The invention relates to a tetrahydrobenzofuran-4-ketoximetriazole
medicine. The
medicine is a cis-isomeride of tetrahydrobenzofuran-4-ketoximetriazole
medicine, and also comprises pharmaceutically acceptable salts and derivatives of the tetrahydrobenzofuran-4-ketoximetriazole medicine. A preparation method of the tetrahydrobenzofuran-4-ketoximetriazole medicine comprises the following steps: preparing 3,6,6-trimethyl-6,7-dihydrobenzofuran-4(5H)-one (intermediate 1) and nitrine (intermediate 2), carrying out a
condensation reaction to convert the intermediate 1 into cis-
oxime (intermediate 3), separating, purifying, alkylating to obtain
propargyl oxime ether (intermediate 4), and carrying out a
copper catalyzed
cycloaddition reaction on the intermediate 4 and the nitrine (intermediate 2) to synthesize 1,2,3-
triazole substituted furocyclohexanone
oxime and a derivative thereof. The above compounds have dual curative effects of antiulcer and
stomach cancer resistance, and can be used in
stomach cancer treatment as alternative medicines.