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Noninvasive blood sugar detection device based on raman scattering spectrum and detection method

A technology of Raman scattering spectroscopy and blood sugar detection, which is applied in the directions of blood characterization devices, spectral diagnosis, diagnostic recording/measurement, etc. It can solve the problems of inaccurate measurement results and low reliability, and achieve wide application prospects and high precision Effect

Active Publication Date: 2020-06-05
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These blood glucose meters require patients to take samples by themselves and use test strips to detect blood sugar. Although blood glucose meters are much more convenient than going to the hospital to detect blood sugar, they can realize real-time detection of blood sugar. Factors such as environmental interference often lead to inaccurate measurement results and low reliability

Method used

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  • Noninvasive blood sugar detection device based on raman scattering spectrum and detection method
  • Noninvasive blood sugar detection device based on raman scattering spectrum and detection method
  • Noninvasive blood sugar detection device based on raman scattering spectrum and detection method

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1: A kind of non-invasive blood glucose detection device based on Raman scattering spectrum, such as figure 1 As shown, it includes a semiconductor laser 1, an optical fiber beam splitter 2, an optical fiber probe 3, an optical filter 5, a Raman spectrometer 6, a first circuit switch 7, a second circuit switch 8, a lock-in amplifier 9, a heart rate measuring instrument 10 and Computer 11, optical fiber beam splitter 2 comprises total fiber bundle 22 and the first bifurcated optical fiber 21 and the second bifurcated optical fiber 23 that branch out from total fiber bundle 22, and the output end of semiconductor laser 1 is connected with the first bifurcated optical fiber 21 , the total optical fiber bundle 22 is connected with the optical fiber probe 3, the second bifurcated optical fiber 23 is connected with the signal input end of the Raman spectrometer 6 through the optical filter 5, and the Raman spectrometer 6 is used to receive the Raman scattered light ...

Embodiment 2

[0038] The non-invasive blood glucose detection device based on Raman scattering spectrum in Example 2 differs from Example 1 in that in Example 2, as figure 2 and image 3 As shown, the fiber optic probe 3 includes a hollow cylinder 31 and a self-focusing lens 32, the hollow cylinder 31 is an opaque hollow cylinder 31, the numerical aperture of the self-focusing lens 32 is 0.25, and the focal length is 3mm, and the self-focusing lens 32 is embedded is mounted on the front end of the central hole 30 of the hollow cylinder 31, the distance between the front end surface of the self-focusing lens 32 and the front end surface of the hollow cylinder 31 is 3 mm, and the rear end of the central hole 30 of the hollow cylinder 31 is pierced with a The connecting optical fiber 33 is facing the rear end of the self-focusing lens 32, the connecting optical fiber 33 is connected with the total optical fiber bundle 22, and the outer side of the connecting optical fiber 33 is provided with ...

Embodiment 3

[0039] Embodiment 3: The non-invasive blood sugar detection method implemented by the non-invasive blood sugar detection device of Embodiment 2, comprising the following steps:

[0040] (1) Select 30 healthy volunteers as measurement objects;

[0041] (2) A volunteer was required to take 300mL of glucose solution with a concentration of 25% by mass after 8 hours of fasting, and then measure the Raman scattering spectrum and human blood glucose concentration in the volunteer's pure blood every 30 minutes, measuring 10 times in total. Each measurement process is:

[0042] (2-1) Ensure that the external environment is stable and the human body is calm, select the human body detection part 4 (in this embodiment, the index finger pulp of the human body), fix the optical fiber probe 3 on the human body detection part 4, and make the optical fiber probe 3 and the human body detection part 4 Skin contact with human detection site 4;

[0043] (2-2) trigger semiconductor laser 1 by co...

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Abstract

The invention discloses a noninvasive blood sugar detection device based on a raman scattering spectrum. The noninvasive blood sugar detection device based on a raman scattering spectrum comprises a semiconductor laser, an optical fiber beam splitter, an optical fiber probe, a light filter, a raman spectrometer, a first circuit switch, a second circuit switch, a phase locking amplifier, a heart rate measuring apparatus and a computer. According to the noninvasive blood sugar detection device based on a raman scattering spectrum disclosed by the invention, raman scattering light contains rich molecular vibration information, the characteristics that the raman scattering spectrum having different molecules has different features are utilized, the raman scattering spectrum is used for recognizing molecules; and through the relative value of a glucose characteristic peak at the position of 1125cm-1 in the raman scattering spectrum in pure blood to the hemoglobin characteristic peak value at the position of 1549cm-1, and real-time human body blood sugar concentration data measured by a blood sugar biochemistry instrument, a standard straight line L of the relationship between the relative peak value of the glucose characteristic peak at the position of 1125cm-1 and the human body blood sugar concentration is constructed, and finally noninvasive real-time detection of the human bodyblood sugar is realized. The noninvasive blood sugar detection device disclosed by the invention has the advantages of being high in precision, pollution-free, harmless to human bodies and the like, and has great application prospects in the field of biological noninvasive detection.

Description

technical field [0001] The invention relates to the technical field of biological non-invasive detection, in particular to a non-invasive blood sugar detection device and detection method based on Raman scattering spectroscopy. Background technique [0002] The population of diabetic patients in the world is increasing day by day, and the population of diabetic patients in China ranks among the top three in the world. The hazards of diabetes to human health include: leading to pancreatic islet failure and renal failure; causing a large amount of glucose to be excreted from the human body with urine, causing osmotic diuresis, which leads to a large amount of dehydration of the human body; damaging blood vessels, causing other complications, such as retina Lesions, cardiovascular and cerebrovascular diseases, etc.; cause neuropathy. Diabetes is so harmful that it is very important for patients to detect and seek medical treatment in time, otherwise they will miss the best tim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1455A61B5/145A61B5/00
CPCA61B5/1455A61B5/14532A61B5/0075A61B5/0033
Inventor 张培晴褚珞耀叶哲浩吕靖轩郑文伟郑逸铭赵恩洋宋宝安张巍
Owner NINGBO UNIV
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