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Device for noninvasively detecting indocyanine green content in bodies

A technology of indocyanine green and detection body, which is applied in the fields of diagnostic recording/measurement, medical science, sensor, etc., can solve problems that have not yet been seen, achieve high consistency, save time, and save storage and management

Active Publication Date: 2020-05-12
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no photoacoustic imaging device or method for detecting ICG content in the body

Method used

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  • Device for noninvasively detecting indocyanine green content in bodies
  • Device for noninvasively detecting indocyanine green content in bodies
  • Device for noninvasively detecting indocyanine green content in bodies

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 ICG detection device of the present invention

[0028] The present invention includes:

[0029] 1) A single-wavelength or multi-wavelength laser emitting device capable of emitting a wavelength of 805nm;

[0030] 2) The photoacoustic signal detection device is responsible for detecting the photoacoustic signal intensity value in blood vessels / blood when the laser emitting device emits light with a wavelength of 805nm;

[0031] 3) The photoacoustic signal conversion device is responsible for converting the photoacoustic signal intensity into ICG concentration.

[0032] The working principle of ICG detection device to detect ICG concentration is as follows:

[0033] Theoretically, the light absorption coefficient is expressed as:

[0034] mu a =e*c*ln 10=2.303 e*c (1)

[0035] In the formula, e is the molar extinction coefficient of the molecular group, and c is the molar concentration. According to the formula (1), it can be known that the light absorpt...

Embodiment 2

[0052] Embodiment 2 ICG detection device of the present invention

[0053] On the basis of Embodiment 1, the detection device of the present invention is also equipped with a photoacoustic tomography imaging system for converting photoacoustic signals into image signals.

Embodiment 3

[0054] Embodiment 3 ICG detection device of the present invention

[0055] On the basis of Embodiment 1 or 2, in order to ensure that the photoacoustic signal only originates in the blood vessel and is not affected by the surrounding skin and subcutaneous soft tissue, the device of the present invention also includes an ultrasonic positioning device, which is used for precise positioning of the intravascular ICG light Acoustic signal analysis and imaging.

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Abstract

The invention provides a device for noninvasively detecting indocyanine green content in bodies. The device includes a laser emitting device that can emit single wavelength or multi-wavelength with the wavelength of 805 nm, and photoacoustic signal detection and conversion devices; and preferably, the device also includes an ultrasonic positioning device, and the ultrasonic positioning device canaccurately detect the indocyanine green content in a blood vessel at a specific position without being disturbed by other tissue. Through the device, the noninvasive detection on the indocyanine greencontent in blood can be realized; rapid assessment on hepatic functional reserve can be realized; and therefore, the device has good commercial prospects.

Description

technical field [0001] The invention relates to a device for noninvasively detecting the content of indocyanine green in the body. Background technique [0002] Liver reserve function refers to the sum of the normal functions that the surviving hepatic parenchymal cells can exert after liver damage. In the field of liver surgery, liver reserve function can be evaluated by injecting indocyanine green (ICG) and detecting the change of ICG content in blood over time; the latter is useful for determining the safe range of hepatectomy and reducing the incidence of postoperative hepatic insufficiency important guiding significance. On the other hand, for non-surgical liver disease patients, liver reserve function will be damaged to varying degrees in patients with hepatitis, liver fibrosis, and liver cirrhosis. China is the country that pays the most social costs for hepatitis B, cirrhosis, and liver cancer in the world, and the assessment of liver reserve function in these pati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/0095A61B2503/40A61B2503/42
Inventor 罗燕邱婷婷
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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