116 results about "Optoacoustic imaging" patented technology

The invention discloses a multi-frame photoacoustic image reconstruction method based on optical flow alignment and depth feature fusion. The method comprises the following steps: S1, obtaining photoacoustic signal data; s2, reconstructing a photoacoustic cross-sectional image; s3, performing optical flow calculation and image alignment; and S4, training the deep feature fusion network. According to the method, through optical flow motion correction and a potential space learning mechanism, space-time information and complementary features in the aligned multiple frames of images are dynamically integrated, complementary information in the multiple frames of images is adaptively fused, noise is suppressed, and finally reconstruction of high signal-to-noise ratio and high spatial resolution images of biological tissues is achieved. Experimental results show that the method can significantly improve image quality, recover image distortion and detail loss caused by motion and noise, and provide a new effective scheme for promoting robust clinical application of a photoacoustic imaging technology.

The invention discloses a lithium battery tab laser welding spot detection method and system, and the method comprises the steps: building a collection system of a multispectral camera, an infrared thermal imaging camera and a photoacoustic imaging module, synchronously collecting the surface optics, internal heat distribution and microstructure characteristics of a welding spot, and reconstructing the internal defect three-dimensional distribution of a preset depth; constructing a feature association matrix, verifying association between features and defects in combination with three-dimensional distribution, and outputting fusion features containing three-dimensional distribution parameters through an attention weighted fusion network; dynamically adjusting visual parameters based on the working condition parameters; detecting defects in combination with fusion features and a causal database, and outputting a process adjustment instruction in advance by a pre-judgment module; and through 3D U-Net, micro defects are segmented and graded. The method covers the full-dimension defects, improves the false defect elimination rate, reduces the defect rate, gives consideration to the detection precision and the production efficiency, and meets the high-reliability detection requirements of the lithium battery tabs.

The invention discloses a preparation method of a silicon dioxide-epoxy resin composite material, the acoustic impedance of the composite material is controlled by adjusting the volume fraction of the silicon dioxide-epoxy resin composite material, an ultrasonic transducer prepared by utilizing the composite material and a preparation process thereof, and an imaging system designed by utilizing the ultrasonic transducer. By designing the matching layer and the backing layer with specific acoustic impedance, seamless fusion of ultrasonic imaging and photoacoustic imaging is realized, the transducer has ultrahigh sensitivity, broadband characteristic and high optical transparency, shows bimodal imaging capability of high contrast and high resolution, and solves the problem that a traditional transparent ultrasonic transducer is insufficient in acoustic performance.

The invention discloses non-contact photoacoustic imaging equipment and method based on leakage Lamb wave detection, in the equipment, a photoacoustic excitation unit excites Lamb waves on the surface of a to-be-detected plate-shaped sample through a photoacoustic effect; the automatic scanning unit drives the to-be-detected plate-shaped sample to move along the scanning direction, so that the two-dimensional full-coverage scanning of the to-be-detected plate-shaped sample by the photoacoustic excitation unit is realized; the signal detection and amplification unit captures the leakage Lamb wave signal and carries out signal amplification; the data acquisition unit acquires the amplified signal in real time and transmits the signal data to the signal processing and imaging end; and the signal processing and imaging end is respectively in communication connection with the photoacoustic excitation unit, the automatic scanning unit and the data acquisition unit, and performs signal acquisition, storage, analysis and imaging processing. The photoacoustic effect excitation technology, the high-sensitivity signal detection technology and the automatic scanning imaging technology are fused, and efficient, accurate and non-contact detection of the surface and subsurface defects of the plate-shaped material is achieved.

The invention relates to the technical field of biomedical imaging, and discloses a photoacoustic-ultrasonic volume imaging method and system based on an annular ultrasonic array, and the method comprises the steps: reconstructing a two-dimensional photoacoustic image and a two-dimensional ultrasonic image; after photoacoustic imaging and ultrasonic synthetic aperture imaging of one imaging plane are completed, the annular ultrasonic array is moved in the direction perpendicular to the imaging plane, photoacoustic images and ultrasonic images of all the imaging planes are repeatedly executed on the next imaging plane, rebuilt and stacked, and a three-dimensional photoacoustic volume image and a three-dimensional ultrasonic volume image are formed; performing spatial pulse response deconvolution processing on the three-dimensional photoacoustic volume image; and fusing the processed three-dimensional photoacoustic volume image and the three-dimensional ultrasonic volume image to generate a three-dimensional bimodal volume image. According to the invention, high-time-resolution opto-acoustic-ultrasonic bimodal three-dimensional imaging is realized by using an annular ultrasonic array and motion scanning, and the high spatial resolution of the image is further ensured through a series of technologies.

The application relates to the field of biological nanotechnology, and provides a multimodal diagnosis and treatment integrated AIE carbon nitride composite nano system and a preparation method thereof. The composite nano system takes selenium-doped carbon nitride nanosheets as a core carrier, realizes active targeting of hepatic stellate cells through VA-PEG2000 modification, simultaneously loads a first AIE photosensitizer and a second AIE photosensitizer with near-infrared two-region emission, and forms a double-photosensitizer composite system. The composite nano system has the dual imaging modalities of near-infrared two-region fluorescence imaging and photoacoustic imaging under the excitation of 660nm and / or 808nm laser, simultaneously generates reactive oxygen through a photodynamic effect to play a treatment function. The application further co-loads an anti-fibrosis drug in the nano system, realizes photodynamic-chemical combined treatment under the guidance of imaging, and solves the technical problems of single imaging modality and insufficient functional integration of an existing liver fibrosis nano diagnosis and treatment system, so that multimodal precise positioning and synergistic enhanced treatment integration of liver fibrosis lesions can be realized.

The application discloses a fouling detection device and method based on photoacoustic imaging, wherein the detection device comprises: a sealed cover with at least one transparent surface; a photoacoustic excitation module comprising a laser, an optical fiber bundle and a plurality of micro-fiber collimators; the micro-fiber collimators are integrated in the transparent surface and used for irradiating laser outside the transparent surface to generate a photoacoustic signal; a photoacoustic collection module arranged along the propagation direction of the photoacoustic signal and used for collecting the photoacoustic signal; and a data processing module in communication connection with the photoacoustic collection module and used for calculating the fouling degree outside the transparent surface according to the collected photoacoustic signal. The application adopts nanosecond-level light pulses to improve the detection accuracy; and the laser sequentially traverses the optical fiber, so that the position of fouling can be accurately located, and a reliable basis is provided for fouling removal.

The invention discloses a preparation method of cryptotanshinone-loaded PDA (Polydopamine) nano drug-loaded particles. The technical scheme adopted by the invention is as follows: the cryptotanshinone is loaded on PDA (Polydopamine) nano particles. Photo-thermal therapy and pharmaceutical chemotherapy are integrated into designed nano-delivery to impart a targeted synergistic effect thereto. In addition, the PDA nanoparticles show photoacoustic imaging capability, and aggregation of the nanoparticles at the ovary part can be monitored in real time. The cryptotanshinone is loaded by utilizing aperture adsorption of PDA and pi-pi conjugation and hydrophobic interaction with the cryptotanshinone, so that a drug delivery system is constructed, the biological solubility and the utilization rate of the cryptotanshinone are improved, a slow release effect is achieved, the application of the cryptotanshinone is widened, and the purpose of treating the polycystic ovarian syndrome is achieved.

The application provides a photoacoustic imaging method using a focused LED light source, solves the problems of insufficient light intensity of the LED light source, inability to realize high-quality photoacoustic imaging, serious electromagnetic interference and difficulty in irradiation in liquid and tissue. The imaging method comprises the following steps: a driving circuit emits a periodic pulse signal with driving capacity, and controls an LED array to periodically emit pulsed light; a 3D printing component is fixed above the LED array, and a hole position corresponds to an LED position; an optical fiber is passed through the 3D printing component, and an input end of the optical fiber is coupled with a light-emitting part of the LED; a plurality of optical fibers are combined into one bundle at the output end of the optical fiber by using an optical fiber combiner, the pulsed light emitted by the plurality of LEDs is superimposed together, the focusing effect is achieved, and high-intensity pulsed light can be obtained at the output end of the combiner; the imaging target is irradiated by using the high-intensity pulsed light at the output end of the combiner, an ultrasonic probe receives an acoustic pressure signal, and photoacoustic imaging is realized through an algorithm.

This invention discloses a wired dual-modal imaging capsule endoscopy system, belonging to the field of medical device technology. The system includes a capsule module, a transmission and control module, a dual-modal imaging module, and a signal analysis module. The capsule module is used to achieve 360° circumferential scanning imaging of the esophageal mucosa. The transmission and control module ensures stable transmission of optical and electrical signals and precise control of capsule movement. The dual-modal imaging module integrates an optical coherence tomography submodule and a photoacoustic imaging submodule to acquire tissue morphology information and microvascular distribution information, respectively. The signal analysis module processes the dual-modal signals. This invention achieves three-dimensional high-resolution integrated imaging of the esophageal mucosa without the need for exogenous labeling agents, significantly improving the detection accuracy of early esophageal cancer and precancerous lesions.

The utility model discloses a photoacoustic imaging probe with a dustproof structure, which comprises a probe main body, a signal acquisition optical window is arranged on the front side of the probe main body, and a dustproof ventilation assembly is arranged on the front side of the probe main body. The dustproof sealing plate is clamped with the clamping groove through the clamping block to seal the signal acquisition optical window, the internal ventilation and water blocking structure can block dust and body fluid from invading and maintain air circulation so as to keep dry, the laser energy transmission efficiency is guaranteed, and the dustproof sealing plate can be quickly overturned and opened through the rotating shaft to be clamped into the groove to achieve fixation during use. The whole operation is convenient and fast, extra tools are not needed, high-frequency scenes are adapted, the manual cleaning frequency is reduced, in addition, the dustproof ventilation assembly is integrally integrated on the front side of the probe body, the structure is compact, no extra space is occupied, sealing stability is ensured through the clamping connection design, and the problem that a traditional split type sealing cover is prone to being lost or losing efficacy is solved.

The invention relates to a handheld photoacoustic imaging device and a photoacoustic imaging system. The handheld photoacoustic imaging device comprises a shell, a light transmission piece, an imaging module and a driving module. The shell is provided with an accommodating cavity; at least part of the light transmission piece is arranged in the accommodating cavity; the flexible separator is arranged in the accommodating cavity and divides the accommodating cavity into a dry cavity and a coupling liquid cavity for accommodating a coupling liquid; the imaging module is connected with the flexible separator, the imaging module comprises an image acquisition part and an ultrasonic transducer, the image acquisition part is used for acquiring an image of an imaging area, and a receiving end of the ultrasonic transducer penetrates into the coupling liquid cavity; the driving module is arranged in the dry cavity, the driving module is connected with the imaging module, and the driving module is used for driving the imaging module to move relative to the shell. According to the handheld photoacoustic imaging device, miniaturization and integrated design can be realized, and meanwhile, the scanning freedom of the imaging module can be kept.

The utility model provides an ultrasonic-photoacoustic composite laparoscope and an ultrasonic-photoacoustic imaging system. The ultrasound-photoacoustic composite laparoscope comprises an insertion part and a head end part, the head end part is connected to the far end of the insertion part, the ultrasound-photoacoustic composite laparoscope further comprises a light guide part, the light guide part is located outside the insertion part, and the far end of the light guide part is connected to the head end part. According to the ultrasonic-photoacoustic composite laparoscope, ultrasonic imaging, photoacoustic imaging and ultrasonic-photoacoustic imaging can be achieved, and therefore large-depth high-resolution, high-contrast and high-sensitivity structural imaging and functional imaging of an organizational body can be achieved, and the accuracy rate of in-vivo diagnosis is greatly improved. According to the ultrasound-photoacoustic composite laparoscope, the light guide part is externally connected to the insertion part, and the overall dimension of the insertion part can be smaller, so that the space utilization rate of the insertion part can be higher, and the effect of the ultrasound-photoacoustic composite laparoscope used for minimally invasive surgery is better.

The embodiment of the invention is suitable for the technical field of medical imaging and photoacoustic imaging, and provides a photoacoustic microscopic imaging system, an imaging method and imaging equipment, and the system comprises a light source excitation assembly which is used for transmitting pulse laser and irradiating a scanning galvanometer after the pulse laser is collimated; the scanning and focusing assembly is used for performing collimation and focusing treatment on the pulse laser reflected by the scanning galvanometer to obtain parallel light, and the parallel light passes through a light-transmitting and sound-reflecting device placed according to a preset angle and then irradiates the tissue surface of the to-be-scanned object; the signal acquisition control assembly is used for receiving an ultrasonic signal generated by the object to be scanned and generating imaging point data capable of being used for photoacoustic microscopic imaging based on the ultrasonic signal; the light-transmitting and sound-reflecting device is a sealed water filling device in which a plurality of hollow glass beads are arranged, and the sealing structure of the light-transmitting and sound-reflecting device is made of quartz materials. By adopting the system, photoacoustic microscopic imaging can be quickly, efficiently and accurately realized.

The invention relates to a sparse regularization photoacoustic imaging de-mixing method and system based on end member automatic extraction. The method comprises the following steps: collecting a multi-wavelength photoacoustic signal and reconstructing a photoacoustic image; based on the photoacoustic image, searching a pixel which enables a convex hull to expand continuously through orthogonal projection, extracting an end member in the photoacoustic image, and performing smoothing processing to obtain an end member curve; and taking the extracted end member curve as priori knowledge, introducing sparse regularization constraint into a target function of photoacoustic imaging unmixing, and solving abundance distribution of each component in the biological tissue by minimizing the target function to obtain an unmixing result. Compared with the prior art, the method has the advantages that the light absorption coefficient of each substance does not need to be obtained as priori knowledge, and the over-fitting resistance is high.

The application discloses a grating sensor for photoacoustic imaging, a photoacoustic probe and a photoacoustic imaging device, and the grating structure is processed by adopting a three-dimensional photoetching process, the design of the external solid structure and the internal periodic structure is combined, the external solid structure and the multiple cavity regions form a significant refractive index difference, and therefore the resonance effect of the grating is enhanced. In the ultrasonic detection process, the periodic resonance effect caused by the refractive index difference of the grating structure can efficiently convert the ultrasonic wave pressure into a light signal and further convert the light signal into an electric signal for photoacoustic imaging. Compared with the conventional ultrasonic sensor, the application provides higher sensitivity and a wider bandwidth, can realize clearer and more accurate imaging effect in high-resolution imaging, and effectively avoids the phenomenon that the ultrasonic sensor in the prior art has poor imaging effect in high-resolution imaging. In addition, the two-photon processing and ultraviolet light curing are adopted to form a significant refractive index difference, and therefore the acoustic spectrum detection capability of photoacoustic endoscopic imaging is improved.

This invention relates to the field of biomedical technology. The invention discloses a method for preparing nanomaterials that can improve the radiosensitivity of tumors and their applications, comprising: S1: dissolving tungsten and copper compounds in an organic solvent in a specific ratio to prepare a mixed solution; S2: transferring the solution to a reaction vessel, adding a surfactant or polymer, and reacting at a certain temperature to form rod-shaped initial nanomaterials; S3: cooling to room temperature, centrifuging and washing to obtain a moist material; S4: drying to obtain Cu-W. 18 O 49 Nanomaterials. The Cu-W of this invention 18 O 49 Nanomaterials can be injected intravenously or intratumorally to target tumors via the EPR effect. When combined with near-infrared light and X-ray therapy, the photothermal effect raises the temperature, improves hypoxia, and enhances the killing effect of radiotherapy. It is suitable for triple-negative breast cancer, etc., inhibiting tumors through the secondary electrons of tungsten, the Fenton reaction of copper ions, and the photothermal effect. It can be monitored by CT or photoacoustic imaging, and can activate the immune response when used in combination with immune checkpoint inhibitors.

The application relates to the technical field of medical imaging, in particular to a photoacoustic magnetic multi-modal imaging system and method for prostate cancer identification, which comprises the following steps: the photoacoustic imaging unit is used for photoacoustic imaging of microvessels in a prostate part; the ultrasonic elastic imaging unit is used for ultrasonic elastic imaging of the prostate part; the magnetic resonance imaging unit is used for magnetic resonance imaging of the prostate part; the multi-modal image fusion unit is used for information fusion of photoacoustic imaging, ultrasonic elastic imaging and magnetic resonance imaging of the prostate part, so as to obtain a multi-modal fusion image of the prostate part. The application adopts high-quality imaging equipment for the prostate part, guarantees high-quality acquisition of the multi-modal images in the imaging stage, and after the high-quality image acquisition is completed, a bidirectional supervision registration network is used to realize registration and fusion of photoacoustic, ultrasonic elastic images and high-resolution magnetic resonance images, so that high-quality images are provided for image identification of prostate cancer.

In accordance with various embodiments of the present disclosure, a device for non-invasive medical imaging is provided. In some embodiments, the device comprises a photonic integrated circuit scale dual frequency comb (DFC), a hand-held wand, and at least one processing element. The wand comprises at least one emission point for emitting light from the DFC at a plurality of different wavelengths and at least three sensors. The wand directs the emitted light at one or more bodily structures. The sensors are adapted to detect acoustic waves from thermo-elastic changes in one or more elements within the bodily structures. The processing element is for generating an optical absorption spectrum from the detected acoustic waves, identifying one or more elements within the bodily structures based on the optical absorption spectrum, and generating a three-dimensional image of the elements based on the optical absorption spectrum from the detected acoustic waves.

The invention discloses a photoacoustic imaging method and a photoacoustic imaging system, and the method comprises the steps: transmitting an ultrasonic wave to a target tissue, and receiving an echo of the ultrasonic wave, so as to obtain an ultrasonic echo signal; generating an ultrasonic image based on the ultrasonic echo signal; transmitting a first laser pulse with a first wavelength and a second laser pulse with a second wavelength to the target tissue, and receiving a first photoacoustic signal corresponding to the first laser pulse and a second photoacoustic signal corresponding to the second laser pulse returned by the target tissue; obtaining an oxyhemoglobin saturation signal based on the first photoacoustic signal and the second photoacoustic signal, and generating an oxyhemoglobin saturation image based on the oxyhemoglobin saturation signal; determining a target area and a reference area of the oxyhemoglobin saturation image; obtaining the first credibility of the oxyhemoglobin saturation signal of the target area; and displaying the oxyhemoglobin saturation image, the ultrasonic image and the first credibility in a display interface. The reliability and effectiveness of the oxyhemoglobin saturation display result can be improved.

The invention belongs to the field of biomedical photonics, photoacoustic imaging and deep learning, and provides an optical absorption coefficient resolving system and method based on photoacoustic imaging and a non-training network, and the method comprises the steps: taking physically-driven Monte Carlo simulation as an optical forward model, and embedding the optical forward model into a neural network frame which does not need to be trained in advance, direct and high-precision inversion from a single initial sound pressure distribution image to optical absorption coefficient distribution is realized through a self-constraint resolving process.

The application relates to the technical field of nanomaterials, and particularly discloses a kind of nanomaterials for stem cell labeling and photoacoustic imaging, a preparation method and application thereof.The application provides a new method capable of stably labeling high-performance photoacoustic nanomaterials on the surface of stem cells in a quick, efficient, specific and non-damaging manner to cell functions, so as to realize high signal-to-noise ratio and long-term dynamic in-vivo tracing of stem cell transplantation fate, and overcome multiple limitations of traditional endocytosis labeling in efficiency, timeliness, specificity and cell compatibility.

The invention relates to a material photoacoustic spectrum measurement method and device. The method comprises the following specific steps: S1, respectively collecting photoacoustic signal data of a standard solution and a to-be-measured solution under different wavelengths; s2, processing the photoacoustic signal data through a reconstruction algorithm to generate an image, and obtaining photoacoustic signal intensity values I of the standard solution and the to-be-detected solution in each region and each scanned wavelength by using the image; and S3, performing double calibration on the obtained photoacoustic signal intensity values I of the standard solution and the solution to be detected to obtain the relative light absorption coefficient of the solution to be detected. The photoacoustic spectrum measuring method based on the photoacoustic imaging system is rapid, convenient and accurate, system operation is simplified, optical differences of biological tissues and instability of a laser system can be effectively coped with, and therefore the consistency of the photoacoustic spectrum and a real optical absorption spectrum is improved, and the measuring accuracy of the photoacoustic spectrum is improved. Therefore, accurate analysis of molecular components in biological tissues is supported.

A method for identifying biological markers using acoustic frequency response is disclosed. The method includes obtaining acoustic information from a received signal from a target location; classifying the acoustic information to provide classified acoustic information based on photoacoustic imaging response using a trained classifier; providing an indication of the classified acoustic information at the target location; and estimating concentration levels from mixtures of photoacoustic-sensitive materials.

The invention belongs to the technical field of biomedical engineering, and relates to a targeted photoacoustic / photothermal diagnosis and treatment integrated traditional Chinese medicine self-assembled nano material as well as a preparation method and application thereof. The invention discloses a targeted photo-acoustic / photo-thermal diagnosis and treatment integrated traditional Chinese medicine self-assembled nano material, which is prepared from the following raw materials: mineral traditional Chinese medicines, other traditional Chinese medicines and a targeting agent, the other traditional Chinese medicines are one or two of plant-derived traditional Chinese medicines and animal-derived traditional Chinese medicines, and the targeting agent is a coupleable targeting agent with carboxyl or amino at the tail end; the particle size of the targeted photoacoustic / photothermal diagnosis and treatment integrated traditional Chinese medicine self-assembled nano material D50 is 2-450 nm; the photo-acoustic / photo-thermal diagnosis and treatment integrated traditional Chinese medicine self-assembled nano material with the targeting property is used for photo-acoustic imaging and photo-thermal treatment. The invention also discloses application of the compound in a photoacoustic imaging contrast agent and a medicine for diagnosing and / or treating tumor diseases.

The application belongs to the technical field of medical imaging, and discloses a deep tissue blood oxygen saturation photoacoustic precise imaging method, which comprises the following steps: S1, obtaining a light flux distribution preliminary model of a to-be-measured region; S2, photoacoustic imaging is performed on the to-be-measured tissue to obtain original photoacoustic imaging data of the to-be-measured tissue; S3, calculating arterial photoacoustic signal intensity; S4, calculating the relative light flux distribution of each arterial region to form an arterial light flux space correction network; S5, introducing the arterial light flux space correction network into the light flux preliminary model to correct the light flux distribution preliminary model, and obtaining the corrected relative light flux distribution; and S6, calculating the blood oxygen saturation of the to-be-measured tissue in the region other than the artery according to the relative light flux of the artery and the to-be-measured tissue imaging region other than the artery, and obtaining the blood oxygen saturation distribution of the entire to-be-measured tissue imaging region. The application calibrates the light flux distribution in the deep tissue through the arterial photoacoustic signal, and realizes the precise measurement of the blood oxygen saturation of the deep tissue.

1. Name of the product in this design: Quick-release interface for photoacoustic endoscopic catheter. 2. Purpose of this design: For quick connection of the catheter of a photoacoustic imaging endoscope probe. 3. The key design feature of this product is its shape. 4. Images or photos that best illustrate the design points: Refer to Figure 1 for the combined state. 5. Other situations requiring explanation: Component 1 is the male connector, and component 2 is the female connector. 6. Other situations requiring explanation: Figure 1 shows the state after component 1 and component 2 are connected, and Figure 2 shows the state when component 1 and component 2 are to be connected.

The invention discloses an ultrasonic detection system and method for an omni-directional large-bandwidth optical fiber ultrasonic sensor, and relates to the field of photoacoustic imaging and ultrasonic detection. In the system, an energy supply module provides pump light for the optical fiber ultrasonic sensor; the optical fiber ultrasonic sensor generates a phase-modulated laser signal under the action of ultrasonic waves; the light amplification module amplifies the laser signal; the interference module divides the amplified laser signal into two paths of optical signals; the two paths of optical signals are reflected by the depolarization module and then form self-coherence interference in the interference module; the depolarization module eliminates polarization state disturbance of the two paths of optical signals; the photoelectric detector converts the interference optical signal into a radio frequency domain electric signal; the signal collecting and demodulating module collects and demodulates the radio frequency domain electric signals, and then ultrasonic response signals corresponding to the extrusion mode and the breathing mode excited by the ultrasonic waves are obtained at the same time. According to the invention, omnidirectional, large-bandwidth and high-sensitivity high-performance ultrasonic detection is realized.