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234 results about "Optoacoustic imaging" patented technology

Optoacoustic imaging is an imaging technology based on the photoacoustic effect, and can be used for obtaining images of structures in turbid environments. The optoacoustic technique combines the accuracy of spectroscopy with the depth resolution of ultrasound.

Multi-frame photoacoustic image reconstruction method based on optical flow alignment and depth feature fusion

The invention discloses a multi-frame photoacoustic image reconstruction method based on optical flow alignment and depth feature fusion. The method comprises the following steps: S1, obtaining photoacoustic signal data; s2, reconstructing a photoacoustic cross-sectional image; s3, performing optical flow calculation and image alignment; and S4, training the deep feature fusion network. According to the method, through optical flow motion correction and a potential space learning mechanism, space-time information and complementary features in the aligned multiple frames of images are dynamically integrated, complementary information in the multiple frames of images is adaptively fused, noise is suppressed, and finally reconstruction of high signal-to-noise ratio and high spatial resolution images of biological tissues is achieved. Experimental results show that the method can significantly improve image quality, recover image distortion and detail loss caused by motion and noise, and provide a new effective scheme for promoting robust clinical application of a photoacoustic imaging technology.
Owner:CHANGCHUN NORMAL UNIV

Puncture needle track prediction method, system and device and medium

The invention discloses a puncture needle track prediction method, system and device and a medium. The method comprises the following steps: acquiring continuous photoacoustic imaging image data when a puncture needle punctures in tissue; processing the photoacoustic imaging image data, extracting a needle point position, and converting each frame of image data into a feature vector about the needle point position; a Transformer model is established, the input quantity of the model is the feature vector of past image data about the position of the needle tip and priori knowledge, and the output quantity of the model is the center coordinate of the needle tip of future image data and the insertion angle of the needle tip in the surrounding tissue. Through data enhancement and constraint injection, a pure data driven model can fuse physical laws and clinical experience, finally real-time and accurate prediction of the motion trail of the puncture needle is achieved, medical employees can be helped to more accurately control the path of the puncture needle in a complex operation environment, the misoperation risk is reduced, and the operation efficiency is improved. And the safety and the accuracy of medical puncture operation are obviously improved.
Owner:QINGPU BRANCH OF ZHONGSHAN HOSPITAL AFFILIATED TO FUDAN UNIV (SHANGHAI QINGPU DISTRICT CENT HOSPITAL)

Endoscopic probe for photoacoustic tomography of cavity side walls

The present invention relates to an endoscopic probe for photoacoustic tomography of cavity side walls, characterized by comprising a hollow tubular probe housing with a closed front end; N acoustic wave receiving windows and M laser output windows formed on the side wall of the tubular probe housing; an array of linear laser output ports connected to a pluggable optical fiber connector via an optical fiber bundle; and an ultrasonic transducer array connected to a multi-channel signal connector via a signal harness. The present invention employs a method of arranging array transducers and array laser outputs on the side wall of the probe, eliminating the need for a reflector. The probe is less than 2 centimeters in size and can be placed in close proximity to the prostate through the rectum for photoacoustic imaging of the prostate, or in close proximity to the inner wall of the rectum for photoacoustic imaging of the inner wall of the rectum. The endoscopic probe provided by the present invention, combined with a photoacoustic imaging system host, utilizes photoacoustic endoscopic imaging technology to perform real-time transrectal prostate imaging and rectal imaging, achieving ideal imaging results.
Owner:SHANGHAI TECH UNIV

Human body peripheral blood vessel photoacoustic three-dimensional imaging device and imaging method thereof

The invention discloses a human body peripheral blood vessel photoacoustic three-dimensional imaging device and an imaging method thereof, and belongs to the field of blood vessel imaging. Through high resolution and functional monitoring capability of photoacoustic imaging, detailed blood vessel structure and blood flow dynamic information are provided, and early recognition and treatment effect evaluation of common lesions such as diabetic foot and peripheral artery diseases are promoted; meanwhile, a mechanical system is adopted, so that the detection front end with relatively high quality can be borne, and stable operation is realized, and a relatively good photoacoustic imaging result is obtained; the system has a highly stable accurate scanning imaging mode, and is convenient for multiple imaging modes of clinical application; through the arrangement of the imaging water tank and the lifting structure of the imaging water tank, switching of imaging modes in a limited space can be ensured, so that the device can be suitable for the layout of a portal type three-dimensional moving device. The system is expected to promote the portability of equipment, reduce the research and development cost of the equipment, be widely applied to clinical practice and community medical treatment, and improve the disease management level.
Owner:PEKING UNIV

Photoacoustic imaging system based on self-learning

The invention relates to the technical field of photoacoustic imaging, in particular to a photoacoustic imaging system based on self-learning, which comprises an acquisition module, a screening module, an actual generation module, an ideal generation module, an adjustment module and an imaging module. According to the method, through constructing a complete closed-loop process of acquisition, screening, evaluation, self-learning optimization and image reconstruction, dynamic regulation and control of photoacoustic imaging quality are realized, and a spectrum texture gradient and an imaging uniformity error jointly define space consistency of an image; the background noise energy level and the laser energy distribution describe the stability of the signal quality; the actual definition index measures the current system performance, and the ideal definition index extracts a potential imaging upper limit under noise interference by means of a self-learning model; and the adjusting module performs adaptive optimization through the comparison result, so that the problems of low recognition accuracy and slow response speed caused by poor adaptability to different tissues due to excessive dependence on a fixed parameter model are effectively solved.
Owner:JIAXING UNIV

Detection method and system for lithium battery tab laser welding spot

The invention discloses a lithium battery tab laser welding spot detection method and system, and the method comprises the steps: building a collection system of a multispectral camera, an infrared thermal imaging camera and a photoacoustic imaging module, synchronously collecting the surface optics, internal heat distribution and microstructure characteristics of a welding spot, and reconstructing the internal defect three-dimensional distribution of a preset depth; constructing a feature association matrix, verifying association between features and defects in combination with three-dimensional distribution, and outputting fusion features containing three-dimensional distribution parameters through an attention weighted fusion network; dynamically adjusting visual parameters based on the working condition parameters; detecting defects in combination with fusion features and a causal database, and outputting a process adjustment instruction in advance by a pre-judgment module; and through 3D U-Net, micro defects are segmented and graded. The method covers the full-dimension defects, improves the false defect elimination rate, reduces the defect rate, gives consideration to the detection precision and the production efficiency, and meets the high-reliability detection requirements of the lithium battery tabs.
Owner:GANZHOU XIONGBO NEW ENERGY TECH CO LTD

Transcranial photoacoustic / thermoacoustic tomography brain imaging informed by adjunct image data

Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.
Owner:CALIFORNIA INST OF TECH

Small animal in-vivo multi-parameter dynamic monitoring method based on photoacoustic imaging

The invention discloses a small animal in-vivo multi-parameter dynamic monitoring method based on photoacoustic imaging, and relates to the technical field of biomedical imaging, and the method comprises the steps: obtaining a photoacoustic signal generated by a small animal under the excitation of pulse laser output by an optical excitation module through an acoustic detection module; reconstructing a photoacoustic image of the photoacoustic signal through a filtering back projection algorithm; calculating the similarity between adjacent images in the photoacoustic image, identifying the image of which the similarity is lower than a set frame threshold value as a cross section slice polluted by respiratory motion artifacts and removing the cross section slice, and replacing the removed image frame by using the interpolation of an adjacent artifact-free image so as to obtain an updated photoacoustic image; selecting a region of interest in the photoacoustic image, and carrying out oxygenation kinetics monitoring, pharmacokinetics monitoring, perfusion kinetics monitoring or nanoparticle in-vivo kinetics monitoring; according to the monitoring method, motion artifacts caused by breathing of the small animals are effectively inhibited, and in-vivo multi-parameter dynamics monitoring of the small animals is achieved.
Owner:ARTIFICIAL INTELLIGENCE RES INST OF HEFEI COMPREHENSIVE NAT SCI CENT (ANHUI ARTIFICIAL INTELLIGENCE LAB)

Head-mounted photoacoustic device for multi-parameter brain function monitoring and closed-loop regulation

The invention discloses a head-mounted photoacoustic device for multi-parameter brain function monitoring and closed-loop regulation and control. The device comprises a nerve-lymph-blood vessel multi-mode imaging monitoring module, a multi-dimensional brain information quantitative analysis module, a closed-loop control module, a light / sound brain regulation and control module and a detachable head-mounted module. The method comprises the following steps: firstly, acquiring brain nerve, lymph and blood vessel information in real time by utilizing a multi-modal imaging monitoring module, then sending data to a multi-dimensional brain information quantitative analysis module, decoding and analyzing multi-dimensional data, extracting key features, performing multi-modal data feature fusion, and establishing an analysis method for quantitatively evaluating the brain microenvironment; therefore, the brain function state is accurately represented. The head-mounted device has the advantages that photoacoustic imaging, fluorescence imaging, optical regulation and control and ultrasonic regulation and control are added into the head-mounted device, closed-loop regulation and control parameters are achieved in a combined mode, and the functions of miniature, wearable and multi-parameter detection of the cerebral vessel-nerve-lymph microenvironment and closed-loop photoacoustic regulation and control are achieved.
Owner:SOUTH CHINA NORMAL UNIV

Super-resolution polarized light acoustic imaging method and device

According to the super-resolution polarized light acoustic imaging device and method, galvanometer scanning is achieved on the surface of a sample, excitation light is modulated in different linear polarization directions on each scanning point on the surface of the sample, and the intensity of photoacoustic signals generated by the sample under the excitation light in the different linear polarization directions is obtained through measurement; an initial photoacoustic image of a sample surface structure is constructed by utilizing photoacoustic signal intensities under exciting light in different linear polarization directions, and the initial photoacoustic image is subjected to phase-locked amplification and three-dimensional deconvolution processing, so that a super-resolution photoacoustic image in each linear polarization state is obtained. Compared with traditional polarized light acoustic imaging, the method has the advantages that the diffraction limit of traditional photoacoustic imaging can be overcome, super-resolution imaging of the surface structure of the sample can be achieved while unmarked imaging is achieved, and finer expression of the structure of the sample is achieved. The method has potential application prospects in the fields of biological imaging and biological tissue surface structure conformation detection.
Owner:SOUTH CHINA NORMAL UNIV

Preparation method of silicon dioxide-epoxy resin composite material, ultrasonic transducer, preparation process of ultrasonic transducer and imaging system

The invention discloses a preparation method of a silicon dioxide-epoxy resin composite material, the acoustic impedance of the composite material is controlled by adjusting the volume fraction of the silicon dioxide-epoxy resin composite material, an ultrasonic transducer prepared by utilizing the composite material and a preparation process thereof, and an imaging system designed by utilizing the ultrasonic transducer. By designing the matching layer and the backing layer with specific acoustic impedance, seamless fusion of ultrasonic imaging and photoacoustic imaging is realized, the transducer has ultrahigh sensitivity, broadband characteristic and high optical transparency, shows bimodal imaging capability of high contrast and high resolution, and solves the problem that a traditional transparent ultrasonic transducer is insufficient in acoustic performance.
Owner:SUZHOU UNIV

Non-contact photoacoustic imaging equipment and method based on leakage Lamb wave detection

The invention discloses non-contact photoacoustic imaging equipment and method based on leakage Lamb wave detection, in the equipment, a photoacoustic excitation unit excites Lamb waves on the surface of a to-be-detected plate-shaped sample through a photoacoustic effect; the automatic scanning unit drives the to-be-detected plate-shaped sample to move along the scanning direction, so that the two-dimensional full-coverage scanning of the to-be-detected plate-shaped sample by the photoacoustic excitation unit is realized; the signal detection and amplification unit captures the leakage Lamb wave signal and carries out signal amplification; the data acquisition unit acquires the amplified signal in real time and transmits the signal data to the signal processing and imaging end; and the signal processing and imaging end is respectively in communication connection with the photoacoustic excitation unit, the automatic scanning unit and the data acquisition unit, and performs signal acquisition, storage, analysis and imaging processing. The photoacoustic effect excitation technology, the high-sensitivity signal detection technology and the automatic scanning imaging technology are fused, and efficient, accurate and non-contact detection of the surface and subsurface defects of the plate-shaped material is achieved.
Owner:SUN YAT SEN UNIV

Joint detection device for electroencephalogram and photoacoustic imaging

The invention provides an electroencephalogram and photoacoustic imaging combined detection device, and relates to the technical field of medical information detection. The joint detection device comprises a conductive composite layer suitable for releasing conductive gel in a state of being in contact with skin; the electroencephalogram electrode is embedded in the conductive composite layer and is suitable for transmitting an electroencephalogram signal to an external signal acquisition device when the conductive composite layer is in contact with the skin; the light-induced ultrasonic transmitter is embedded in one end of the conductive composite layer and is constructed to be capable of converting light energy into ultrasonic energy so as to send out an ultrasonic signal and detect nerves and blood vessels under the skin; and the photoinduced ultrasonic receiver is embedded at the other end of the conductive composite layer and is suitable for receiving the ultrasonic signal reflected by the nerve blood vessel and obtaining the spatial information of the nerve blood vessel by using the reflected ultrasonic signal, so that the spatial information of the nerve blood vessel is associated with the electroencephalogram signal, and an electroencephalogram with a target temporal-spatial resolution is obtained.
Owner:WENZHOU SAFETY (EMERGENCY) RES INST TIANJIN UNIV

Photoacoustic-ultrasonic volume imaging method and system based on annular ultrasonic array

The invention relates to the technical field of biomedical imaging, and discloses a photoacoustic-ultrasonic volume imaging method and system based on an annular ultrasonic array, and the method comprises the steps: reconstructing a two-dimensional photoacoustic image and a two-dimensional ultrasonic image; after photoacoustic imaging and ultrasonic synthetic aperture imaging of one imaging plane are completed, the annular ultrasonic array is moved in the direction perpendicular to the imaging plane, photoacoustic images and ultrasonic images of all the imaging planes are repeatedly executed on the next imaging plane, rebuilt and stacked, and a three-dimensional photoacoustic volume image and a three-dimensional ultrasonic volume image are formed; performing spatial pulse response deconvolution processing on the three-dimensional photoacoustic volume image; and fusing the processed three-dimensional photoacoustic volume image and the three-dimensional ultrasonic volume image to generate a three-dimensional bimodal volume image. According to the invention, high-time-resolution opto-acoustic-ultrasonic bimodal three-dimensional imaging is realized by using an annular ultrasonic array and motion scanning, and the high spatial resolution of the image is further ensured through a series of technologies.
Owner:UNIV OF SCI & TECH OF CHINA

Photoacoustic imaging method and photoacoustic imaging system

The invention discloses a photoacoustic imaging method and a photoacoustic imaging system, and the method comprises the steps: transmitting laser to an imaging target, and receiving a photoacoustic signal returned by the imaging target; determining the light intensity of the laser, and determining the absorption coefficient of the skin layer of the imaging target according to the photoacoustic signal and the light intensity of the laser; obtaining a luminous flux distribution result corresponding to the absorption coefficient of the skin layer, wherein the luminous flux distribution result is used for representing luminous flux distribution conditions of the biological tissue under different imaging depths; acquiring photoacoustic image data of the imaging target; compensating the photoacoustic image data based on the luminous flux distribution result to obtain compensated photoacoustic image data; and generating a photoacoustic image according to the compensated photoacoustic image data. The photoacoustic data is compensated according to the luminous flux distribution result corresponding to the absorption coefficient of the skin layer, and the quality and precision of the photoacoustic image can be improved.
Owner:SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD

Laparoscope system integrated with multi-modal image fusion

The invention belongs to the field of laparoscopes, and particularly relates to an integrated multi-modal image fusion laparoscope system which comprises a laparoscope body, a multi-modal image acquisition module, an image fusion processing module, a display control module and an energy supply module. The laparoscope body is integrally designed, and a plurality of image acquisition probes are arranged at the front end of the laparoscope body and used for acquiring image information in different modes; corresponding optical conduction and signal transmission lines are integrated in the lens body, so that acquired image information can be stably and efficiently transmitted to a rear-end module; the multi-mode image acquisition module comprises a white light imaging unit, a fluorescence imaging unit, an ultrasonic imaging unit and a photoacoustic imaging unit which are respectively used for acquiring image data of different modes. The system is reasonable in design, provides comprehensive operation area information for doctors by integrating various image modalities and realizing efficient fusion, improves the operation precision and operation efficiency, and is high in expandability.
Owner:HENAN XIAOGU MEDICAL TECH CO LTD

System and method for placement of a vascular device

PCT designated stageWO2025198858A1SurgeryCatheterRadiologyVascular device
A medical system includes an elongate vascular device having an optical fiber and a sensor module configured to detect pressure pulses at the skin surface resulting light pulses projected from a distal tip of the optical fiber within the vasculature of a patient. Logic of a system console processes pressure pulse data using photo-acoustic imaging techniques to obtain an image the vasculature. The processing also can include determining properties of the vasculature, such as a cross-sectional size of the vasculature, and determines therefrom a location of the distal tip.
Owner:BARD ACCESS SYSTEMS INC

Apparatus and method for modular ultrasound and photoacoustic imaging and interactive guidance using a position-tracked modular imaging framework

A method operable to track reconstruction of a tissue volume from disjoint acoustic sensors. The method includes placing modular acoustic elements individually at positions with respect to the tissue volume, tracking the positions of the modular acoustic elements individually, creating a volumetric distribution map of the tracked modular acoustic elements, registering the volumetric distribution map, and reconstructing an image of the tissue volume or transmit a focused ultrasound by providing the registered distribution map to a beamforming algorithm.
Owner:JOHNS HOPKINS UNIVERSITY

Multimodal fusion detection apparatus and method based on optical pumping and photoacoustic imaging

A multimodal fusion detection apparatus and method based on optical pumping and photoacoustic imaging are provided, relating to the field of fusion detection technology. In the apparatus, the atomic vapor cell detection path and the first laser irradiation path are both directed toward a target region and at least partially overlap. In this way, the detection paths of optical pumping and photoacoustic imaging are at least partially coincident, ensuring that electrophysiological signals and blood oxygen signals originate from the same tissue region and avoiding the spacing constraints of conventional sensors. Thus, the detection path of the atomic vapor cell can be used for both magnetic field detection and photoacoustic detection, enabling simultaneous acquisition of magnetic and photoacoustic signals at a single detection point, achieving hardware reuse for multimodal fusion detection at the same location and time, reducing device size, and minimizing crosstalk among multimodal sensors.
Owner:WESTLAKE UNIV

Handheld device and system for optoacoustic sensing, in particular imaging

The disclosure relates to a handheld device for optoacoustic imaging of an object, wherein the device comprises: i) at least one VCSEL sensor unit comprising a vertical-cavity surface-emitting laser (VCSEL), a laser resonator and a photodiode provided in and / or at the laser resonator and being arranged and / or configured to illuminate the object with first electromagnetic radiation emerging from the laser resonator, allow second electromagnetic radiation, which has been reflected and / or scattered by the object in response to illuminating the object with the first electromagnetic radiation, to enter the laser resonator and mix and / or interfere with the first electromagnetic radiation, whereby an interference signal is obtained, and detect the interference signal with the photodiode, wherein the at least one electronic controller is configured to derive, based on the detected interference signal, positional information regarding a position and / or distance and / or movement of the at least one VCSEL sensor unit and / or the handheld device relative to the object; and / or ii) at least one vertical-cavity surface-emitting laser (VCSEL) configured to illuminate the object with first electromagnetic radiation, a detector, in particular an optical or ultrasound detector, configured to, in particular incoherently, detect a response signal, in particular an optical signal or an ultrasound signal, emanating from the object in response to illuminating the object with the first electromagnetic radiation, wherein the at least one electronic controller is configured to derive, based on the detected response signal, a time measure characterizing a duration (time of flight) it takes for the first electromagnetic radiation to travel from the VCSEL to the object and, after reflection or conversion into an ultrasound wave by the object, back to the detector, and to derive positional information regarding a height position and / or distance of the at least one VCSEL and / or handheld device relative to the object. The disclosure further relates to an according handheld device for ultrasound imaging and an according system for optoacoustic or ultrasound imaging.
Owner:ITHERA MEDICAL

A multi-modal diagnosis and treatment integrated AIE carbon nitride composite nano system and a preparation method thereof

PendingCN122624699ADual imagingLiver fibrosis
The application relates to the field of biological nanotechnology, and provides a multimodal diagnosis and treatment integrated AIE carbon nitride composite nano system and a preparation method thereof. The composite nano system takes selenium-doped carbon nitride nanosheets as a core carrier, realizes active targeting of hepatic stellate cells through VA-PEG2000 modification, simultaneously loads a first AIE photosensitizer and a second AIE photosensitizer with near-infrared two-region emission, and forms a double-photosensitizer composite system. The composite nano system has the dual imaging modalities of near-infrared two-region fluorescence imaging and photoacoustic imaging under the excitation of 660nm and / or 808nm laser, simultaneously generates reactive oxygen through a photodynamic effect to play a treatment function. The application further co-loads an anti-fibrosis drug in the nano system, realizes photodynamic-chemical combined treatment under the guidance of imaging, and solves the technical problems of single imaging modality and insufficient functional integration of an existing liver fibrosis nano diagnosis and treatment system, so that multimodal precise positioning and synergistic enhanced treatment integration of liver fibrosis lesions can be realized.
Owner:LUOXI MEDICAL TECH (HANGZHOU) CO LTD

A Multi-modal Skin Disease Analysis Method Based on Deep Learning

The present invention relates to a multimodal skin disease analysis method based on deep learning, and relates to the field of auxiliary diagnosis technology. The present invention uses a photoacoustic imaging device to scan, and a dermatoscope to photograph the affected area of the skin disease to obtain photoacoustic imaging data and skin images of the affected area; aligns the photoacoustic imaging with the skin image, fills the space according to the skin image, and then combines it with the skin image to obtain multimodal skin data; constructs and pre-trains a skin analysis model based on multimodal skin data; the pre-trained skin analysis model analyzes the collected multimodal skin data to obtain skin disease analysis results. The present application constructs multimodal skin data, provides multivariate data support, and ensures that disease analysis is accurate and reliable. The skin analysis model extracts skin image feature maps and photoacoustic imaging feature maps of different scales to cover the association between features of different sizes and skin diseases of different specifications; uses another modality data to strengthen its own modality to better combine the two modality features; and has strong interpretability.
Owner:AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV

A fouling detection device and method based on photoacoustic imaging

The application discloses a fouling detection device and method based on photoacoustic imaging, wherein the detection device comprises: a sealed cover with at least one transparent surface; a photoacoustic excitation module comprising a laser, an optical fiber bundle and a plurality of micro-fiber collimators; the micro-fiber collimators are integrated in the transparent surface and used for irradiating laser outside the transparent surface to generate a photoacoustic signal; a photoacoustic collection module arranged along the propagation direction of the photoacoustic signal and used for collecting the photoacoustic signal; and a data processing module in communication connection with the photoacoustic collection module and used for calculating the fouling degree outside the transparent surface according to the collected photoacoustic signal. The application adopts nanosecond-level light pulses to improve the detection accuracy; and the laser sequentially traverses the optical fiber, so that the position of fouling can be accurately located, and a reliable basis is provided for fouling removal.
Owner:OCEANOGRAPHIC INSTR RES INST SHANDONG ACAD OF SCI

Preparation method of cryptotanshinone-loaded PDA (Personal Digital Assistant) nano drug-loaded particles

The invention discloses a preparation method of cryptotanshinone-loaded PDA (Polydopamine) nano drug-loaded particles. The technical scheme adopted by the invention is as follows: the cryptotanshinone is loaded on PDA (Polydopamine) nano particles. Photo-thermal therapy and pharmaceutical chemotherapy are integrated into designed nano-delivery to impart a targeted synergistic effect thereto. In addition, the PDA nanoparticles show photoacoustic imaging capability, and aggregation of the nanoparticles at the ovary part can be monitored in real time. The cryptotanshinone is loaded by utilizing aperture adsorption of PDA and pi-pi conjugation and hydrophobic interaction with the cryptotanshinone, so that a drug delivery system is constructed, the biological solubility and the utilization rate of the cryptotanshinone are improved, a slow release effect is achieved, the application of the cryptotanshinone is widened, and the purpose of treating the polycystic ovarian syndrome is achieved.
Owner:SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE

A photoacoustic imaging method using a focused LED light source

The application provides a photoacoustic imaging method using a focused LED light source, solves the problems of insufficient light intensity of the LED light source, inability to realize high-quality photoacoustic imaging, serious electromagnetic interference and difficulty in irradiation in liquid and tissue. The imaging method comprises the following steps: a driving circuit emits a periodic pulse signal with driving capacity, and controls an LED array to periodically emit pulsed light; a 3D printing component is fixed above the LED array, and a hole position corresponds to an LED position; an optical fiber is passed through the 3D printing component, and an input end of the optical fiber is coupled with a light-emitting part of the LED; a plurality of optical fibers are combined into one bundle at the output end of the optical fiber by using an optical fiber combiner, the pulsed light emitted by the plurality of LEDs is superimposed together, the focusing effect is achieved, and high-intensity pulsed light can be obtained at the output end of the combiner; the imaging target is irradiated by using the high-intensity pulsed light at the output end of the combiner, an ultrasonic probe receives an acoustic pressure signal, and photoacoustic imaging is realized through an algorithm.
Owner:NANJING UNIV

A wired bimodal imaging capsule endoscopy system

This invention discloses a wired dual-modal imaging capsule endoscopy system, belonging to the field of medical device technology. The system includes a capsule module, a transmission and control module, a dual-modal imaging module, and a signal analysis module. The capsule module is used to achieve 360° circumferential scanning imaging of the esophageal mucosa. The transmission and control module ensures stable transmission of optical and electrical signals and precise control of capsule movement. The dual-modal imaging module integrates an optical coherence tomography submodule and a photoacoustic imaging submodule to acquire tissue morphology information and microvascular distribution information, respectively. The signal analysis module processes the dual-modal signals. This invention achieves three-dimensional high-resolution integrated imaging of the esophageal mucosa without the need for exogenous labeling agents, significantly improving the detection accuracy of early esophageal cancer and precancerous lesions.
Owner:BEIHANG UNIV

Photoacoustic imaging probe with dustproof structure

The utility model discloses a photoacoustic imaging probe with a dustproof structure, which comprises a probe main body, a signal acquisition optical window is arranged on the front side of the probe main body, and a dustproof ventilation assembly is arranged on the front side of the probe main body. The dustproof sealing plate is clamped with the clamping groove through the clamping block to seal the signal acquisition optical window, the internal ventilation and water blocking structure can block dust and body fluid from invading and maintain air circulation so as to keep dry, the laser energy transmission efficiency is guaranteed, and the dustproof sealing plate can be quickly overturned and opened through the rotating shaft to be clamped into the groove to achieve fixation during use. The whole operation is convenient and fast, extra tools are not needed, high-frequency scenes are adapted, the manual cleaning frequency is reduced, in addition, the dustproof ventilation assembly is integrally integrated on the front side of the probe body, the structure is compact, no extra space is occupied, sealing stability is ensured through the clamping connection design, and the problem that a traditional split type sealing cover is prone to being lost or losing efficacy is solved.
Owner:WUHAN XIN MICROELECTRONICS TECH CO LTD

Diagnosis and treatment integrated nano platform, preparation method and application thereof

The invention provides a diagnosis and treatment integrated nano platform as well as a preparation method and application thereof. According to the diagnosis and treatment integrated nano platform, an organic-inorganic nano hybrid is constructed through structure optimization and function integration, four modes of PTT, PDT, SDT and CDT are organically combined innovatively, and efficient synergistic treatment of GBM is achieved through real-time monitoring of photoacoustic imaging. First, a dOMV encapsulation strategy significantly improves the ability to penetrate through the blood brain barrier. Meanwhile, the IEICO-4F has a strong near-infrared absorption characteristic and has a synergistic effect with the high catalytic activity of the mesoporous platinum nanoparticles. Under the laser / ultrasonic excitation condition, the diagnosis and treatment integrated nano platform shows excellent photo-thermal conversion performance, the Fenton reaction rate can be increased, endogenous hydrogen peroxide can be continuously catalyzed to be decomposed to generate oxygen, and the tumor hypoxia state is effectively relieved. The series of reactions further enhance the generation of ROS, activate a Caspase-1 / GSDMD mediated pyroptosis pathway, finally achieve an efficient tumor inhibition effect, and successfully break through the limitation of a single treatment mode.
Owner:ZHEJIANG PROVINCIAL PEOPLES HOSPITAL

Photoacoustic imaging method and photoacoustic imaging system

A photoacoustic imaging method and system are disclosed. The method includes, in a first photoacoustic imaging mode, controlling a photoacoustic composite probe to emit a laser beam once toward the tissue to be measured to obtain a frame of photoacoustic image; in a second photoacoustic imaging mode, controlling the photoacoustic composite probe to emit a laser beam at least twice toward the tissue to be measured to obtain a frame of photoacoustic image; and switching from the first photoacoustic imaging mode to the second photoacoustic imaging mode when detecting that the movement speed of the photoacoustic composite probe is less than a first preset threshold. By detecting the movement speed of the photoacoustic composite probe and determining the switch between the first photoacoustic imaging mode and the second photoacoustic imaging mode, the method satisfies the user's different photoacoustic image requirements when the photoacoustic composite probe is moved at different speeds.
Owner:SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD