New application of corylagin in the preparation of anti-sleep deprivation injury drugs

A technology of sleep deprivation and drug action, applied in the field of biomedicine, can solve the problems of less research, achieve the effect of improving the body condition, reducing the damage of body functions, and improving the level of cholinergic

Active Publication Date: 2021-11-16
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

Chinese herbal medicine has always had the advantages of treating complex chronic diseases with multiple components and multiple targets. At present, there are few discussions on traditional Chinese medicine and ethnic medicine in the research of sleep deprivation treatment

Method used

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  • New application of corylagin in the preparation of anti-sleep deprivation injury drugs
  • New application of corylagin in the preparation of anti-sleep deprivation injury drugs
  • New application of corylagin in the preparation of anti-sleep deprivation injury drugs

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Embodiment Construction

[0013] The present invention will be further described below in conjunction with the embodiments.

[0014] Animal experiment:

[0015] 1 Materials and methods

[0016] 1.1 Experimental animals and groups

[0017] animals and groups

[0018] SPF grade Kunming mice (provided by the Experimental Animal Center of Air Force Military Medical University), weighing (18-20) g, were randomly divided into a control group, a model group, and a Corilagin group, with 12 mice in each group. Before the experiment, let the mice familiarize themselves with the environment for 1 week.

[0019] 1.2. Preparation of sleep deprivation model and method of administration

[0020] 1.2.1 Establishment of sleep deprivation model

[0021] The mouse model was established by the small platform water environment method. A mouse box was made according to the literature, and there was a platform with a diameter of 6.0 cm and a height of 8.0 cm. Fill the surrounding area with water, the water surface is ...

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Abstract

The present invention relates to the new application of Corilagin in the preparation of sleep deprivation medicine. The mouse sleep model was established by using the small platform water environment method, and the Morris maze / platform experiment was carried out to investigate the learning and memory ability, and further detected the oxidoreductase and cholinergic indicators of the hippocampal tissue. The results showed that the administration of corilagin significantly improved the behavioral disorders of sleep-deprived mice, relieved the oxidative stress damage of hippocampus tissue, and strengthened the cholinergic system. It is suggested that Corilagin can significantly improve the behavior of sleep-deprived mice, and has a certain application prospect in coping with high-intensity continuous operations.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the novel use of Corilagin in anti-sleep deprivation injury. Background technique [0002] Sleep is an important physiological activity necessary for individual survival and development, and it plays a key role in the body's body temperature regulation, energy balance, and immune function. At present, WHO estimates that more than 300 million patients in the world have sleep disorders, and the number of sleep disorders directly related to social stress and neuropsychiatric diseases may be as high as 30%. According to reports, almost half of insomniacs are accompanied by various mental diseases, and the diseases caused by sleep disorders account for more than 80% of the total number of various diseases. Sleep disturbance has become an increasingly prominent medical and public health problem. In addition, passive sleep deprivation caused by sudden natural disasters and war conditions has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7024A61P25/00A61P39/00
CPCA61K31/7024A61P25/00A61P39/00
Inventor 丁一文爱东王文军王婧雯郭超贾娜高凯赵超窦芳
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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