89 results about "Imipenem" patented technology

Substituted bicyclic beta-lactams of Formula I: (I), are β-lactamase inhibitors, wherein a, X, R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with β-lactam antibiotics. In particular, the compounds can be employed with a β-lactam antibiotics (e.g., imipenem, piperacillin, or ceftazidime) against microorganisms resistant to β-lactam antibiotics due to the presence of the β-lactamases.

The present invention relates to an improved, cost effective and industrially advantageous process for the preparation of imipenem.

The invention discloses a carboxyl-containing polymer, a preparation method and application thereof, as well as a preparation method of a supported catalyst and an imipenem antibiotic intermediate. The polymer is polymerized by three monomers with different structures. The carboxyl-containing polymer is a cross-linked polymer, contains a large number of benzene rings on a polymer chain, and can improve the rigidity and hardness of the polymer so as to effectively improve the mechanical properties of the polymer. Simultaneously, a carboxyl group is taken as a main functional group in the polymer and taken as a carrier, and a metal in the prepared supported metal catalyst has relatively good connection stability with the polymer through coordination reaction of the carboxyl group with the heavy metal. The stability of the supported metal catalyst can be improved through the factors in the two aspects, and the catalyst can be repeatedly used without losing catalytic activity. Simultaneously, the loss of active ingredients in the heavy metal can be reduced, and the production cost can be reduced.

The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity, which comprises dissolving crude imipenerm in warm water to which some base has been added to obtain a solution, subjecting the resultant solution to activated carbon treatment, and adding an organic solvent to precipitate imipienem monohydrate as a crystalline product.

The invention relates to methods and instruments for determining the resistances of microbes to antibiotics, in particular those microbes which produce beta-lactamases. The method determines the resistance of the microbes in less than an hour by incubating a tiny quantity of the microbes on a mass spectrometric sample support plate after they have been combined with a dosed quantity of a suitable antibiotic, for example the beta-lactam antibiotic imipenem, and by direct mass spectrometric measurement of the breakdown of the antibiotic by the microbial enzymes.