10 results about "Large artery" patented technology

The invention belongs to the field of in-vitro diagnostic reagents, and particularly relates to application of a reagent for detecting biomarkers in serum in preparation of a cerebral arterial thrombosis diagnostic kit. The invention determines that the concentrations of lactic acid, isoleucine, fumaric acid, ketoglutaric acid, hypoxanthine, tyrosine, histidine and inosine in serum of a cerebral arterial thrombosis (IS) patient are significantly related to major atherosclerosis (LAA) and minor artery occlusion (SAO), so that the concentrations of the biomarkers can be used as a basis for diagnosing IS and distinguishing LAA and SAO.

This invention discloses a method and system for predicting severe ischemic events in the nervous system caused by large vessel arteritis based on multimodal deep learning. Belonging to the field of intelligent medical image analysis and clinical risk prediction technology, the method includes: acquiring the patient's magnetic resonance angiography data and clinical information; preprocessing the image data; extracting three-dimensional morphological feature vectors from the point cloud of the blood vessel surface based on a point cloud neural network; extracting blood vessel wall feature vectors from the images based on a three-dimensional convolutional neural network; encoding clinical information to generate clinical feature vectors based on a pre-trained basic model; fusing the above three feature vectors to generate a multimodal fusion feature representation; and outputting an individualized risk score based on this fusion feature through a discrete-time survival analysis model. This invention, through multimodal deep collaborative modeling, achieves automated deep fusion analysis of three-dimensional vascular morphology, blood vessel wall structure, and clinical information, significantly improving prediction accuracy, objectivity, and clinical applicability.

The invention discloses a cerebrovascular reactivity evaluation method for non-invasive calculation of a breath-holding index, and belongs to the field of hemodynamics numerical calculation and multi-scale modeling. The method comprises the following steps: constructing a one-dimensional (1D) arteriole hemodynamic model based on an allotactic scale law; constructing a main artery three-dimensional (3D) model, and coupling the main artery three-dimensional (3D) model with the arteriole one-dimensional model and the microcirculation zero-dimensional (0D) model to form a whole-brain 3D-1D-0D geometric multi-scale hemodynamic model; based on blood flow related data obtained in the experiment process, parameterization description is conducted on arteriole radius changes and microcirculation resistance changes; a breath holding index (BHI) is calculated by numerical solution of the geometric multi-scale model. According to the method, the non-invasive numerical calculation of the breath-holding index can be realized without directly implementing a breath-holding experiment or an external stimulation condition, and a stable and repeatable calculation means is provided for quantitative analysis and related engineering application of cerebrovascular hemodynamic behaviors.

The application relates to the technical field of cerebral vascular disease prediction, in particular to a large arteriosclerotic cerebral stroke risk prediction method and system. The application can effectively evaluate the risk of cerebral vascular disease, especially cerebral stroke, by combining multiple indexes and image group characteristic data, can obtain score data reflecting the risk development state of the current cerebral stroke, and can more intuitively determine the wind direction degree through the score data, so that the overall automatic prediction of cerebral stroke is realized.

The invention relates to the technical field of pelvic model hemostasis devices, in particular to a hemostasis model device for simulating after pelvic artery bleeding, which comprises a bottom box body, a mesh plate is arranged in the bottom box body, a pelvic model is fixedly mounted on the mesh plate, a bleeding simulation assembly is arranged on the pelvic model, and the bleeding simulation assembly comprises a storage cylinder. The storage barrel is communicated with the bottom box body through a backflow pipe, a micro conveying pump is arranged on one side of the storage barrel, the water inlet end of the micro conveying pump is communicated with the interior of the storage barrel through a suction pipe, a conveying pipe is fixedly installed at the water outlet end of the micro conveying pump, a three-way pipe is fixedly installed at the end of the conveying pipe, and a three-way valve is fixedly installed on the three-way pipe; one water outlet end pipe body of the three-way pipe is fixedly provided with a direct flow pipe, and the other water outlet end pipe body of the three-way pipe is fixedly provided with a simulation pipe; the simulation pipe is provided with a fracture hole, and the end part of the simulation pipe is fixedly provided with a plugging end. The device facilitates simulation experiments and is convenient to operate and use.

The invention belongs to the technical field of minimally invasive interventional medical instruments, and discloses a medicine-carrying balloon catheter for treating pulmonary artery stenosis caused by takayasteritis, which comprises a handle, one end of the handle is fixedly connected with one end of a near-end rod, the other end of the near-end rod is fixedly connected with one end of a far-end rod, the other end of the far-end rod is fixedly connected with a balloon, and the balloon is fixedly connected with a catheter. The balloon is divided into a circular truncated cone shape and a cylindrical shape; the drug coating is arranged on the outer surface of the balloon, and the drug coating is used for carrying treatment drugs; the triangular wires are arranged on the outer side wall of the balloon in the length direction of the balloon. Through balloon dilatation and the micro-cutting effect of the triangular wire, the pulmonary artery stenosis part is effectively dilated, meanwhile, anti-inflammatory and anti-proliferation drugs are released in a targeted mode, inflammatory response and vascular intimal hyperplasia are inhibited, the restenosis occurrence rate is reduced, and the balloon dilatation triangular wire has the advantages of being high in safety and adaptability, remarkable in treatment effect and the like.

There was a need for safe and effective treatments for pulmonary hypertension, especially pulmonary arterial hypertension (PAH). The inventors discovered dysregulation of the kynurenine pathway (KP) in the lungs of PAH patients, marked by an imbalance of KP metabolites and upregulation of key enzymes, particularly kynurenine 3-monooxygenase (KMO). This disclosure pertains to a kynurenine-3-monooxygenase inhibitor for use in the treatment or prevention of pulmonary hypertension, in particular pulmonary arterial hypertension. The kynurenine-3- monooxygenase inhibitor is effective in reducing vascular and cardiac remodeling, decreasing right ventricular systolic pressure, reducing pulmonary ventricular resistance, decreasing medial hypertrophy of large arteries, lowering the proportion of muscularized and occluded small arteries and decreasing right ventricular hypertrophy.

The present application belongs to the technical field of diagnostic biomarkers, and particularly relates to a biomarker for diagnosing and / or monitoring ischemic events of Takayasu arteritis, application of the biomarker in preparation of a device for diagnosing and / or monitoring ischemic events of Takayasu arteritis, and a device for diagnosing and / or monitoring Takayasu arteritis comprising the biomarker. The present application discloses a biomarker for diagnosing and / or monitoring ischemic events of Takayasu arteritis, which comprises at least three of CD19+ B cell count, FABP3 level, leptin level, C4 level and IgA level. Compared with traditional vascular imaging evaluation, serum marker detection is more convenient, causes less damage to patients, and is free of radiation, and can not only dynamically monitor the degree of vascular damage and potential ischemic lesions of organs of a patient, but also precisely grasp possible biological processes in the body of the patient. The combination of multiple indexes can improve the accuracy of disease evaluation and avoid the risk of false positive or false negative in single index judgment.

The invention discloses a saline-alkali soil variable-speed corrugated disc-three-dimensional mouse way construction all-in-one machine, and belongs to the technical field of agricultural machinery. The all-in-one machine comprises a rack, land wheels, a main power variable-speed corrugated disc ditching device, a vibration subsoiling shovel device, a three-dimensional mouse channel construction device and a soil crushing and pressing roller. Efficient ditching and soil crushing are achieved through rotation and vibration composite motion of the corrugated disc; the vibration subsoiler is matched with the three-dimensional rat channel construction device to form a capillary-main artery type three-dimensional drainage and ventilation structure, so that the problems of soil hardening and salt accumulation of the saline-alkali land are effectively solved; and the soil crushing and pressing roller further crushes soil blocks and flattens the earth surface. The device integrates the functions of ditching, deep scarification, rat channel construction and soil crushing and pressing, is suitable for improvement of moderate to severe saline-alkali soil, and has the advantages of high operation efficiency, high adaptability, energy conservation, environmental protection and the like.

The invention provides a nitrosothiol modified vascular anastomosis device which comprises a tubular structure, a plurality of wire grooves are formed in the outer surface of the tubular structure, a nitric oxide release coating is loaded on the outer surface of the tubular structure, and the nitric oxide release coating is coated on the outer surface of the tubular structure. The nitric oxide release coating is a polydopamine coating, and S-nitroso-N-acetyl-DL-penicillamine is chemically grafted on the surface of the polydopamine coating. The invention further provides a preparation method of the nitrosothiol modified vascular anastomosis device. The preparation method comprises a design method of the vascular anastomosis device and a preparation method of the nitric oxide release coating. The nitrosothiol modified anastomosis device has the advantages that anastomosis is rapid, anastomosis strength is high, nitric oxide can be continuously released, growth of endothelial cells at the vascular anastomosis position is promoted, adhesion of platelets is inhibited, artery anastomosis operation in the main artery operation process can be effectively simplified, and the anastomosis effect is good. The endothelialization process of the blood vessel at the anastomotic stoma can be promoted, and the long-term patency rate of the blood vessel is increased.