329 results about "Blood component" patented technology

A method of preparing sterile human placental allografts by providing a human placental tissue from a donor within 24 hours to 72 hours post-childbirth; removing any visible blood, blood clots, and / or blood components from the human placental tissue without scraping or scrubbing the human placental tissue to preserve structural integrity of the human placental tissue; washing the human placental tissue in an isotonic solution while maintaining the structural integrity of the human placental tissue; dehydrating the human placental tissue thereby forming the dehydrated human placental tissue; resizing the dehydrated human placental tissue into dehydrated human placental tissue portions having predetermined sizes; and sterilizing the dehydrated human placental tissue portions of step (e) thereby forming the sterile human placental allograft. Also disclosed is a sterile human placental allograft produced by the method.

A method of preparing sterile human placental allografts by providing a human placental tissue from a donor within 24 hours to 72 hours post-childbirth; removing any visible blood, blood clots, and / or blood components from the human placental tissue without scraping or scrubbing the human placental tissue to preserve structural integrity of the human placental tissue; washing the human placental tissue in an isotonic solution while maintaining the structural integrity of the human placental tissue; dehydrating the human placental tissue thereby forming the dehydrated human placental tissue; resizing the dehydrated human placental tissue into dehydrated human placental tissue portions having predetermined sizes; and sterilizing the dehydrated human placental tissue portions of step (e) thereby forming the sterile human placental allograft. Also disclosed is a sterile human placental allograft produced by the method.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

The invention relates to the technical field of hemodialysis monitoring, and provides a hemodialysis on-line monitoring system and method, and the system comprises a data acquisition module which is used for collecting blood physiological parameters in a dialysis pipeline in real time; the blood component analysis module is connected with a blood loop of the dialysis machine and is used for detecting serum iron, ferritin and ferritin saturation indexes on line; and the data processing module is used for calculating the risk index of anemia, evaluating the iron utilization rate, constructing a model for measuring the iron deficiency erythropoiesis trend according to the collected and analyzed data, and training and optimizing the model. According to the method, individual parameters of patients are fused, personalized calculation is performed for iron metabolism rates and dialysis parameters of different patients, and data such as iron content, blood flow and dialysis fluid volume are acquired online in real time, so that iron concentration and infusion rate are accurately matched with real-time iron metabolism requirements of the patients, and anemia of the patients in the dialysis process is reduced.

The invention discloses a blood component separation system and a control method, and belongs to the field of blood separation.The system comprises a centrifugal device, a blood supply pipeline, an air detector valve and a blood pump, a liquid outlet of the centrifugal device is connected with a separation pipeline, and the separation pipeline is sequentially connected with a first plasma bag and a second plasma bag; a centrifugal pressure sensor, a centrifugal high-speed camera and a red blood cell sensor; and the control center comprises a data acquisition module, a data analysis module and a centrifugal control module. The control method comprises steps S1 to S4. Dynamic intelligent regulation and control and automatic control of the blood component centrifugal separation system are achieved, the centrifugal effect is optimized through the image recognition technology, the image recognition technology is superior to the photoelectric recognition technology in the prior art, excessive centrifugation is avoided, meanwhile, the centrifugal quality is guaranteed, and the quality and activity of separated blood components are effectively guaranteed.

The invention discloses a method for controlling the compaction degree of a left heart and a right heart in an extracorporeal circulation operation, which comprises the following steps of: in an in-vitro environment, mounting a peristaltic pump at a left heart inlet and a right heart inlet of an extracorporeal circulation device; a liquid inlet of the peristaltic pump is connected with a liquid inlet pump, and a liquid outlet of the peristaltic pump is connected with a liquid outlet pump; and finally, a first pressure measuring structure and a second pressure measuring structure are arranged on the sides, away from the peristaltic pump, of the liquid inlet pump and the liquid outlet pump correspondingly, and the pressure of the liquid inlet pump and the pressure of the liquid outlet pump are adjusted to be-20 mmHg. The negative pressure of the liquid inlet pump is adjusted through the first pressure measuring structure, and the negative pressure of the liquid outlet pump is adjusted through the second pressure measuring structure, so that the purpose of quantifying the adjusting mode is achieved, and the adjusting mode is accurate, rapid and high in reliability; the peristaltic pump can effectively avoid the occurrence of risks such as blood component damage, hemolysis, gas embolism and the like caused by reduction of the amount of blood conveyed by the pump, insufficient blood supply or direct interruption of blood circulation due to the condition that a pipe body connected with the peristaltic pump is shrunken or cannot be sucked during an operation.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

The invention discloses an ultra-stable anti-bioadhesion coating as well as a preparation method and application thereof, and belongs to the technical field of functional materials. The coating provided by the invention comprises a component A and a component B, the component A comprises nanoparticles, carboxyl silicone oil, a silane coupling agent and a solvent; the component B comprises a base material and a solvent; the nano-particles comprise at least one of silicon nano-particles, iron nano-particles or zinc nano-particles; the base material comprises epoxy resin. Through cooperation of the component A and the component B, the carboxyl silicone oil and the functionalized nanoparticles are combined and embedded into a matrix material, the formed coating can be used for preparing an ultra-stable anti-bioadhesion coating, the stability is good, the durability is good, adhesion of blood components, protein, bacteria, cells and the like can be effectively reduced, and the anti-bioadhesion performance of the coating is improved. The coating and the coating prepared from the coating have good application prospects in implantable medical equipment.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

The invention belongs to the technical field of medical treatment, and discloses a preparation process for accurately regulating and controlling the component proportion of a blood product. The process comprises the following steps: blood collection and pretreatment; blood components are accurately separated; performing real-time component detection; intelligent regulation and control and closed-loop feedback are realized; and optimizing a finished product and monitoring quality. According to the preparation process capable of accurately regulating and controlling the component proportion of the blood product, by integrating AI intelligent control, microfluid separation, real-time sensor detection, dynamic feedback regulation and control and other technologies, high-precision, automatic and intelligent blending of blood components is achieved. The AI intelligent optimization algorithm is adopted, the composition proportion is dynamically adjusted, and the precision error of a finished product is reduced to be within + / -1% from traditional + / -5%. Intelligent feedback closed-loop control avoids deviation caused by human intervention, and the consistency is improved. In the traditional centrifugal separation, parameters need to be manually adjusted, and the separation efficiency is low, while the micro-fluid centrifugal technology is adopted in the method, efficient separation can be completed within 5-10 minutes, and the overall productivity is improved by 30%-50%.

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

To improve sport performance by analyzing body balance, blood components, and a muscle amount of an individual athlete and proposing an appropriate daily training and meal amount.SOLUTION: A system includes means for analyzing body balance, blood components, and a muscle amount of an individual athlete, and means for proposing an appropriate daily training and meal amount.SELECTED DRAWING: Figure 1

Apparatus, systems and methods are disclosed relating to certain aspects of blood processing, collecting or storing, including method and system for automated authentication, processing device with scanner, blood container with two dimensional barcode, blood collection containers, blood container label and related tracking method, integrated container system, and processing device with sterile connection device.

The invention provides an adsorbent with a heparin slow release function, a preparation method of the adsorbent and a hemoperfusion device, and belongs to the technical field of adsorbent resin. The preparation method comprises the following steps: firstly preparing epoxy group-containing cross-linked porous resin, then reacting with an amino acid compound, and carrying out amino acid grafting modification on the surface of the epoxy group-containing cross-linked porous resin by utilizing the reaction between an epoxy group and an amino group, so that the blood compatibility is improved, and the interaction between the adsorbent and blood components is changed; furthermore, the amino acid modified adsorption resin is cross-linked by using an amido-containing micromolecule cross-linking agent, so that on one hand, the cross-linking degree, the pore structure and the surface property of the adsorbent are changed, and the interaction between the adsorbent and heparin is adjusted, and on the other hand, the specific interaction with heparin is increased by introducing an amine group; the adsorbent has the performance of adsorbing heparin and slowly releasing the heparin, the clinical use amount and use frequency of the heparin are reduced, and the clinical treatment safety is improved.

The utility model provides dialysis and separation equipment for umbilical cord blood. The dialysis and separation equipment comprises a first separation plate, a second separation plate, a bag and dredging units, wherein the first separation plate and the second separation plate are composed of filter membranes and impermeable membranes, the bag is made of flexible materials, and the dredging units are arranged on the two sides of the bag and used for squeezing. The filter membrane and the impermeable membrane are tightly combined to form an outlet, and the bag is divided into three cavities which are respectively used for treating umbilical cord blood and controlling liquid flow through a catheter and a valve. The dredging unit periodically extrudes the bag through the extrusion part and the control part, so that the filter membrane is prevented from being blocked. The equipment can effectively separate blood components through the matching of the filter membranes with different pore diameters and functions, and realizes a reliable, effective, simple and economical umbilical cord blood dialysis and separation mode.

A method for estimating an amount of blood loss within a waste container of a medical waste collection system, wherein an imaging device is supported by a device holder. The method includes analyzing an image, such as image frames of a video stream, to determine a fluid volume and a blood composition within a waste substance. These images may be adjusted based on a reference marker, and the method includes segmenting the images to determine blood, meniscus, and non-blood categories. A fluid meniscus of the waste material may be identified and mapped to a canonical coordinate space for pixel-to-volume conversion. Calibration data associated with the reference marker may be used to achieve this. At least one region of interest associated with an insert disposed within a waste container is analyzed. The estimated amount of blood loss may be displayed in real time based on the determined fluid volume and blood composition.

The invention provides purpleflower holly seed kidney-clearing granules and a detection method for analyzing components entering blood, and the detection method for analyzing the components of the purpleflower holly seed kidney-clearing granules comprises the following steps: determining a test solution by adopting an ultra-high performance liquid chromatography-high resolution mass spectrometry method, and determining 103 components in the test solution, and reference is provided for quality control and clinical application guidance of the purpleflower holly seed kidney-clearing granules. The detection method comprises the following steps: preparing blank plasma and administration plasma into a test solution, determining the test solution by adopting an ultra-high performance liquid chromatography-high resolution mass spectrometry combined method, and identifying 77 compounds including 20 prototype components and 57 metabolites, the method can reflect the drug-derived component condition after the drug enters the blood, makes up the blank of qualitative detection of the blood-entering component of the Ilex chinensis kidney-clearing granules, and provides a basis for further research on the metabolic cycle and metabolic pathway of the drug.

The invention relates to the technical field of traditional Chinese medicine analysis, and discloses a codonopsis pilosula root traditional Chinese medicine in-blood pharmacodynamic substance mass spectrometry imaging method and application thereof, and the method comprises the following steps: S1, pharmacodynamic research and serum drug chemical analysis of codonopsis pilosula treatment diseases: (1) establishment of an animal model: taking a spleen deficiency model as an example, (2) serum drug chemical analysis, and (3) establishment of an animal model: taking a spleen deficiency model as an example; and S2, researching the distribution of the blood-entering components in the traditional Chinese medicine. Differential distribution of various medicinal effect substances in different tissues of the plant is accurately identified and positioned by utilizing a mass spectrum imaging technology, and deep mass spectrum imaging analysis is quickly performed on the tissues of the target micro-region, so that the type and content information of the components entering the blood is obtained; according to the technology, space metabonomics is added, and the whole action mechanism of the codonopsis pilosula for treating diseases is explored, including codonopsis pilosula pharmacodynamics research and searching of pharmacodynamic substance components and spatial distribution of the pharmacodynamic substance components in codonopsis pilosula roots.

A method for collecting plasma includes determining the weight and hematocrit of a donor, and inserting a venous-access device into the donor. The method then withdraws blood from the donor through a draw line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate (1) a percentage of anticoagulant in the collected plasma component, and (2) a volume of pure plasma collected within the plasma collection container. The volume of pure plasma may be based, at least in part, on the calculated percentage of anticoagulant. The method may continue until a target volume of pure plasma is collected within the plasma collection container.

The invention discloses a continuous domain bound state sensor based on a composite prism all-dielectric metasurface, which is composed of periodically arranged unit structures, and each unit structure comprises a barium fluoride substrate layer and a group of silicon structure layers stacked on the barium fluoride substrate layer; the silicon structure layer comprises two first composite prisms arranged along a main diagonal line and two second composite prisms arranged along an auxiliary diagonal line, and the main diagonal line and the auxiliary diagonal line are in a crossed state; the tips of the two first composite prisms and the tips of the two second composite prisms are arranged in opposite directions, and the first composite prisms and the second composite prisms are of asymmetric structures; when polarized light is vertically incident, the resonance response of the ring dipole is excited, and two Fano formants are formed; the sensor has ultrahigh sensitivity and quality factor in a middle-infrared band, and can be applied to gas sensing and detection of various components of blood.

A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing / collecting until the calculated volume of pure plasma equals the target plasma collection volume.

A method comprising: detecting a start of a donation process; in response to detecting the start of the donation process, providing an output; determining an amount of time remaining for the donation process; updating the output in response to detecting the amount of time remaining for the donation process; detecting pressure loss; updating the output in response to detecting the pressure loss; detecting the end of the donation process; and updating the output in response to detecting an end of the donation process. The donation process may include plasma donation using a blood component separation machine. Detecting the initiation of the donation process may include detecting the flow of the fluid. The output may include one or more of the following: light and sound. The output may be provided on one side of the blood component separation machine.

The invention relates to the technical field of blood detection, and discloses a blood quality visual detection device which comprises a detection box, a detection platform and an oscillation mechanism, a detection chamber and a storage chamber are arranged in the detection box, and the blood quality visual detection device further comprises a lead screw adjusting mechanism fixedly installed on the inner wall of the detection chamber; a CCD camera and a coaxial light source mechanism are installed on the front face of the lead screw adjusting mechanism in a transmission mode. According to the technical scheme, the driving assembly drives the rotating platform to intermittently rotate, the rotating platform drives the oscillating mechanism to rotate to be meshed with the forward and reverse transmission assembly, the forward and reverse transmission assembly drives the oscillating mechanism to swing in a reciprocating mode through synchronous forward and reverse rotation, and therefore a turbulence effect is generated on blood in a blood bag, and blood components are evenly distributed; a clear and uniform sample image is ensured to be obtained during visual detection; meanwhile, the disturbed blood smooths the protrusions of the blood bag and flattens the blood bag, it is guaranteed that an optical detection path is clear, and the reliability and accuracy of blood visual detection are improved.

The invention discloses a method for identifying a blood vessel in an endoscope image and an endoscope system. The method for identifying the blood vessel in the endoscope image comprises the following steps: acquiring a multi-channel image formed by endoscope imaging; time sequence points of all points in all RGB channels in the to-be-analyzed area in the multi-channel image are extracted, and normalization processing is carried out; according to the time sequence point of each point in each RGB channel in the to-be-analyzed area, respectively calculating the time sequence point of the mean value of each RGB channel in the to-be-analyzed area, and carrying out normalization processing; according to the normalized time sequence point of each point in each RGB channel in the to-be-analyzed area, determining a PPG amplitude for representing blood fluctuation information at each point; determining an average amplitude for representing blood fluctuation information according to a time sequence point of an average value of each RGB channel in the normalized region to be analyzed; and determining a blood vessel region according to the PPG amplitude of each point, the average amplitude, the penetration depth of the light sources with different wavelengths to human tissues and the difference of the absorption characteristics of blood components.

The invention relates to the technical field of peritoneal dialysis in the nephrology department, and discloses a peritoneal dialysis catheter anti-blocking device in the nephrology department, the peritoneal dialysis catheter anti-blocking device comprises a peritoneal dialysis catheter, an inflow tube and an anti-blocking mechanism are fixedly installed outside the peritoneal dialysis catheter, a rotating shaft is rotatably connected to the interior of a drainage tube, and propeller blades are fixedly installed outside the rotating shaft. An equipment box is fixedly mounted on the right side of the drainage tube, and a micro motor is fixedly mounted in the equipment box. According to the anti-blocking device for the peritoneal dialysis catheter in the nephrology department, when the micro motor drives the rotating shaft to rotate, the propeller blades slowly stir dialysate in the peritoneal dialysis catheter, and a directional vortex is formed; according to the design, liquid flowing is accelerated, protein, blood components and mineral substances are effectively prevented from being adsorbed or precipitated on the tube wall, the problem of blockage caused by standing is solved, meanwhile, the process does not need to depend on drugs, the operation process is simplified, early-stage tiny sediments can be preventively removed, and the catheter is kept unobstructed.

The invention discloses a method for detecting in-blood components of Wulan thirteen-ingredient decoction powder for treating black vein disease, and relates to the technical field of in-vivo metabolism of drugs, and the method specifically comprises the following steps: S1, collecting a biological sample: respectively collecting blank plasma and drug-containing plasma for later use; s2, preparing a biological sample: treating the blank plasma and the drug-containing plasma to obtain a blank serum sample and a drug-containing serum sample for later use; s3, preparing an in-vitro test sample: treating the Wulan thirteen-ingredient decoction powder to obtain a traditional Chinese medicine sample for later use; and S4, respectively taking the blank serum, the drug-containing serum and 10 microliters of the traditional Chinese medicine sample, carrying out LC-MS / MS analysis, and determining the blood-entering components based on the detection result. The method disclosed by the invention can more comprehensively reveal the characteristics of the drug-derived components after the drug enters the blood, and fills the blank in the fields of qualitative analysis of the components of the Wulan thirteen-ingredient decoction powder entering the blood and quantitative detection of all effective components in the Wulan thirteen-ingredient decoction powder.

Blood is conveyed from a source into a separator, which separates at least one target blood component from the blood. The target blood component is then conveyed out of the separator, with the procedure continuing until an initial target amount of blood to be processed has been conveyed from the source into the separator and the target blood component separated from the initial target amount of blood to be processed has been conveyed out of the separator as an actual yield of the target blood component. An adjusted target amount of blood to be processed is then determined based at least in part on the difference between a target yield of the target blood component and the actual yield. The initial target amount of blood to be processed is then replaced with the adjusted target amount of blood to be processed when next executing the procedure.

The invention discloses blood component single sampling equipment capable of monitoring in real time in the field of blood treatment equipment. The equipment comprises a blood sampling module, a centrifugal separation module, a component collection module and an anticoagulant conveying module, and further integrates a multi-dimensional real-time monitoring system and a closed-loop self-adaptive regulation and control module. The multi-dimensional real-time monitoring system comprises an online micro-fluidic component detection unit, a physiological parameter monitoring unit and an equipment operation monitoring unit, can realize real-time online detection of blood component purity, cell activity and pollutant residue in the separation process, and synchronously monitors circulation physiological parameters of a blood donor and an equipment operation state at the same time; the closed-loop self-adaptive regulation and control module can dynamically adjust parameters such as the centrifugal rotating speed, the fluid pump speed and the anticoagulant ratio according to real-time monitoring data, and precise closed-loop control over the separation process is achieved. The quality stability of blood single-sampling components can be remarkably improved, meanwhile, the operation risk is greatly reduced, and the method is suitable for clinical blood component single-sampling and preparation scenes.

Exemplary embodiments provide an optical penile blood flow measuring technology for the monitoring of neurological and vascular function of structures at surgical risk. The measuring principle is to rely on optical absorption properties of blood components for penile blood flow monitoring. Certain embodiments use different wavelengths to measure changes in hemoglobin concentrations and are particularly advantageous in continuous, autonomous monitoring with real-time feedback to surgeons for potential intervention and decision-making in a timely manner. The measurements results can be used to provide real-time feedback to surgeons operating on the patient, or for off-line analysis and evaluation. Certain embodiments can operate autonomously in the continuous measurement mode, a synchronized mode, or a triggered mode, reducing the need of highly-skilled apparatus operators, allowing automatic and real-time warning to surgeons when operating in areas while preserving the functions of critical nerves, resulting in improved clinical outcomes and reducing operation costs.

The present invention pertains to the field of medicine and relates to a bag used for the collection, storage and separation of blood derivatives. The present patent is designed to enable the collection and separation of blood components in a single bag, suitable for generating fractionated bags and blood sample aliquots. This practice eliminates the risk of contamination due to the transfer and / or exposure of the blood products. The invention relates to a bag (1) composed of two superimposed polymeric films (2) and (3) sealed along their perimeter, and provided at its two ends with connectors (4), (5), (6), and (7), and handles (8) and (9), respectively; the bag (1) comprises an hourglass-shaped narrowing (10), formed by two trapezoidal seams (11) and (12) arranged opposite each other; the narrowing (10) has a length of between 6 mm and 15 mm (preferably 10 cm), a width of between 2 cm and 6 cm (preferably 4 cm), and angles (α), (β), (γ), and (δ) of between 10° and 60° (preferably 20°), while two or more demarcation lines (13) and (14) are placed transversely on both faces, on the narrowed region (11).