243 results about "Blood component" patented technology

A method of preparing sterile human placental allografts by providing a human placental tissue from a donor within 24 hours to 72 hours post-childbirth; removing any visible blood, blood clots, and / or blood components from the human placental tissue without scraping or scrubbing the human placental tissue to preserve structural integrity of the human placental tissue; washing the human placental tissue in an isotonic solution while maintaining the structural integrity of the human placental tissue; dehydrating the human placental tissue thereby forming the dehydrated human placental tissue; resizing the dehydrated human placental tissue into dehydrated human placental tissue portions having predetermined sizes; and sterilizing the dehydrated human placental tissue portions of step (e) thereby forming the sterile human placental allograft. Also disclosed is a sterile human placental allograft produced by the method.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

The invention relates to the technical field of hemodialysis monitoring, and provides a hemodialysis on-line monitoring system and method, and the system comprises a data acquisition module which is used for collecting blood physiological parameters in a dialysis pipeline in real time; the blood component analysis module is connected with a blood loop of the dialysis machine and is used for detecting serum iron, ferritin and ferritin saturation indexes on line; and the data processing module is used for calculating the risk index of anemia, evaluating the iron utilization rate, constructing a model for measuring the iron deficiency erythropoiesis trend according to the collected and analyzed data, and training and optimizing the model. According to the method, individual parameters of patients are fused, personalized calculation is performed for iron metabolism rates and dialysis parameters of different patients, and data such as iron content, blood flow and dialysis fluid volume are acquired online in real time, so that iron concentration and infusion rate are accurately matched with real-time iron metabolism requirements of the patients, and anemia of the patients in the dialysis process is reduced.

The invention discloses a blood component separation system and a control method, and belongs to the field of blood separation.The system comprises a centrifugal device, a blood supply pipeline, an air detector valve and a blood pump, a liquid outlet of the centrifugal device is connected with a separation pipeline, and the separation pipeline is sequentially connected with a first plasma bag and a second plasma bag; a centrifugal pressure sensor, a centrifugal high-speed camera and a red blood cell sensor; and the control center comprises a data acquisition module, a data analysis module and a centrifugal control module. The control method comprises steps S1 to S4. Dynamic intelligent regulation and control and automatic control of the blood component centrifugal separation system are achieved, the centrifugal effect is optimized through the image recognition technology, the image recognition technology is superior to the photoelectric recognition technology in the prior art, excessive centrifugation is avoided, meanwhile, the centrifugal quality is guaranteed, and the quality and activity of separated blood components are effectively guaranteed.

The invention discloses a method for controlling the compaction degree of a left heart and a right heart in an extracorporeal circulation operation, which comprises the following steps of: in an in-vitro environment, mounting a peristaltic pump at a left heart inlet and a right heart inlet of an extracorporeal circulation device; a liquid inlet of the peristaltic pump is connected with a liquid inlet pump, and a liquid outlet of the peristaltic pump is connected with a liquid outlet pump; and finally, a first pressure measuring structure and a second pressure measuring structure are arranged on the sides, away from the peristaltic pump, of the liquid inlet pump and the liquid outlet pump correspondingly, and the pressure of the liquid inlet pump and the pressure of the liquid outlet pump are adjusted to be-20 mmHg. The negative pressure of the liquid inlet pump is adjusted through the first pressure measuring structure, and the negative pressure of the liquid outlet pump is adjusted through the second pressure measuring structure, so that the purpose of quantifying the adjusting mode is achieved, and the adjusting mode is accurate, rapid and high in reliability; the peristaltic pump can effectively avoid the occurrence of risks such as blood component damage, hemolysis, gas embolism and the like caused by reduction of the amount of blood conveyed by the pump, insufficient blood supply or direct interruption of blood circulation due to the condition that a pipe body connected with the peristaltic pump is shrunken or cannot be sucked during an operation.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

The invention discloses an ultra-stable anti-bioadhesion coating as well as a preparation method and application thereof, and belongs to the technical field of functional materials. The coating provided by the invention comprises a component A and a component B, the component A comprises nanoparticles, carboxyl silicone oil, a silane coupling agent and a solvent; the component B comprises a base material and a solvent; the nano-particles comprise at least one of silicon nano-particles, iron nano-particles or zinc nano-particles; the base material comprises epoxy resin. Through cooperation of the component A and the component B, the carboxyl silicone oil and the functionalized nanoparticles are combined and embedded into a matrix material, the formed coating can be used for preparing an ultra-stable anti-bioadhesion coating, the stability is good, the durability is good, adhesion of blood components, protein, bacteria, cells and the like can be effectively reduced, and the anti-bioadhesion performance of the coating is improved. The coating and the coating prepared from the coating have good application prospects in implantable medical equipment.

The invention belongs to the technical field of medical treatment, and discloses a preparation process for accurately regulating and controlling the component proportion of a blood product. The process comprises the following steps: blood collection and pretreatment; blood components are accurately separated; performing real-time component detection; intelligent regulation and control and closed-loop feedback are realized; and optimizing a finished product and monitoring quality. According to the preparation process capable of accurately regulating and controlling the component proportion of the blood product, by integrating AI intelligent control, microfluid separation, real-time sensor detection, dynamic feedback regulation and control and other technologies, high-precision, automatic and intelligent blending of blood components is achieved. The AI intelligent optimization algorithm is adopted, the composition proportion is dynamically adjusted, and the precision error of a finished product is reduced to be within + / -1% from traditional + / -5%. Intelligent feedback closed-loop control avoids deviation caused by human intervention, and the consistency is improved. In the traditional centrifugal separation, parameters need to be manually adjusted, and the separation efficiency is low, while the micro-fluid centrifugal technology is adopted in the method, efficient separation can be completed within 5-10 minutes, and the overall productivity is improved by 30%-50%.

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

The utility model provides dialysis and separation equipment for umbilical cord blood. The dialysis and separation equipment comprises a first separation plate, a second separation plate, a bag and dredging units, wherein the first separation plate and the second separation plate are composed of filter membranes and impermeable membranes, the bag is made of flexible materials, and the dredging units are arranged on the two sides of the bag and used for squeezing. The filter membrane and the impermeable membrane are tightly combined to form an outlet, and the bag is divided into three cavities which are respectively used for treating umbilical cord blood and controlling liquid flow through a catheter and a valve. The dredging unit periodically extrudes the bag through the extrusion part and the control part, so that the filter membrane is prevented from being blocked. The equipment can effectively separate blood components through the matching of the filter membranes with different pore diameters and functions, and realizes a reliable, effective, simple and economical umbilical cord blood dialysis and separation mode.

The invention provides purpleflower holly seed kidney-clearing granules and a detection method for analyzing components entering blood, and the detection method for analyzing the components of the purpleflower holly seed kidney-clearing granules comprises the following steps: determining a test solution by adopting an ultra-high performance liquid chromatography-high resolution mass spectrometry method, and determining 103 components in the test solution, and reference is provided for quality control and clinical application guidance of the purpleflower holly seed kidney-clearing granules. The detection method comprises the following steps: preparing blank plasma and administration plasma into a test solution, determining the test solution by adopting an ultra-high performance liquid chromatography-high resolution mass spectrometry combined method, and identifying 77 compounds including 20 prototype components and 57 metabolites, the method can reflect the drug-derived component condition after the drug enters the blood, makes up the blank of qualitative detection of the blood-entering component of the Ilex chinensis kidney-clearing granules, and provides a basis for further research on the metabolic cycle and metabolic pathway of the drug.

The invention discloses a continuous domain bound state sensor based on a composite prism all-dielectric metasurface, which is composed of periodically arranged unit structures, and each unit structure comprises a barium fluoride substrate layer and a group of silicon structure layers stacked on the barium fluoride substrate layer; the silicon structure layer comprises two first composite prisms arranged along a main diagonal line and two second composite prisms arranged along an auxiliary diagonal line, and the main diagonal line and the auxiliary diagonal line are in a crossed state; the tips of the two first composite prisms and the tips of the two second composite prisms are arranged in opposite directions, and the first composite prisms and the second composite prisms are of asymmetric structures; when polarized light is vertically incident, the resonance response of the ring dipole is excited, and two Fano formants are formed; the sensor has ultrahigh sensitivity and quality factor in a middle-infrared band, and can be applied to gas sensing and detection of various components of blood.

A method comprising: detecting a start of a donation process; in response to detecting the start of the donation process, providing an output; determining an amount of time remaining for the donation process; updating the output in response to detecting the amount of time remaining for the donation process; detecting pressure loss; updating the output in response to detecting the pressure loss; detecting the end of the donation process; and updating the output in response to detecting an end of the donation process. The donation process may include plasma donation using a blood component separation machine. Detecting the initiation of the donation process may include detecting the flow of the fluid. The output may include one or more of the following: light and sound. The output may be provided on one side of the blood component separation machine.

The invention relates to the technical field of blood detection, and discloses a blood quality visual detection device which comprises a detection box, a detection platform and an oscillation mechanism, a detection chamber and a storage chamber are arranged in the detection box, and the blood quality visual detection device further comprises a lead screw adjusting mechanism fixedly installed on the inner wall of the detection chamber; a CCD camera and a coaxial light source mechanism are installed on the front face of the lead screw adjusting mechanism in a transmission mode. According to the technical scheme, the driving assembly drives the rotating platform to intermittently rotate, the rotating platform drives the oscillating mechanism to rotate to be meshed with the forward and reverse transmission assembly, the forward and reverse transmission assembly drives the oscillating mechanism to swing in a reciprocating mode through synchronous forward and reverse rotation, and therefore a turbulence effect is generated on blood in a blood bag, and blood components are evenly distributed; a clear and uniform sample image is ensured to be obtained during visual detection; meanwhile, the disturbed blood smooths the protrusions of the blood bag and flattens the blood bag, it is guaranteed that an optical detection path is clear, and the reliability and accuracy of blood visual detection are improved.

The invention discloses a method for identifying a blood vessel in an endoscope image and an endoscope system. The method for identifying the blood vessel in the endoscope image comprises the following steps: acquiring a multi-channel image formed by endoscope imaging; time sequence points of all points in all RGB channels in the to-be-analyzed area in the multi-channel image are extracted, and normalization processing is carried out; according to the time sequence point of each point in each RGB channel in the to-be-analyzed area, respectively calculating the time sequence point of the mean value of each RGB channel in the to-be-analyzed area, and carrying out normalization processing; according to the normalized time sequence point of each point in each RGB channel in the to-be-analyzed area, determining a PPG amplitude for representing blood fluctuation information at each point; determining an average amplitude for representing blood fluctuation information according to a time sequence point of an average value of each RGB channel in the normalized region to be analyzed; and determining a blood vessel region according to the PPG amplitude of each point, the average amplitude, the penetration depth of the light sources with different wavelengths to human tissues and the difference of the absorption characteristics of blood components.

The invention relates to the technical field of peritoneal dialysis in the nephrology department, and discloses a peritoneal dialysis catheter anti-blocking device in the nephrology department, the peritoneal dialysis catheter anti-blocking device comprises a peritoneal dialysis catheter, an inflow tube and an anti-blocking mechanism are fixedly installed outside the peritoneal dialysis catheter, a rotating shaft is rotatably connected to the interior of a drainage tube, and propeller blades are fixedly installed outside the rotating shaft. An equipment box is fixedly mounted on the right side of the drainage tube, and a micro motor is fixedly mounted in the equipment box. According to the anti-blocking device for the peritoneal dialysis catheter in the nephrology department, when the micro motor drives the rotating shaft to rotate, the propeller blades slowly stir dialysate in the peritoneal dialysis catheter, and a directional vortex is formed; according to the design, liquid flowing is accelerated, protein, blood components and mineral substances are effectively prevented from being adsorbed or precipitated on the tube wall, the problem of blockage caused by standing is solved, meanwhile, the process does not need to depend on drugs, the operation process is simplified, early-stage tiny sediments can be preventively removed, and the catheter is kept unobstructed.

Blood is conveyed from a source into a separator, which separates at least one target blood component from the blood. The target blood component is then conveyed out of the separator, with the procedure continuing until an initial target amount of blood to be processed has been conveyed from the source into the separator and the target blood component separated from the initial target amount of blood to be processed has been conveyed out of the separator as an actual yield of the target blood component. An adjusted target amount of blood to be processed is then determined based at least in part on the difference between a target yield of the target blood component and the actual yield. The initial target amount of blood to be processed is then replaced with the adjusted target amount of blood to be processed when next executing the procedure.

The invention discloses blood component single sampling equipment capable of monitoring in real time in the field of blood treatment equipment. The equipment comprises a blood sampling module, a centrifugal separation module, a component collection module and an anticoagulant conveying module, and further integrates a multi-dimensional real-time monitoring system and a closed-loop self-adaptive regulation and control module. The multi-dimensional real-time monitoring system comprises an online micro-fluidic component detection unit, a physiological parameter monitoring unit and an equipment operation monitoring unit, can realize real-time online detection of blood component purity, cell activity and pollutant residue in the separation process, and synchronously monitors circulation physiological parameters of a blood donor and an equipment operation state at the same time; the closed-loop self-adaptive regulation and control module can dynamically adjust parameters such as the centrifugal rotating speed, the fluid pump speed and the anticoagulant ratio according to real-time monitoring data, and precise closed-loop control over the separation process is achieved. The quality stability of blood single-sampling components can be remarkably improved, meanwhile, the operation risk is greatly reduced, and the method is suitable for clinical blood component single-sampling and preparation scenes.

The present invention pertains to the field of medicine and relates to a bag used for the collection, storage and separation of blood derivatives. The present patent is designed to enable the collection and separation of blood components in a single bag, suitable for generating fractionated bags and blood sample aliquots. This practice eliminates the risk of contamination due to the transfer and / or exposure of the blood products. The invention relates to a bag (1) composed of two superimposed polymeric films (2) and (3) sealed along their perimeter, and provided at its two ends with connectors (4), (5), (6), and (7), and handles (8) and (9), respectively; the bag (1) comprises an hourglass-shaped narrowing (10), formed by two trapezoidal seams (11) and (12) arranged opposite each other; the narrowing (10) has a length of between 6 mm and 15 mm (preferably 10 cm), a width of between 2 cm and 6 cm (preferably 4 cm), and angles (α), (β), (γ), and (δ) of between 10° and 60° (preferably 20°), while two or more demarcation lines (13) and (14) are placed transversely on both faces, on the narrowed region (11).

A method for collecting blood components, comprising: separating a first amount of plasma from whole blood; separating a total amount of collectable platelets from whole blood available after separating the first amount of plasma; if the total collection amount after the separation of the total amount of platelets is less than a maximum value adjusted by real-time data related to collection, then separating a second amount of plasma from the whole blood available after the separation of the total amount of platelets, and then separating a total amount of erythrocytes from the whole blood available after the separation of the second amount of plasma; and if the total collection amount is at a maximum adjusted by the real-time data relating to the collection, separating a total amount of red blood cells from the whole blood available after separating the total amount of platelets.

The present invention discloses a method for separating components after centrifugation of blood cells, which belongs to the field of medical technology. It is achieved by utilizing the photosensitivity of the sensor and the difference in relative light absorption of each component after blood cell separation; after centrifugation, the blood cells are separated into a red blood cell layer, a buffy coat, and platelet-poor plasma. When each phase passes through the sensor, the relative light absorption characteristics of each phase are different, thereby accurately monitoring the blood layer. When each phase of the present invention passes through the sensor, the light absorption characteristics of the blood components are different, and accurate blood layer monitoring is performed based on this principle. The composition of the prepared product phase and subphase can be changed by changing the preset hematocrit. The sensor pipeline part that matches the sensor is a flat pipeline with a cross-section that is close to a large and flat rounded rectangle. It is made of a material with good light transmittance such as polycarbonate, so that light of different wavelengths emitted by the LED light emitter can pass through the flat pipeline vertically and be received by the light receiver.

This disclosure relates to a method and device for determining the hemoglobin level of a mammal. The device includes several light-emitting diodes, one or more sensors, and a processor.

1. The name of this design product: Portable health instrument. 2. Purpose of the product of this design: used to conduct preliminary examination or screening of users to obtain information about blood composition, human organs and system functional status. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

Described herein is a composition comprising porous particles, wherein the porous particles comprise an organic polymer and further comprise functional groups that selectively and reversibly bind blood components. Also described herein is method of dispersing a medical composition in a filtration unit, the method comprising the steps of: providing a vessel comprising a medical composition: securing the vessel to a filtration unit; and depositing the composition into the filtration unit; wherein the medical composition comprises porous particles comprising at least one organic polymer; the filtration unit comprises a filtration membrane having hollow fiber pores; and the average diameter of the porous particles is larger than the hollow fiber pores of the filtration membrane. Also described herein is a method of synthesizing polymer beads.

The application relates to the technical field of pharmaceutical analysis, and discloses a pharmacokinetic analysis method of Tongwei Xiaozheng medicinal liquid, which adopts Q-Orbitrap high-resolution liquid chromatography-mass spectrometry to analyze the concentration of Jasmonic acid in blood components of the Tongwei Xiaozheng medicinal liquid in rat plasma, establishes a plasma concentration determination method for the blood original component Jasmonic acid, carries out methodological verification such as specificity, precision and accuracy, and then calculates pharmacokinetic parameters. In the Tongwei Xiaozheng medicinal liquid, 92 blood components are identified, 17 of which are original components and 75 of which are metabolites, the application firstly determines that Jasmonic acid is one of the blood original components of the Tongwei Xiaozheng medicinal liquid, and reveals the pharmacokinetic characteristics of the Jasmonic acid in normal and model rats. The method has strong specificity, high sensitivity and good reproducibility, and can provide a scientific basis for the research on the pharmacodynamic material basis of the Tongwei Xiaozheng medicinal liquid, the establishment of quality control standards and the clinical rational use of drugs.

A method and system for communicating estimated blood loss parameters of a patient to a user, the method comprising: receiving data representative of an image, of a fluid receiver; automatically detecting a region within the image associated with a volume of fluid received at the fluid receiver, the volume of fluid including a blood component; calculating an estimated amount of the blood component present in the volume of fluid based upon a color parameter represented in the region, and determining a bias error associated with the estimated amount of the blood component; updating an analysis of an aggregate amount of the blood component and an aggregate bias error associated with blood loss of the patient, based upon the estimated amount of the blood component and the bias error; and providing information from the analysis of the aggregate amount of the blood component and the aggregate bias error, to the user.

The utility model discloses a kind of blood component automatic identification devices of integrated multispectral sensor, comprising: equipment main body, clamping mechanism and rack, the rack is arranged in equipment main body inside, clamping mechanism includes circular bottom plate, the fixed clamping plate for clamping test tube and the adjusting pressure plate for adjusting the clamping force of fixed clamping plate, the utility model is by being arranged clamping mechanism, not only can be when test tube is placed to the inside of rack, test tube is clamped and fixed, can guarantee test tube in rack to stability, can in mixing process, avoid test tube to shake, collide and make liquid in test tube cannot be fully mixed, leading to uneven distribution of component in sample, affect the accuracy of subsequent detection, and the clamping force of fixed mechanism to test tube can be adjusted according to the size of test tube, to meet the clamping fixed demand of test tube of different size.

Systems and methods for estimating a blood volume within a canister. The system may include means for detecting a fluid level of the fluid, such as a float sensor mechanism disposed within the canister. An imaging device captures an image of the fluid within the canister. A processor determines an estimated concentration of a blood component in the fluid based on the image. The processor determines a canister volume of the fluid based on the detected fluid level, and estimates the blood volume within the canister based on the estimated concentration of the blood component and the determined canister volume. The processor may trigger the imaging device to capture the image based on a change in the canister volume. An insert may be arranged within the canister and positioned adjacent to and offset from a transparent region of the canister.

The present disclosure is directed to a method and device to determine a value of a blood constituent of a mammal. The device includes a plurality of light emitting diodes, one or more sensors and a processor.