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371 results about "Optoacoustic imaging" patented technology

Optoacoustic imaging is an imaging technology based on the photoacoustic effect, and can be used for obtaining images of structures in turbid environments. The optoacoustic technique combines the accuracy of spectroscopy with the depth resolution of ultrasound.

Multi-layer circuit board quality detection method and system

The invention relates to the technical field of electronic manufacturing quality detection, and discloses a multilayer circuit board quality detection method and system, and the method comprises the steps: collecting the surface interference fringe data of a circuit board through a computer-generated holography technology, and reconstructing the three-dimensional position of an alignment mark; internal stress distribution is detected through a photoacoustic coupling system, and a three-dimensional stress tensor field is reconstructed; establishing a PCB deformation dynamic model by using a multi-layer time sequence deep learning network; establishing a stress deformation correlation model through a physical information graph neural network; realizing feed-forward compensation and process optimization according to a dynamic prediction result; according to the method, computer-generated holography, photoacoustic imaging and deep learning technologies are integrated, the registration precision and internal stress distribution of the multilayer circuit board can be detected in a lossless and high-precision mode, the dynamic change trend of the multilayer circuit board can be predicted, active compensation and process optimization are achieved, and the product quality and the manufacturing yield are effectively improved.
Owner:SHENZHEN ZHONGYUAN CIRCUIT TECH CO LTD

Photoacoustic spectrum-confocal Raman spectrum multi-view-field high-dimensional imaging method and device

The invention discloses a photoacoustic spectrum-confocal Raman spectrum multi-view-field high-dimensional imaging method and a photoacoustic spectrum-confocal Raman spectrum multi-view-field high-dimensional imaging device. Nanosecond pulse laser with adjustable wavelength is generated through a continuous spectrum nanosecond pulser and a narrow-band spectrum tuning module and cooperates with a microscopic detection module, a depth imaging module, a galvanometer system and an electric displacement table to obtain spatial three-dimensional data, a photoacoustic spectrum and a Raman spectrum under multiple view fields; shallow photoacoustic spectrum-Raman spectrum tomography and deep three-dimensional photoacoustic imaging are realized; correcting a photoacoustic spectrum quantitative error by using a spectrum decoupling algorithm, and fusing the multi-view-field data to generate multi-view-field high-dimensional photoacoustic spectrum-Raman spectrum data; high-dimensional data features are extracted based on a 3D convolution instance segmentation network, and quantitative analysis and spatial distribution visualization of blood oxygen, inflammatory factors and the like are achieved. According to the method, the limitation that substances are difficult to analyze in photoacoustic imaging is overcome, the contradiction between the imaging resolution and the penetration depth is solved, and an accurate analysis means is provided for diagnosis of diseases such as knee osteoarthritis and sepsis.
Owner:ZHEJIANG UNIV

Photoacoustic imaging method and photoacoustic imaging system

The invention discloses a photoacoustic imaging method and a photoacoustic imaging system, and the method comprises the steps: obtaining the ultrasonic image data of an imaging target, and determining the biological tissue type of the imaging target based on the features of the ultrasonic image data; a luminous flux distribution result corresponding to the biological tissue type is determined, and the luminous flux distribution result is generated after a simulation target tissue corresponding to the biological tissue type of the imaging target is irradiated by laser in the simulation imaging process of the simulation target tissue; the light source is used for representing luminous flux distribution conditions of biological tissues relative to the body surface under different imaging depths; obtaining photoacoustic image data of the imaging target; determining compensation parameters of the photoacoustic image data based on the luminous flux distribution result; compensating the photoacoustic image data based on the compensation parameter to obtain compensated photoacoustic image data; and generating a photoacoustic image according to the compensated photoacoustic image data. According to the invention, the quality and precision of the photoacoustic image can be improved.
Owner:SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD +1

Enhanced photoacoustic microscopic imaging method based on physical degradation learning

ActiveCN119599890Areduce resolutionreduce contrastMicroscopic imageMicro imaging
The invention discloses an enhanced photoacoustic microscopic imaging method based on physical degradation learning, which comprises the following steps of: on the basis of a photoacoustic imaging principle, degrading an image of a real photoacoustic microscopic image to the ground into a low-quality photoacoustic microscopic image through physical model degradation learning with variability. A high-quality photoacoustic microscopic imaging image is used as a target of supervised training, deep learning is used as a basis, the high-quality photoacoustic microscopic imaging image is input into a self-designed convolutional neural network with an attention mechanism for network training, the quality of a reconstructed image is evaluated until the reconstruction quality reaches the standard, and otherwise, the above steps are executed again. And inputting a real low-quality photoacoustic image into the trained neural network to obtain a reconstructed high-resolution photoacoustic image. According to the method, the resolution ratio and the contrast ratio of the deep photoacoustic microscopic image can be effectively improved, meanwhile, the photoacoustic microscopic image can be denoised, the dependence on the data set can be effectively reduced due to the fact that the data set is obtained through the physical model, and the reconstruction effect under different environments can be improved.
Owner:NANJING UNIV OF SCI & TECH

Photoacoustic endoscopic imaging system and method based on polarized light multi-angle rotary scanning

The invention provides a photoacoustic endoscopic imaging system and method based on polarized light multi-angle rotary scanning, and belongs to the technical field of photoacoustic imaging, the photoacoustic endoscopic imaging system comprises a control system, a light source system, a light path system, an endoscope probe, a data acquisition system and a data reconstruction system, the control system is connected with the light source system and the data acquisition system, and the light path system is connected with the data reconstruction system. The light source system, the light path system and the endoscope probe are sequentially connected, and the data acquisition system is respectively connected with the endoscope probe and the data reconstruction system; the light path system at least comprises a hollow servo motor and a half-wave plate, and the hollow servo motor is used for responding to the time sequence pulse signal and controlling the half-wave plate to rotate by multiple preset angles so as to adjust the polarization direction of the linearly polarized light. The hollow servo motor and the half-wave plate are combined, the polarization direction of light can be rapidly and accurately adjusted, multi-angle scanning is achieved, the imaging speed is remarkably increased, multiple images can be obtained in a shorter time, and the device is suitable for clinical scenes needing real-time feedback.
Owner:SOUTH CHINA NORMAL UNIV +1

Multi-frame photoacoustic image reconstruction method based on optical flow alignment and depth feature fusion

The invention discloses a multi-frame photoacoustic image reconstruction method based on optical flow alignment and depth feature fusion. The method comprises the following steps: S1, obtaining photoacoustic signal data; s2, reconstructing a photoacoustic cross-sectional image; s3, performing optical flow calculation and image alignment; and S4, training the deep feature fusion network. According to the method, through optical flow motion correction and a potential space learning mechanism, space-time information and complementary features in the aligned multiple frames of images are dynamically integrated, complementary information in the multiple frames of images is adaptively fused, noise is suppressed, and finally reconstruction of high signal-to-noise ratio and high spatial resolution images of biological tissues is achieved. Experimental results show that the method can significantly improve image quality, recover image distortion and detail loss caused by motion and noise, and provide a new effective scheme for promoting robust clinical application of a photoacoustic imaging technology.
Owner:CHANGCHUN NORMAL UNIV

Aza-boron dipyrromethene dye molecule with near-infrared second-region absorption and preparation method and application of aza-boron dipyrromethene dye molecule

The invention provides an aza-BODIPY dye molecule with near-infrared two-region absorption, 4-cyanophenyl is used as an electron acceptor for modification at 1, 7 sites, thiophene-triphenylamine is used as a strong electron donor for modification at 3, 5 sites, an aza-BODIPY dye with extremely strong intramolecular charge transfer is constructed, the absorption spectrum of the aza-BODIPY dye is extended to 1100 nm, and after the aza-BODIPY dye molecule forms an aggregation state, the absorption spectrum of the aza-BODIPY dye molecule has strong absorption spectrum. The aza-BODIPY dye molecule has the advantages that the absorption spectrum of the aza-BODIPY dye molecule is extended to 1250nm, the aza-BODIPY dye molecule has good absorption in an NIR-II region, and the nano-particles prepared by self-assembling the aza-BODIPY dye molecule and the amphiphilic polymer F127 show 46.2% of high photothermal conversion efficiency under the excitation of 1060nm laser, can be used for photoacoustic imaging and photothermal therapy, and can be used for preparing the nano-particles. The problems that tissue penetrability is insufficient and deep tumors cannot be diagnosed and treated in traditional tumor light diagnosis and treatment are solved.
Owner:TAIZHOU POLYTECHNIC COLLEGE

Photoacoustic imaging image processing system and method based on particle swarm optimization

The invention provides a photoacoustic imaging image processing system and method based on a particle swarm algorithm. A noise suppression module carries out noise suppression processing on a preprocessed photoacoustic imaging image based on the particle swarm algorithm to obtain a first photoacoustic imaging image; the edge extraction module extracts an edge image from the first photoacoustic imaging image based on an edge detection algorithm; and the detail enhancement module performs detail enhancement on the edge image, and fuses the edge image after detail enhancement and the first photoacoustic imaging image to obtain a second photoacoustic imaging image. Noise of a photoacoustic imaging image is suppressed through a particle swarm algorithm, detail enhancement is performed after an edge image is extracted, effective noise suppression and image detail enhancement are realized, the definition and contrast of the image are improved, and the real-time application requirement is met.
Owner:SHANGHAI SOUNDWISE TECHNOLOGY CO LTD

Puncture needle track prediction method, system and device and medium

The invention discloses a puncture needle track prediction method, system and device and a medium. The method comprises the following steps: acquiring continuous photoacoustic imaging image data when a puncture needle punctures in tissue; processing the photoacoustic imaging image data, extracting a needle point position, and converting each frame of image data into a feature vector about the needle point position; a Transformer model is established, the input quantity of the model is the feature vector of past image data about the position of the needle tip and priori knowledge, and the output quantity of the model is the center coordinate of the needle tip of future image data and the insertion angle of the needle tip in the surrounding tissue. Through data enhancement and constraint injection, a pure data driven model can fuse physical laws and clinical experience, finally real-time and accurate prediction of the motion trail of the puncture needle is achieved, medical employees can be helped to more accurately control the path of the puncture needle in a complex operation environment, the misoperation risk is reduced, and the operation efficiency is improved. And the safety and the accuracy of medical puncture operation are obviously improved.
Owner:QINGPU BRANCH OF ZHONGSHAN HOSPITAL AFFILIATED TO FUDAN UNIV (SHANGHAI QINGPU DISTRICT CENT HOSPITAL)

Focused ultrasound transcranial nerve regulation and control platform and method based on photoacoustic imaging

The invention discloses a focused ultrasound transcranial nerve regulation and control platform and method based on photoacoustic imaging. The system comprises a synchronous pulse generator, a pulse ultrasound transmitting system, a photoacoustic signal collecting system and a fixing device. According to the method, the limitation of other imaging monitoring modes is overcome, monitoring is carried out by utilizing the characteristics of non-invasiveness, high resolution and high contrast of photoacoustic imaging, the TUS progress can be monitored for providing real-time dynamic imaging, and functional information can be provided; photoacoustic imaging is applied to focused ultrasound transcranial nerve regulation for the first time. And meanwhile, by utilizing high sound resolution and high optical contrast of photoacoustic imaging, the strongest photoacoustic signal can be provided in a near-infrared region for hemoglobin of a seat endogenous contrast agent, so that the PAT becomes an ideal imaging tool for detecting cerebral hemodynamics. In addition, key pathophysiological parameters are evaluated through functional imaging provided by the PAT, and the method can be used for evaluating brain changes in the low-intensity focused ultrasound stimulation process.
Owner:CHONGQING MEDICAL UNIVERSITY

Endoscopic probe for photoacoustic tomography of cavity side walls

The present invention relates to an endoscopic probe for photoacoustic tomography of cavity side walls, characterized by comprising a hollow tubular probe housing with a closed front end; N acoustic wave receiving windows and M laser output windows formed on the side wall of the tubular probe housing; an array of linear laser output ports connected to a pluggable optical fiber connector via an optical fiber bundle; and an ultrasonic transducer array connected to a multi-channel signal connector via a signal harness. The present invention employs a method of arranging array transducers and array laser outputs on the side wall of the probe, eliminating the need for a reflector. The probe is less than 2 centimeters in size and can be placed in close proximity to the prostate through the rectum for photoacoustic imaging of the prostate, or in close proximity to the inner wall of the rectum for photoacoustic imaging of the inner wall of the rectum. The endoscopic probe provided by the present invention, combined with a photoacoustic imaging system host, utilizes photoacoustic endoscopic imaging technology to perform real-time transrectal prostate imaging and rectal imaging, achieving ideal imaging results.
Owner:SHANGHAI TECH UNIV

Human body peripheral blood vessel photoacoustic three-dimensional imaging device and imaging method thereof

The invention discloses a human body peripheral blood vessel photoacoustic three-dimensional imaging device and an imaging method thereof, and belongs to the field of blood vessel imaging. Through high resolution and functional monitoring capability of photoacoustic imaging, detailed blood vessel structure and blood flow dynamic information are provided, and early recognition and treatment effect evaluation of common lesions such as diabetic foot and peripheral artery diseases are promoted; meanwhile, a mechanical system is adopted, so that the detection front end with relatively high quality can be borne, and stable operation is realized, and a relatively good photoacoustic imaging result is obtained; the system has a highly stable accurate scanning imaging mode, and is convenient for multiple imaging modes of clinical application; through the arrangement of the imaging water tank and the lifting structure of the imaging water tank, switching of imaging modes in a limited space can be ensured, so that the device can be suitable for the layout of a portal type three-dimensional moving device. The system is expected to promote the portability of equipment, reduce the research and development cost of the equipment, be widely applied to clinical practice and community medical treatment, and improve the disease management level.
Owner:PEKING UNIV

Multi-modal skin disease analysis method based on deep learning

The invention relates to a multi-modal skin disease analysis method based on deep learning, and relates to the technical field of auxiliary diagnosis. A photoacoustic imaging device is used for scanning, a dermatoscope is used for shooting a skin disease affected part, and photoacoustic imaging data and a skin image of the affected part are obtained; aligning the photoacoustic image with a skin image, filling according to a skin image space, and combining with the skin image to obtain multi-modal skin data; constructing and pre-training a skin analysis model based on the multi-modal skin data; the pre-trained skin analysis model analyzes the collected multi-modal skin data to obtain a skin disease analysis result. The multi-modal skin data is constructed, multivariate data support is provided, and it is ensured that disease analysis is accurate and reliable. The skin analysis model extracts different scales of skin image feature maps and photoacoustic imaging feature maps so as to cover correlation between different sizes of features and different specifications of skin diseases; the other modal data is used to reinforce the own modal, and the two modal features are better combined; and the interpretability is high.
Owner:AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV

A photoacoustic microscopy imaging system based on a high-speed focuser

The present invention discloses a photoacoustic microscopy imaging system based on a high-speed focuser. The photoacoustic microscopy imaging system includes a light source component, a single-mode fiber coupling component, a high-speed focuser component, a light beam scanning component, a reflective bracket, a signal acquisition component and a computer. The present invention adopts a mobile focusing design. During the photoacoustic imaging point scanning process, the displacement of the double-cemented lens is controlled by the movement of a fast linear motor, and then the focal position of the light beam is adjusted, so that during the scanning process, the focal plane at any position always coincides with the imaging surface. The present invention establishes an imaging method for automatically adjusting the focal plane by adopting a high-speed focuser, which effectively improves the image signal-to-noise ratio and resolution, and is low in price and easy to operate. The present invention adjusts the imaging in real time according to the photoacoustic signal fed back during the scanning process, and can perform photoacoustic microscopy imaging of any unknown surface, which has broad research prospects and application value.
Owner:SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Apparatus for automated blood pressure monitoring and methods thereof

Several methods of automatically measuring blood pressure are disclosed, which may include applying a photoacoustic imaging band or patch coupled to a transducer or detector capable of detecting an imaging signal to an extremity of a patient. The detector may also include an ultrasonic or photoacoustic means of determining blood pressure. A device for automatically measuring blood pressure utilizing several methods and having a variety of configurations for obtaining blood pressure data from a patient is also disclosed.
Owner:JOHNS HOPKINS UNIVERSITY

Photoacoustic imaging system based on self-learning

The invention relates to the technical field of photoacoustic imaging, in particular to a photoacoustic imaging system based on self-learning, which comprises an acquisition module, a screening module, an actual generation module, an ideal generation module, an adjustment module and an imaging module. According to the method, through constructing a complete closed-loop process of acquisition, screening, evaluation, self-learning optimization and image reconstruction, dynamic regulation and control of photoacoustic imaging quality are realized, and a spectrum texture gradient and an imaging uniformity error jointly define space consistency of an image; the background noise energy level and the laser energy distribution describe the stability of the signal quality; the actual definition index measures the current system performance, and the ideal definition index extracts a potential imaging upper limit under noise interference by means of a self-learning model; and the adjusting module performs adaptive optimization through the comparison result, so that the problems of low recognition accuracy and slow response speed caused by poor adaptability to different tissues due to excessive dependence on a fixed parameter model are effectively solved.
Owner:JIAXING UNIV

Limited-view-angle photoacoustic image artifact suppression method, system and device and medium

The invention relates to the technical field of photoacoustic imaging, and discloses a limited-view-angle photoacoustic image artifact suppression method, system and device and a medium. The method comprises the following steps: generating a reconstructed limited-view-angle photoacoustic image and a corresponding full-view-angle photoacoustic image through an image reconstruction algorithm; adding a sub-graph extraction module in each hierarchy except the first hierarchy of the U-Net model, and extracting a sub-graph sequence; optimizing artifact suppression model parameters based on the loss function of the structural similarity index and the average absolute value error of the limited view angle photoacoustic image and the corresponding full view angle photoacoustic image, and selecting an optimal artifact suppression model; and inputting a limited view angle photoacoustic image constructed based on an actually collected limited view angle photoacoustic signal into the trained artifact suppression model, and outputting a post-processing image after artifact suppression. The method has a good post-processing result for the photoacoustic image with the limited visual angle, artifacts can be basically and effectively inhibited, and part of loss information in the image is recovered.
Owner:ARTIFICIAL INTELLIGENCE RES INST OF HEFEI COMPREHENSIVE NAT SCI CENT (ANHUI ARTIFICIAL INTELLIGENCE LAB)

Detection method and system for lithium battery tab laser welding spot

The invention discloses a lithium battery tab laser welding spot detection method and system, and the method comprises the steps: building a collection system of a multispectral camera, an infrared thermal imaging camera and a photoacoustic imaging module, synchronously collecting the surface optics, internal heat distribution and microstructure characteristics of a welding spot, and reconstructing the internal defect three-dimensional distribution of a preset depth; constructing a feature association matrix, verifying association between features and defects in combination with three-dimensional distribution, and outputting fusion features containing three-dimensional distribution parameters through an attention weighted fusion network; dynamically adjusting visual parameters based on the working condition parameters; detecting defects in combination with fusion features and a causal database, and outputting a process adjustment instruction in advance by a pre-judgment module; and through 3D U-Net, micro defects are segmented and graded. The method covers the full-dimension defects, improves the false defect elimination rate, reduces the defect rate, gives consideration to the detection precision and the production efficiency, and meets the high-reliability detection requirements of the lithium battery tabs.
Owner:GANZHOU XIONGBO NEW ENERGY TECH CO LTD

Integrated polarization, multi-wavelength and multi-frequency photoacoustic tomography device and imaging method

The invention discloses an integrated polarization, multi-wavelength and multi-frequency photoacoustic tomography device, which comprises a light source assembly, a polarization assembly, a signal receiving assembly and a signal processing assembly, and is characterized in that the light source assembly is used for generating collimated pulse laser with different wavelengths, and the polarization assembly can enable the pulse laser with different wavelengths to generate a polarization state; the polarization angle of the light beam is changed, the signal receiving assembly can detect a photoacoustic signal after the polarized light irradiates a sample, the signal processing assembly is used for amplifying and collecting the photoacoustic signal, the multi-wavelength light source is adopted as an excitation light source, and the polarization assembly enables the laser of each wavelength to generate a polarization state; according to the multi-wavelength multi-frequency photoacoustic imaging system and the multi-wavelength multi-frequency photoacoustic imaging method, a plurality of ultrasonic transducers with different center frequencies are utilized to detect photoacoustic signals, so that polarized light acoustic imaging, multi-wavelength photoacoustic imaging and multi-frequency photoacoustic imaging can be combined, and the purpose of multi-angle and multi-parameter biomedical imaging is achieved.
Owner:GUANGZHOU MEDICAL UNIV

Transcranial photoacoustic / thermoacoustic tomography brain imaging informed by adjunct image data

Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.
Owner:CALIFORNIA INST OF TECH

Dual-wavelength photoacoustic remote sensing imaging system for non-contact absolute temperature measurement

The invention relates to the technical field of photoacoustic imaging, and particularly provides a dual-wavelength photoacoustic remote sensing imaging system for non-contact absolute temperature measurement. The dual-wavelength photoacoustic remote sensing imaging system for non-contact absolute temperature measurement comprises a signal control assembly, an excitation light path assembly, a beam combination light path assembly and a scanning imaging assembly, and the signal control assembly comprises an editable logic gate array, control software and a remote sensing imaging subsystem. The excitation light path assembly, the detection light path assembly and the scanning imaging assembly are electrically connected with the signal control assembly and are controlled by signals sent by the signal control assembly; by means of the dual-wavelength photoacoustic remote sensing imaging system, high-spatial-resolution structural images / functional images of biological tissues can be obtained in a non-invasive and non-contact mode, the dual-wavelength photoacoustic remote sensing imaging system can be suitable for absolute temperature measurement of biological tissues such as open tissues and chronic tissue damage which are not suitable for coupling liquid, and the application range is widened.
Owner:HARBIN INSTITUTE OF TECHNOLOGY (SHENZHEN) (INSTITUTE OF SCIENCE AND TECHNOLOGY INNOVATION HARBIN INSTITUTE OF TECHNOLOGY SHENZHEN)

Photoacoustic imaging method and system based on data analysis

The invention relates to the technical field of photoacoustic imaging, in particular to a photoacoustic imaging method and system based on data analysis, and the method comprises the steps: determining the imaging state of an initial photoacoustic image according to an image abnormal coefficient and a detection domain variable value, and determining an analysis mode according to the imaging state; in the detection anomaly analysis, determining a first optimization mode according to the noise modulation coefficient; in tissue influence analysis, a second optimization mode is determined according to a distortion influence coefficient and a regional dislocation coefficient, and the second optimization mode is that an adjustment mode is determined according to a blood flow influence index, or a compensation mode is determined according to a tissue difference coefficient and deviation uniformity; the adjusting mode is that the detection angle range is adjusted according to the blood flow influence index, or the laser repetition frequency is adjusted according to the distortion influence coefficient, the compensation mode is characteristic frequency compensation or related frequency compensation, and the image quality of photoacoustic imaging can be improved.
Owner:JIAXING UNIV

Small animal in-vivo multi-parameter dynamic monitoring method based on photoacoustic imaging

The invention discloses a small animal in-vivo multi-parameter dynamic monitoring method based on photoacoustic imaging, and relates to the technical field of biomedical imaging, and the method comprises the steps: obtaining a photoacoustic signal generated by a small animal under the excitation of pulse laser output by an optical excitation module through an acoustic detection module; reconstructing a photoacoustic image of the photoacoustic signal through a filtering back projection algorithm; calculating the similarity between adjacent images in the photoacoustic image, identifying the image of which the similarity is lower than a set frame threshold value as a cross section slice polluted by respiratory motion artifacts and removing the cross section slice, and replacing the removed image frame by using the interpolation of an adjacent artifact-free image so as to obtain an updated photoacoustic image; selecting a region of interest in the photoacoustic image, and carrying out oxygenation kinetics monitoring, pharmacokinetics monitoring, perfusion kinetics monitoring or nanoparticle in-vivo kinetics monitoring; according to the monitoring method, motion artifacts caused by breathing of the small animals are effectively inhibited, and in-vivo multi-parameter dynamics monitoring of the small animals is achieved.
Owner:ARTIFICIAL INTELLIGENCE RES INST OF HEFEI COMPREHENSIVE NAT SCI CENT (ANHUI ARTIFICIAL INTELLIGENCE LAB)

Cardiovascular disease detection method based on image analysis

The invention discloses a cardiovascular disease detection method based on image analysis, and particularly relates to the technical field of cardiovascular disease detection. Whether further detection is needed or not is judged by evaluating the distribution uniformity of microbubbles at the vascular branches and the development degree of myocardial tissue lesions. If further detection is needed, the photoacoustic imaging technology is adopted, the saturation degree of photoacoustic signals is analyzed, and a nonlinear signal demodulation algorithm is combined, so that the detection accuracy of the tiny calcification in the cardiovascular system is evaluated. By analyzing the influence of the cardiovascular tissue fiber arrangement direction on the optical signal propagation path, the abnormal degree of the lesion area fiber structure is evaluated. The cardiac muscle tissue lesion degree, the micro calcification detection accuracy and the abnormal degree of the fiber structure are comprehensively analyzed, the severity of the cardiovascular disease is evaluated, whether clinical intervention measures are needed or not is judged, early diagnosis and accurate evaluation of the cardiovascular disease are achieved, and the diagnosis efficiency and accuracy are improved.
Owner:THE THIRD AFFILIATED CLINICAL HOSPITAL OF CHANGCHUN UNIV OF TRADITIONAL CHINESE MEDICINE

Head-mounted photoacoustic device for multi-parameter brain function monitoring and closed-loop regulation

The invention discloses a head-mounted photoacoustic device for multi-parameter brain function monitoring and closed-loop regulation and control. The device comprises a nerve-lymph-blood vessel multi-mode imaging monitoring module, a multi-dimensional brain information quantitative analysis module, a closed-loop control module, a light / sound brain regulation and control module and a detachable head-mounted module. The method comprises the following steps: firstly, acquiring brain nerve, lymph and blood vessel information in real time by utilizing a multi-modal imaging monitoring module, then sending data to a multi-dimensional brain information quantitative analysis module, decoding and analyzing multi-dimensional data, extracting key features, performing multi-modal data feature fusion, and establishing an analysis method for quantitatively evaluating the brain microenvironment; therefore, the brain function state is accurately represented. The head-mounted device has the advantages that photoacoustic imaging, fluorescence imaging, optical regulation and control and ultrasonic regulation and control are added into the head-mounted device, closed-loop regulation and control parameters are achieved in a combined mode, and the functions of miniature, wearable and multi-parameter detection of the cerebral vessel-nerve-lymph microenvironment and closed-loop photoacoustic regulation and control are achieved.
Owner:SOUTH CHINA NORMAL UNIV

Super-resolution polarized light acoustic imaging method and device

According to the super-resolution polarized light acoustic imaging device and method, galvanometer scanning is achieved on the surface of a sample, excitation light is modulated in different linear polarization directions on each scanning point on the surface of the sample, and the intensity of photoacoustic signals generated by the sample under the excitation light in the different linear polarization directions is obtained through measurement; an initial photoacoustic image of a sample surface structure is constructed by utilizing photoacoustic signal intensities under exciting light in different linear polarization directions, and the initial photoacoustic image is subjected to phase-locked amplification and three-dimensional deconvolution processing, so that a super-resolution photoacoustic image in each linear polarization state is obtained. Compared with traditional polarized light acoustic imaging, the method has the advantages that the diffraction limit of traditional photoacoustic imaging can be overcome, super-resolution imaging of the surface structure of the sample can be achieved while unmarked imaging is achieved, and finer expression of the structure of the sample is achieved. The method has potential application prospects in the fields of biological imaging and biological tissue surface structure conformation detection.
Owner:SOUTH CHINA NORMAL UNIV

Preparation method of silicon dioxide-epoxy resin composite material, ultrasonic transducer, preparation process of ultrasonic transducer and imaging system

The invention discloses a preparation method of a silicon dioxide-epoxy resin composite material, the acoustic impedance of the composite material is controlled by adjusting the volume fraction of the silicon dioxide-epoxy resin composite material, an ultrasonic transducer prepared by utilizing the composite material and a preparation process thereof, and an imaging system designed by utilizing the ultrasonic transducer. By designing the matching layer and the backing layer with specific acoustic impedance, seamless fusion of ultrasonic imaging and photoacoustic imaging is realized, the transducer has ultrahigh sensitivity, broadband characteristic and high optical transparency, shows bimodal imaging capability of high contrast and high resolution, and solves the problem that a traditional transparent ultrasonic transducer is insufficient in acoustic performance.
Owner:SUZHOU UNIV

Non-contact photoacoustic imaging equipment and method based on leakage Lamb wave detection

The invention discloses non-contact photoacoustic imaging equipment and method based on leakage Lamb wave detection, in the equipment, a photoacoustic excitation unit excites Lamb waves on the surface of a to-be-detected plate-shaped sample through a photoacoustic effect; the automatic scanning unit drives the to-be-detected plate-shaped sample to move along the scanning direction, so that the two-dimensional full-coverage scanning of the to-be-detected plate-shaped sample by the photoacoustic excitation unit is realized; the signal detection and amplification unit captures the leakage Lamb wave signal and carries out signal amplification; the data acquisition unit acquires the amplified signal in real time and transmits the signal data to the signal processing and imaging end; and the signal processing and imaging end is respectively in communication connection with the photoacoustic excitation unit, the automatic scanning unit and the data acquisition unit, and performs signal acquisition, storage, analysis and imaging processing. The photoacoustic effect excitation technology, the high-sensitivity signal detection technology and the automatic scanning imaging technology are fused, and efficient, accurate and non-contact detection of the surface and subsurface defects of the plate-shaped material is achieved.
Owner:SUN YAT SEN UNIV

Joint detection device for electroencephalogram and photoacoustic imaging

The invention provides an electroencephalogram and photoacoustic imaging combined detection device, and relates to the technical field of medical information detection. The joint detection device comprises a conductive composite layer suitable for releasing conductive gel in a state of being in contact with skin; the electroencephalogram electrode is embedded in the conductive composite layer and is suitable for transmitting an electroencephalogram signal to an external signal acquisition device when the conductive composite layer is in contact with the skin; the light-induced ultrasonic transmitter is embedded in one end of the conductive composite layer and is constructed to be capable of converting light energy into ultrasonic energy so as to send out an ultrasonic signal and detect nerves and blood vessels under the skin; and the photoinduced ultrasonic receiver is embedded at the other end of the conductive composite layer and is suitable for receiving the ultrasonic signal reflected by the nerve blood vessel and obtaining the spatial information of the nerve blood vessel by using the reflected ultrasonic signal, so that the spatial information of the nerve blood vessel is associated with the electroencephalogram signal, and an electroencephalogram with a target temporal-spatial resolution is obtained.
Owner:WENZHOU SAFETY (EMERGENCY) RES INST TIANJIN UNIV