61 results about "Arterial occlusion" patented technology

A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period. Based upon the detected characteristics of the artery before and after occlusion, as well as the PWV, the system can determine the endothelial dysfunction and arterial health of the patient.

The invention discloses an instrument for arterial occlusion lesion treating and the application thereof. The instrument comprises a vascular ultrasound catheter, a treating micro catheter and a treating guiding line. The vascular ultrasound catheter and the treating micro catheter are integrally connected in parallel. One part of the treating guiding line is placed in the treating micro catheter, and the other part of the treating guiding line penetrates out of the treating micro catheter from a side wall outlet. According to the instrument, the vascular ultrasound catheter and the treating micro catheter are integrally connected in parallel, a double-cavity micro catheter is used for adjusting the treating guiding line to enter a vessel true lumen, thrombus is sucked out through the treating guiding line, and post-operation hidden danger is removed through one-time curing. The problem that in an intervention recanalization treating operation of blocking of coronary arteries, peripheral arteries and other organ pipelines, a treating guiding line cannot enter a true lumen easily is solved.

The invention relates to prostaglandin microemulsion-gel preparation and a preparation method thereof. The preparation comprises prostaglandin E1 or the derivative thereof, oil, emulsifier, assistant for emulsifying agent, gel substrate and water, and also possibly comprises a permeation accelerator, a preparation stabilizer, an antioxidant and antiseptics. The preparation has the advantages of good percutaneous permeability, no stimulation to skin and mucous membrane, simple preparation technique and stable quality, the preparation can be used for treating diseases such as ulcer of limbs caused by erectile dysfunction and chronic arterial occlusion and rest pain of limbs caused by microcirculatory disturbance.

The use of a collagenase containing formulation for degrading collagen within an occlusive atherosclerotic plaque in a chronic fibrotic occlusion, chronically occluded animal tube or cavity. A medical-related apparatus is provided comprising a medical-related device having provided thereto a therapeutic amount of a collagen degrading composition comprising a proteiolytic enzyme containing formulation. A method is provided for treating chronically occluded animal tubes and cavities by administering a therapeutic effective amount of a proteolytic enzyme-containing formulation adjacent to an occluding atherosclerotic plaque, waiting for a pre-angioplasty waiting period, followed by crossing the plaque with an angioplasty guide wire.

The invention provides phascolosoma esculenta plasmin, which is extracted from phascolosoma esculenta, and has double activities of directly dissolving fibrin and kinase. The phychemical performance of the plasmin is that: the molecular weight is between 28,000 and 32,000, the isoelectric point is between 4.6 and 6.6, the dissolution activity of fibrin does not change greatly under a temperature range between 30 and 70 DEG C, and the stability range to the pH value is between 5.0 and 9.0. The phascolosoma esculenta plasmin has the direct fibrin and kinase dissolving activities, has simple extracting process, low preparation cost and easily obtained raw materials, can be developed into intravenous injection, contains the plasmin capable of directly dissolving thrombus, and is expected to obtain better effect in treating catheter assisted thrombolysis treating peripheral arterial occlusion and deep venous thrombosis.

The invention relates to an auxiliary bandaging device for an elastic bandage, and belongs to the technical field of medical equipment. The auxiliary bandaging device is used for the postoperative hemostasis bandaging of the elastic bandage, and is characterized by comprising an upper fixing plate and a lower fixing plate, wherein the upper fixing plate is placed at a waist, the inner lateral surface of the upper fixing plate imitates the shape of the waist, and the outer lateral surface of the upper fixing plate is provided with salient points, grooves, fixing holes or sheaths; the lower fixing plate is placed outside thighs, the inner lateral surface of the lower fixing plate imitates the shapes of the thighs, and the outer lateral surface of the lower fixing plate is provided with salient points, grooves, fixing holes or sheaths; and the auxiliary bandaging device also comprises a front fixing plate an a rear fixing plate according to actual requirements. After patients do operation, the elastic bandage winds on the auxiliary bandaging device, so that the elastic bandage can be prevented from sliding and curling effectively; and compared with the conventional bandage hemostasis method, the auxiliary bandaging device has the advantage that after the auxiliary bandaging device is adopted, the bandage is not tied in flesh, so that the pain of the patients is relieved effectively. By using the auxiliary bandaging device for the elastic bandage, pressure can be reduced at any time according to actual requirements, so that the arterial occlusion of lower limbs and deep venous thrombosis of the patients are avoided.

Disclosed are a vascular disease examination system capable of examining and diagnosing vascular diseases such as arterial obliteration by determining the feature quantities of blood flow velocity waveforms or blood pressure waveforms or blood flow rates, and a bypass vascular diagnosing system. A blood flow velocity or blood pressure at a target location of the body is measured A waveform analysis unit 4 determines the feature quantity of a blood flow waveform (or blood pressure waveform), for displaying on an output unit 5. The feature quantity includes a time constant, Fourier transform value, differentiated value, integrated value, rise/fall time, and sharpness or gradient of rise. Feature quantity of a blood flow velocity waveform (or blood pressure waveform) indicated in numeric value enables a correct examination/diagnosis.

Featured are methods for non-invasive assessment of vascular reactivity. The methods of the invention use phase contrast magnetic resonance imaging angiography and use the image data thereby acquired to measure shear rate, radius of the vasculature and flow through the vasculature. According to one aspect, such acquisition of image data occurs before and during, an arterial occlusion and according to another aspect such acquisition of image data occurs before during and after arterial occlusion. The disclosed methods of the invention allow for reproducible, non-invasive diagnosis of early stage indicators of atherosclerosis.

A method for digital thermal monitoring assessment of vascular function comprising a temporary arterial occlusion using a pneumatic cuff positioned on a subject's upper limb, monitoring skin temperature at the fingertip of the occluded limb for a period of time before, during, and after the occlusion, calculating a Zero Reactivity Curve based on variables including start temperature, room temperature, and the slope of temperature decline during the occlusion, and assessing vascular function based on comparing the Zero Reactivity Curve and the observed temperature rebound after the occlusion is removed. A vascular reactivity monitoring apparatus for measuring skin surface temperature comprising an inflatable cuff for placement around a subject's limb, a digital thermal measuring device and photoplethysmography measuring device for placement on a finger of the subject's limb wearing the cuff and a second digital monitoring device and photoplethysmography measuring device for placement on a finger of the subject's contralateral limb.

Devices, and methods for synchronizing cerebro-hemodynamic signals are disclosed. In one aspect, the devices and methods may include synchronizing first and second signals indicative of hemodynamic characteristics within a subject's brain. Differences may be determined between the synchronized signals and used to provide information for diagnosing changes in arterial occlusion. Differences between the synchronized signals may include differences, such as timing delays, between signature features of the synchronized signals. The first and second signals may be indicative of hemodynamic characteristics in first and second hemisphere's of a subject's brain. The first and second signals may be bioimpedance signals.

A thrombolysis catheter apparatus is disclosed comprising: (a) an elongated thrombolysis catheter portion comprising a plurality of independently controllable electroactive polymer actuators, which provide a curvature to the thrombolysis catheter based upon received control signals; (b) a control unit coupled to the plurality of actuators and sending the control signals to the plurality of actuators; and (c) an occlusion removal device. Also disclosed is a method of treating an arterial occlusion by advancing the thrombolysis catheter portion through the arterial vasculature of a patient to a position proximate the occlusion, while controlling the shape of the thrombolysis catheter portion using the control unit. The occlusion is then removed using the occlusion removal device.

The invention discloses a blood flow guiding dense net stent. The dense net stent is formed by a plurality of independent net pipe stents. A plurality of multiple independent net pipe stents can penetrate through one another to form an independent net pipe stent, and the independent net pipe stent is formed by weaving metal wires, anti-thrombus polymer fibers and polymer fibers for promoting endothelialization of vascular cells; when used for interventional therapy of aneurysm, the blood flow guiding dense net stent has good anti-thrombus and endothelialization promotion performance of a cardiovascular stent, and the diameter of the stent meshes is gradually increased along with gradual closure of the aneurysm and vascular reconstruction, so that artery occlusion of perforator and collateral branches in a coverage area of the interventional stent can be effectively prevented; the safety and effectiveness of vascular reconstruction are greatly improved; meanwhile, due to the fact that the metal wires with different diameters and the polymer fibers are used, the dense net stent is rigid and soft, good radial supporting force can be kept, and safety and effectiveness of the stent are further guaranteed; and the stent is simple in preparation process and low in cost, and can be used for automatic production.

The invention relates to an integrated stent for an aortoiliac artery. The integrated stent comprises a metal stent and a lamination layer on the metal stent, the metal stent comprises a main portion, a first branch portion and a second branch portion to form an integrated Y shape matched with an inner cavity shape of the aortoiliac artery, and the main portion, the first branch portion and the second branch portion are communicated with one another. The metal stent is a tubular stent formed by braiding of metal wires. Instead of previous split stents used in the aortoiliac artery, the integrated stent for the aortoiliac artery is an integrated stent for treatment in occlusive cavity of the aortoiliac artery; owing to integration of the main portion, the first branch portion and the second branch portion, the whole stent is steady and prevented from displacement under high-speed blood impact; in addition, due to a large aortoiliac artery occlusive lesion range, the integrated stent guarantees complete isolation of lesions without influences on subsequent far-end lesion intra-cavity treatment on the premise of safe and effective release.

The invention belongs to the technical field of medicament, and discloses a bilobalide and a use of derivative thereof in treating encephaledema, especially encephaledema caused by cerebral ischemia. Research results show that the bilobalide can reduce the brain tissue water content and the cerebral infarction area of a permanent medium-sized arterial occlusion model animal. The mechanism of the bilobalide for weakening the formation of encephaledema is to lower the mRNA transcription level of aquaporin 1, 4 and 9 and the expression level of protein in different stages. The bilobalide can be combined with a pharmaceutically acceptable carrier to be prepared into a clinically acceptable injection, a transdermal preparation or an oral administration preparation for treating the encephaledema.

The invention discloses a method for evaluating collateral vessels and tissue function based on cerebral blood flow, which comprises the following steps of: firstly, registering cerebral blood flow graphs with multiple delay times of a patient diagnosed with major artery occlusion infarction to realize one-to-one correspondence on a spatial anatomical structure; secondly, removing cerebral shellsand extracerebral structures of the cerebral blood flow graphs with multiple delay times after registration, and calculating cerebral blood flow difference graphs with multiple delay times; then, visualizing cerebral collateral blood circulation conditions, and quantifying collateral blood flow related information, such as collateral blood flow distribution range, velocity, flow and the like; andfinally, by combining with the infarction core area of the patient diagnosed with the major artery occlusion infarction, evaluating the ischemic penumbra, such as the size, volume and position of theischemic penumbra.

The invention provides a femoral artery puncture suture device. The installing end of a needle pushing tube is installed in the middle of an arc-shaped puncture needle. Two ends of a suture line are respectively fixed to two ends of the arc-shaped puncture needle. The middle of the suture line is fixed to the operating end of the needle pushing tube. The arc-shaped puncture needle is made from memory alloy. The arc-shaped puncture needle is arranged in a catheter sheath, and needle points at two ends are in inward stress-compressed shapes. When the needle pushing tube pushes the arc-shaped puncture needle output of the catheter sheath, the needle points at the two ends of the arc-shaped puncture needle are outwards released to be in memory shapes. The arc-shaped puncture needle of the femoral artery puncture suture device is put in a femoral artery puncture port by using the memory alloy and penetrates out from inside to outside, the suture line penetrates out, accordingly inner diaphragm floating caused by artery atherosclerotic plaque lifting due to threading from outside to inside is avoided, interlayer and secondary thrombosis formation possibly occurred under blood impact is avoided, and accordingly the complication of arterial occlusion is avoided.

The present invention relates to a method for generating a non-human model animal of an arterial occlusive disease, wherein the method is characterized in that an artery is occluded at a specific site by ligating it or with an autologous blood clot. In particular, the present invention relates to a method and a kit for generating a cardiac infarction model, as well as a cardiac infarction animal model obtained by employing the method or kit, characterized in that in a non-human experimental animal, a blood vessel is ligated downstream of an arterial site of the heart to be occluded, followed by occluding the artery at said site. In addition, the present invention also relates to a method and a system for generating a non-human animal model of arterial embolus, as well as an arterial embolus animal model obtained by employing the method or system, characterized by adding an coagulating agent to autologous blood to form an autologous blood clot and subsequently employing an angiographic apparatus in delivering the autologous blood clot into an artery.

A diagnostic ECG system analyzes lead traces for evidence of ST elevation in the lead signals. The pattern of ST elevation in leads having predetermined vantage points to the electrical activity of the heart and, in some instances, the presence of ST depression in certain other leads, identifies a specific coronary artery or branch as the culprit coronary artery for an acute ischemic event. ECG measurements which are associated with the identity of specific arterial occlusion locations are calculated and used to form a classifier of the probability of occlusion at different locations. The location identified as having the highest probability is indicated to a user as the most likely occlusion location.