120 results about "Blood component" patented technology

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

The invention relates to the technical field of blood detection, and discloses a blood quality visual detection device which comprises a detection box, a detection platform and an oscillation mechanism, a detection chamber and a storage chamber are arranged in the detection box, and the blood quality visual detection device further comprises a lead screw adjusting mechanism fixedly installed on the inner wall of the detection chamber; a CCD camera and a coaxial light source mechanism are installed on the front face of the lead screw adjusting mechanism in a transmission mode. According to the technical scheme, the driving assembly drives the rotating platform to intermittently rotate, the rotating platform drives the oscillating mechanism to rotate to be meshed with the forward and reverse transmission assembly, the forward and reverse transmission assembly drives the oscillating mechanism to swing in a reciprocating mode through synchronous forward and reverse rotation, and therefore a turbulence effect is generated on blood in a blood bag, and blood components are evenly distributed; a clear and uniform sample image is ensured to be obtained during visual detection; meanwhile, the disturbed blood smooths the protrusions of the blood bag and flattens the blood bag, it is guaranteed that an optical detection path is clear, and the reliability and accuracy of blood visual detection are improved.

The invention discloses a method for identifying a blood vessel in an endoscope image and an endoscope system. The method for identifying the blood vessel in the endoscope image comprises the following steps: acquiring a multi-channel image formed by endoscope imaging; time sequence points of all points in all RGB channels in the to-be-analyzed area in the multi-channel image are extracted, and normalization processing is carried out; according to the time sequence point of each point in each RGB channel in the to-be-analyzed area, respectively calculating the time sequence point of the mean value of each RGB channel in the to-be-analyzed area, and carrying out normalization processing; according to the normalized time sequence point of each point in each RGB channel in the to-be-analyzed area, determining a PPG amplitude for representing blood fluctuation information at each point; determining an average amplitude for representing blood fluctuation information according to a time sequence point of an average value of each RGB channel in the normalized region to be analyzed; and determining a blood vessel region according to the PPG amplitude of each point, the average amplitude, the penetration depth of the light sources with different wavelengths to human tissues and the difference of the absorption characteristics of blood components.

The invention discloses blood component single sampling equipment capable of monitoring in real time in the field of blood treatment equipment. The equipment comprises a blood sampling module, a centrifugal separation module, a component collection module and an anticoagulant conveying module, and further integrates a multi-dimensional real-time monitoring system and a closed-loop self-adaptive regulation and control module. The multi-dimensional real-time monitoring system comprises an online micro-fluidic component detection unit, a physiological parameter monitoring unit and an equipment operation monitoring unit, can realize real-time online detection of blood component purity, cell activity and pollutant residue in the separation process, and synchronously monitors circulation physiological parameters of a blood donor and an equipment operation state at the same time; the closed-loop self-adaptive regulation and control module can dynamically adjust parameters such as the centrifugal rotating speed, the fluid pump speed and the anticoagulant ratio according to real-time monitoring data, and precise closed-loop control over the separation process is achieved. The quality stability of blood single-sampling components can be remarkably improved, meanwhile, the operation risk is greatly reduced, and the method is suitable for clinical blood component single-sampling and preparation scenes.

The present invention pertains to the field of medicine and relates to a bag used for the collection, storage and separation of blood derivatives. The present patent is designed to enable the collection and separation of blood components in a single bag, suitable for generating fractionated bags and blood sample aliquots. This practice eliminates the risk of contamination due to the transfer and / or exposure of the blood products. The invention relates to a bag (1) composed of two superimposed polymeric films (2) and (3) sealed along their perimeter, and provided at its two ends with connectors (4), (5), (6), and (7), and handles (8) and (9), respectively; the bag (1) comprises an hourglass-shaped narrowing (10), formed by two trapezoidal seams (11) and (12) arranged opposite each other; the narrowing (10) has a length of between 6 mm and 15 mm (preferably 10 cm), a width of between 2 cm and 6 cm (preferably 4 cm), and angles (α), (β), (γ), and (δ) of between 10° and 60° (preferably 20°), while two or more demarcation lines (13) and (14) are placed transversely on both faces, on the narrowed region (11).

A method for collecting blood components, comprising: separating a first amount of plasma from whole blood; separating a total amount of collectable platelets from whole blood available after separating the first amount of plasma; if the total collection amount after the separation of the total amount of platelets is less than a maximum value adjusted by real-time data related to collection, then separating a second amount of plasma from the whole blood available after the separation of the total amount of platelets, and then separating a total amount of erythrocytes from the whole blood available after the separation of the second amount of plasma; and if the total collection amount is at a maximum adjusted by the real-time data relating to the collection, separating a total amount of red blood cells from the whole blood available after separating the total amount of platelets.

This disclosure relates to a method and device for determining the hemoglobin level of a mammal. The device includes several light-emitting diodes, one or more sensors, and a processor.

The application relates to the technical field of pharmaceutical analysis, and discloses a pharmacokinetic analysis method of Tongwei Xiaozheng medicinal liquid, which adopts Q-Orbitrap high-resolution liquid chromatography-mass spectrometry to analyze the concentration of Jasmonic acid in blood components of the Tongwei Xiaozheng medicinal liquid in rat plasma, establishes a plasma concentration determination method for the blood original component Jasmonic acid, carries out methodological verification such as specificity, precision and accuracy, and then calculates pharmacokinetic parameters. In the Tongwei Xiaozheng medicinal liquid, 92 blood components are identified, 17 of which are original components and 75 of which are metabolites, the application firstly determines that Jasmonic acid is one of the blood original components of the Tongwei Xiaozheng medicinal liquid, and reveals the pharmacokinetic characteristics of the Jasmonic acid in normal and model rats. The method has strong specificity, high sensitivity and good reproducibility, and can provide a scientific basis for the research on the pharmacodynamic material basis of the Tongwei Xiaozheng medicinal liquid, the establishment of quality control standards and the clinical rational use of drugs.

The utility model discloses a kind of blood component automatic identification devices of integrated multispectral sensor, comprising: equipment main body, clamping mechanism and rack, the rack is arranged in equipment main body inside, clamping mechanism includes circular bottom plate, the fixed clamping plate for clamping test tube and the adjusting pressure plate for adjusting the clamping force of fixed clamping plate, the utility model is by being arranged clamping mechanism, not only can be when test tube is placed to the inside of rack, test tube is clamped and fixed, can guarantee test tube in rack to stability, can in mixing process, avoid test tube to shake, collide and make liquid in test tube cannot be fully mixed, leading to uneven distribution of component in sample, affect the accuracy of subsequent detection, and the clamping force of fixed mechanism to test tube can be adjusted according to the size of test tube, to meet the clamping fixed demand of test tube of different size.

The present disclosure is directed to a method and device to determine a value of a blood constituent of a mammal. The device includes a plurality of light emitting diodes, one or more sensors and a processor.

The utility model provides a plasma sampling device, which belongs to the technical field of medical instruments and comprises a sampling barrel and a connecting sleeve. A plurality of liquid inlets which are transversely distributed are circumferentially formed in the bottom of the sampling barrel, a push-pull rod is longitudinally arranged in an inner cavity of the sampling barrel, a piston plate is arranged at the lower end of the push-pull rod, the piston plate is axially and slidably sealed along the inner cavity of the sampling barrel, and an operation part is arranged at the upper end of the push-pull rod; the sampling barrel is sleeved with the connecting sleeve, a plurality of elastic pull rods are arranged in the circumferential direction of the connecting sleeve, and a clamping plate is arranged at the tail end of each elastic pull rod and clamped to the outer edge of the upper end opening of the separating barrel. According to the plasma sampling device provided by the utility model, the sampling barrel can be stably fixed in the middle of the upper part of the separating barrel, so that the sampling barrel can be prevented from shaking in the sampling process. The plasma is horizontally sucked into the sampling barrel through the plurality of liquid inlets which are transversely arranged, so that rising liquid flow can be prevented from carrying blood components on the lower layer, and the real characteristics of the plasma can be accurately reflected.

The application provides a non-invasive blood separation process monitoring method and system based on infrared imaging, and relates to the technical field of medical detection and biological separation, and comprises the following steps: acquiring an infrared image sequence of a blood separation device through an infrared camera, and capturing the thermal radiation distribution characteristics of blood components; adopting a sliding window Kalman filtering algorithm to perform time domain noise reduction on the infrared image sequence, and adaptively adjusting the sliding window length, dynamically updating the noise covariance, and outputting the noise-reduced infrared image; processing the noise-reduced infrared image based on a multi-model switching convolutional neural network architecture, dynamically selecting and loading a convolutional neural network model matched with the current blood separation stage, so as to extract blood separation interface morphological characteristics; and calculating key separation parameters based on the separation interface morphological characteristics, and triggering an early warning signal when the parameters are abnormal. The application realizes non-invasive dynamic monitoring of clinical blood separation.

Provided herein are improved methods of producing cells, including T-cells and CAR T-cells. Also provided herein are methods of producing cells, such as T-cells and CAR T-cells, that can be obtained from blood using a method incorporating membrane filtration and ammonium chloride potassium (ACK) buffer to isolate the cells from other blood components.

The invention belongs to the field of blood glucose detection, and relates to a high-sensitivity blood glucose noninvasive detection method and system based on polarized terahertz photoacoustic, which combines the advantages of terahertz wave band detection and photoacoustic detection, fully utilizes the chiral characteristics of glucose molecules, and adopts polarized terahertz photoacoustic to detect the blood glucose concentration. Polarization optical rotation change information is extracted through the time domain photoacoustic signal; by selecting the characteristic absorption wave band of glucose and utilizing the difference between glucose and other blood components in chiral characteristics, the influence of water and other high-concentration ions on terahertz signals is remarkably reduced, so that the selectivity and the anti-interference capability of blood glucose detection are effectively improved; terahertz non-ionizing radiation is adopted as an excitation source, no ionizing injury risk is caused to a human body, and the device is suitable for long-term repeated detection and is expected to be popularized and applied in wearable or bedside monitoring equipment.

The invention discloses a whole blood leukocyte-depleted multi-component double-filter blood united bag which comprises a main collection bag, a red blood cell storage bag, a plasma storage bag, a platelet-rich plasma storage bag, and a main collection pipeline, a first transfer pipeline and a second transfer pipeline which are communicated with one another. The core improvement lies in that the first transfer pipeline is provided with a first leukocyte-depleting filter special for red blood cells, and the second transfer pipeline is provided with a second leukocyte-depleting filter special for platelet-rich plasma. The double filters solve the problem that a single filter cannot give consideration to characteristics of different blood components, and synchronous and optimized leukocyte removal treatment of red blood cells and platelet-rich plasma in a closed system is realized. Besides, a sampling pipeline, an anti-needling protection device, a bypass pipeline, an SAG-M additive bag and the like are integrated in the linked bag, so that the blood component yield and activity are improved, and the operation safety and the flow flexibility are guaranteed at the same time.

The invention relates to a blood shearing device and a blood compatibility evaluation method. The blood shearing device comprises an objective table, a fixing support, a supporting beam, a stator, a rotor and a driving source. The device can simultaneously adjust the roughness and wettability of the material surface, breaks through the limitation that only a single factor can be researched in the prior art, and provides a more comprehensive platform for systematically evaluating the blood compatibility; in the experimental method, red blood cell hemolysis is detected, and the degradation condition of plasma protein is evaluated synchronously, so that the overall injury mode of blood components under the action of an artificial surface can be reflected more truly. Experimental basis can be provided for material selection and surface optimization of blood contact type medical instruments such as an artificial heart pump, an ECMO and a hemodialysis machine, the clinical complication risk can be reduced, and development of artificial organs and blood purification technologies is promoted.

The present invention is provided with a four-wavelength light emitter that emits four kinds of wavelengths of light toward a predetermined site on a living body; a light receiver that receives the four kinds of wavelengths of light transmitted through the predetermined site on the living body; a received light intensity information acquirer that acquires received light intensity information for the four wavelengths on the basis of an optical signal received by the light receiver; an absorbance time change value acquirer that finds time change values of the absorbances corresponding to the four wavelengths on the basis of the received light intensity information of the four wavelengths; a calibration data table that stores calibration data for finding a predetermined component in blood based on the absorbance time change values; and a component concentration acquirer that finds the concentration of the predetermined component in the blood.

Systems and methods are provided for separating blood components from whole blood. A blood processing device, as part of a blood processing system, has a controller configured to operate the blood processing device based on a plurality of collection protocols. The blood processing device is wirelessly connected to a remote computing device configured to maintain a plurality of collection protocols. At least one additional computing device is configured to update one or more of the plurality of collection protocols on said remote computing device by communicating changes to a protocol maintained on the remote computing device which updates the plurality of collection protocols at the controller of the blood processing device.

The invention relates to the technical field of medical instruments, in particular to a filter membrane for an autoblood transfusion device and a preparation method of the filter membrane, and the filter membrane comprises a pre-filter layer, a fine filter layer and a support layer which are stacked in sequence; the pre-filtering layer is prepared from a blend of polyethersulfone and polyvinyl alcohol through an electrostatic spinning process, the fiber diameter is in gradient distribution, and nanoscale pores are further formed in the surface of the pre-filtering layer; according to the filtering membrane, through specific structural arrangement, the use requirement of high filtering precision can be met, strict medical safety standards can be met, the large flux and the good anti-blocking performance are achieved, the pre-filtering layer intercepts large-particle impurities in advance, the filtering effect is good, and the filtering effect is good. The material selection and the structural design of each layer are reasonable, smooth flowing of blood is ensured, the biocompatibility is excellent, adsorption and damage to blood components are reduced, and the continuity and the reliability of the filtering process are ensured due to the good mechanical stability of the layer composite structure.

The present invention relates to a system for collecting, separating, concentrating, and reinfusing blood components from whole blood. The system further includes cell modification. The system includes a blood processing device and a fluid flow circuit.

Systems and methods are provided for improving efficiency and quality of plasma being removed from a blood separation chamber. The system includes a separation chamber in which plasma is separated from cellular blood components, a pump for moving the plasma and an outlet line for removing the separated plasma from the blood separation chamber. An optical sensor assembly is configured to monitor the blood separation chamber and measure an interface position between the separated component and the plasma, and to generate an output indicative of the measured interface position. A controller is programmed to utilize a lipid concentration input of the blood and to set an original lipemia offset, a lipemia threshold and lipemia final setpoint from a predetermined database, and to use a proportional-integral-derivative control loop to assess the actual interface position plus the lipemia threshold to adjust and achieve a final lipemia setpoint for use during separation procedures.

The disclosure provides methods for enriching a component from a biological sample. The component includes nucleic acids, proteins, cells, exosomes and mixtures thereof. The method includes contacting the biological sample with an adsorption media on a solid substrate to form a complex comprising the adsorption media and the component; and separating the biological sample from the complex to provide a captured component.

The invention discloses a blood component analysis device and method based on gas chromatography-tandem mass spectrometry, and belongs to the technical field of chemical substance detection. Comprising an analyzer body, a sample injection mechanism used for sample injection is fixedly installed on the analyzer body, a storage disc and a sample rotating disc are arranged on the analyzer body, two oppositely-arranged supporting frames are arranged on the analyzer body, installation plates are fixedly connected to the supporting frames, an installation block is fixedly installed between the two installation plates, and the interior of the installation block is hollow. A sliding block is slidably connected into the mounting block, a connecting support arm is fixedly connected to the sliding block, and an arc-shaped positioning block is fixedly mounted at one end, far away from the sliding block, of the connecting support arm. By starting the second push rod, the multiple groups of clamping blocks can be driven to synchronously clamp a plurality of sample bottles on the same circumference, the operation is efficient and flexible, and the working efficiency is improved. Therefore, the working efficiency is improved, the equipment utilization rate is improved, and the blood component analysis and detection period is shortened.

The invention discloses a UPLC-HRMS (Ultra Performance Liquid Chromatography-High Resolution Mass Spectrometry) combined identification method for a Yankenning blood-entering component, which comprises the following steps: detecting chemical components in Yankenning by adopting an ultra-high performance liquid chromatography-high resolution mass spectrometry Q-Exactive HFX combined instrument; the method comprises the following steps: carrying out primary fragment spectrogram information matching, carrying out secondary fragment spectrogram information matching, carrying out structure identification on chemical substances in a sample, carrying out strict manual secondary check on an identification result of substances with high response intensity in the traditional Chinese medicine, comparing components in a medicinal material YKN sample, a blank control group sample, an administration group sample and a blank group + YKN sample, carrying out identification analysis, determining migration components in blood, and carrying out quantitative analysis on the migration components in the blood. And a support is provided for further clarification of the pharmacodynamic material basis of the Yankening.

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette (22) includes a cassette main body (23) made of a soft material to which heat sterilization is applicable. The cassette main body (23) is provided with a retransfusion line (44). The retransfusion line (44) is provided with a reservoir (47) configured to temporarily store a blood component to be returned to a blood donor. The reservoir (47) is pressed by a retransfusion pump (49) to discharge the blood component from the reservoir (47).

The invention discloses a blood component monitoring method and device based on a visual identification technology. The device comprises a sensor host and a sensor probe. The sensor host comprises a bottom shell, an image processing mainboard, an elastic buckle, an upper cover, a key, a display unit, a lock ring and a mounting bracket; the image processing mainboard and the elastic buckle are fixed on the bottom shell, the key and the display unit are fixed on the upper cover, and the upper cover and the bottom shell are fixed through the locking ring and are integrally installed on the installation support. The sensor probe comprises a probe shell, a probe fixing plate and a camera. The image of the centrifugal cup in the blood centrifugal separation process is collected through the camera, the blood components are analyzed through the image recognition technology, and accurate recognition of the blood components is achieved; and meanwhile, the mounting position of the centrifugal cup can be automatically monitored. The device is simple in structure, reliable in performance and low in cost, and has higher recognition accuracy and efficiency compared with a traditional photoelectric sensor recognition method.

Systems and methods are provided for controlling the location of an interface between separated blood components within a centrifuge. An optical monitoring assembly determines the current position of the interface, with the current position and a plurality of input parameters being transmitted from a controller to a neural network. The neural network employs artificial intelligence techniques to analyze the current interface position and at least one of the input parameters to determine a modification to be made to at least one procedural parameter so as to move the interface from its current position to a target position. The neural network transmits a signal that is indicative of the modification to the controller, which implements the modification so as to move the interface toward the target position, with the modification being to an inflow rate, a centrifuge rotation rate, an outflow rate, and / or the location of the target interface position.