20 results about "Large artery" patented technology

The invention belongs to the field of in-vitro diagnostic reagents, and particularly relates to application of a reagent for detecting biomarkers in serum in preparation of a cerebral arterial thrombosis diagnostic kit. The invention determines that the concentrations of lactic acid, isoleucine, fumaric acid, ketoglutaric acid, hypoxanthine, tyrosine, histidine and inosine in serum of a cerebral arterial thrombosis (IS) patient are significantly related to major atherosclerosis (LAA) and minor artery occlusion (SAO), so that the concentrations of the biomarkers can be used as a basis for diagnosing IS and distinguishing LAA and SAO.

This invention discloses a method and system for predicting severe ischemic events in the nervous system caused by large vessel arteritis based on multimodal deep learning. Belonging to the field of intelligent medical image analysis and clinical risk prediction technology, the method includes: acquiring the patient's magnetic resonance angiography data and clinical information; preprocessing the image data; extracting three-dimensional morphological feature vectors from the point cloud of the blood vessel surface based on a point cloud neural network; extracting blood vessel wall feature vectors from the images based on a three-dimensional convolutional neural network; encoding clinical information to generate clinical feature vectors based on a pre-trained basic model; fusing the above three feature vectors to generate a multimodal fusion feature representation; and outputting an individualized risk score based on this fusion feature through a discrete-time survival analysis model. This invention, through multimodal deep collaborative modeling, achieves automated deep fusion analysis of three-dimensional vascular morphology, blood vessel wall structure, and clinical information, significantly improving prediction accuracy, objectivity, and clinical applicability.

The invention discloses a cerebrovascular reactivity evaluation method for non-invasive calculation of a breath-holding index, and belongs to the field of hemodynamics numerical calculation and multi-scale modeling. The method comprises the following steps: constructing a one-dimensional (1D) arteriole hemodynamic model based on an allotactic scale law; constructing a main artery three-dimensional (3D) model, and coupling the main artery three-dimensional (3D) model with the arteriole one-dimensional model and the microcirculation zero-dimensional (0D) model to form a whole-brain 3D-1D-0D geometric multi-scale hemodynamic model; based on blood flow related data obtained in the experiment process, parameterization description is conducted on arteriole radius changes and microcirculation resistance changes; a breath holding index (BHI) is calculated by numerical solution of the geometric multi-scale model. According to the method, the non-invasive numerical calculation of the breath-holding index can be realized without directly implementing a breath-holding experiment or an external stimulation condition, and a stable and repeatable calculation means is provided for quantitative analysis and related engineering application of cerebrovascular hemodynamic behaviors.

Conventionally, the arterial input function is determined by administering a contrast agent and measuring the responsive magnetic signal in a reference voxel located in a large artery such as the middle cerebral artery. By instead measuring the signal in a voxel of the choroid plexus, a more accurate profile for the arterial input function may be obtained. The metabolic activity in the choroid plexus is negligible, which provides greater certainty for signal sampling.

The application relates to the technical field of cerebral vascular disease prediction, in particular to a large arteriosclerotic cerebral stroke risk prediction method and system. The application can effectively evaluate the risk of cerebral vascular disease, especially cerebral stroke, by combining multiple indexes and image group characteristic data, can obtain score data reflecting the risk development state of the current cerebral stroke, and can more intuitively determine the wind direction degree through the score data, so that the overall automatic prediction of cerebral stroke is realized.

The present invention relates to the field of medical data monitoring technology, and in particular to a dynamic pulse monitoring and analysis system for cardiovascular diseases. The system utilizes a pulse big data analysis module to analyze the pulse information of all disease samples in a current large database. Based on the statistics of the pulse information, the pathological correlation degree of each pulse with the cardiovascular disease can be determined. By separately analyzing the pulse ratio information in two time periods and combining it with the pathological correlation degree, the cardiovascular monitoring attention of each patient can be quantified. Combining the elasticity decrease of the large arteries and the emergency performance of the small arteries can more effectively reflect the overall monitoring attention of each patient. Based on the overall monitoring attention, medical staff can focus on monitoring key patients. The present invention improves the efficiency of pulse monitoring and avoids delays in the condition of key patients.

The invention discloses a main artery elastic reservoir simulation device, and relates to the technical field of medical teaching equipment. The device comprises a simulation left ventricle unit and a simulation right ventricle unit, wherein the simulation left ventricle unit is composed of a balloon capable of absorbing water and compressing and jetting water; the interior of the auxiliary part is composed of an adjusting pipe; and the simulated aorta unit is a main pipeline, and one end of the main pipeline is connected with the right side of the auxiliary component. Compared with the prior art, the device has the advantages that by simulating the processes of left ventricular ejection and main artery elastic retraction and comparing the elastic hose and the non-elastic hard tube, the action mechanism of the main artery blood vessel elastic storage device in the heart ejection process can be visually and vividly displayed, the abstract physiological process is converted into visual demonstration, and the demonstration efficiency is improved. And students are helped to understand related knowledge of blood circulation in cardiac physiology.

The invention relates to the technical field of medical data monitoring, in particular to a dynamic pulse condition monitoring and analyzing system for cardiovascular diseases. According to the system, the pulse condition big data analysis module is used for analyzing pulse condition information of all disease samples in the current big database, and the pathological association degree of each pulse condition to the cardiovascular disease can be determined based on statistics of the pulse condition information. The pulse condition proportion information in two time periods is independently analyzed, and the cardiovascular monitoring attention degree of each patient can be quantified in combination with the pathological association degree. The overall monitoring attention degree of each patient is more effectively reflected by combining the main artery elasticity decline degree and the small artery emergency expression degree, and medical staff can carry out key monitoring on key patients based on the overall monitoring attention degree. The pulse condition monitoring efficiency is improved, and disease delay of key patients is avoided.

The invention relates to the technical field of pelvic model hemostasis devices, in particular to a hemostasis model device for simulating after pelvic artery bleeding, which comprises a bottom box body, a mesh plate is arranged in the bottom box body, a pelvic model is fixedly mounted on the mesh plate, a bleeding simulation assembly is arranged on the pelvic model, and the bleeding simulation assembly comprises a storage cylinder. The storage barrel is communicated with the bottom box body through a backflow pipe, a micro conveying pump is arranged on one side of the storage barrel, the water inlet end of the micro conveying pump is communicated with the interior of the storage barrel through a suction pipe, a conveying pipe is fixedly installed at the water outlet end of the micro conveying pump, a three-way pipe is fixedly installed at the end of the conveying pipe, and a three-way valve is fixedly installed on the three-way pipe; one water outlet end pipe body of the three-way pipe is fixedly provided with a direct flow pipe, and the other water outlet end pipe body of the three-way pipe is fixedly provided with a simulation pipe; the simulation pipe is provided with a fracture hole, and the end part of the simulation pipe is fixedly provided with a plugging end. The device facilitates simulation experiments and is convenient to operate and use.

The invention discloses a non-invasive blood pressure measurement method, device and equipment and a storage medium. The method comprises the following steps: preprocessing signal data of a pressure sensor; performing feature extraction on the envelope signal curve to obtain the maximum amplitude of the envelope signal curve, and calculating to obtain a plurality of first widths, a plurality of second widths, a plurality of first amplitudes and a plurality of second amplitudes according to the maximum amplitude; the extracted feature values are input into a classification model, the classification model classifies the envelope signal curve according to the input feature values, and the blood pressure type of the envelope signal curve is obtained; and calculating and acquiring a first ratio coefficient of systolic pressure and a second ratio coefficient of diastolic pressure of the blood pressure type by utilizing a least square method. The method can better adapt to processing of data such as large pulse pressure difference, arteriosclerosis and individual difference, the universality and accuracy of the method are improved, and the problem of measurement precision in the prior art is solved.

The invention belongs to the technical field of minimally invasive interventional medical instruments, and discloses a medicine-carrying balloon catheter for treating pulmonary artery stenosis caused by takayasteritis, which comprises a handle, one end of the handle is fixedly connected with one end of a near-end rod, the other end of the near-end rod is fixedly connected with one end of a far-end rod, the other end of the far-end rod is fixedly connected with a balloon, and the balloon is fixedly connected with a catheter. The balloon is divided into a circular truncated cone shape and a cylindrical shape; the drug coating is arranged on the outer surface of the balloon, and the drug coating is used for carrying treatment drugs; the triangular wires are arranged on the outer side wall of the balloon in the length direction of the balloon. Through balloon dilatation and the micro-cutting effect of the triangular wire, the pulmonary artery stenosis part is effectively dilated, meanwhile, anti-inflammatory and anti-proliferation drugs are released in a targeted mode, inflammatory response and vascular intimal hyperplasia are inhibited, the restenosis occurrence rate is reduced, and the balloon dilatation triangular wire has the advantages of being high in safety and adaptability, remarkable in treatment effect and the like.

The application provides an external artificial urethral sphincter device, adopts an external double air bag pressure control structure design, adjusts the size of the pressure of the air bag on the urethra by controlling the size of the inflation amount of the air bag, and realizes free urine control. Through the double air bag integrated design, the volume of the device is reduced, the device is convenient to carry, the image of the patient is maintained during use, and the experience of the patient is improved. The external artificial urethral sphincter device saves the cost of the artificial urethral sphincter implantation surgery and reduces the economic pressure of the patient. In addition, the structure of the external artificial urethral sphincter device is similar to the shape of the penis, when inflated, the extrusion force generated on the two sides of the air bag for fixing the penis is offset by the force for extruding the air bag, the aorta of the penis is prevented from being extruded, and tissue necrosis is prevented.

There was a need for safe and effective treatments for pulmonary hypertension, especially pulmonary arterial hypertension (PAH). The inventors discovered dysregulation of the kynurenine pathway (KP) in the lungs of PAH patients, marked by an imbalance of KP metabolites and upregulation of key enzymes, particularly kynurenine 3-monooxygenase (KMO). This disclosure pertains to a kynurenine-3-monooxygenase inhibitor for use in the treatment or prevention of pulmonary hypertension, in particular pulmonary arterial hypertension. The kynurenine-3- monooxygenase inhibitor is effective in reducing vascular and cardiac remodeling, decreasing right ventricular systolic pressure, reducing pulmonary ventricular resistance, decreasing medial hypertrophy of large arteries, lowering the proportion of muscularized and occluded small arteries and decreasing right ventricular hypertrophy.

The present invention provides an emergency-type multi-stage catheter blood pump that can be rapidly implanted minimally invasively at the aortic valve position to provide left ventricular assistance and save the lives of patients with acute heart failure. The outer diameter of the catheter blood pump is about 4-5 mm, and it is composed of a multi-stage axial flow impeller, a guide vane and a first-stage mixed flow impeller. It can increase the flow rate and (or) lift of the blood pump to meet the working conditions of left ventricular assistance. Its pump casing, impeller, guide vane and transmission shaft are all made of tough materials, which can produce bending deformation and can operate in a bent state, which is convenient for minimally invasive implantation of the blood pump and ventricular assistance in curved blood vessels. During left ventricular assistance, the pump is minimally implanted by puncturing the aorta of the leg or arm, and enters the aortic arch using laparoscopic technology, reaches the aortic valve along the ascending aorta, and enters the left ventricle through the aortic valve. Its driving device is located outside the body, the inlet is located in the left ventricle, and the outlet is located in the ascending aorta or aortic arch. No inlet and outlet pipes are required, and left ventricular assistance is directly performed.

The present application belongs to the technical field of diagnostic biomarkers, and particularly relates to a biomarker for diagnosing and / or monitoring ischemic events of Takayasu arteritis, application of the biomarker in preparation of a device for diagnosing and / or monitoring ischemic events of Takayasu arteritis, and a device for diagnosing and / or monitoring Takayasu arteritis comprising the biomarker. The present application discloses a biomarker for diagnosing and / or monitoring ischemic events of Takayasu arteritis, which comprises at least three of CD19+ B cell count, FABP3 level, leptin level, C4 level and IgA level. Compared with traditional vascular imaging evaluation, serum marker detection is more convenient, causes less damage to patients, and is free of radiation, and can not only dynamically monitor the degree of vascular damage and potential ischemic lesions of organs of a patient, but also precisely grasp possible biological processes in the body of the patient. The combination of multiple indexes can improve the accuracy of disease evaluation and avoid the risk of false positive or false negative in single index judgment.

The invention discloses a saline-alkali soil variable-speed corrugated disc-three-dimensional mouse way construction all-in-one machine, and belongs to the technical field of agricultural machinery. The all-in-one machine comprises a rack, land wheels, a main power variable-speed corrugated disc ditching device, a vibration subsoiling shovel device, a three-dimensional mouse channel construction device and a soil crushing and pressing roller. Efficient ditching and soil crushing are achieved through rotation and vibration composite motion of the corrugated disc; the vibration subsoiler is matched with the three-dimensional rat channel construction device to form a capillary-main artery type three-dimensional drainage and ventilation structure, so that the problems of soil hardening and salt accumulation of the saline-alkali land are effectively solved; and the soil crushing and pressing roller further crushes soil blocks and flattens the earth surface. The device integrates the functions of ditching, deep scarification, rat channel construction and soil crushing and pressing, is suitable for improvement of moderate to severe saline-alkali soil, and has the advantages of high operation efficiency, high adaptability, energy conservation, environmental protection and the like.

Provided are method and device for non-invasive detection of central arterial pressure and other intraluminal large arterial pressures. Blood flow and vascular elasticity are the main factors affecting pulse waveform acquisition. A midstream airbag strap can be positioned at the same level as an intraluminal large artery in a human body, and an upstream signal channel can be positioned close to the trunk of the human body and thus is very close to the intraluminal large artery so that the influence of the vascular elasticity is minimized. On the basis of the relationship between the pressure in a blood vessel and the pressure of the airbag strap outside the blood vessel under the condition that the width of the midstream airbag strap is sufficient.

The present invention relates to a highly expandable hemostatic material, which comprises 10 - 50 parts of polyvinyl alcohol and 0.5 - 10 parts of modified polysaccharide, wherein the modified polysaccharide is selected from one or more of sodium carboxymethyl cellulose and carboxymethyl chitosan. The present invention also relates to a preparation method of the hemostatic material. The hemostatic material of the present invention has better expansibility and water absorbency, and at the same time has a better hemostatic effect, has good biocompatibility, can be used for first aid hemostasis, especially for bleeding caused by large artery and vein injuries, and can also be used for tamponade hemostasis of bleeding in a confined space, such as nosebleed and ballistic wound hemostasis.

A three-channel pulse wave signal sensing strap, which is divided into an upstream signal channel, a midstream signal channel and a downstream signal channel according to the blood flow direction. The upstream signal channel is a strap body with an internal inflatable airbag or attached with an electronic signal sensor. The midstream signal channel is a strap body with an internal inflatable airbag. The downstream signal channel is a strap body with an internal inflatable airbag or attached with an electronic signal sensor. Among them, the inflatable airbag in the midstream signal channel can block arterial blood flow when inflated. The internal inflatable airbags of the upstream, midstream and downstream signal channels are respectively docked with three corresponding connection sockets of the main body of the non-invasive blood pressure measurement device through air ducts. The electronic signal sensors of the upstream signal channel and the downstream signal channel are respectively docked with two corresponding connection sockets of the main body of the non-invasive blood pressure measurement device through signal connecting wires. The range of the interval distance between the edge of the upstream signal channel and the edge of the midstream signal channel is 0 to 20 centimeters. It can accurately measure the central arterial pressure and the intraluminal large artery pressure.

The invention provides a nitrosothiol modified vascular anastomosis device which comprises a tubular structure, a plurality of wire grooves are formed in the outer surface of the tubular structure, a nitric oxide release coating is loaded on the outer surface of the tubular structure, and the nitric oxide release coating is coated on the outer surface of the tubular structure. The nitric oxide release coating is a polydopamine coating, and S-nitroso-N-acetyl-DL-penicillamine is chemically grafted on the surface of the polydopamine coating. The invention further provides a preparation method of the nitrosothiol modified vascular anastomosis device. The preparation method comprises a design method of the vascular anastomosis device and a preparation method of the nitric oxide release coating. The nitrosothiol modified anastomosis device has the advantages that anastomosis is rapid, anastomosis strength is high, nitric oxide can be continuously released, growth of endothelial cells at the vascular anastomosis position is promoted, adhesion of platelets is inhibited, artery anastomosis operation in the main artery operation process can be effectively simplified, and the anastomosis effect is good. The endothelialization process of the blood vessel at the anastomotic stoma can be promoted, and the long-term patency rate of the blood vessel is increased.