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A registration method for MRI perfusion-diffusion images in acute ischemic stroke

An ischemic stroke and magnetic resonance technology, applied in medical science, diagnosis, diagnostic recording/measurement, etc., can solve problems such as difficult to solve the problem of accurate registration of DWI and ASL, avoid excessive loss of detailed information, help Effect of stroke diagnosis and prognosis judgment, avoiding artifacts and noise

Active Publication Date: 2022-04-26
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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Problems solved by technology

The commercial stroke processing software RAPID (rapid processing of perfusion and diffusion) can extract brain parameter maps of interest from MRI diffusion-weighted images (DWI) and perfusion-weighted images (PWI) (M. Straka, G.W.Albers, R. Bammer, Real-time diffusion-perfusion mismatch analysis in acutestroke, J. Magnetic Resonance Imaging, 32, 1024-1037, 2010), but it is difficult to solve the DWI and ASL precise registration problem

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  • A registration method for MRI perfusion-diffusion images in acute ischemic stroke
  • A registration method for MRI perfusion-diffusion images in acute ischemic stroke

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[0022] In order to facilitate those of ordinary skill in the art to understand and implement the present invention, the present invention will be described in further detail below in conjunction with the examples. It should be understood that the implementation examples described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0023] A registration method for magnetic resonance perfusion-diffusion images of acute ischemic stroke, comprising the following steps:

[0024] Step 1, preprocessing, aims to make the MRI perfusion-diffusion images of stroke consistent in terms of spatial resolution and improve registration accuracy.

[0025]Template space (Montreal Neurological Institute, MNI 152) can provide the spatial location of different anatomical structures of the brain, such as white matter, gray matter, frontal lobe, parietal lobe, occipital lobe, temporal lobe, putamen, posterior sulcus gyrus, thalamus...

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Abstract

The invention discloses a registration method of magnetic resonance perfusion-diffusion images for acute ischemic stroke. Firstly, through preprocessing such as resampling, the spatial resolution of structural images, functional images and template spaces of stroke is consistent. ;Secondly, the structural image of stroke is registered to the template space to obtain the deformation vector field; then, the functional image of stroke (cerebral blood flow map and diffusion-weighted image) is mapped to the template space by using the deformation vector field to realize stroke The perfusion images and diffusion images correspond to the spatial anatomical positions; finally, the clinical diagnosis and treatment indicators such as the mismatch, size, volume, and location of the infarct core / penumbra in the MRI diffusion-perfusion images of stroke are quantitatively analyzed. Accurate registration of stroke magnetic resonance perfusion-diffusion images helps to effectively evaluate the time window and tissue window of stroke patients, benefiting patients.

Description

technical field [0001] The invention belongs to the technical field of magnetic resonance imaging and digital images, and in particular relates to a magnetic resonance perfusion-diffusion image registration method for acute ischemic stroke. Background technique [0002] Stroke (also known as stroke) is a common cerebrovascular disease with an incidence rate of 246.8 / 100,000 and a mortality rate of 114.8 / 100,000, of which ischemic stroke accounts for about 87%, and cerebral hemorrhage accounts for about 10%. Subarachnoid hemorrhage accounts for about 3%, which brings a heavy burden to the society. Acute ischemic stroke, also known as acute cerebral infarction, is a focal brain dysfunction disease caused by interruption of blood supply to local brain tissue, accounting for 69.6% of stroke in my country. Once the onset occurs, the key to treatment and prognosis is to accurately define the period of the disease (time window), rescue the ischemic penumbra (tissue window), strive...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/055
CPCA61B5/055A61B5/0033A61B5/0042
Inventor 周欣娄昕邓鹤王成孙献平叶朝辉
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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