the amount of time remaining for the donation process; detecting pressure loss; updating the output in response to detecting the pressure loss; detecting the end of the donation process; and updating the output in response to detecting an end of the donation process. The donation process may include plasma donation using a blood component separation machine. Detecting the initiation of the donation process may include detecting the flow of the fluid. The output may include one or more of the following: light and sound. The output may be provided on one side of the blood component separation machine.

The invention relates to the technical field of blood detection, and discloses a blood quality visual detection device which comprises a detection box, a detection platform and an oscillation mechanism, a detection chamber and a storage chamber are arranged in the detection box, and the blood quality visual detection device further comprises a lead screw adjusting mechanism fixedly installed on the inner wall of the detection chamber; a CCD camera and a coaxial light source mechanism are installed on the front face of the lead screw adjusting mechanism in a transmission mode. According to the technical scheme, the driving assembly drives the rotating platform to intermittently rotate, the rotating platform drives the oscillating mechanism to rotate to be meshed with the forward and reverse transmission assembly, the forward and reverse transmission assembly drives the oscillating mechanism to swing in a reciprocating mode through synchronous forward and reverse rotation, and therefore a turbulence effect is generated on blood in a blood bag, and blood components are evenly distributed; a clear and uniform sample image is ensured to be obtained during visual detection; meanwhile, the disturbed blood smooths the protrusions of the blood bag and flattens the blood bag, it is guaranteed that an optical detection path is clear, and the reliability and accuracy of blood visual detection are improved.

The invention discloses a method for identifying a blood vessel in an endoscope image and an endoscope system. The method for identifying the blood vessel in the endoscope image comprises the following steps: acquiring a multi-channel image formed by endoscope imaging; time sequence points of all points in all RGB channels in the to-be-analyzed area in the multi-channel image are extracted, and normalization processing is carried out; according to the time sequence point of each point in each RGB channel in the to-be-analyzed area, respectively calculating the time sequence point of the mean value of each RGB channel in the to-be-analyzed area, and carrying out normalization processing; according to the normalized time sequence point of each point in each RGB channel in the to-be-analyzed area, determining a PPG amplitude for representing blood fluctuation information at each point; determining an average amplitude for representing blood fluctuation information according to a time sequence point of an average value of each RGB channel in the normalized region to be analyzed; and determining a blood vessel region according to the PPG amplitude of each point, the average amplitude, the penetration depth of the light sources with different wavelengths to human tissues and the difference of the absorption characteristics of blood components.

The invention relates to the technical field of peritoneal dialysis in the nephrology department, and discloses a peritoneal dialysis catheter anti-blocking device in the nephrology department, the peritoneal dialysis catheter anti-blocking device comprises a peritoneal dialysis catheter, an inflow tube and an anti-blocking mechanism are fixedly installed outside the peritoneal dialysis catheter, a rotating shaft is rotatably connected to the interior of a drainage tube, and propeller blades are fixedly installed outside the rotating shaft. An equipment box is fixedly mounted on the right side of the drainage tube, and a micro motor is fixedly mounted in the equipment box. According to the anti-blocking device for the peritoneal dialysis catheter in the nephrology department, when the micro motor drives the rotating shaft to rotate, the propeller blades slowly stir dialysate in the peritoneal dialysis catheter, and a directional vortex is formed; according to the design, liquid flowing is accelerated, protein, blood components and mineral substances are effectively prevented from being adsorbed or precipitated on the tube wall, the problem of blockage caused by standing is solved, meanwhile, the process does not need to depend on drugs, the operation process is simplified, early-stage tiny sediments can be preventively removed, and the catheter is kept unobstructed.

The invention discloses blood component single sampling equipment capable of monitoring in real time in the field of blood treatment equipment. The equipment comprises a blood sampling module, a centrifugal separation module, a component collection module and an anticoagulant conveying module, and further integrates a multi-dimensional real-time monitoring system and a closed-loop self-adaptive regulation and control module. The multi-dimensional real-time monitoring system comprises an online micro-fluidic component detection unit, a physiological parameter monitoring unit and an equipment operation monitoring unit, can realize real-time online detection of blood component purity, cell activity and pollutant residue in the separation process, and synchronously monitors circulation physiological parameters of a blood donor and an equipment operation state at the same time; the closed-loop self-adaptive regulation and control module can dynamically adjust parameters such as the centrifugal rotating speed, the fluid pump speed and the anticoagulant ratio according to real-time monitoring data, and precise closed-loop control over the separation process is achieved. The quality stability of blood single-sampling components can be remarkably improved, meanwhile, the operation risk is greatly reduced, and the method is suitable for clinical blood component single-sampling and preparation scenes.

The present invention pertains to the field of medicine and relates to a bag used for the collection, storage and separation of blood derivatives. The present patent is designed to enable the collection and separation of blood components in a single bag, suitable for generating fractionated bags and blood sample aliquots. This practice eliminates the risk of contamination due to the transfer and / or exposure of the blood products. The invention relates to a bag (1) composed of two superimposed polymeric films (2) and (3) sealed along their perimeter, and provided at its two ends with connectors (4), (5), (6), and (7), and handles (8) and (9), respectively; the bag (1) comprises an hourglass-shaped narrowing (10), formed by two trapezoidal seams (11) and (12) arranged opposite each other; the narrowing (10) has a length of between 6 mm and 15 mm (preferably 10 cm), a width of between 2 cm and 6 cm (preferably 4 cm), and angles (α), (β), (γ), and (δ) of between 10° and 60° (preferably 20°), while two or more demarcation lines (13) and (14) are placed transversely on both faces, on the narrowed region (11).

A method for collecting blood components, comprising: separating a first amount of plasma from whole blood; separating a total amount of collectable platelets from whole blood available after separating the first amount of plasma; if the total collection amount after the separation of the total amount of platelets is less than a maximum value adjusted by real-time data related to collection, then separating a second amount of plasma from the whole blood available after the separation of the total amount of platelets, and then separating a total amount of erythrocytes from the whole blood available after the separation of the second amount of plasma; and if the total collection amount is at a maximum adjusted by the real-time data relating to the collection, separating a total amount of red blood cells from the whole blood available after separating the total amount of platelets.

The present invention discloses a method for separating components after centrifugation of blood cells, which belongs to the field of medical technology. It is achieved by utilizing the photosensitivity of the sensor and the difference in relative light absorption of each component after blood cell separation; after centrifugation, the blood cells are separated into a red blood cell layer, a buffy coat, and platelet-poor plasma. When each phase passes through the sensor, the relative light absorption characteristics of each phase are different, thereby accurately monitoring the blood layer. When each phase of the present invention passes through the sensor, the light absorption characteristics of the blood components are different, and accurate blood layer monitoring is performed based on this principle. The composition of the prepared product phase and subphase can be changed by changing the preset hematocrit. The sensor pipeline part that matches the sensor is a flat pipeline with a cross-section that is close to a large and flat rounded rectangle. It is made of a material with good light transmittance such as polycarbonate, so that light of different wavelengths emitted by the LED light emitter can pass through the flat pipeline vertically and be received by the light receiver.

This disclosure relates to a method and device for determining the hemoglobin level of a mammal. The device includes several light-emitting diodes, one or more sensors, and a processor.

1. The name of this design product: Portable health instrument. 2. Purpose of the product of this design: used to conduct preliminary examination or screening of users to obtain information about blood composition, human organs and system functional status. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The application relates to the technical field of pharmaceutical analysis, and discloses a pharmacokinetic analysis method of Tongwei Xiaozheng medicinal liquid, which adopts Q-Orbitrap high-resolution liquid chromatography-mass spectrometry to analyze the concentration of Jasmonic acid in blood components of the Tongwei Xiaozheng medicinal liquid in rat plasma, establishes a plasma concentration determination method for the blood original component Jasmonic acid, carries out methodological verification such as specificity, precision and accuracy, and then calculates pharmacokinetic parameters. In the Tongwei Xiaozheng medicinal liquid, 92 blood components are identified, 17 of which are original components and 75 of which are metabolites, the application firstly determines that Jasmonic acid is one of the blood original components of the Tongwei Xiaozheng medicinal liquid, and reveals the pharmacokinetic characteristics of the Jasmonic acid in normal and model rats. The method has strong specificity, high sensitivity and good reproducibility, and can provide a scientific basis for the research on the pharmacodynamic material basis of the Tongwei Xiaozheng medicinal liquid, the establishment of quality control standards and the clinical rational use of drugs.

The utility model discloses a kind of blood component automatic identification devices of integrated multispectral sensor, comprising: equipment main body, clamping mechanism and rack, the rack is arranged in equipment main body inside, clamping mechanism includes circular bottom plate, the fixed clamping plate for clamping test tube and the adjusting pressure plate for adjusting the clamping force of fixed clamping plate, the utility model is by being arranged clamping mechanism, not only can be when test tube is placed to the inside of rack, test tube is clamped and fixed, can guarantee test tube in rack to stability, can in mixing process, avoid test tube to shake, collide and make liquid in test tube cannot be fully mixed, leading to uneven distribution of component in sample, affect the accuracy of subsequent detection, and the clamping force of fixed mechanism to test tube can be adjusted according to the size of test tube, to meet the clamping fixed demand of test tube of different size.

The present disclosure is directed to a method and device to determine a value of a blood constituent of a mammal. The device includes a plurality of light emitting diodes, one or more sensors and a processor.

Provided herein are compact sensor continuously and wirelessly senses blood constituents including a mm-wave newly designed sensor validates its ability to correlate received base-band power levels variations, rather than S-parameters, with the variations in blood glucose levels of serum [FBS] and in that of the jugular veins and carotid arteries for animals and humans.

The utility model provides a plasma sampling device, which belongs to the technical field of medical instruments and comprises a sampling barrel and a connecting sleeve. A plurality of liquid inlets which are transversely distributed are circumferentially formed in the bottom of the sampling barrel, a push-pull rod is longitudinally arranged in an inner cavity of the sampling barrel, a piston plate is arranged at the lower end of the push-pull rod, the piston plate is axially and slidably sealed along the inner cavity of the sampling barrel, and an operation part is arranged at the upper end of the push-pull rod; the sampling barrel is sleeved with the connecting sleeve, a plurality of elastic pull rods are arranged in the circumferential direction of the connecting sleeve, and a clamping plate is arranged at the tail end of each elastic pull rod and clamped to the outer edge of the upper end opening of the separating barrel. According to the plasma sampling device provided by the utility model, the sampling barrel can be stably fixed in the middle of the upper part of the separating barrel, so that the sampling barrel can be prevented from shaking in the sampling process. The plasma is horizontally sucked into the sampling barrel through the plurality of liquid inlets which are transversely arranged, so that rising liquid flow can be prevented from carrying blood components on the lower layer, and the real characteristics of the plasma can be accurately reflected.

The application provides a non-invasive blood separation process monitoring method and system based on infrared imaging, and relates to the technical field of medical detection and biological separation, and comprises the following steps: acquiring an infrared image sequence of a blood separation device through an infrared camera, and capturing the thermal radiation distribution characteristics of blood components; adopting a sliding window Kalman filtering algorithm to perform time domain noise reduction on the infrared image sequence, and adaptively adjusting the sliding window length, dynamically updating the noise covariance, and outputting the noise-reduced infrared image; processing the noise-reduced infrared image based on a multi-model switching convolutional neural network architecture, dynamically selecting and loading a convolutional neural network model matched with the current blood separation stage, so as to extract blood separation interface morphological characteristics; and calculating key separation parameters based on the separation interface morphological characteristics, and triggering an early warning signal when the parameters are abnormal. The application realizes non-invasive dynamic monitoring of clinical blood separation.

Provided herein are improved methods of producing cells, including T-cells and CAR T-cells. Also provided herein are methods of producing cells, such as T-cells and CAR T-cells, that can be obtained from blood using a method incorporating membrane filtration and ammonium chloride potassium (ACK) buffer to isolate the cells from other blood components.

The present invention provides a recombinant type IV collagen composition for repairing basement membrane and soothing and reducing redness. The inventors found that the recombinant type IV collagen described in the specification of this patent inhibits the phosphorylation of VE-cadherin protein by mediating the PKCα / PYK2 / Src signaling pathway, protects the tight junctions between endothelial cells, prevents the leakage of blood components, and reduces vascular permeability; it can also improve the dissociation of the VE-cadherin complex caused by oxidative stress and maintain the homeostasis of the endothelial barrier; therefore, it has good effects of repairing the basement membrane barrier and soothing and reducing redness. The inventors also first discovered that the repair peptide (GAAGLPGPK) has the effects of repairing the basement membrane barrier, soothing and reducing redness, and the combination of a certain proportion of the recombinant type IV collagen and the repair peptide shows synergistic effects in repairing the basement barrier and soothing and reducing redness.

A separation assembly for a blood component separation system includes a first media bag, a second media bag, a container, and a separation device. The first media bag contains a first fluid medium. A second fluid medium is contained in the second medium bag. The container is configured to contain a third fluid medium. The separation device comprises a first pipeline and a second pipeline. The first conduit has a first fitting configured to be coupled to a first media bag. The first conduit defines a first length. The second conduit has a second fitting configured to be coupled to a second media bag. The second conduit defines a second length different from the first length. The separation device may also include a third conduit configured to be coupled to the container.

A method of preparing sterile human placental allografts by providing a human placental tissue from a donor within 24 hours to 72 hours post-childbirth; removing any visible blood, blood clots, and / or blood components from the human placental tissue without scraping or scrubbing the human placental tissue to preserve structural integrity of the human placental tissue; washing the human placental tissue in an isotonic solution while maintaining the structural integrity of the human placental tissue; dehydrating the human placental tissue thereby forming the dehydrated human placental tissue; resizing the dehydrated human placental tissue into dehydrated human placental tissue portions having predetermined sizes; and sterilizing the dehydrated human placental tissue portions of step (e) thereby forming the sterile human placental allograft. Also disclosed is a sterile human placental allograft produced by the method.

The invention belongs to the field of blood glucose detection, and relates to a high-sensitivity blood glucose noninvasive detection method and system based on polarized terahertz photoacoustic, which combines the advantages of terahertz wave band detection and photoacoustic detection, fully utilizes the chiral characteristics of glucose molecules, and adopts polarized terahertz photoacoustic to detect the blood glucose concentration. Polarization optical rotation change information is extracted through the time domain photoacoustic signal; by selecting the characteristic absorption wave band of glucose and utilizing the difference between glucose and other blood components in chiral characteristics, the influence of water and other high-concentration ions on terahertz signals is remarkably reduced, so that the selectivity and the anti-interference capability of blood glucose detection are effectively improved; terahertz non-ionizing radiation is adopted as an excitation source, no ionizing injury risk is caused to a human body, and the device is suitable for long-term repeated detection and is expected to be popularized and applied in wearable or bedside monitoring equipment.

The invention discloses a whole blood leukocyte-depleted multi-component double-filter blood united bag which comprises a main collection bag, a red blood cell storage bag, a plasma storage bag, a platelet-rich plasma storage bag, and a main collection pipeline, a first transfer pipeline and a second transfer pipeline which are communicated with one another. The core improvement lies in that the first transfer pipeline is provided with a first leukocyte-depleting filter special for red blood cells, and the second transfer pipeline is provided with a second leukocyte-depleting filter special for platelet-rich plasma. The double filters solve the problem that a single filter cannot give consideration to characteristics of different blood components, and synchronous and optimized leukocyte removal treatment of red blood cells and platelet-rich plasma in a closed system is realized. Besides, a sampling pipeline, an anti-needling protection device, a bypass pipeline, an SAG-M additive bag and the like are integrated in the linked bag, so that the blood component yield and activity are improved, and the operation safety and the flow flexibility are guaranteed at the same time.

The invention relates to a blood shearing device and a blood compatibility evaluation method. The blood shearing device comprises an objective table, a fixing support, a supporting beam, a stator, a rotor and a driving source. The device can simultaneously adjust the roughness and wettability of the material surface, breaks through the limitation that only a single factor can be researched in the prior art, and provides a more comprehensive platform for systematically evaluating the blood compatibility; in the experimental method, red blood cell hemolysis is detected, and the degradation condition of plasma protein is evaluated synchronously, so that the overall injury mode of blood components under the action of an artificial surface can be reflected more truly. Experimental basis can be provided for material selection and surface optimization of blood contact type medical instruments such as an artificial heart pump, an ECMO and a hemodialysis machine, the clinical complication risk can be reduced, and development of artificial organs and blood purification technologies is promoted.

The invention provides a double-position centrifugal plasma purification system, and belongs to the technical field of plasma purification. Comprising a plasma collection system, a plasma adsorption system and a liquid feedback system, the plasma collection system and the liquid feedback system are both connected with a blood supplier to form a blood closed-loop conveying loop, and the plasma adsorption system is connected with the plasma collection system and the liquid feedback system; the plasma collecting system comprises two centrifugal machines and further comprises a back-flushing cleaning system, and the two centrifugal machines are alternately connected with the plasma collecting system and the back-flushing cleaning system through a first control valve and a second control valve. The centrifugal machine after each round of blood separation is flushed through the backflushing cleaning system, blood residues in a container of the centrifugal machine are avoided, free hemoglobin rising caused by long-time centrifugation of blood components is avoided, and the effect of improving the safety and reliability of the blood purification process is achieved.