6 results about "Corilagin" patented technology

The invention discloses an application of an RUNX2 inhibitor in preparation of a medicine for treating vascular calcification related diseases, and the RUNX2 inhibitor comprises an ester compound which is selected from at least one of Corilagin, 1, 2, 3, 6-tetragalloylglucose, NADP (Nicotinamide Adenine Dinucleotide Phosphate), Stafib-2 and uridine triphosphate sodium salt. The ester compound provided by the invention is used as a drug for inhibiting vascular calcification and progression of the RUNX2 inhibitor, and provides a new thought, a target spot and a small molecule drug for treatment of vascular calcification. The five small molecule compounds have good drug safety and a strong vascular calcification inhibition effect, and can be used as candidate drugs for inhibiting vascular calcification.

The invention discloses an application of corilagin in preparation of a medicine for treating and / or preventing a non-alcoholic fatty liver disease. It is proved for the first time that corilagin can reduce lipid accumulation and inhibit oxidative stress through an Nrf2-ARE endogenous antioxidant pathway, has an obvious improvement effect on the non-alcoholic fatty liver disease, and it is proved that corilagin is expected to serve as an alternative medicine for treating the NAFLD, and the corilagin can be used as a medicine for treating the NAFLD. The potential application value is realized on the improvement and treatment of the NAFLD disease.

This invention relates to the field of traditional Chinese medicine analysis, and particularly to a method for determining the content of multiple components in Terminalia chebula and constructing its characteristic fingerprint spectrum. The method provided by this invention can simultaneously determine chebulin, gallic acid, 4-galloshikimic acid, 5-galloshikimic acid, punicalin (punicalin A&B), corilagin, 1,3,6-tri-O-galloyl-β-D-glucose, chebulin, urolithin M5, chebulin tannic acid, chebulin-lintannic acid, and ellagic acid in Terminalia chebula. It exhibits high sensitivity, good precision, repeatability, and stability, and can be used to detect the tannin content in the extract at each step of the tannin extraction process, as well as for related detection in the study and quality evaluation of tannin components in Terminalia chebula. It can also be used to construct the characteristic fingerprint spectrum of Terminalia chebula. This method can also be used for determining the content of tannin compounds and constructing their characteristic fingerprint spectrum in Terminalia chebula, which contains similar tannin compounds to Terminalia chebula.

The invention discloses a corilagin molecular imprinting electrochemical sensor as well as a preparation method and application thereof. The sensor comprises a glassy carbon electrode substrate, a boric acid functionalized Mxene conductive affinity composite material layer covering the glassy carbon electrode substrate and a corilagin molecularly imprinted polymer layer located on the surface of the boric acid functionalized Mxene conductive affinity composite material layer. The preparation method comprises the following steps: preparing a boric acid functionalized Mxene composite material and preparing a modification liquid; dispensing the modified liquid on the pretreated glassy carbon electrode to prepare a modified electrode; immobilizing corilagin template molecules through boric acid affinity reaction; carrying out surface molecular imprinting polymerization; and eluting the template molecules to form an imprinting cavity, thereby obtaining the sensor. The sensor disclosed by the invention has excellent conductivity, high selectivity and high sensitivity by constructing an integrated structure of a conductive nano skeleton and a dual recognition layer, and is wide in corilagin detection linear range, low in detection limit and good in stability.

The invention provides a method for detecting multiple active ingredients in fructus chebulae immaturus and application. According to the present invention, the aqueous solvent extraction method is performed on the fructus chebulae immaturus powder, such that the acetonitrile and the aqueous solution containing 0.04-0.06% of formic acid are adopted to determine the mobile phase system and the gradient elution process, and the simultaneous detection of the six active components such as gallic acid, punicalagin (punicalagin A and punicalagin B), corilagin, myrobalan tannic acid, ellagic acid and myrobalan acid in the fructus chebulae immaturus can be achieved within 40 min. The method for determining the content of the terminalia chebula hance has the advantages that the method is high in precision, repeatability, specificity and stability, high in practical operability, low in cost and short in detection time, quality controllability of terminalia chebula hance medicinal materials and preparations thereof is guaranteed, and scientific basis is provided for quality control and standardization of terminalia chebula hance.

This invention discloses a novel use of corilagin or a pharmaceutically acceptable salt thereof in the preparation of medicaments for the treatment and / or prevention of human papillomavirus (HPV) infection and related diseases. This invention is the first to discover and demonstrate that corilagin can downregulate the expression of HPV E6 and / or E7 oncogenic proteins, thereby inhibiting viral activity and blocking the malignant transformation process driven by the virus. Based on this original discovery, corilagin or a pharmaceutically acceptable salt thereof can be used to prepare medicaments or pharmaceutical compositions for the prevention and / or treatment of persistent HPV infection, reversal of cervical intraepithelial neoplasia, adjuvant therapy for cervical cancer, and treatment of other HPV-related diseases (including but not limited to oropharyngeal HPV infection, anal HPV infection, vulvar intraepithelial neoplasia, etc.), preferably prepared as a mucosal topical dosage form. This discovery provides a novel, structurally well-defined small molecule drug candidate for the prevention and treatment of HPV-related diseases.