The invention discloses a dual-mode imaging method and system for skin blood perfusion characterization, which can be used for monitoring skin blood perfusion and solves the problems that in the prior art, when skin blood perfusion is monitored, skin blood flow velocity distribution and blood volume pulse waves cannot be obtained at the same time, and skin blood perfusion cannot be comprehensively evaluated. According to the dual-mode imaging method for skin blood perfusion characterization, two video imaging systems are adopted for synchronous control, blood volume and laser speckle video images are collected in real time and synchronously processed, blood flow velocity distribution and blood volume pulse waves are obtained at the same time, and real-time and comprehensive monitoring of blood perfusion of the skin to be detected is achieved. In order to achieve the method, the invention further provides a dual-mode imaging system for skin blood perfusion characterization, and the system comprises a laser light source, a collimation beam expander, a green light source, a beam splitter, a first optical filter, a first video imaging module, a second optical filter, a polaroid and a second video imaging module.