40 results about "Light delivery" patented technology

To provide a UV light delivery device for performing intra-corporeal ultraviolet therapy.SOLUTION: The device includes an elongated body separating a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space and a cooling tube. In some examples, the UV light source is configured to emit light with wavelengths with a desired intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.SELECTED DRAWING: Figure 69

Exemplary diagnostic systems and methods involve delivering multispectral light to a tissue of a patient, detecting light from the tissue, and analyzing the tissue based on the detected light. Light delivery can be achieved using a multi-dispersion element monochromator apparatus that includes a broad spectrum light source, a rotating body, and multiple dispersion elements in operative association with the rotating body.

A compact UV light delivery device comprises a UV LED, integrated into the compact UV light delivery device, to generate a UV beam; a homogenizing beam coupler, to receive the UV beam from the UV LED, and to homogenize the UV beam such that a measure of non-uniformity of the output homogenized beam is smaller than the measure of non-uniformity of the received UV beam; an illumination optics, to receive the homogenized beam and to forward it as an illumination beam; a spatial light modulator, to modulate the illumination beam into a modulated beam according to a procedure profile; a projection optics, to receive and to project the modulated beam as a projection beam through its objective into an eye of a patient; and a binocular-free imaging system, to image the eye of the patient via the same objective, and to present the image on a user interface.

A spectroscopy system comprising: a light delivery channel; a light receiving channel; and a reflective element; wherein the spectroscopy system is configurable in: a calibration arrangement in which light delivered from the light delivery channel is reflected from the reflective element and received in the light receiving channel; and a measurement arrangement in which light delivered from the light delivery channel travels through an object to be analysed and is received in the light receiving channel.

A temperature-tolerant, shock and vibration resistant absolute pressure sensor may be constructed by joining a ruggedized lens assembly and optical fiber assembly to create a stable beam of collimated light. The lens may be captured by brazing or welding to high-strength spherical metal components. The light delivery assembly may be comprised of a metal jacketed optical fiber, ceramic ferrule, and metal alignment sleeves that are mechanically and / or chemically joined to one another using high temperature sealing glass preforms or brazing materials. The optical fiber assembly may be joined to the lens assembly securing the end face of the optical fiber in the operative focal position relative to the lens. The joined assembly results in a structure where no parts are subject to movement even at extreme temperatures or when subjected to severe shock and vibration. All the air-to-glass interfaces may have anti-reflection coatings to reduce optical losses, back reflection, and false signals. This rugged collimated beam assembly may be joined to a sensor assembly comprised of a diaphragm and window which comprise a Fabry-Perot interferometer. The external wetted surfaces of the diaphragm may be coated to reflect the radiant energy or with passive conductive and convective arrangements to keep the sensor cool and to minimize the long-term change in sensitivity of the diaphragm due to oxidation. The resulting sensors can be further enhanced by attaching the sensor to an absolute, hermetically sealed connector comprised of a lens assembly which is aligned and welded to the sensor transducer body. The resulting sensors can be further enhanced with windows for collecting UV energy and may use wide spectral band optical fibers to multiplex UV, visible, and IR energy from the sensing environment. These enhancements can be used to detect the presence of a flame and to make temperature measurements resulting in safety-certified optical sensors for use in many harsh industrial applications.

Disclosed herein is an implantable or wearable, flexible, miniaturized microimaging suited for localized brain fluorescent imaging. The microimaging device is implemented on a Parylene photonics platform, which is biocompatible and fabricated using scalable planar microfabrication techniques, enabling customizable design, size, and number of channels (pixels). Operating across the entire visible spectrum. The microimaging device functions effectively both for coherent and scattered light. The microimaging device can be implanted into the brain of freely moving animals, where one or more waveguides could be dedicated to light delivery and the rest of the waveguides for collecting and relaying the fluorescent image to image the tissue structure and function.

An ophthalmic instrument (10) for crosslinking of the sclera (5) of an eye (1) is presented. The ophthalmic instrument (10) comprises a periocular arm (11) which extends from a proximal end (12) to a distal end (13) and which comprises a bend (14) to reach along at least part of an outer contour of the eye (1) with an inside face (15) of the periocular arm (11). An opening (16) is arranged through the inside face (15) at or near the distal end (13) of the periocular arm (11). A light delivery device (17) is arranged in the opening (16) of the periocular arm (11) to deliver light for local crosslinking of the sclera (5) of an eye (1) positioned adjacent to the inside face (15) of the periocular arm (11).

A photodynamic therapy light delivery system can comprise a light source and a light delivery catheter, including an expandable distal section, to be advanced to a treatment area in a closed state, and to be expanded to form a flow channel, and configured to have an outer compliant portion to compliantly press against the treatment area; wherein the space between the blood flow channel and outer portion of the catheter can be filled with a balloon, inflated with a fluid transparent or translucent at the treatment wavelengths; a shaft and a proximal section, together configured to advance the expandable distal section to the treatment area, and to receive the light from the light source at the proximal section and to forward the light to the expandable distal section; and side-emitting optical fibers, positioned in the expandable distal section, to receive the light and to illuminate the treatment area.

Methods and systems one or more for performing intra-luminal ultraviolet therapy for treating and / or ameliorating a gastrointestinal tract inflammation and / or infection are provided. In one example, a light delivery catheter may include a light emitting portion and non-illuminating portion, wherein the light emitting portion may include one or more UV transparent balloons. In some examples, the UV light source is configured to emit narrow-band light having wavelengths in a range between 335 nm and 349 nm.

Systems, devices and methods for controlled intramedullary delivery of light (frequencies from about 380 nm to about 500 nm) to treat tissue or bones disorders, including osteomyelitis, by a flexible fiber are provided, where the light is delivered in a circumferential fashion around the fiber, and where the energy delivered from the fiber is of a similar average intensity at the front end and back end of the fiber, and in between. The methods and systems deliver intramedullary light to the canal over long lengths via a minimally invasive pathway to a bone. The methods and systems deliver and maintain a light delivery system within the canal of the bone to provide single or multiple doses of light to kill, eliminate, remove or reduce bacteria, viruses, fungus and pathogens, without removal of the light fiber system, thereby providing single or multiple treatments.

A compact UV light delivery device comprises a UV LED, integrated into the compact UV light delivery device, to generate a UV beam; a homogenizing beam coupler, to receive the UV beam from the UV LED, and to homogenize the UV beam such that a measure of non-uniformity of the output homogenized beam is smaller than the measure of non-uniformity of the received UV beam; an illumination optics, to receive the homogenized beam and to forward it as an illumination beam; a spatial light modulator, to modulate the illumination beam into a modulated beam according to a procedure profile; a projection optics, to receive and to project the modulated beam as a projection beam through its objective into an eye of a patient; and a binocular-free imaging system, to image the eye of the patient via the same objective, and to present the image on a user interface.

System, devices, and methods for providing treatment to tissue are disclosed herein. In some embodiments, a device is provided that includes a delivery catheter having an elongated shaft and an inner lumen therethrough, the delivery catheter being configured to pass through tissue such that a distal end of the delivery catheter is positioned at a target tissue, a support in the form of an inner slidable tube that is configured to be positioned inside the inner lumen of the delivery catheter, the support being configured to provide rigid or semi-rigid support for the delivery catheter during insertion of the delivery catheter through tissue, and one or more optical fibers configured to pass through the inner slidable tube and being configured to deliver light energy to provide an antimicrobial effect to the target tissue.

System, devices, and methods for providing treatment to tissue are disclosed herein. In some embodiments, a device is provided that includes a delivery catheter having an elongated shaft and an inner lumen therethrough, the delivery catheter being configured to pass through tissue such that a distal end of the delivery catheter is positioned at a target tissue, a support in the form of an inner slidable tube that is configured to be positioned inside the inner lumen of the delivery catheter, the support being configured to provide rigid or semi-rigid support for the delivery catheter during insertion of the delivery catheter through tissue, and one or more optical fibers configured to pass through the inner slidable tube and being configured to deliver light energy to provide an antimicrobial effect to the target tissue.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separating a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space and a cooling tube. In some examples, the UV light source is configured to emit light with wavelengths with a desired intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.

A compact UV light delivery device comprises a UV LED, integrated into the compact UV light delivery device, to generate a UV beam; a homogenizing beam coupler, to receive the UV beam from the UV LED, and to homogenize the UV beam such that a measure of non-uniformity of the output homogenized beam is smaller than the measure of non-uniformity of the received UV beam; an illumination optics, to receive the homogenized beam and to forward it as an illumination beam; a spatial light modulator, to modulate the illumination beam into a modulated beam according to a procedure profile; a projection optics, to receive and to project the modulated beam as a projection beam through its objective into an eye of a patient; and a binocular-free imaging system, to image the eye of the patient via the same objective, and to present the image on a user interface.

Modulation of foreign body responses in living tissue, and more particularly, devices and related methods for light-based modulation of foreign body responses in living tissue are disclosed. Light sources are disclosed that provide light with characteristics for modulation of foreign body responses that may be elicited by percutaneous and / or subcutaneous devices, including medical devices and other consumer electronic devices. Light delivery structures are disclosed that propagate light from the light sources to irradiate associated subcutaneous tissues. Modulation of foreign body responses may include inhibiting collagen and fibrous tissue generation, modulating inflammation and healing, and / or increasing nitric oxide production and / or release. By modulating foreign body responses associated with percutaneous and / or subcutaneous devices, performance characteristics and lifetimes of such devices may be improved.

Embodiments generally relate to a light collection apparatus and a method thereof. A light collection apparatus may comprise at least one light collecting element having a tapered body configured to propagate light from its proximal end to its distal end, at least one light intercepting face disposed at the proximal end of the tapered body, and a light delivery section projecting from the distal end of the tapered body, wherein the at least one light intercepting face is coupled to a light source such that light radiating from the light source is intercepted by the at least one light intercepting face, propagates through the tapered body and is delivered from a distal end of the light delivery section of the light collection apparatus, wherein the light source is configured to radiate antimicrobial blue light.

A compact UV light delivery device comprises a UV LED, integrated into the compact UV light delivery device, to generate a UV beam; a homogenizing beam coupler, to receive the UV beam from the UV LED, and to homogenize the UV beam such that a measure of non-uniformity of the output homogenized beam is smaller than the measure of non-uniformity of the received UV beam; an illumination optics, to receive the homogenized beam and to forward it as an illumination beam; a spatial light modulator, to modulate the illumination beam into a modulated beam according to a procedure profile; a projection optics, to receive and to project the modulated beam as a projection beam through its objective into an eye of a patient; and a binocular-free imaging system, to image the eye of the patient via the same objective, and to present the image on a user interface.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.

A compact UV light delivery device comprises a UV LED, integrated into the compact UV light delivery device, to generate a UV beam; a homogenizing beam coupler, to receive the UV beam from the UV LED, and to homogenize the UV beam such that a measure of non-uniformity of the output homogenized beam is smaller than the measure of non-uniformity of the received UV beam; an illumination optics, to receive the homogenized beam and to forward it as an illumination beam; a spatial light modulator, to modulate the illumination beam into a modulated beam according to a procedure profile; a projection optics, to receive and to project the modulated beam as a projection beam through its objective into an eye of a patient; and a binocular-free imaging system, to image the eye of the patient via the same objective, and to present the image on a user interface.

While clinical treatment of actinic keratosis by photodynamic therapy (PDT) is widely practiced, there is well-known variability in response, primarily caused by heterogeneous accumulation and PDT-induced photobleaching of the photosensitizer protoporphyrin IX (PpIX) between patients and between lesions. One of the key factors in regularizing this treatment would be to have an easily accessible indicator of PpIX present in the lesions at the time of light delivery. Described herein, a smartphone-based fluorescence imager was developed to allow simple quantitative photography of the lesions and their PpIX levels.

Systems and methods for transcranial light therapy address the deficiencies inherent in previous light therapy devices. Improved adjustability of the location, placement, and directionality of the applied light, thereby improving efficiency of transcranial light delivery and facilitating customization of fitment of the light therapy devices to users of differently sized and differently shaped human heads and hair is provided. Improved mechanisms and methods for controlling light therapy application at each of a plurality of light application locations are also provided, such that light therapy treatments can be highly customized for each individual and / or therapy purpose. Simultaneous, sequential, or separate ocular visible light therapy is also available, thereby increasing the options for customized therapy modalities. The therapy devices are highly modular, permitting simplified repair and maintenance of device components upon component failure and allowing unnecessary device components to be removed from the device when not being used, thereby increasing user comfort.

A technique is proposed for integrating optical components into a compact endoscopic system. In one instance, this involves combining a single / multimode fiber (or fiber bundle) and multiple metalenses using a ferrule and mounts. Specifically, the fiber is housed within the ferrule, which includes a protrusion that fits into a mount where the metalenses are securely positioned and aligned with the fiber. The integrated system allows light input through the fiber to interact with and be manipulated by the metalenses, enabling light delivery and focusing onto a target area. This configuration holds potential for miniaturized medical imaging across various modalities such as optical coherence tomography, fluorescence microscopy, and Raman spectroscopy.

An electromagnetic radiation (EMR) delivery system for delivering EMR at wavelengths, intensities, exposures, and durations to locations inside and / or outside a patient's body in, on, and surrounding a tubular structure such as a tube, catheter, and / or a catheter extension to prevent, reduce, and / or eliminate infectious agents in, on, or surrounding the tubular structure. A smart light engine box generates the therapeutic EMR, controls treatments, and monitors the health of the system. A fiber optic disposable, introduced and positioned by an introducer assembly, makes at-home use of the EMR delivery system possible. Specific embodiments of the EMR delivery system for use with peritoneal dialysis catheters, dialysis accesses, and hemodialysis accesses are also disclosed.

A compact UV light delivery device comprises a UV LED, integrated into the compact UV light delivery device, to generate a UV beam; a homogenizing beam coupler, to receive the UV beam from the UV LED, and to homogenize the UV beam such that a measure of non-uniformity of the output homogenized beam is smaller than the measure of non-uniformity of the received UV beam; an illumination optics, to receive the homogenized beam and to forward it as an illumination beam; a spatial light modulator, to modulate the illumination beam into a modulated beam according to a procedure profile; a projection optics, to receive and to project the modulated beam as a projection beam through its objective into an eye of a patient; and a binocular-free imaging system, to image the eye of the patient via the same objective, and to present the image on a user interface.

A technique is proposed for integrating optical components into a compact endoscopic system. In one instance, this involves combining a single / multimode fiber (or fiber bundle) and multiple metalenses using a ferrule and mounts. Specifically, the fiber is housed within the ferrule, which includes a protrusion that fits into a mount where the metalenses are securely positioned and aligned with the fiber. The integrated system allows light input through the fiber to interact with and be manipulated by the metalenses, enabling light delivery and focusing onto a target area. This configuration holds potential for miniaturized medical imaging across various modalities such as optical coherence tomography, fluorescence microscopy, and Raman spectroscopy.