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A device for non-invasive detection of indocyanine green content in the body

A technology of indocyanine green and detection body, which is applied in the fields of diagnostic recording/measurement, medical science, sensor, etc., can solve problems that have not yet been seen, achieve high consistency, save time, and save storage and management

Active Publication Date: 2021-03-02
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no photoacoustic imaging device or method for detecting ICG content in the body

Method used

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  • A device for non-invasive detection of indocyanine green content in the body
  • A device for non-invasive detection of indocyanine green content in the body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 ICG detection device of the present invention

[0028] The present invention includes:

[0029] 1) A single-wavelength or multi-wavelength laser emitting device capable of emitting a wavelength of 805nm;

[0030] 2) The photoacoustic signal detection device is responsible for detecting the photoacoustic signal intensity value in blood vessels / blood when the laser emitting device emits light with a wavelength of 805nm;

[0031] 3) The photoacoustic signal conversion device is responsible for converting the photoacoustic signal intensity into ICG concentration.

[0032] The working principle of ICG detection device to detect ICG concentration is as follows:

[0033] Theoretically, the light absorption coefficient is expressed as:

[0034] mu a =e*c*ln 10=2.303 e*c (1)

[0035] In the formula, e is the molar extinction coefficient of the molecular group, and c is the molar concentration. According to the formula (1), it can be known that the light absorpt...

Embodiment 2

[0052] Embodiment 2 ICG detection device of the present invention

[0053] On the basis of Embodiment 1, the detection device of the present invention is also equipped with a photoacoustic tomography imaging system for converting photoacoustic signals into image signals.

Embodiment 3

[0054] Embodiment 3 ICG detection device of the present invention

[0055] On the basis of Embodiment 1 or 2, in order to ensure that the photoacoustic signal only comes from the blood vessel and is not affected by the surrounding skin and subcutaneous soft tissue, the device of the present invention also includes an ultrasonic positioning device, which is used for the precise location of the photoacoustic signal of the ICG in the blood vessel. Acoustic signal analysis and imaging.

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Abstract

The invention provides a device for detecting the content of indocyanine green in the body, which includes: a single-wavelength or multi-wavelength laser emitting device with a wavelength of 805nm, and a photoacoustic signal detection and conversion device. The present invention preferably also includes an ultrasonic positioning device, which can accurately detect the content of indocyanine green in a blood vessel at a specific location without interference from other tissues. The invention can realize the non-invasive detection of the content of indocyanine green in the blood, realize the rapid evaluation of the liver reserve function, and has good commercialization prospect.

Description

technical field [0001] The invention relates to a device for noninvasively detecting the content of indocyanine green in the body. Background technique [0002] Liver reserve function refers to the sum of the normal functions that the surviving hepatic parenchymal cells can exert after liver damage. In the field of liver surgery, liver reserve function can be evaluated by injecting indocyanine green (ICG) and detecting the change of ICG content in blood over time; the latter is useful for determining the safe range of hepatectomy and reducing the incidence of postoperative hepatic insufficiency important guiding significance. On the other hand, for non-surgical liver disease patients, liver reserve function will be damaged to varying degrees in patients with hepatitis, liver fibrosis, and liver cirrhosis. China is the country that pays the most social costs for hepatitis B, cirrhosis, and liver cancer in the world, and the assessment of liver reserve function in these pati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00
CPCA61B5/0095A61B2503/40A61B2503/42
Inventor 罗燕邱婷婷
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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