Method for evaluating collateral vessels and tissue function based on cerebral blood flow

Abstract

The invention discloses a method for evaluating collateral vessels and tissue function based on cerebral blood flow, which comprises the following steps of: firstly, registering cerebral blood flow graphs with multiple delay times of a patient diagnosed with major artery occlusion infarction to realize one-to-one correspondence on a spatial anatomical structure; secondly, removing cerebral shellsand extracerebral structures of the cerebral blood flow graphs with multiple delay times after registration, and calculating cerebral blood flow difference graphs with multiple delay times; then, visualizing cerebral collateral blood circulation conditions, and quantifying collateral blood flow related information, such as collateral blood flow distribution range, velocity, flow and the like; andfinally, by combining with the infarction core area of the patient diagnosed with the major artery occlusion infarction, evaluating the ischemic penumbra, such as the size, volume and position of theischemic penumbra.

Description

technical field [0001] The invention belongs to the technical field of magnetic resonance imaging and medical image processing, and in particular relates to a collateral vessel and tissue function evaluation method based on cerebral blood flow. Background technique [0002] The currently widely used method is to use the perfusion imaging method of contrast agent injection to obtain the pixel-level contrast agent inflow-time curve, so as to obtain multiple parameters that can reflect hemodynamics, such as average transit time, time to peak, Peak reaction time, etc., determine the severe hypoperfusion area by limiting the time threshold, so as to form a mismatch with the brain tissue death area to reflect the ischemic penumbra. However, the limitations of this method are obvious. Firstly, it may not be the ischemic penumbra in the true sense to reflect severe hypoperfusion simply by setting the time threshold. It also includes benign hypoperfusion areas. Secondly, the above-me...

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Problems solved by technology

Cerebral collateral circulation is divided into three levels, among which the third-level collateral circulation is related to the ischemic penumbra, which often refers to the rapid establishment of small arteries after the occurrence of ischemic stroke to supply blood to the ischemic penumbra. This kind of tertiary collateral circulation imaging can well reflect the existence and extent of the ischemic penumbra; although the existing imaging technology can image the first and second-order collateral circulation, it is difficult to visualize the tertiary collateral circulation. It is still a difficult point, which makes it difficult to evaluate the ischemic penumbra based on the visualization of collateral circulation

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