The present invention relates to an aztreonam compound preparation method, which comprises the following operation steps: (1) dissolving and mixing a compound represented by a formula (I) and a compound represented by a formula (II) with an organic solvent, adding an alkali at a room temperature, carrying out a complete stirring reaction, cooling to a temperature of -20-10 DEG C, adding trifluoroacetic acid in a dropwise manner, stirring, filtering, and drying the filter cake to obtain a compound represented by a formula (III); and dissolving the compound represented by the formula (III) in formic acid, adding anisole, cooling to a temperature of -20-10 DEG C, adding hydrochloric acid in a dropwise manner, stirring, adding ethyl acetate, stirring, filtering, washing the filter cake with ethyl acetate, and drying to obtain the aztreonam compound represented by a formula (IV). Compared with the aztreonam compound preparation method in the prior art, the aztreonam compound preparation method of the present invention has characteristics of stable raw material source, low price, low cost, short reaction period, simple operation, high yield, less three-waste, environmental pollution reduction and high product purity, and is suitable for industrial production. The formula I, II, III and IV are as the follows.