A gas sensor for sensing the presence of a gas includes an IR source, a microphone, a reference gas substantially similar to the gas to be detected, a reference body defining a reference chamber therein, the reference chamber having a pressure port coupled to the microphone, and a broad-band optical window through which at least IR wavelengths corresponding to absorption peaks of the predetermined gas may pass. The window is disposed between the IR source and reference chamber. The reference gas is contained within the reference chamber between the optical window and the microphone. The sensor can be included in a hand-held gas detection instrument having power supply, an outer shell, a circuit board assembly including sensor circuitry, a suction pump, actuation controls and status indicators. A probe defining a lumen therethrough supplies the sample gas.