The invention relates to a chopping stable instrument amplifier, comprising a low-gain high-frequency closed circuit, a high-gain low-frequency closed circuit, and a residual RRL (Ripple Reduction Loop); wherein the low-gain high-frequency closed circuit consists of an operational amplifier Gm3 and an operational amplifier Gm4; the high-gain low-frequency closed circuit consists of a chopper CH1,an operational amplifier Gm1, a chopper CH2, an operational amplifier Gm2, a switched capacitor notch filter NOTCH and the operational amplifier Gm4; and the residual RRL consists of induction capacitors C41 and C42, a cascode buffer Cascade Buffer 1, a chopper CH3, a cascade buffer Cascade Buffer 2, an integrating capacitor Cint, and an operational amplifier Gm5. The chopping stable instrument amplifier of the invention has the beneficial effects that: through the low-gain high-frequency closed circuit and the high-gain low-frequency closed circuit, offset voltage and 1 / f noise of a circuit can be effectively eliminated, and bandwidth of the circuit can be greatly raised, on that basis the RRL is introduced to effectively reduce the amplitude of the ripple output by the circuit, thus thewhole circuit noise is optimized, low-noise output is achieved, thereby improving circuit accuracy.