356 results about "Optoacoustic imaging" patented technology

A photoacoustic medical imaging device may include a substrate, an array of ultrasonic transducers on the substrate, at least one groove etched on the substrate, at least one optical fiber, and at least one facet. Each optical fiber is disposed in one of the grooves. Each facet is etched in one of the grooves and coated with a layer of metal having high infrared reflectivity. Each optical fiber is configured to guide infrared light from a light source through the fiber and toward the respective facet. The facet is configured to reflect the infrared light toward a target.

A photoacoustic imaging device includes an array of light sources configured and arranged to illuminate a target region and an array of ultrasonic transducers between the array of light sources and the target region. The array of transducers may be fixedly coupled to the array of light sources, and the array of ultrasonic transducers may be configured and arranged to receive ultrasound transmissions from the target region.

Various embodiments of the present invention provide for a photoacoustic imaging probe for use in a photoacoustic imaging system, whereby the probe is comprised of a cohesive composite, acoustic lens incorporating aspheric geometry and exhibiting low or practically no measurable dispersion of acoustic waves constructed of at least one material with a low acoustic impedance and attenuation and a relatively low acoustic velocity and at least one other material with a low acoustic impedance and attenuation and a relatively high acoustic velocity. The probe is housed in a conduit filled with a low acoustic velocity and low acoustic impedance fluid such as water or mineral oil. The lens may be designed as a telecentric lens, an acoustic zoom lens, a catadioptric lens, or a reflective lens. The lens focuses acoustic waves on an acoustic imager which detects the image. The acoustic imager may be designed as a 2 dimensional array of transducers. Research to date indicates that within the range of acoustic frequencies of interest, 1 MHz-50 MHz and preferable 2 MHz-10 MHz, there exists little velocity variation within the materials of interest, and the lens design approach may currently be considered to be essentially monochromatic. The acoustic waves can be generated when an emitting light source illuminates a test subject comprising materials that generate acoustic waves at differing intensities and / or frequencies when illuminated with light, for example tissue containing blood vessels, wherein the blood vessels excite and generate an acoustic pulse. The probe has an acoustic window made of a material with low acoustic impedance which allows the acoustic pulse to enter the probe without distortion and then may be reflected by a mirror onto the acoustic lens. The probe may include the emitting light source and an optical window to allow light emitting from said light source to illuminate the test subject.

A method of enhancing detection for a specific object in a body. A nanoparticulate is administered to the body for location in an area to be explored for detection of the object, if present. The nanoparticulate is at least partially metallic, has a formed non-spherical shape having a minimal characteristic dimension in the range from about 1 to about 3000 nanometers, and has a formed composition capable of producing thermal pressure either in the nanoparticulate or in the object greater than the object could produce in the absence of the nanoparticulate. Electromagnetic radiation is directed into the body. The electromagnetic radiation has a specific wavelength or spectrum of wavelengths in the range from 300 nm to 300 mm selected so that the wavelength or wavelength spectrum is longer by a factor of at least 3 than the minimum characteristic dimension of the nanoparticulate. The nanoparticulate absorbs the electromagnetic radiation more than would one or more non-aggregated spherically shaped particles of the same total volume with a composition identical to the nanoparticulate. The nanoparticulate produces an enhanced optoacoustic signal resulting from the absorption that is received and converted into an electronic signal and presented for assessment of the at least one parameter by a human or a machine.

The invention relates to the technical field of photoacoustic imaging and discloses a rapid photoacoustic tomography device and a rapid photoacoustic tomography method based on limited-angle scanning. The method comprises the following steps of: transmitting pulse laser into an imaging sample to generate a photoacoustic signal, acquiring the photoacoustic signal at a limited position on an arc through an ultrasonic detector unit, amplifying the signal through a signal amplifier, converting the photoacoustic signal into an electric signal through an analog / digital (A / D) converter, and finally transmitting the electric signal to an oscilloscope to finish digital signal acquisition; inputting the photoacoustic signal of the imaging sample into a computer, performing filtering and Fourier transform processing on the photoacoustic signal through the computer, extracting the frequency domain information of the photoacoustic signal according to experiment conditions, establishing a forward projection operator and a measurement matrix, and performing reconstruction imaging on the signal based on a quick thinning algorithm through the computer. The method and the device have the advantages of short signal acquisition time, high reconstruction speed, convenience in operation, high adaptability, high expansibility and the like.

The invention discloses an internal rectal optical, optoacoustic and ultrasonic multimode imaging endoscope which comprises a sleeve, an optoacoustic signal activating component, an ultrasonic signal activating and collecting component, an optical imaging component and an image reconstructing and displaying component. A device comprises a compact internal rectal optical, optoacoustic and ultrasonic multimode imaging endoscope, three kinds of imaging can be performed simultaneously, multi-parameter physical information and multi-scale structural images in recta can be acquired. The invention further provides a configuration scheme of the whole device and a method for utilizing the device for imaging. Three imaging techniques are highly integrated into one set of instrument, each imaging technique is optimized, and combination of three rectal endoscopic imaging methods of optical imaging, optoacoustic imaging and ultrasonic imaging is realized. The integrated endoscope combines specific advantages of three imaging modes, rectal physical images with multi-parameter information and multi-scale structural characteristics can be acquired, and application requirements of a rectal endoscope on medicine can be met better.

The invention discloses an ultra-small MoS2 nanosheet. The surface of the MoS2 nanosheet is modified with polyvinylpyrrolidone, and the diameter of the modified MoS2 nanosheet ranges from 15 nm to 25 nm. The invention further discloses a preparation method of the ultra-small MoS2 nanosheet. The preparation method comprises the following steps: a sulfur source and a molybdenum source are dissolved in water and stirred until the resources are completely dissolved; polyvinylpyrrolidone is dissolved in the solution of the sulfur source and the molybdenum source; the solution is transferred into a stainless steel reaction kettle with a polyphenyl lining for closed reaction, a reaction product is washed with an ethanolamine water solution and distilled water, and the ultra-small MoS2 nanosheet with the surface modified with polyvinylpyrrolidone is obtained. The invention further provides an application of the ultra-small MoS2 nanosheet as a photo-thermal conversion material. The ultra-small MoS2 nanosheet has good colloid stability, photo-thermal conversion capacity and photo-acoustic imaging capacity and has broad application prospect in the fields of tumor treatment and the like.

The prostate gland or other region of interest is stimulated with laser light, resulting in ultrasound waves (photoacoustic effect) which are focused by an acoustic lens and captured by a specific 1- or 2D sensor array and subsequently displayed as a C-scan on a computer screen. The amplitude of the ultrasound waves generated by laser stimulation is proportional to the optical absorption of the tissue element at that spatial location. Variability in tissue absorption results in C-scan image contrast. The photoacoustic imaging is combined with an ultrasound C-scan image produced with a plane ultrasound wave applied to the region of interest.

The utility model is applicable to the field of medical device and provides a microcirculation in meridian skin tissue real-time monitoring method, system and probe head. The method comprises the following steps: firstly, computer controls laser device to output laser according to certain frequency; secondly, the laser is conducted to probe head through optical fiber so as to irradiate tissue to be measured; thirdly, ultrasonic transducer inside the probe head receives ultrasonic signals generated by the tissue, and then transmits the ultrasonic signals back to computer; finally, the computer generates images according to the ultrasonic signals in the tissue. The embodiment can obtain microcirculation information in meridian skin tissue by utilizing photocoustic imaging technology, solve the problem of real-time monitoring of microcirculation in meridian skin tissue and provides basis or guidance for early diagnosis and treatment of related diseases. The microcirculation in meridian skin tissue real-time monitoring method, system and probe head is characterized in that photocoustic imaging is performed towards the meridian skin tissue in the process of acupuncture without moving the probe head and tissue so that real-time monition of microcirculation in meridian skin tissue is achieved.

The present application discloses optical microscopy systems and related method that use modulation techniques and contrast agents to enable the systems to detect nonlinear photoacoustic signals with high spectrum sensitivity and frequency selectivity for imaging. A laser beam is amplitude modulated for pure sinusoidal modulation using either the loss modulation technique or the single light amplitude modulation technique. The sample used in the invention is an endogenous contrast agent by itself or is treated by at least one exogenous contrast agent to produce or enhance photoacoustic effect induced by multi-photon absorption. The modulated laser beam is focused via a focusing device onto a sample which absorbs multiple photons simultaneously and generates ultrasonic (acoustic) waves via nonlinear photoacoustic effect. The ultrasonic waves are received and transformed into electrical signals and the frequency signals within the electrical signals are detected and recorded to create images.

A WS2-PVP nanometer sheet is provided. The surface of a WS2 nanometer sheet is modified with polyvinylpyrrolidone. The invention also provides a preparing method of the WS2-PVP nanometer sheet. The method includes dissolving a sulfur source and a tungsten source into a solvent, stirring to fully dissolve the sources, dissolving a polymer into the solution of the sulfur source and the tungsten source under stirring to obtain a mixed solution of the sulfur source, the tungsten source and the polymer, transferring the prepared solution to a stainless steel reaction kettle having a poly(p-phenylene) liner, reacting under a sealed condition for a certain period of time, centrifuging for separation, and cleaning the prepared product the is the two-dimensional WS2-PVP nanometer sheet the surface of which is modified with the polymer and which has good colloid stability. The invention also provides applications of the WS2-PVP nanometer sheet as a photo-thermal conversion material. The nanometer sheet has excellent photo-thermal conversion, computed tomography and photoacoustic imaging capabilities, and is expected to be used for efficient cooperative diagnosis and treatment for tumor.

The invention belongs to the technical field of photoacoustic detection, and discloses a transceiving integrated all-optical ultrasonic transducer device and a preparation method thereof. The device comprises a structured base (2), a suspension film (3), a double-clad fiber (1) and an F-P cavity (4), wherein the F-P cavity is constructed by the cooperation of the structured base, the suspension film and the double-clad fiber; the suspension film is a composite photoacoustic conversion film, laser beam energy of an excitation light can absorbed and the laser beam energy can be converted into ultrasonic waves which is emitted outwards, and transmission of sound waves are realized; and meanwhile, the ultrasonic echo can be received, acoustic wave return signals are sensed by deformation, thecavity length of the F-P cavity and the returned detection optical signals are influenced, and the returned detection optical signals are detected, so that receiving of sound waves can be realized. According to the invention, the structures of all components and the cooperation working mode of the components are improved, the whole process of ultrasonic transmission and reception can be completedon one suspension film by utilizing the suspension film and the F-P cavity which is further constructed, the device is more compact in structure, the photoacoustic imaging operation is simpler, and the result is more accurate.