39results about How to "Realize non-invasive testing" patented technology

The invention discloses a kit for early screening of the lung cancer based on peripheral blood. The kit comprises a connector, a PCR primer and a capture probe. The connector comprises a Tag sequence,a Poly N sequence, a first hairpin sequence, a second hairpin sequence, a first index sequence, a first common primer combination sequence, a second common primer combination sequence and dUTP, and the first index sequence is used for distinguishing different peripheral blood samples; the PCR primer is a primer designed for 358 genes which are related to the pulmonary nodule and indirectly influence proliferation and differentiation of cells, and the PCR primer is used for being combined with the connector; the capture probe is a probe designed for the 358 genes which are related to the pulmonary nodule and indirectly influence proliferation and differentiation of the cells, and the capture probe is used for capturing a cfDNA area of plasma in the peripheral blood samples. The provided kit can be applied to early disease screening of the lung cancer, and the pulmonary nodule is diagnosed in a noninvasive and high-sensitivity mode.

The invention provides a device for detecting the content of indocyanine green in the body, which includes: a single-wavelength or multi-wavelength laser emitting device with a wavelength of 805nm, and a photoacoustic signal detection and conversion device. The present invention preferably also includes an ultrasonic positioning device, which can accurately detect the content of indocyanine green in a blood vessel at a specific location without interference from other tissues. The invention can realize the non-invasive detection of the content of indocyanine green in the blood, realize the rapid evaluation of the liver reserve function, and has good commercialization prospect.

The present invention provides a bladder cancer detection kit and its application, by detecting at least one of miR-423-5p, miR-203-3p, miR-21-5p, and miR-30b-5p in tumor-derived exosomes To provide a kit and system that can detect tumors using urine as a biological sample, with high stability and accurate quantification. It is a fast, low-cost, high-accuracy, and high-sensitivity kit .

The invention relates to a system for measuring the conduction time of pulse waves between cerebral arteries and cerebral veins. The system comprises a signal acquisition device, a signal processing device and a display device, wherein the signal acquisition device is connected with the signal processing device through a communication interface module; and the output end of the signal processing device is connected with the display device. The cerebral blood flow signal acquisition method comprises the following steps: 1) arranging a fixed probe device with two cerebral blood flow signal acquisition devices; 2) synchronously acquiring cerebral blood flow signals; and 3) exchanging the positions of the two cerebral blood flow signal acquisition devices. The medicinal uses of the system are as follows: 1) synchronously acquiring the cerebral blood flow signals of ipsilateral encephalic large arteries (aorta) and encephalic deep veins of a person to be tested at a resting state; and 2) measuring the time difference of the two cerebral blood flow signals. Through the system provided by the invention, noninvasive detection is realized on the conduction time of pulse waves between the cerebral arteries and the cerebral veins; and the clinical practicality is strong, the stiffness of cerebral arteriolae can be accurately and directly reflected, and the risk of apoplexy is estimated, thus being beneficial for early discovering and preventing cerebral arteriosclerosis of patients.

The non -invasive blood glucose detection device based on the Raman scattering spectrometer includes semiconductor lasers, fiber fiber signs, optical fiber probes, filters, Raman spectrometers, first circuit switches, second circuit switchesYimen computer; the present invention uses the rich molecular vibration information contained in Raman's scattered light, and uses different molecular scattering spectra to identify the molecules with the Raman scattered spectrum, through the pure blood, through the pure blood1125cm in Raman scattering spectrum ‑1 Glucose characteristic peak for 1549cm ‑1 The relative values of the peak value of hemoglobin at the point and the real -time human blood glucose concentration data measured by the blood glucose biochemical meter measurement, establish 1125cm ‑1 The relative peak of glucose characteristics peaks and human blood glucose concentration standards straight line L, eventually realized non -invasive and real -time testing of human blood sugar; the present invention has the advantages of high accuracy, pollution -free, harmless to the human body, and in the field of biological non -invasive testing.Wide application prospects.

The invention relates to a prostate cancer early diagnosis or prognosis evaluation marker lncRNA malat1 and application thereof. The marker is an exosome-derived long-chain non-coding RNA (lncRNA) malat1, has a good indicating effect on the early diagnosis of a prostate cancer, can realize the non-invasive detection on the prostate cancer and has higher sensitivity and specificity when being compared with a conventional prostate cancer non-invasive detection method, thereby clinically avoiding the unnecessary puncture biopsy for prostate cancer suspected patients. In addition, the marker alsohas a good prediction effect on the prognosis of the prostate cancer and favorably guides the recurrence monitoring and the early clinical intervention of the patients.

The invention provides an age testing method based on skin image information processing, and attempts to provide medical workers with a new simple and non-invasive age estimation method by mining the texture information of the skin surface that changes with age. Firstly, the skin image of the ventral middle part of the forearm was collected non-invasively, and then the collected skin image was preprocessed and feature extracted to obtain the relevant parameters of the skin groove and skin crest, and the correlation between these parameters and age was analyzed by statistical methods. A mathematical model for inferring age. The statistical results show that the skin texture parameters in this method have a high linear correlation with age, and the age inference model obtained by statistical analysis can be tested to obtain a high accuracy rate, which proves the validity of the method in this paper to infer age , and due to its low cost, it is expected to be used for objective inference of medical age.

The invention discloses a detection method and an application of lung cancer genes. According to the application, the detection method comprises the following steps: constructing a cfDNA library, and conducting hybrid capturing on the cfDNA library by virtue of 12659 probes which are designed in accordance with 105 lung cancer associated genes, sequencing the genes by virtue of a computer, and conducting data analysis on a sequencing result, so that comprehensive and accurate lung cancer gene information is obtained. According to the application, the detection method can implement with a small amount of peripheral blood, so that noninvasive detection is actually achieved. The detection method disclosed by the invention, by capturing, sequencing and analyzing important lung cancer genes in ctDNA, can be used for screening lung cancer in the early stage; therefore, related medication gene mutation information is provided for patients with the lung cancer, and an important reference is provided for the early diagnosis of the lung cancer, personalized accurate medication guidance, effectiveness evaluation and prognosis dynamic monitoring.

The invention provides a method for constructing and detecting ALK gene fusion mutation library comprising the following steps: 1) extracting DNA and fragmenting it; 2) constructing a DNA pre-library; 3) circularizing DNA; 4) using ALK specific PCR amplification was performed with specific primers, and the target region was enriched to generate the final library. The invention also provides a kit for constructing a library for detecting ALK gene fusion mutations and a method for detecting ALK gene fusion mutations. The library construction method targeted at ALK recombination hotspots provided by the present invention combined with the second-generation high-throughput sequencing technology has excellent sensitivity, and can accurately detect information on ALK gene fusion mutations using plasma DNA or tissue DNA as starting materials. In addition, when plasma DNA is used as the starting material, the present invention also realizes the non-invasive detection of ALK gene fusion mutation and crizotinib resistance mutation.

The invention provides a blood glucose detecting method based on a near-infrared technology. The method comprises the steps of conducting near-infrared light radiation on an object to be detected and measuring a blood-flow volume change at the same time to obtain near-infrared spectroscopic data and blood-flow volume pulse wave data as detecting data; predicting the detecting data according to a preestablished blood glucose detecting model to obtain a blood glucose detecting result. Besides, the invention further provides a blood glucose detecting system based on the near-infrared technology and an electronic device. According to the blood glucose detecting device and method based on the near-infrared technology and the electronic device, non-invasive detection of blood glucose can be achieved, the operation is convenient, and the safety is high.